{"id":"https://openalex.org/W3012733742","doi":"https://doi.org/10.1200/jco.19.02808","title":"Risk of Prostate Cancer Associated With Familial and Hereditary Cancer Syndromes","display_name":"Risk of Prostate Cancer Associated With Familial and Hereditary Cancer Syndromes","publication_year":2020,"publication_date":"2020-03-24","ids":{"openalex":"https://openalex.org/W3012733742","doi":"https://doi.org/10.1200/jco.19.02808","mag":"3012733742","pmid":"https://pubmed.ncbi.nlm.nih.gov/32208047","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7255976"},"language":"en","primary_location":{"id":"doi:10.1200/jco.19.02808","doi":"https://doi.org/10.1200/jco.19.02808","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.19.02808","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7255976","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002190901","display_name":"Jennifer Beebe\u2010Dimmer","orcid":"https://orcid.org/0000-0002-4320-739X","observed_orcids":["https://orcid.org/0000-0002-4320-739X"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]},{"id":"https://openalex.org/I4210090317","display_name":"The Barbara Ann Karmanos Cancer Institute","ror":"https://ror.org/00ee40h97","country_code":"US","type":"facility","lineage":["https://openalex.org/I2800590384","https://openalex.org/I4210090317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer L. Beebe-Dimmer","raw_affiliation_strings":["Barbara Ann Karmanos Cancer Institute, Detroit, MI","Department of Oncology, Wayne State University School of Medicine, Detroit, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barbara Ann Karmanos Cancer Institute, Detroit, MI","institution_ids":["https://openalex.org/I4210090317"]},{"raw_affiliation_string":"Department of Oncology, Wayne State University School of Medicine, Detroit, MI","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021878134","display_name":"Ashley L. Kapron","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashley L. Kapron","raw_affiliation_strings":["University of Utah, Salt Lake City, UT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Utah, Salt Lake City, UT","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037111300","display_name":"Alison M. Fraser","orcid":"https://orcid.org/0000-0003-1681-698X","observed_orcids":["https://orcid.org/0000-0003-1681-698X"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alison M. Fraser","raw_affiliation_strings":["Huntsman Cancer Institute, University of Utah, Salt Lake City, UT","University of Utah, Salt Lake City, UT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huntsman Cancer Institute, University of Utah, Salt Lake City, UT","institution_ids":["https://openalex.org/I2801159745"]},{"raw_affiliation_string":"University of Utah, Salt Lake City, UT","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049615387","display_name":"Ken Robert Smith","orcid":"https://orcid.org/0000-0003-0682-3705","observed_orcids":["https://orcid.org/0000-0003-0682-3705"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ken R. Smith","raw_affiliation_strings":["Huntsman Cancer Institute, University of Utah, Salt Lake City, UT","University of Utah, Salt Lake City, UT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huntsman Cancer Institute, University of Utah, Salt Lake City, UT","institution_ids":["https://openalex.org/I2801159745"]},{"raw_affiliation_string":"University of Utah, Salt Lake City, UT","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010980781","display_name":"Kathleen A. Cooney","orcid":"https://orcid.org/0000-0003-3831-6943","observed_orcids":["https://orcid.org/0000-0003-3831-6943"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathleen A. Cooney","raw_affiliation_strings":["Duke University School of Medicine, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University School of Medicine, Durham, NC","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.0107,"has_fulltext":false,"cited_by_count":62,"citation_normalized_percentile":{"value":0.95514564,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"38","issue":"16","first_page":"1807","last_page":"1813"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.4514000117778778,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.4514000117778778,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.2985999882221222,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.09139999747276306,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9670000076293945},{"id":"https://openalex.org/keywords/hereditary-cancer-syndromes","display_name":"hereditary cancer","score":0.8230000138282776},{"id":"https://openalex.org/keywords/hereditary-prostate-cancer","display_name":"hereditary prostate cancer","score":0.8230000138282776},{"id":"https://openalex.org/keywords/hereditary-breast-and-ovarian-cancer-syndrome","display_name":"hereditary breast and ovarian cancer","score":0.9760000109672546},{"id":"https://openalex.org/keywords/lynch-syndrome","display_name":"Lynch syndrome","score":1.0},{"id":"https://openalex.org/keywords/family-history-medicine","display_name":"family history (medicine)","score":0.9290000200271606},{"id":"https://openalex.org/keywords/early-onset-prostate-cancer","display_name":"early-onset prostate cancer","score":0.8579999804496765},{"id":"https://openalex.org/keywords/relative-risk","display_name":"relative risk","score":0.6660000085830688},{"id":"https://openalex.org/keywords/genetic-testing","display_name":"genetic testing","score":0.7850000262260437},{"id":"https://openalex.org/keywords/cancer-surveillance","display_name":"cancer surveillance","score":0.6140000224113464},{"id":"https://openalex.org/keywords/utah-population-database","display_name":"Utah Population Database","score":0.7300000190734863}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8763415813446045},{"id":"https://openalex.org/C2781179581","wikidata":"https://www.wikidata.org/wiki/Q2857712","display_name":"Family history","level":2,"score":0.6634809374809265},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.6295560002326965},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6178986430168152},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.601722240447998},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.5598849058151245},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5083844065666199},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.480829119682312},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.47320860624313354},{"id":"https://openalex.org/C73269764","wikidata":"https://www.wikidata.org/wiki/Q954529","display_name":"Poisson regression","level":3,"score":0.45365798473358154},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.4158937931060791},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.24011605978012085},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003123","descriptor_name":"Colorectal Neoplasms, Hereditary Nonpolyposis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D003123","descriptor_name":"Colorectal Neoplasms, Hereditary Nonpolyposis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003123","descriptor_name":"Colorectal Neoplasms, Hereditary Nonpolyposis","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010375","descriptor_name":"Pedigree","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014589","descriptor_name":"Utah","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017668","descriptor_name":"Age of Onset","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018426","descriptor_name":"SEER Program","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040941","descriptor_name":"Heredity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061325","descriptor_name":"Hereditary Breast and Ovarian Cancer Syndrome","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D061325","descriptor_name":"Hereditary Breast and Ovarian Cancer Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D061325","descriptor_name":"Hereditary Breast and Ovarian Cancer Syndrome","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1200/jco.19.02808","doi":"https://doi.org/10.1200/jco.19.02808","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.19.02808","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7255976","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7255976","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Oncol","raw_type":"Text"},{"id":"pmid:32208047","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32208047","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical oncology : official journal of the American Society of Clinical Oncology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7255976","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7255976","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Oncol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G3351322984","display_name":null,"funder_award_id":"HHSN261201800016C","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W106733404","https://openalex.org/W1558007424","https://openalex.org/W1578291413","https://openalex.org/W1912154593","https://openalex.org/W1971781813","https://openalex.org/W1975839434","https://openalex.org/W1984653140","https://openalex.org/W2004429375","https://openalex.org/W2034024919","https://openalex.org/W2040610908","https://openalex.org/W2041772218","https://openalex.org/W2059057685","https://openalex.org/W2059130445","https://openalex.org/W2059824805","https://openalex.org/W2064512804","https://openalex.org/W2105551609","https://openalex.org/W2113587565","https://openalex.org/W2116284235","https://openalex.org/W2128793721","https://openalex.org/W2135959527","https://openalex.org/W2142961927","https://openalex.org/W2166783472","https://openalex.org/W2178232667","https://openalex.org/W2225530246","https://openalex.org/W2235405584","https://openalex.org/W2462985846","https://openalex.org/W2472699929","https://openalex.org/W2510940971","https://openalex.org/W2515113327","https://openalex.org/W2517590028","https://openalex.org/W2532983422","https://openalex.org/W2545704016","https://openalex.org/W2548922979","https://openalex.org/W2567290427","https://openalex.org/W2579423964","https://openalex.org/W2587831721","https://openalex.org/W2744090059","https://openalex.org/W2774213581","https://openalex.org/W2809139858","https://openalex.org/W2911188335","https://openalex.org/W4211087830"],"related_works":["https://openalex.org/W2946869770","https://openalex.org/W2082171571","https://openalex.org/W3020928169","https://openalex.org/W2889772055","https://openalex.org/W2955416528","https://openalex.org/W2050244045","https://openalex.org/W1549290306","https://openalex.org/W2941981759","https://openalex.org/W1471983997","https://openalex.org/W2517590028"],"abstract_inverted_index":{"PURPOSE:":[0],"Recently":[1],"developed":[2],"clinical":[3],"guidelines":[4],"suggest":[5],"that":[6,92,268],"men":[7,61],"in":[8,26,65,152,220,262],"families":[9],"with":[10,62,143,159,200,213,225,254],"specific":[11],"cancer":[12,20,52,247],"syndromes,":[13],"such":[14],"as":[15],"hereditary":[16,106],"breast":[17],"and":[18,110,114,197,206,249,264,274],"ovarian":[19],"(HBOC),":[21],"consider":[22],"genetic":[23,229,272],"testing,":[24],"especially":[25],"the":[27,39,178,226,241],"setting":[28],"of":[29,38,57,89,105,175,228,243],"aggressive":[30],"disease.":[31,256],"However,":[32],"although":[33],"a":[34,54,66,90,155],"family":[35,239],"history":[36],"(FH)":[37],"same":[40],"disease":[41,219,232],"among":[42],"close":[43],"relatives":[44],"is":[45,69],"an":[46],"established":[47],"risk":[48,59,181,242],"factor":[49],"for":[50,60,103,115,147,168,182,217],"prostate":[51],"(PC),":[53],"direct":[55],"comparison":[56],"PC":[58,107,118,120,184,244],"each":[63,144,169],"syndrome":[64,112],"single":[67],"population":[68],"needed.":[70],"METHODS:":[71],"The":[72,209],"Utah":[73],"Population":[74],"Database":[75],"was":[76,101,250],"used":[77],"to":[78,163,192,231],"identify":[79],"619,630":[80],"men,":[81],"age":[82],"\u2265":[83],"40":[84],"years,":[85],"who":[86],"were":[87,125,150,215],"members":[88],"pedigree":[91,222],"included":[93],"at":[94],"least":[95],"3":[96],"consecutive":[97],"generations.":[98],"Each":[99],"man":[100],"evaluated":[102],"FH":[104,170,174,214,248],"(HPC),":[108],"HBOC,":[109],"Lynch":[111],"(LS)":[113],"his":[116],"own":[117],"status.":[119],"occurrences":[121],"(N":[122],"=":[123],"36,360)":[124],"classified":[126],"into":[127],"one":[128],"or":[129],"more":[130],"subtypes:":[131],"early":[132],"onset":[133],"(EO),":[134],"lethal,":[135],"and/or":[136],"clinically":[137],"significant.":[138],"Relative":[139],"risks":[140,211],"(RRs)":[141],"associated":[142,212,253],"subtype,":[145],"adjusted":[146],"important":[148],"covariables,":[149],"calculated":[151],"STATA":[153],"using":[154],"modified":[156],"Poisson":[157],"regression":[158],"robust":[160],"error":[161],"variances":[162],"obtain":[164],"corresponding":[165],"RR":[166,203],"CIs":[167],"definition.":[171],"RESULTS:":[172],"An":[173],"HPC":[176],"conveyed":[177],"greatest":[179],"relative":[180],"all":[183,221],"subtypes":[185],"combined":[186],"(RR,":[187],"2.30;":[188],"95%":[189],"CI,":[190],"2.22":[191],"2.40),":[193],"followed":[194],"by":[195,246],"HBOC":[196],"LS":[198],"(both":[199],"1":[201],"<":[202,204],"2":[205],"statistically":[207],"significant).":[208],"strongest":[210],"observed":[216],"EO":[218,255],"types,":[223],"consistent":[224],"contribution":[227],"factors":[230],"occurrence.":[233],"CONCLUSION:":[234],"In":[235],"this":[236],"large,":[237],"population-based,":[238],"database,":[240],"varied":[245],"most":[251],"strongly":[252],"These":[257],"results":[258],"are":[259],"critically":[260],"valuable":[261],"understanding":[263],"targeting":[265],"high-risk":[266],"populations":[267],"would":[269],"benefit":[270],"from":[271],"screening":[273],"enhanced":[275],"surveillance.":[276]},"counts_by_year":[{"year":2026,"cited_by_count":13},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-03-27T00:00:00"}