{"id":"https://openalex.org/W3012742907","doi":null,"title":"A systematic review and meta-analysis of randomized controlled trials, juxtaposing the control of glycemia and blood pressure between large dose empagliflozin and placebo among type 1 diabetes patients.","display_name":"A systematic review and meta-analysis of randomized controlled trials, juxtaposing the control of glycemia and blood pressure between large dose empagliflozin and placebo among type 1 diabetes patients.","publication_year":2020,"publication_date":"2020-03-01","ids":{"openalex":"https://openalex.org/W3012742907","mag":"3012742907","pmid":"https://pubmed.ncbi.nlm.nih.gov/32206059","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7069660"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7069660","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7069660/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7069660/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Health Sci (Qassim)","raw_type":"Text"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7069660/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013536258","display_name":"Sumanta Saha","orcid":"https://orcid.org/0000-0003-0996-8846","observed_orcids":["https://orcid.org/0000-0003-0996-8846"]},"institutions":[{"id":"https://openalex.org/I4210140595","display_name":"National Institute of Research in Tuberculosis","ror":"https://ror.org/03qp1eh12","country_code":"IN","type":"facility","lineage":["https://openalex.org/I37048141","https://openalex.org/I4210140595"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sumanta Saha","raw_affiliation_strings":["Department of Health Research, National Institute for Research in Tuberculosis, Chennai, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Research, National Institute for Research in Tuberculosis, Chennai, Tamil Nadu, India","institution_ids":["https://openalex.org/I4210140595"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088898081","display_name":"Sujata Saha","orcid":"https://orcid.org/0000-0003-2009-6786","observed_orcids":["https://orcid.org/0000-0003-2009-6786"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sujata Saha","raw_affiliation_strings":["Department of Mathematics, Mankar College, Mankar, West Bengal, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, Mankar College, Mankar, West Bengal, India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1275,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.1430696,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"14","issue":"2","first_page":"40","last_page":"52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9330999851226807,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9330999851226807,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.06369999796152115,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/empagliflozin","display_name":"empagliflozin","score":1.0},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9929999709129333},{"id":"https://openalex.org/keywords/glycemic-control","display_name":"glycemic control","score":0.9649999737739563},{"id":"https://openalex.org/keywords/blood-pressure-control","display_name":"blood pressure control","score":0.7310000061988831},{"id":"https://openalex.org/keywords/sglt2-inhibitors","display_name":"SGLT2 inhibitors","score":0.8600000143051147},{"id":"https://openalex.org/keywords/insulin-therapy","display_name":"insulin therapy","score":0.7770000100135803},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.8830000162124634},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.574999988079071},{"id":"https://openalex.org/keywords/systolic-blood-pressure","display_name":"systolic blood pressure","score":0.7289999723434448},{"id":"https://openalex.org/keywords/diastolic-blood-pressure","display_name":"diastolic blood pressure","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C2775887513","wikidata":"https://www.wikidata.org/wiki/Q5373824","display_name":"Empagliflozin","level":4,"score":0.91654372215271},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9135862588882446},{"id":"https://openalex.org/C2777538456","wikidata":"https://www.wikidata.org/wiki/Q311213","display_name":"Glycated hemoglobin","level":4,"score":0.7400079965591431},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.6912590265274048},{"id":"https://openalex.org/C2780473172","wikidata":"https://www.wikidata.org/wiki/Q5572518","display_name":"Glycemic","level":3,"score":0.6111011505126953},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5929630994796753},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.550704836845398},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5476722121238708},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5446746349334717},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5212912559509277},{"id":"https://openalex.org/C2781232474","wikidata":"https://www.wikidata.org/wiki/Q124407","display_name":"Type 1 diabetes","level":3,"score":0.4843374490737915},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.38437896966934204},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.38016843795776367},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.27860188484191895},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.15252023935317993},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:7069660","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7069660/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7069660/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Health Sci (Qassim)","raw_type":"Text"},{"id":"pmid:32206059","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32206059","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of health sciences","raw_type":"Journal Article"},{"id":"mag:3012742907","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32206059","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7069660","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7069660/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7069660/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Health Sci (Qassim)","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3012742907.pdf","grobid_xml":"https://content.openalex.org/works/W3012742907.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W12475499","https://openalex.org/W12670753","https://openalex.org/W1247968195","https://openalex.org/W1612849928","https://openalex.org/W1968593921","https://openalex.org/W1990025047","https://openalex.org/W2072040765","https://openalex.org/W2099670937","https://openalex.org/W2105824687","https://openalex.org/W2111155556","https://openalex.org/W2125435699","https://openalex.org/W2138173919","https://openalex.org/W2146681227","https://openalex.org/W2147234629","https://openalex.org/W2148513135","https://openalex.org/W2345908908","https://openalex.org/W2470197143","https://openalex.org/W2576440140","https://openalex.org/W2588681363","https://openalex.org/W2755899227","https://openalex.org/W2756104796","https://openalex.org/W2793706442","https://openalex.org/W2800710621","https://openalex.org/W2802343919","https://openalex.org/W2803721928","https://openalex.org/W2884098600","https://openalex.org/W2902077203","https://openalex.org/W2946441652","https://openalex.org/W2992632965","https://openalex.org/W3022903699"],"related_works":["https://openalex.org/W4205407752","https://openalex.org/W4407114908","https://openalex.org/W2556749067","https://openalex.org/W3028361107","https://openalex.org/W2803721928","https://openalex.org/W3203146662","https://openalex.org/W2981527269","https://openalex.org/W2898471340","https://openalex.org/W2144950248","https://openalex.org/W2990243698"],"abstract_inverted_index":{"OBJECTIVES:":[0],"While":[1],"empagliflozin":[2,52,171],"(25":[3],"mg)":[4],"is":[5,26,186],"used":[6],"to":[7,34,121,177,188,193],"treat":[8],"type-2":[9],"diabetes":[10,23],"mellitus":[11,24],"patients":[12,181],"with":[13,73,182],"optimum":[14,183],"renal":[15,41],"functioning,":[16],"its":[17],"efficacy":[18],"and":[19,44,54,71,78,87,89,102,116,152,195],"safety":[20],"in":[21,67,96,132,140,175,179],"type-1":[22],"(T1DM)":[25],"not":[27,155],"yet":[28],"established.":[29],"Therefore,":[30],"this":[31],"study":[32,137],"aimed":[33],"compare":[35],"insulin-treated":[36],"T1DM":[37,180],"patients'":[38],"(with":[39],"adequate":[40],"functioning)":[42],"glycemic":[43,190],"blood":[45,99,104,149,202],"pressure":[46,100,105,150,203],"control":[47,191],"between":[48,157,206],"the":[49,108,111,123,158,199,207],"25":[50,172],"mg":[51,173],"recipients":[53],"placebo":[55,194],"recipients.":[56],"METHODS:":[57],"or":[58],"more":[59],"were":[60,65,114],"eligible":[61],"for":[62],"inclusion.":[63],"Trials":[64],"searched":[66],"PubMed,":[68],"EMBASE,":[69],"SCOPUS,":[70],"CENTRAL":[72],"no":[74],"restriction":[75],"on":[76,201],"date":[77],"language.":[79],"Risk":[80],"of":[81,83,92,110,148,170],"bias":[82],"trials":[84],"was":[85,119,130,138],"assessed":[86],"mean":[88,125],"standard":[90],"deviation":[91],"glycated":[93],"hemoglobin":[94],"(HbA1c,":[95],"%),":[97],"systolic":[98],"(mmHg),":[101],"diastolic":[103],"(mmHg)":[106],"at":[107],"end":[109],"trial":[112],"period":[113],"collected,":[115],"random-effects":[117],"meta-analysis":[118,129],"done":[120,131],"estimate":[122],"weighted":[124],"difference":[126],"(WMD).":[127],"The":[128,146],"Stata":[133],"statistical":[134],"software.":[135],"This":[136],"conducted":[139],"June":[141],"2019.":[142],"RESULTS:":[143],"=":[144],"0%).":[145],"WMD":[147],"(systolic":[151],"diastolic)":[153],"did":[154],"vary":[156],"treatment":[159],"groups.":[160],"CONCLUSION:":[161],"Evidence":[162],"(of":[163],"moderate":[164],"quality)":[165],"suggests":[166],"that":[167],"daily":[168],"administration":[169],"tablets":[174],"adjunct":[176],"insulin":[178,196],"kidney":[184],"functioning":[185],"useful":[187],"achieve":[189],"compared":[192,208],"therapy.":[197],"However,":[198],"effect":[200],"remained":[204],"indistinguishable":[205],"interventions.":[209]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2020-03-27T00:00:00"}