{"id":"https://openalex.org/W3012450644","doi":"https://doi.org/10.1007/s10637-020-00918-1","title":"Phase 1 study to evaluate safety, tolerability and pharmacokinetics of a novel intra-tympanic administered thiosulfate to prevent cisplatin-induced hearing loss in cancer patients","display_name":"Phase 1 study to evaluate safety, tolerability and pharmacokinetics of a novel intra-tympanic administered thiosulfate to prevent cisplatin-induced hearing loss in cancer patients","publication_year":2020,"publication_date":"2020-03-10","ids":{"openalex":"https://openalex.org/W3012450644","doi":"https://doi.org/10.1007/s10637-020-00918-1","mag":"3012450644","pmid":"https://pubmed.ncbi.nlm.nih.gov/32157599","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7497691"},"language":"en","primary_location":{"id":"doi:10.1007/s10637-020-00918-1","doi":"https://doi.org/10.1007/s10637-020-00918-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10637-020-00918-1","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10637-020-00918-1.pdf","source":{"id":"https://openalex.org/S6037287","display_name":"Investigational New Drugs","issn_l":"0167-6997","issn":["0167-6997","1573-0646"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigational New Drugs","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s10637-020-00918-1.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046645678","display_name":"Vissia Viglietta","orcid":"https://orcid.org/0009-0005-6270-0904","observed_orcids":["https://orcid.org/0009-0005-6270-0904","https://orcid.org/0000-0002-7809-1833"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Vissia Viglietta","raw_affiliation_strings":["Decibel Therapeutics, 1325 Boylston Street, Suite 500, Boston, MA, 02215, USA. vviglietta@decibeltx.com","Decibel Therapeutics, 1325 Boylston Street, Suite 500, Boston, MA, 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Decibel Therapeutics, 1325 Boylston Street, Suite 500, Boston, MA, 02215, USA. vviglietta@decibeltx.com","institution_ids":[]},{"raw_affiliation_string":"Decibel Therapeutics, 1325 Boylston Street, Suite 500, Boston, MA, 02215, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111459924","display_name":"Fuxin Shi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fuxin Shi","raw_affiliation_strings":["Decibel Therapeutics, 1325 Boylston Street, Suite 500, Boston, MA, 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Decibel Therapeutics, 1325 Boylston Street, Suite 500, Boston, MA, 02215, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Qi-Ying Hu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qi-Ying Hu","raw_affiliation_strings":["Decibel Therapeutics, 1325 Boylston Street, Suite 500, Boston, MA, 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Decibel Therapeutics, 1325 Boylston Street, Suite 500, Boston, MA, 02215, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100989816","display_name":"Yong Ren","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yong Ren","raw_affiliation_strings":["Decibel Therapeutics, 1325 Boylston Street, Suite 500, Boston, MA, 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Decibel Therapeutics, 1325 Boylston Street, Suite 500, Boston, MA, 02215, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039028716","display_name":"John Keilty","orcid":"https://orcid.org/0009-0001-3174-5553","observed_orcids":["https://orcid.org/0009-0001-3174-5553"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Keilty","raw_affiliation_strings":["Decibel Therapeutics, 1325 Boylston Street, Suite 500, Boston, MA, 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Decibel Therapeutics, 1325 Boylston Street, Suite 500, Boston, MA, 02215, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111266118","display_name":"Heather M Wolff","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Heather Wolff","raw_affiliation_strings":["Decibel Therapeutics, 1325 Boylston Street, Suite 500, Boston, MA, 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Decibel Therapeutics, 1325 Boylston Street, Suite 500, Boston, MA, 02215, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ryan McCarthy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ryan McCarthy","raw_affiliation_strings":["Decibel Therapeutics, 1325 Boylston Street, Suite 500, Boston, MA, 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Decibel Therapeutics, 1325 Boylston Street, Suite 500, Boston, MA, 02215, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065212794","display_name":"Jason T. Kropp","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jason Kropp","raw_affiliation_strings":["Decibel Therapeutics, 1325 Boylston Street, Suite 500, Boston, MA, 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Decibel Therapeutics, 1325 Boylston Street, Suite 500, Boston, MA, 02215, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110341230","display_name":"Pete Weber","orcid":"https://orcid.org/0009-0006-5025-254X","observed_orcids":["https://orcid.org/0009-0006-5025-254X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pete Weber","raw_affiliation_strings":["Decibel Therapeutics, 1325 Boylston Street, Suite 500, Boston, MA, 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Decibel Therapeutics, 1325 Boylston Street, Suite 500, Boston, MA, 02215, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072018531","display_name":"John R. Soglia","orcid":"https://orcid.org/0000-0002-2041-4548","observed_orcids":["https://orcid.org/0000-0002-2041-4548"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Soglia","raw_affiliation_strings":["Decibel Therapeutics, 1325 Boylston Street, Suite 500, Boston, MA, 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Decibel Therapeutics, 1325 Boylston Street, Suite 500, Boston, MA, 02215, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5046645678"],"corresponding_institution_ids":[],"apc_list":{"value":3860,"currency":"USD","value_usd":3860},"apc_paid":{"value":3860,"currency":"USD","value_usd":3860},"fwci":2.8532,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.8955809,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"38","issue":"5","first_page":"1463","last_page":"1471"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.6269999742507935,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.6269999742507935,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.3257000148296356,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10283","display_name":"Hearing Loss and Rehabilitation","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/3616","display_name":"Speech and Hearing"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cisplatin-induced-hearing-loss","display_name":"cisplatin-induced hearing loss","score":0.8989999890327454},{"id":"https://openalex.org/keywords/cisplatin-ototoxicity","display_name":"cisplatin ototoxicity","score":0.9369999766349792},{"id":"https://openalex.org/keywords/sodium-thiosulfate","display_name":"sodium thiosulfate","score":0.9610000252723694},{"id":"https://openalex.org/keywords/intratympanic-administration","display_name":"intratympanic administration","score":0.8550000190734863},{"id":"https://openalex.org/keywords/sodium-hyaluronate","display_name":"sodium hyaluronate","score":0.777999997138977},{"id":"https://openalex.org/keywords/cochlear-drug-delivery","display_name":"cochlear drug delivery","score":0.8600000143051147},{"id":"https://openalex.org/keywords/otoprotection","display_name":"otoprotection","score":0.878000020980835},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7160000205039978},{"id":"https://openalex.org/keywords/safety-and-tolerability","display_name":"safety and tolerability","score":0.8669999837875366},{"id":"https://openalex.org/keywords/single-ascending-dose","display_name":"single ascending dose","score":0.7289999723434448},{"id":"https://openalex.org/keywords/chemotherapy-side-effects","display_name":"chemotherapy side effects","score":0.6069999933242798}],"concepts":[{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.8959977626800537},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7376370429992676},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6593873500823975},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.6255754828453064},{"id":"https://openalex.org/C2780493683","wikidata":"https://www.wikidata.org/wiki/Q16035842","display_name":"Hearing loss","level":2,"score":0.5761510133743286},{"id":"https://openalex.org/C2778534666","wikidata":"https://www.wikidata.org/wiki/Q1351381","display_name":"Ototoxicity","level":4,"score":0.5619210600852966},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3848823606967926},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.3183516561985016},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.3139599561691284},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2733638882637024},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.228013277053833}],"mesh":[{"descriptor_ui":"D000069555","descriptor_name":"Injection, Intratympanic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013885","descriptor_name":"Thiosulfates","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D013885","descriptor_name":"Thiosulfates","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D013885","descriptor_name":"Thiosulfates","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013885","descriptor_name":"Thiosulfates","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D034381","descriptor_name":"Hearing Loss","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D034381","descriptor_name":"Hearing Loss","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064368","descriptor_name":"Healthy Volunteers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s10637-020-00918-1","doi":"https://doi.org/10.1007/s10637-020-00918-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10637-020-00918-1","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10637-020-00918-1.pdf","source":{"id":"https://openalex.org/S6037287","display_name":"Investigational New Drugs","issn_l":"0167-6997","issn":["0167-6997","1573-0646"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigational New Drugs","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7497691","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7497691","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Invest New Drugs","raw_type":"Text"},{"id":"pmid:32157599","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32157599","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigational new drugs","raw_type":"Clinical Trial, Phase I"}],"best_oa_location":{"id":"doi:10.1007/s10637-020-00918-1","doi":"https://doi.org/10.1007/s10637-020-00918-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10637-020-00918-1","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10637-020-00918-1.pdf","source":{"id":"https://openalex.org/S6037287","display_name":"Investigational New Drugs","issn_l":"0167-6997","issn":["0167-6997","1573-0646"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigational New Drugs","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3012450644.pdf","grobid_xml":"https://content.openalex.org/works/W3012450644.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1570988221","https://openalex.org/W1998147719","https://openalex.org/W2023201283","https://openalex.org/W2026953014","https://openalex.org/W2049970371","https://openalex.org/W2053351827","https://openalex.org/W2059430040","https://openalex.org/W2077359511","https://openalex.org/W2092964823","https://openalex.org/W2131784114","https://openalex.org/W2156234545","https://openalex.org/W2165216232","https://openalex.org/W2398259333","https://openalex.org/W2408224823","https://openalex.org/W2557305032","https://openalex.org/W2567399239","https://openalex.org/W2625060173","https://openalex.org/W2768737575","https://openalex.org/W2809505594","https://openalex.org/W2918160149"],"related_works":["https://openalex.org/W4410591809","https://openalex.org/W4400916325","https://openalex.org/W3135730267","https://openalex.org/W2889917536","https://openalex.org/W4417035446","https://openalex.org/W2842355219","https://openalex.org/W2918160149","https://openalex.org/W2055439285","https://openalex.org/W2092964823","https://openalex.org/W4394993360"],"abstract_inverted_index":{"Cisplatin":[0],"is":[1,60],"a":[2,20,64],"widely":[3],"used":[4],"chemotherapy":[5],"for":[6,75],"the":[7,80,88,95,142,189,196,201],"treatment":[8],"of":[9,67,82,85,113,151,183,200],"certain":[10],"solid":[11],"tumors.":[12],"Ototoxicity":[13],"and":[14,52,134,136,173,186,198],"subsequent":[15],"permanent":[16],"hearing":[17,41],"loss":[18,42],"remain":[19],"serious":[21],"dose-limiting":[22],"side":[23],"effect":[24],"associated":[25],"with":[26,176],"cisplatin":[27,48,92,166,215,219],"treatment.":[28],"To":[29],"date,":[30],"no":[31],"therapies":[32],"have":[33],"been":[34],"approved":[35],"to":[36,91,109,188,206],"prevent":[37],"or":[38],"treat":[39],"cisplatin-induced":[40,57],"(CIHL).":[43],"Sodium":[44],"thiosulfate":[45,69,86,130,159],"effectively":[46],"inactivates":[47],"through":[49],"covalent":[50],"binding":[51],"may":[53],"provide":[54],"protection":[55],"against":[56],"ototoxicity.":[58],"DB-020":[59,114,152,170,210],"being":[61],"developed":[62],"as":[63,181],"novel":[65],"formulation":[66],"sodium":[68,73],"pentahydrate":[70],"in":[71,154,158,211],"1%":[72],"hyaluronate":[74],"intratympanic":[76,149],"injection":[77],"(IT),":[78],"enabling":[79],"delivery":[81],"high":[83],"concentrations":[84],"into":[87,106],"cochlea":[89],"prior":[90],"administration.":[93],"In":[94],"DB-020-002":[96],"phase":[97],"1a":[98],"single-ascending":[99],"dose":[100],"study,":[101,204],"healthy":[102],"volunteers":[103],"were":[104,139],"enrolled":[105],"5":[107,125],"cohorts":[108],"receive":[110],"different":[111],"doses":[112],"via":[115],"IT":[116,190],"injection.":[117],"Cohorts":[118],"1-4":[119],"received":[120,126],"unilateral":[121],"injections":[122],"while":[123],"Cohort":[124],"bilateral":[127],"injections.":[128],"Plasma":[129],"pharmacokinetics":[131],"was":[132,171],"measured,":[133],"safety":[135],"audiometric":[137],"data":[138],"collected":[140],"throughout":[141],"study.":[143],"This":[144],"study":[145],"has":[146],"demonstrated":[147],"that":[148],"administration":[150,191],"results":[153,194],"nominal":[155],"systemic":[156],"increases":[157],"levels,":[160],"hence":[161],"it":[162],"should":[163],"not":[164],"compromise":[165],"anti-tumor":[167,220],"efficacy.":[168,221],"Furthermore,":[169],"safe":[172],"well":[174],"tolerated":[175],"most":[177],"adverse":[178],"events":[179],"reported":[180],"transient,":[182],"mild-to-moderate":[184],"severity":[185],"related":[187],"procedure.":[192],"These":[193],"support":[195],"design":[197],"execution":[199],"ongoing":[202],"proof-of-concept":[203],"DB-020-002,":[205],"assess":[207],"otoprotection":[208],"using":[209],"cancer":[212],"patients":[213],"receiving":[214],"without":[216],"negatively":[217],"impacting":[218]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-03-23T00:00:00"}
