{"id":"https://openalex.org/W3012647438","doi":"https://doi.org/10.3906/biy-1909-12","title":"Doxorubucin inhibits miR-140 expression and upregulates PD-L1 expression in HCT116 cells, opposite to MDA-MB231 cells","display_name":"Doxorubucin inhibits miR-140 expression and upregulates PD-L1 expression in HCT116 cells, opposite to MDA-MB231 cells","publication_year":2019,"publication_date":"2019-12-23","ids":{"openalex":"https://openalex.org/W3012647438","doi":"https://doi.org/10.3906/biy-1909-12","mag":"3012647438","pmid":"https://pubmed.ncbi.nlm.nih.gov/32123492","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7049454"},"language":"en","primary_location":{"id":"doi:10.3906/biy-1909-12","doi":"https://doi.org/10.3906/biy-1909-12","is_oa":true,"landing_page_url":"https://doi.org/10.3906/biy-1909-12","pdf_url":"https://doi.org/10.3906/biy-1909-12","source":{"id":"https://openalex.org/S116550310","display_name":"TURKISH JOURNAL OF BIOLOGY","issn_l":"1300-0152","issn":["1300-0152","1303-6092"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","ddh","doaj","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-1","tr-dizin"],"host_organization":"https://openalex.org/P4310318422","host_organization_name":"Scientific and Technological Research Council of Turkey (TUBITAK)","host_organization_lineage":["https://openalex.org/P4310318422"],"host_organization_lineage_names":["Scientific and Technological Research Council of Turkey (TUBITAK)"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TURKISH JOURNAL OF BIOLOGY","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.3906/biy-1909-12","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031661170","display_name":"Noel Mopouguini Naba","orcid":"https://orcid.org/0000-0003-4228-6003","observed_orcids":["https://orcid.org/0000-0003-4228-6003"]},"institutions":[{"id":"https://openalex.org/I48912391","display_name":"Istanbul Technical University","ror":"https://ror.org/059636586","country_code":"TR","type":"education","lineage":["https://openalex.org/I48912391"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"NABA, NOEL MOPOUGUINI","raw_affiliation_strings":["Department of Molecular Biology and Genetics, Faculty of Science and Letters, \u0130stanbul Technical University, Maslak, \u0130stanbul Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Faculty of Science and Letters, \u0130stanbul Technical University, Maslak, \u0130stanbul Turkey","institution_ids":["https://openalex.org/I48912391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064790692","display_name":"Nazife Tolay","orcid":"https://orcid.org/0000-0002-3295-4082","observed_orcids":["https://orcid.org/0000-0002-3295-4082"]},"institutions":[{"id":"https://openalex.org/I134235054","display_name":"Sabanc\u0131 \u00dcniversitesi","ror":"https://ror.org/049asqa32","country_code":"TR","type":"education","lineage":["https://openalex.org/I134235054"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"TOLAY, NAZ\u0130FE","raw_affiliation_strings":["Molecular Biology, Genetics, and Bioengineering Program, Faculty of Engineering and Natural Sciences,Sabanc\u0131 University, Tuzla, \u0130stanbul Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Biology, Genetics, and Bioengineering Program, Faculty of Engineering and Natural Sciences,Sabanc\u0131 University, Tuzla, \u0130stanbul Turkey","institution_ids":["https://openalex.org/I134235054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061886998","display_name":"Batu Erman","orcid":"https://orcid.org/0000-0003-2180-7607","observed_orcids":["https://orcid.org/0000-0003-2180-7607"]},"institutions":[{"id":"https://openalex.org/I134235054","display_name":"Sabanc\u0131 \u00dcniversitesi","ror":"https://ror.org/049asqa32","country_code":"TR","type":"education","lineage":["https://openalex.org/I134235054"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"ERMAN, MEHMET BATU","raw_affiliation_strings":["Molecular Biology, Genetics, and Bioengineering Program, Faculty of Engineering and Natural Sciences,Sabanc\u0131 University, Tuzla, \u0130stanbul Turkey","SUNUM Nanotechnology Research Center, Sabanc\u0131 University, \u0130stanbul Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Biology, Genetics, and Bioengineering Program, Faculty of Engineering and Natural Sciences,Sabanc\u0131 University, Tuzla, \u0130stanbul Turkey","institution_ids":["https://openalex.org/I134235054"]},{"raw_affiliation_string":"SUNUM Nanotechnology Research Center, Sabanc\u0131 University, \u0130stanbul Turkey","institution_ids":["https://openalex.org/I134235054"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006841412","display_name":"Ayca Sayi\u2010Yazgan","orcid":"https://orcid.org/0000-0002-9015-8244","observed_orcids":["https://orcid.org/0000-0002-9015-8244"]},"institutions":[{"id":"https://openalex.org/I48912391","display_name":"Istanbul Technical University","ror":"https://ror.org/059636586","country_code":"TR","type":"education","lineage":["https://openalex.org/I48912391"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"YAZGAN, AY\u00c7A SAYI","raw_affiliation_strings":["Department of Molecular Biology and Genetics, Faculty of Science and Letters, \u0130stanbul Technical University, Maslak, \u0130stanbul Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Faculty of Science and Letters, \u0130stanbul Technical University, Maslak, \u0130stanbul Turkey","institution_ids":["https://openalex.org/I48912391"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.836,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.75111385,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"44","issue":"1","first_page":"15","last_page":"23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9071999788284302,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9071999788284302,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.08730000257492065,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.9520000219345093},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.8809999823570251},{"id":"https://openalex.org/keywords/mir-140","display_name":"miR-140","score":0.9919999837875366},{"id":"https://openalex.org/keywords/mir-34a","display_name":"miR-34a","score":0.9990000128746033},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8740000128746033},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.875},{"id":"https://openalex.org/keywords/microrna-regulation","display_name":"microRNA regulation","score":0.8090000152587891},{"id":"https://openalex.org/keywords/3-untranslated-region","display_name":"3' untranslated region","score":0.7680000066757202},{"id":"https://openalex.org/keywords/hct116-cells","display_name":"HCT116 cells","score":0.9419999718666077},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cell-surface-localization","display_name":"cell surface localization","score":0.6200000047683716},{"id":"https://openalex.org/keywords/tumor-immune-evasion","display_name":"tumor immune evasion","score":0.43299999833106995},{"id":"https://openalex.org/keywords/drug-resistance-mechanisms","display_name":"drug resistance mechanisms","score":0.32199999690055847}],"concepts":[{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.6652846336364746},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.6170705556869507},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.6086710691452026},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6041731238365173},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.530781626701355},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5279363989830017},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.5094667077064514},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.49285364151000977},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.4879419207572937},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4829549193382263},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4704757332801819},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4692630171775818},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4429464042186737},{"id":"https://openalex.org/C2778236600","wikidata":"https://www.wikidata.org/wiki/Q592324","display_name":"Immunofluorescence","level":3,"score":0.4306100606918335},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4165520966053009},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.35509344935417175},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2409830093383789},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22478002309799194},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2029632329940796},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.1443062424659729},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.12088131904602051},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06434446573257446},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3906/biy-1909-12","doi":"https://doi.org/10.3906/biy-1909-12","is_oa":true,"landing_page_url":"https://doi.org/10.3906/biy-1909-12","pdf_url":"https://doi.org/10.3906/biy-1909-12","source":{"id":"https://openalex.org/S116550310","display_name":"TURKISH JOURNAL OF BIOLOGY","issn_l":"1300-0152","issn":["1300-0152","1303-6092"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","ddh","doaj","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-1","tr-dizin"],"host_organization":"https://openalex.org/P4310318422","host_organization_name":"Scientific and Technological Research Council of Turkey (TUBITAK)","host_organization_lineage":["https://openalex.org/P4310318422"],"host_organization_lineage_names":["Scientific and Technological Research Council of Turkey (TUBITAK)"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TURKISH JOURNAL OF BIOLOGY","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7049454","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7049454","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turk J Biol","raw_type":"Text"},{"id":"pmid:32123492","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32123492","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turkish journal of biology = Turk biyoloji dergisi","raw_type":"Journal Article"},{"id":"pmh:oai:bura.brunel.ac.uk:2438/30119","doi":null,"is_oa":true,"landing_page_url":"https://bura.brunel.ac.uk/handle/2438/30119","pdf_url":"http://bura.brunel.ac.uk/bitstream/2438/30119/1/FullText.pdf","source":{"id":"https://openalex.org/S4306401473","display_name":"Brunel University Research Archive (BURA) (Brunel University London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I59433898","host_organization_name":"Brunel University of London","host_organization_lineage":["https://openalex.org/I59433898"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:polen.itu.edu.tr:11527/35759","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11527/35759","pdf_url":null,"source":{"id":"https://openalex.org/S4306400460","display_name":"Istanbul Technical University Academic Open Archive (Istanbul Technical University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I48912391","host_organization_name":"Istanbul Technical University","host_organization_lineage":["https://openalex.org/I48912391"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.3906/biy-1909-12","doi":"https://doi.org/10.3906/biy-1909-12","is_oa":true,"landing_page_url":"https://doi.org/10.3906/biy-1909-12","pdf_url":"https://doi.org/10.3906/biy-1909-12","source":{"id":"https://openalex.org/S116550310","display_name":"TURKISH JOURNAL OF BIOLOGY","issn_l":"1300-0152","issn":["1300-0152","1303-6092"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","ddh","doaj","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-1","tr-dizin"],"host_organization":"https://openalex.org/P4310318422","host_organization_name":"Scientific and Technological Research Council of Turkey (TUBITAK)","host_organization_lineage":["https://openalex.org/P4310318422"],"host_organization_lineage_names":["Scientific and Technological Research Council of Turkey (TUBITAK)"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TURKISH JOURNAL OF BIOLOGY","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3012647438.pdf"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W951317561","https://openalex.org/W1994001196","https://openalex.org/W2057329290","https://openalex.org/W2084506491","https://openalex.org/W2106926141","https://openalex.org/W2121988130","https://openalex.org/W2123424099","https://openalex.org/W2131602018","https://openalex.org/W2135810600","https://openalex.org/W2156383220","https://openalex.org/W2159532100","https://openalex.org/W2160834915","https://openalex.org/W2168491140","https://openalex.org/W2173135538","https://openalex.org/W2270816365","https://openalex.org/W2341601510","https://openalex.org/W2514017219","https://openalex.org/W2516619560","https://openalex.org/W2560367415","https://openalex.org/W2754385324","https://openalex.org/W2755529729","https://openalex.org/W2770366458","https://openalex.org/W2770878260","https://openalex.org/W2792984991","https://openalex.org/W2796017384","https://openalex.org/W2917837889","https://openalex.org/W4211264672"],"related_works":["https://openalex.org/W7073713343","https://openalex.org/W4313857728","https://openalex.org/W2991261208","https://openalex.org/W3150672388","https://openalex.org/W4402985515","https://openalex.org/W2990708297","https://openalex.org/W4245298012","https://openalex.org/W6990693708","https://openalex.org/W3148865127","https://openalex.org/W1903537786"],"abstract_inverted_index":{"One":[0],"of":[1,45,64,77,93,124,143,233],"the":[2,40,43,73,78,140,144,152,197,231],"most":[3],"challenging":[4],"problems":[5],"in":[6,31,42,47,95,115,128,148,160,200,208,214,221,237,248,253,262,278,284],"colorectal":[7],"cancer":[8,34,52,266],"(CRC)":[9],"is":[10,24,29],"resistance":[11],"to":[12,26,56,196,260],"chemotherapy":[13],"drugs":[14],"such":[15],"as":[16],"doxorubicin":[17],"(DOX).":[18],"The":[19],"programmed":[20],"death":[21],"ligand-1":[22],"(PD-L1)":[23],"related":[25],"chemoresistance":[27],"and":[28,50,66,84,97,106,126,131,185,274],"overexpressed":[30],"several":[32],"human":[33],"cell":[35,182,198,224],"types.":[36,225,267],"Here,":[37],"we":[38,60,121,135,227],"investigated":[39,136],"changes":[41],"expression":[44,62,99,123,159,179,184,206,219,241],"PD-L1":[46,58,98,113,147,158,178,194,234,240,273],"DOX-treated":[48,129,201,209,215,223,279],"CRC":[49,83],"breast":[51],"(BRC)":[53],"cells.":[54,133,203,217,239,286],"Also,":[55,268],"address":[57],"regulation,":[59],"assessed":[61,122],"levels":[63],"miR-140":[65,125,138,205,236,275],"miR-34a,":[67],"two":[68,264],"microRNAs":[69],"that":[70,193],"can":[71,167,242],"target":[72],"3'":[74,141],"UTR":[75,142],"region":[76],"gene":[79,145],"encoding":[80,146],"PD-L1.":[81],"HCT116":[82,116,130,149,161,181,202,210,238,249,280],"MDA-MB-231":[85,132,176,216,254,285],"BRC":[86],"cells":[87,117,150,250],"were":[88],"treated":[89],"with":[90,172,246],"various":[91],"doses":[92],"DOX":[94,188,247,261],"culture":[96],"was":[100,276],"quantified":[101],"using":[102,151],"qRT-PCR,":[103],"flow":[104],"cytometry,":[105],"western":[107],"blot":[108],"analysis.":[109],"We":[110,190],"also":[111],"evaluated":[112],"localization":[114],"by":[118,170,235],"immunofluorescence.":[119],"Next,":[120],"miR-34a":[127],"Finally,":[134,226],"whether":[137],"targets":[139],"p2FP-RNAi":[153],"RNAi":[154],"reporter":[155],"vector":[156],"system.":[157],"cells,":[162,211,255,281],"while":[163],"low":[164],"at":[165],"baseline,":[166],"be":[168],"induced":[169],"treatment":[171,245],"0.5":[173],"\u00b5M":[174],"DOX.":[175],"baseline":[177],"exceeded":[180],"maximal":[183],"decreased":[186,207],"following":[187,244],"treatment.":[189],"further":[191],"demonstrated":[192],"localizes":[195],"surface":[199],"While":[204],"it":[212],"increased":[213,220],"MiR-34a":[218],"both":[222],"present":[228],"evidence":[229],"for":[230],"regulation":[232],"increase":[243],"but":[251,282],"decrease":[252],"suggesting":[256],"a":[257,269],"distinct":[258],"response":[259],"these":[263],"different":[265],"negative":[270],"correlation":[271],"between":[272],"observed":[277],"not":[283]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2020-03-27T00:00:00"}
