{"id":"https://openalex.org/W3012831111","doi":"https://doi.org/10.1074/jbc.ra120.012525","title":"Endorepellin evokes an angiostatic stress signaling cascade in endothelial cells","display_name":"Endorepellin evokes an angiostatic stress signaling cascade in endothelial cells","publication_year":2020,"publication_date":"2020-03-23","ids":{"openalex":"https://openalex.org/W3012831111","doi":"https://doi.org/10.1074/jbc.ra120.012525","mag":"3012831111","pmid":"https://pubmed.ncbi.nlm.nih.gov/32205445","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7212646"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.ra120.012525","doi":"https://doi.org/10.1074/jbc.ra120.012525","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.ra120.012525","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.ra120.012525","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036208680","display_name":"Aastha Kapoor","orcid":"https://orcid.org/0000-0002-7954-9113","observed_orcids":["https://orcid.org/0000-0002-7954-9113"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]},{"id":"https://openalex.org/I4210106595","display_name":"Sidney Kimmel Cancer Center","ror":"https://ror.org/010h6g454","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210106595"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aastha Kapoor","raw_affiliation_strings":["Department of Pathology, Anatomy, and Cell Biology and the Cancer Cell Biology and Signaling Program, Kimmel Cancer Center, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107"],"raw_orcid":"https://orcid.org/0000-0002-7954-9113","affiliations":[{"raw_affiliation_string":"Department of Pathology, Anatomy, and Cell Biology and the Cancer Cell Biology and Signaling Program, Kimmel Cancer Center, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107","institution_ids":["https://openalex.org/I149251103","https://openalex.org/I4210106595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014379165","display_name":"Carolyn G. Chen","orcid":"https://orcid.org/0000-0003-4933-6544","observed_orcids":["https://orcid.org/0000-0003-4933-6544"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]},{"id":"https://openalex.org/I4210106595","display_name":"Sidney Kimmel Cancer Center","ror":"https://ror.org/010h6g454","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210106595"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carolyn G. Chen","raw_affiliation_strings":["Department of Pathology, Anatomy, and Cell Biology and the Cancer Cell Biology and Signaling Program, Kimmel Cancer Center, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107"],"raw_orcid":"https://orcid.org/0000-0003-4933-6544","affiliations":[{"raw_affiliation_string":"Department of Pathology, Anatomy, and Cell Biology and the Cancer Cell Biology and Signaling Program, Kimmel Cancer Center, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107","institution_ids":["https://openalex.org/I149251103","https://openalex.org/I4210106595"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030553564","display_name":"Renato V. Iozzo","orcid":"https://orcid.org/0000-0002-5908-5112","observed_orcids":["https://orcid.org/0000-0002-5908-5112"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]},{"id":"https://openalex.org/I4210106595","display_name":"Sidney Kimmel Cancer Center","ror":"https://ror.org/010h6g454","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210106595"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Renato V. Iozzo","raw_affiliation_strings":["Department of Pathology, Anatomy, and Cell Biology and the Cancer Cell Biology and Signaling Program, Kimmel Cancer Center, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 renato.iozzo@jefferson.edu","Department of Pathology, Anatomy, and Cell Biology and the Cancer Cell Biology and Signaling Program, Kimmel Cancer Center, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107"],"raw_orcid":"https://orcid.org/0000-0002-5908-5112","affiliations":[{"raw_affiliation_string":"Department of Pathology, Anatomy, and Cell Biology and the Cancer Cell Biology and Signaling Program, Kimmel Cancer Center, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 renato.iozzo@jefferson.edu","institution_ids":["https://openalex.org/I149251103","https://openalex.org/I4210106595"]},{"raw_affiliation_string":"Department of Pathology, Anatomy, and Cell Biology and the Cancer Cell Biology and Signaling Program, Kimmel Cancer Center, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107","institution_ids":["https://openalex.org/I149251103","https://openalex.org/I4210106595"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5030553564"],"corresponding_institution_ids":["https://openalex.org/I149251103","https://openalex.org/I4210106595"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.2149,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.76722652,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"295","issue":"19","first_page":"6344","last_page":"6356"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.4975999891757965,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.4975999891757965,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.3716000020503998,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.0681999996304512,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endorepellin","display_name":"endorepellin","score":1.0},{"id":"https://openalex.org/keywords/perlecan","display_name":"perlecan","score":0.902999997138977},{"id":"https://openalex.org/keywords/vegfr2","display_name":"VEGFR2","score":0.7799999713897705},{"id":"https://openalex.org/keywords/perk","display_name":"PERK","score":0.6510000228881836},{"id":"https://openalex.org/keywords/eif2alpha","display_name":"eIF2\u03b1","score":0.9769999980926514},{"id":"https://openalex.org/keywords/atf4","display_name":"ATF4","score":0.9980000257492065},{"id":"https://openalex.org/keywords/gadd45a","display_name":"GADD45A","score":0.9990000128746033},{"id":"https://openalex.org/keywords/unfolded-protein-response","display_name":"unfolded protein response","score":0.7870000004768372},{"id":"https://openalex.org/keywords/stress-signaling","display_name":"stress signaling","score":0.625},{"id":"https://openalex.org/keywords/angiostasis","display_name":"angiostasis","score":0.8939999938011169},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.9459999799728394},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.7229999899864197},{"id":"https://openalex.org/keywords/tunicamycin","display_name":"tunicamycin","score":0.7549999952316284},{"id":"https://openalex.org/keywords/vessel-sprouting","display_name":"vessel sprouting","score":0.8130000233650208}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6260743737220764},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5896923542022705},{"id":"https://openalex.org/C22731427","wikidata":"https://www.wikidata.org/wiki/Q2071346","display_name":"Perlecan","level":4,"score":0.5655497312545776},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5410758852958679},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.4736971855163574},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.41819146275520325},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37308967113494873},{"id":"https://openalex.org/C2779335624","wikidata":"https://www.wikidata.org/wiki/Q407976","display_name":"Proteoglycan","level":3,"score":0.3506990671157837},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.33787572383880615},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.19864726066589355},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.06600528955459595}],"mesh":[{"descriptor_ui":"D000097642","descriptor_name":"GADD45 Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015852","descriptor_name":"Eukaryotic Initiation Factor-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015852","descriptor_name":"Eukaryotic Initiation Factor-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019812","descriptor_name":"Heparan Sulfate Proteoglycans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019812","descriptor_name":"Heparan Sulfate Proteoglycans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019892","descriptor_name":"eIF-2 Kinase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019892","descriptor_name":"eIF-2 Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051701","descriptor_name":"Activating Transcription Factor 4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051701","descriptor_name":"Activating Transcription Factor 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D061307","descriptor_name":"Human Umbilical Vein Endothelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D061307","descriptor_name":"Human Umbilical Vein Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.ra120.012525","doi":"https://doi.org/10.1074/jbc.ra120.012525","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.ra120.012525","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:32205445","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32205445","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7212646","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7212646/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmh:oai:jdc.jefferson.edu:pacbfp-1299","doi":null,"is_oa":true,"landing_page_url":"https://jdc.jefferson.edu/pacbfp/295","pdf_url":null,"source":{"id":"https://openalex.org/S4210178181","display_name":"The Medicine Forum","issn_l":"2325-2863","issn":["2325-2863"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Department of Pathology, Anatomy, and Cell Biology Faculty Papers","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1074/jbc.ra120.012525","doi":"https://doi.org/10.1074/jbc.ra120.012525","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.ra120.012525","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1543217726","display_name":"Connective Tissue and Regenration Medicine Training Program","funder_award_id":"T32AR052273","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G2183386414","display_name":"The Biology of Perlecan in Cancer and Angiogenesis","funder_award_id":"R01CA047282","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G860411865","display_name":"Altered Proteoglycan Gene Expression and Cancer","funder_award_id":"R01CA039481","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":81,"referenced_works":["https://openalex.org/W1596010730","https://openalex.org/W1608430181","https://openalex.org/W1732769832","https://openalex.org/W1924112666","https://openalex.org/W1952042241","https://openalex.org/W1964050579","https://openalex.org/W1964251746","https://openalex.org/W1970195253","https://openalex.org/W1970606334","https://openalex.org/W1974242642","https://openalex.org/W1977603207","https://openalex.org/W1979782246","https://openalex.org/W1980438612","https://openalex.org/W1984652255","https://openalex.org/W1989460846","https://openalex.org/W1991250346","https://openalex.org/W1994044160","https://openalex.org/W1995494201","https://openalex.org/W2004547943","https://openalex.org/W2012018673","https://openalex.org/W2014318831","https://openalex.org/W2016000163","https://openalex.org/W2020040573","https://openalex.org/W2025483501","https://openalex.org/W2026362430","https://openalex.org/W2026788579","https://openalex.org/W2027821655","https://openalex.org/W2031180783","https://openalex.org/W2035205542","https://openalex.org/W2036369638","https://openalex.org/W2040630551","https://openalex.org/W2041650871","https://openalex.org/W2043945957","https://openalex.org/W2047721737","https://openalex.org/W2050841722","https://openalex.org/W2054838993","https://openalex.org/W2058078649","https://openalex.org/W2058593070","https://openalex.org/W2059083151","https://openalex.org/W2067621609","https://openalex.org/W2069265196","https://openalex.org/W2070669362","https://openalex.org/W2072320843","https://openalex.org/W2084544719","https://openalex.org/W2084557652","https://openalex.org/W2087200546","https://openalex.org/W2091774189","https://openalex.org/W2094678479","https://openalex.org/W2104303171","https://openalex.org/W2107091249","https://openalex.org/W2114360920","https://openalex.org/W2120736516","https://openalex.org/W2127308245","https://openalex.org/W2127848114","https://openalex.org/W2134197723","https://openalex.org/W2139568257","https://openalex.org/W2148816291","https://openalex.org/W2158344068","https://openalex.org/W2163285372","https://openalex.org/W2165064047","https://openalex.org/W2166156136","https://openalex.org/W2166825418","https://openalex.org/W2180884065","https://openalex.org/W2418536297","https://openalex.org/W2498658513","https://openalex.org/W2511273639","https://openalex.org/W2551010543","https://openalex.org/W2564166541","https://openalex.org/W2586591698","https://openalex.org/W2605910555","https://openalex.org/W2746646106","https://openalex.org/W2799423725","https://openalex.org/W2808136993","https://openalex.org/W2809435772","https://openalex.org/W2890624098","https://openalex.org/W2906567604","https://openalex.org/W2918906100","https://openalex.org/W2999803737","https://openalex.org/W3005130296","https://openalex.org/W3007032661","https://openalex.org/W6684620952"],"related_works":["https://openalex.org/W2012018673","https://openalex.org/W2041650871","https://openalex.org/W1984652255","https://openalex.org/W2130422938","https://openalex.org/W2072320843","https://openalex.org/W7144629984","https://openalex.org/W2031180783","https://openalex.org/W2092516074","https://openalex.org/W6987727421","https://openalex.org/W2511273639"],"abstract_inverted_index":{"Endorepellin,":[0],"the":[1,5,30,81,86,110,139],"C-terminal":[2],"fragment":[3],"of":[4,36,47,76,84,90,106,109,148],"heparan":[6],"sulfate":[7],"proteoglycan":[8],"perlecan,":[9],"influences":[10],"various":[11],"signaling":[12,33,93,184],"pathways":[13],"in":[14,50,114,185],"endothelial":[15,186],"cells":[16],"by":[17,166,176],"binding":[18],"to":[19,118,151,190],"VEGFR2.":[20],"In":[21],"this":[22,91],"study,":[23],"we":[24,100],"discovered":[25],"that":[26,163],"soluble":[27],"endorepellin":[28,43,120,152],"activates":[29],"canonical":[31],"stress":[32,92,142,183],"pathway":[34],"consisting":[35],"PERK,":[37],"eIF2\u03b1,":[38],"ATF4,":[39],"and":[40,72,126],"GADD45\u03b1.":[41,73],"Specifically,":[42],"evoked":[44],"transient":[45],"activation":[46],"VEGFR2,":[48],"which,":[49],"turn,":[51],"phosphorylated":[52,60],"PERK":[53,59,77,125,168],"at":[54,62],"Thr":[55],"980":[56],".":[57],"Subsequently,":[58],"eIF2\u03b1":[61,79],"Ser":[63],"51":[64],",":[65],"upregulating":[66],"its":[67],"downstream":[68],"effector":[69,88],"proteins":[70],"ATF4":[71],"RNAi-mediated":[74],"knockdown":[75],"or":[78],"abrogated":[80],"endorepellin-mediated":[82],"up-regulation":[83],"GADD45\u03b1,":[85],"ultimate":[87],"protein":[89,181],"cascade.":[94],"To":[95],"functionally":[96],"validate":[97],"these":[98],"findings,":[99],"utilized":[101],"an":[102,160,178],"ex":[103],"vivo":[104],"model":[105],"angiogenesis.":[107],"Exposure":[108],"aortic":[111,149],"rings":[112,150],"embedded":[113],"3D":[115],"fibrillar":[116],"collagen":[117],"recombinant":[119],"for":[121,153],"2\u20134":[122],"h":[123],"activated":[124],"induced":[127],"GADD45\u03b1":[128],"vis":[129,131],"\u00e0":[130],"vehicle-treated":[132],"counterparts.":[133],"Similar":[134],"effects":[135],"were":[136],"obtained":[137],"with":[138],"established":[140],"cellular":[141],"inducer":[143],"tunicamycin.":[144],"Notably,":[145],"chronic":[146],"exposure":[147],"7\u20139":[154],"days":[155],"markedly":[156],"suppressed":[157],"vessel":[158],"sprouting,":[159],"angiostatic":[161],"effect":[162],"was":[164],"rescued":[165],"blocking":[167],"kinase":[169],"activity.":[170],"Our":[171],"findings":[172],"unravel":[173],"a":[174],"mechanism":[175],"which":[177,188],"extracellular":[179],"matrix":[180],"evokes":[182],"cells,":[187],"leads":[189],"angiostasis.":[191]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-03-27T00:00:00"}