{"id":"https://openalex.org/W3012961191","doi":"https://doi.org/10.1158/1538-7445.sabcs19-p3-09-05","title":"Abstract P3-09-05: Predictive markers of response to durvalumab concurrent with nab-paclitaxel and dose dense doxorubicin cyclophosphamide (ddAC) neoadjuvant therapy for triple negative breast cancer (TNBC)","display_name":"Abstract P3-09-05: Predictive markers of response to durvalumab concurrent with nab-paclitaxel and dose dense doxorubicin cyclophosphamide (ddAC) neoadjuvant therapy for triple negative breast cancer (TNBC)","publication_year":2020,"publication_date":"2020-02-15","ids":{"openalex":"https://openalex.org/W3012961191","doi":"https://doi.org/10.1158/1538-7445.sabcs19-p3-09-05","mag":"3012961191"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.sabcs19-p3-09-05","doi":"https://doi.org/10.1158/1538-7445.sabcs19-p3-09-05","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.sabcs19-p3-09-05","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066496998","display_name":"Kim Blenman","orcid":"https://orcid.org/0000-0001-6070-0728","observed_orcids":["https://orcid.org/0000-0001-6070-0728"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kim RM Blenman","raw_affiliation_strings":["Yale University, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100371880","display_name":"Xiaotong Li","orcid":"https://orcid.org/0000-0003-1644-6835","observed_orcids":["https://orcid.org/0000-0003-1644-6835"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaotong Li","raw_affiliation_strings":["Yale University, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087940597","display_name":"Micha\u0142 Marczyk","orcid":"https://orcid.org/0000-0003-2508-5736","observed_orcids":["https://orcid.org/0000-0003-2508-5736"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michal Marczyk","raw_affiliation_strings":["Yale University, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033137375","display_name":"Tess A. O\u2019Meara","orcid":"https://orcid.org/0000-0002-4778-2842","observed_orcids":["https://orcid.org/0000-0002-4778-2842"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tess O'Meara","raw_affiliation_strings":["Yale University, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066080145","display_name":"Vesal Yaghoobi","orcid":"https://orcid.org/0000-0001-6534-1293","observed_orcids":["https://orcid.org/0000-0001-6534-1293"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vesal Yaghoobi","raw_affiliation_strings":["Yale University, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086711331","display_name":"Vignesh Gunasekharan","orcid":"https://orcid.org/0000-0002-2471-8485","observed_orcids":["https://orcid.org/0000-0002-2471-8485"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vignesh Gunasekharan","raw_affiliation_strings":["Yale University, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046963012","display_name":"Tristen S. Park","orcid":"https://orcid.org/0000-0001-5842-9422","observed_orcids":["https://orcid.org/0000-0001-5842-9422"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tristen Park","raw_affiliation_strings":["Yale University, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027326018","display_name":"David L. Rimm","orcid":"https://orcid.org/0000-0001-5820-4397","observed_orcids":["https://orcid.org/0000-0001-5820-4397"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Rimm","raw_affiliation_strings":["Yale University, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021113979","display_name":"Lajos Pusztai","orcid":"https://orcid.org/0000-0001-9632-6686","observed_orcids":["https://orcid.org/0000-0001-9632-6686"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lajos Pusztai","raw_affiliation_strings":["Yale University, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"80","issue":"4_Supplement","first_page":"P3","last_page":"09"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.03689999878406525,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/durvalumab","display_name":"durvalumab","score":0.8529999852180481},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.8159999847412109},{"id":"https://openalex.org/keywords/neoadjuvant-immunotherapy","display_name":"neoadjuvant immunotherapy","score":0.8980000019073486},{"id":"https://openalex.org/keywords/nab-paclitaxel","display_name":"nab-paclitaxel","score":0.9190000295639038},{"id":"https://openalex.org/keywords/pathological-complete-response","display_name":"pathological complete response","score":0.9670000076293945},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.9760000109672546},{"id":"https://openalex.org/keywords/immune-cell-density","display_name":"immune cell density","score":0.8059999942779541},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9139999747276306},{"id":"https://openalex.org/keywords/cd68-macrophages","display_name":"CD68+ macrophages","score":0.9409999847412109},{"id":"https://openalex.org/keywords/tumor-inflammation","display_name":"tumor inflammation","score":0.6079999804496765},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.4090000092983246}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6002610921859741},{"id":"https://openalex.org/C2780110267","wikidata":"https://www.wikidata.org/wiki/Q7843332","display_name":"Triple-negative breast cancer","level":4,"score":0.5464017987251282},{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.5071725845336914},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4315507411956787},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4246104955673218},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4162047207355499},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4100317060947418},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40578949451446533},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3994526267051697},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3968483805656433},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2546548843383789},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1915445327758789}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.sabcs19-p3-09-05","doi":"https://doi.org/10.1158/1538-7445.sabcs19-p3-09-05","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.sabcs19-p3-09-05","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4225898639","https://openalex.org/W2912529632","https://openalex.org/W3008580471","https://openalex.org/W3044594121","https://openalex.org/W3009939571","https://openalex.org/W3127886518","https://openalex.org/W3129557755","https://openalex.org/W3159104171","https://openalex.org/W7129549823","https://openalex.org/W3166161359"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"The":[2],"goal":[3],"of":[4,160,204,239,241,289,311,315,330,373,377,420,444],"this":[5,342],"analysis":[6],"was":[7,132,135,212,234,272,354],"to":[8,26,169,201,236,392,422],"identify":[9],"immune":[10,123,180,378],"cell":[11,124,258,278,369],"types":[12],"and":[13,78,93,102,116,130,143,179,182,187,260,268,299,319,321,361,382,395,427],"mRNA":[14],"expression":[15,288,314,372,380],"signatures":[16,194,298,324,335,381],"that":[17],"are":[18,387],"associated":[19,243,307,326,338,388],"with":[20,30,107,157,223,244,250,308,327,339,389,425],"pathologic":[21,245],"complete":[22],"response":[23,190,281,340,385,421],"(pCR:":[24],"ypT0/N0)":[25],"neoadjuvant":[27,393,433],"durvalumab":[28,423],"concurrent":[29,424],"weekly":[31],"nab-paclitaxel":[32,426],"(100":[33],"mg/m2)":[34],"x":[35,40],"12":[36],"followed":[37],"by":[38,88],"ddAC":[39],"4":[41],"chemotherapy":[42],"in":[43,69,126,173,266,276,341],"stage":[44],"I-III":[45],"triple":[46,436],"negative":[47,437],"breast":[48,438],"cancer":[49,439],"(TNBC).":[50],"Methods:":[51],"Pre-treatment":[52],"core":[53,84,138],"needle":[54],"biopsies":[55,85,139],"were":[56,86,96,147,195,217,305,325,336],"obtained":[57],"from":[58,137],"57":[59],"patients":[60],"(n=25":[61],"pCR,":[62,251],"n=32":[63],"residual":[64,331],"disease":[65],"(RD))":[66],"who":[67],"participated":[68],"Phase":[70],"I/II":[71],"clinical":[72],"trial":[73],"(NCT02489448)":[74],"for":[75,90,226,263,356,435],"RNA":[76,134,285],"sequencing":[77],"histology":[79],"assessment.":[80],"Formalin-fixed":[81],"paraffin-embedded":[82],"(FFPE)":[83],"stained":[87],"immunofluorescence":[89],"CD8,":[91],"CD68":[92,277],"cytokeratin,":[94],"images":[95],"acquired":[97],"on":[98,149],"the":[99,108,127,174,284,300,349,357,445],"Vectra-Polaris":[100],"system":[101],"analyzed":[103],"using":[104,152,197,219],"InForm":[105],"software":[106],"adaptive":[109],"segmentation":[110],"into":[111,141],"three":[112],"compartments:":[113],"Tumor,":[114],"Stroma,":[115],"All":[117],"(Tumor":[118],"+":[119,359,363],"Stroma).":[120],"Correlation":[121,176],"between":[122,177,280],"density":[125,259,279],"tissue":[128],"compartments":[129],"pCR":[131,178,351],"assessed.":[133],"extracted":[136],"collected":[140],"RNAlater":[142],"poly-A":[144],"enriched":[145],"mRNAs":[146],"sequenced":[148],"Illumina":[150],"platform":[151],"NovaSeq":[153],"paired-end,":[154],"100bp":[155],"fragments,":[156],"a":[158,261,374],"depth":[159],"50":[161],"million":[162],"reads.":[163],"Six":[164],"specimens":[165],"failed":[166],"QC":[167],"due":[168],"insufficient":[170],"tumor":[171,267,301],"cells":[172],"sample.":[175],"markers":[181,419],"previously":[183],"published":[184],"immune,":[185],"proliferation":[186],"DNA":[188,383],"damage":[189,384],"deficiency":[191,386],"(DDRD)":[192],"gene":[193,303,323,334,347,379],"assessed":[196],"logistic":[198],"regression.":[199],"Due":[200],"high":[202,287,371],"overlap":[203],"genes":[205,216,242],"across":[206],"signatures,":[207],"no":[208,273],"multiple":[209,227],"testing":[210],"correction":[211,225],"done.":[213],"Differentially":[214],"expressed":[215],"found":[218],"DESeq2":[220],"R":[221],"package":[222],"Benjamini-Hochberg":[224],"testing.":[228],"Broadside,":[229],"an":[230],"interaction":[231],"mining":[232],"tool,":[233],"used":[235],"extract":[237],"sets":[238],"combinations":[240],"response.":[246],"Results:":[247],"In":[248],"cases":[249],"we":[252],"detected":[253],"significantly":[254,306],"higher":[255,264,309,328],"overall":[256],"CD8":[257,265,368],"trend":[262],"stroma":[269],"compartments.":[270],"There":[271],"significant":[274],"difference":[275],"groups.":[282],"At":[283,345],"level,":[286,348],"DDRD,":[290],"IFN\u03b3,":[291],"T-cell,":[292],"B-cell,":[293],"dendritic":[294],"cell,":[295],"M1":[296],"macrophage":[297],"inflammation":[302],"signature":[304],"rate":[310,329],"pCR.":[312],"High":[313,367],"epithelial":[316],"mesenchymal":[317],"transition":[318],"TGF\u03b2":[320],"IL8/VEGF":[322],"disease.":[332],"Proliferation":[333],"not":[337],"TNBC":[343],"population.":[344],"individual":[346],"highest":[350],"predictive":[352],"value":[353],"observed":[355],"STAT1":[358],"PCF11":[360],"LAMP3":[362],"SDR39U1":[364],"doublets.":[365],"Conclusion:":[366],"density,":[370],"broad":[375],"range":[376],"greater":[390],"sensitivity":[391],"anti-PD-L1":[394],"chemotherapy.":[396],"Citation":[397],"Format:":[398],"Kim":[399],"RM":[400],"Blenman,":[401],"Xiaotong":[402],"Li,":[403],"Michal":[404],"Marczyk,":[405],"Tess":[406],"O'Meara,":[407],"Vesal":[408],"Yaghoobi,":[409],"Vignesh":[410],"Gunasekharan,":[411],"Tristen":[412],"Park,":[413],"David":[414],"Rimm,":[415],"Lajos":[416],"Pusztai.":[417],"Predictive":[418],"dose":[428],"dense":[429],"doxorubicin":[430],"cyclophosphamide":[431],"(ddAC)":[432],"therapy":[434],"(TNBC)":[440],"[abstract].":[441],"In:":[442],"Proceedings":[443],"2019":[446,452],"San":[447,455],"Antonio":[448],"Breast":[449],"Cancer":[450,461],"Symposium;":[451],"Dec":[453],"10-14;":[454],"Antonio,":[456],"TX.":[457],"Philadelphia":[458],"(PA):":[459],"AACR;":[460],"Res":[462],"2020;80(4":[463],"Suppl):Abstract":[464],"nr":[465],"P3-09-05.":[466]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2020-04-03T00:00:00"}