{"id":"https://openalex.org/W3012407808","doi":null,"title":"Implementation of Open Fetal Surgery for Spina Bifida in the UK","display_name":"Implementation of Open Fetal Surgery for Spina Bifida in the UK","publication_year":2019,"publication_date":"2019-10-28","ids":{"openalex":"https://openalex.org/W3012407808","mag":"3012407808"},"language":"en","primary_location":{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10082217","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10082217/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028311219","display_name":"Adalina Sacco","orcid":"https://orcid.org/0000-0002-9182-9628","observed_orcids":["https://orcid.org/0000-0002-9182-9628"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Adalina Sacco","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9182-9628","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5028311219"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11833","display_name":"Spinal Dysraphism and Malformations","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11833","display_name":"Spinal Dysraphism and Malformations","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12716","display_name":"Congenital Anomalies and Fetal Surgery","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12552","display_name":"Fetal and Pediatric Neurological Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/open-fetal-surgery","display_name":"open fetal surgery","score":0.8889999985694885},{"id":"https://openalex.org/keywords/spina-bifida","display_name":"spina bifida","score":0.9890000224113464},{"id":"https://openalex.org/keywords/maternal-morbidity","display_name":"maternal morbidity","score":0.7860000133514404},{"id":"https://openalex.org/keywords/cost-analysis","display_name":"cost analysis","score":0.6060000061988831},{"id":"https://openalex.org/keywords/patient-experience","display_name":"patient experience","score":0.5839999914169312},{"id":"https://openalex.org/keywords/long-term-outcomes","display_name":"long-term outcomes","score":0.5059999823570251},{"id":"https://openalex.org/keywords/neurodevelopmental-outcomes","display_name":"neurodevelopmental outcomes","score":0.6159999966621399},{"id":"https://openalex.org/keywords/prenatal-diagnosis","display_name":"prenatal diagnosis","score":0.31700000166893005},{"id":"https://openalex.org/keywords/multidisciplinary-collaboration","display_name":"multidisciplinary collaboration","score":0.4729999899864197},{"id":"https://openalex.org/keywords/ventriculoperitoneal-shunt","display_name":"ventriculoperitoneal shunt","score":0.7179999947547913},{"id":"https://openalex.org/keywords/hindbrain-herniation","display_name":"hindbrain herniation","score":0.7120000123977661},{"id":"https://openalex.org/keywords/preterm-birth","display_name":"preterm birth","score":0.4300000071525574},{"id":"https://openalex.org/keywords/health-care-utilization","display_name":"health care utilization","score":0.5669999718666077}],"concepts":[{"id":"https://openalex.org/C2777122282","wikidata":"https://www.wikidata.org/wiki/Q1480305","display_name":"Fetal surgery","level":5,"score":0.9395028948783875},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7476546168327332},{"id":"https://openalex.org/C2778478650","wikidata":"https://www.wikidata.org/wiki/Q844717","display_name":"Spina bifida","level":2,"score":0.7409298419952393},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.4807964861392975},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.43609052896499634},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.34540021419525146},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.3136613965034485},{"id":"https://openalex.org/C201614185","wikidata":"https://www.wikidata.org/wiki/Q396833","display_name":"In utero","level":4,"score":0.11383756995201111},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10082217","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10082217/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},{"id":"mag:3012407808","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10082217/","pdf_url":null,"source":{"id":"https://openalex.org/S4306508231","display_name":"Doctoral thesis, UCL (University College London).","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":196,"referenced_works":["https://openalex.org/W188340325","https://openalex.org/W1483605136","https://openalex.org/W1526377823","https://openalex.org/W1534678246","https://openalex.org/W1542399206","https://openalex.org/W1552454844","https://openalex.org/W1594519129","https://openalex.org/W1594661722","https://openalex.org/W1598112366","https://openalex.org/W1608854422","https://openalex.org/W1712814714","https://openalex.org/W1779284264","https://openalex.org/W1906838633","https://openalex.org/W1917408715","https://openalex.org/W1920276562","https://openalex.org/W1923538805","https://openalex.org/W1958333218","https://openalex.org/W1965069305","https://openalex.org/W1965252352","https://openalex.org/W1966707688","https://openalex.org/W1971741474","https://openalex.org/W1971898507","https://openalex.org/W1972614164","https://openalex.org/W1972845143","https://openalex.org/W1973295614","https://openalex.org/W1974453260","https://openalex.org/W1978670621","https://openalex.org/W1981243303","https://openalex.org/W1982347263","https://openalex.org/W1983701320","https://openalex.org/W1986849191","https://openalex.org/W1990043986","https://openalex.org/W1990260157","https://openalex.org/W1990416993","https://openalex.org/W1990679241","https://openalex.org/W1991158223","https://openalex.org/W1991863808","https://openalex.org/W1994682215","https://openalex.org/W1995503073","https://openalex.org/W2000784779","https://openalex.org/W2001774406","https://openalex.org/W2002975394","https://openalex.org/W2006033004","https://openalex.org/W2007328295","https://openalex.org/W2007344602","https://openalex.org/W2007702120","https://openalex.org/W2008982730","https://openalex.org/W2010113746","https://openalex.org/W2011103187","https://openalex.org/W2014313665","https://openalex.org/W2014889952","https://openalex.org/W2015694021","https://openalex.org/W2017525642","https://openalex.org/W2018855746","https://openalex.org/W2018882696","https://openalex.org/W2019290835","https://openalex.org/W2019610662","https://openalex.org/W2021046839","https://openalex.org/W2024107655","https://openalex.org/W2025649092","https://openalex.org/W2025932021","https://openalex.org/W2027231033","https://openalex.org/W2027292312","https://openalex.org/W2027630274","https://openalex.org/W2028720542","https://openalex.org/W2029312474","https://openalex.org/W2031090243","https://openalex.org/W2031641663","https://openalex.org/W2033219513","https://openalex.org/W2034335082","https://openalex.org/W2035359966","https://openalex.org/W2036817658","https://openalex.org/W2039589349","https://openalex.org/W2039788905","https://openalex.org/W2040069812","https://openalex.org/W2041013023","https://openalex.org/W2042903814","https://openalex.org/W2043490735","https://openalex.org/W2044533248","https://openalex.org/W2045184344","https://openalex.org/W2045390769","https://openalex.org/W2046619780","https://openalex.org/W2048151432","https://openalex.org/W2048401644","https://openalex.org/W2048975708","https://openalex.org/W2051211149","https://openalex.org/W2051522925","https://openalex.org/W2052261495","https://openalex.org/W2053410406","https://openalex.org/W2054570472","https://openalex.org/W2057892905","https://openalex.org/W2059479740","https://openalex.org/W2060513218","https://openalex.org/W2060765514","https://openalex.org/W2063388547","https://openalex.org/W2064229322","https://openalex.org/W2067241464","https://openalex.org/W2067351166","https://openalex.org/W2069542055","https://openalex.org/W2069760209","https://openalex.org/W2073012954","https://openalex.org/W2073414849","https://openalex.org/W2073569289","https://openalex.org/W2073579854","https://openalex.org/W2073701082","https://openalex.org/W2075769984","https://openalex.org/W2076655436","https://openalex.org/W2078856438","https://openalex.org/W2081135435","https://openalex.org/W2083757217","https://openalex.org/W2084676246","https://openalex.org/W2087587565","https://openalex.org/W2089397734","https://openalex.org/W2089660136","https://openalex.org/W2090157363","https://openalex.org/W2090750156","https://openalex.org/W2091153544","https://openalex.org/W2092544667","https://openalex.org/W2093245985","https://openalex.org/W2093602031","https://openalex.org/W2093926796","https://openalex.org/W2096998881","https://openalex.org/W2100335423","https://openalex.org/W2101383839","https://openalex.org/W2101620705","https://openalex.org/W2103966730","https://openalex.org/W2109821968","https://openalex.org/W2117580391","https://openalex.org/W2117682155","https://openalex.org/W2120197364","https://openalex.org/W2122033695","https://openalex.org/W2123506942","https://openalex.org/W2123676036","https://openalex.org/W2135233841","https://openalex.org/W2135433478","https://openalex.org/W2136645287","https://openalex.org/W2141008218","https://openalex.org/W2143708472","https://openalex.org/W2148044501","https://openalex.org/W2149159653","https://openalex.org/W2156098321","https://openalex.org/W2159516830","https://openalex.org/W2160034124","https://openalex.org/W2164063517","https://openalex.org/W2164234656","https://openalex.org/W2167107449","https://openalex.org/W2171901939","https://openalex.org/W2173611394","https://openalex.org/W2174039454","https://openalex.org/W2184397160","https://openalex.org/W2190730178","https://openalex.org/W2196477493","https://openalex.org/W2197462212","https://openalex.org/W2227926169","https://openalex.org/W2288477245","https://openalex.org/W2301159137","https://openalex.org/W2326116276","https://openalex.org/W2326313505","https://openalex.org/W2328668884","https://openalex.org/W2336792944","https://openalex.org/W2341405723","https://openalex.org/W2350578442","https://openalex.org/W2397865909","https://openalex.org/W2426070319","https://openalex.org/W2462774343","https://openalex.org/W2476352939","https://openalex.org/W2490272968","https://openalex.org/W2499835487","https://openalex.org/W2530707966","https://openalex.org/W2538767621","https://openalex.org/W2588773667","https://openalex.org/W2592636424","https://openalex.org/W2596180815","https://openalex.org/W2601600007","https://openalex.org/W2605869044","https://openalex.org/W2610170647","https://openalex.org/W2612891587","https://openalex.org/W2614969739","https://openalex.org/W2617876510","https://openalex.org/W2705120698","https://openalex.org/W2724583690","https://openalex.org/W2748403572","https://openalex.org/W2750386227","https://openalex.org/W2762406039","https://openalex.org/W2782234924","https://openalex.org/W2782946218","https://openalex.org/W2782966938","https://openalex.org/W2783342503","https://openalex.org/W2790962082","https://openalex.org/W2792429726","https://openalex.org/W2794298429","https://openalex.org/W2801765767","https://openalex.org/W2802886799","https://openalex.org/W2805824889","https://openalex.org/W2809675711","https://openalex.org/W2889690955"],"related_works":["https://openalex.org/W2966060723","https://openalex.org/W2984482739","https://openalex.org/W2923453665","https://openalex.org/W4319061362","https://openalex.org/W4411183681","https://openalex.org/W4413163124","https://openalex.org/W2884709411","https://openalex.org/W2990184482","https://openalex.org/W7004858399","https://openalex.org/W2415730943"],"abstract_inverted_index":{"Spina":[0],"bifida":[1,426],"is":[2,232,279,409,437],"a":[3,61,68,129,139,156,216,285],"congenital":[4],"neurological":[5],"condition":[6],"with":[7,77,165,190,365,393],"lifelong":[8],"physical":[9],"and":[10,32,73,91,125,147,182,203,208,287,298,332,342,359,384,391,399,436,442],"mental":[11],"effects.":[12],"Open":[13],"fetal":[14,62,149,166,181,308],"repair":[15],"of":[16,43,52,82,93,99,110,145,170,193,224,249,266,307,320,346,354,424,449],"the":[17,36,50,89,97,134,161,168,191,221,242,247,257,261,274,296,305],"spinal":[18],"lesion":[19],"has":[20,95,401],"been":[21,96,318,363,402],"shown":[22],"to":[23,48,58,114,126,154,175,210,219,333,379,431],"improve":[24],"hindbrain":[25],"herniation,":[26],"ventriculoperitoneal":[27],"shunting":[28],"rates,":[29],"independent":[30],"mobility":[31],"bladder":[33],"outcomes":[34,144,361,376],"for":[35,86,179,184,304,381,421],"child":[37],"and,":[38],"despite":[39],"an":[40,107,280],"increased":[41],"risk":[42,51,169],"prematurity,":[44],"does":[45],"not":[46,237],"seem":[47],"increase":[49],"neurodevelopmental":[53],"impairment.":[54],"//":[55,104,187,277,324,405],"We":[56,325,372],"proposed":[57],"set":[59,197],"up":[60,198],"surgery":[63,230,245],"centre":[64,130],"in":[65,75,133,321,329,349,433,439],"London,":[66],"as":[67,151],"joint":[69],"venture":[70],"between":[71],"UCLH":[72,341],"GOSH":[74],"collaboration":[76],"UZ":[78],"Leuven,":[79],"Belgium.":[80],"Implementation":[81],"this":[83,146,152,199,225,227,400,407],"treatment":[84],"option":[85],"patients":[87,328,339,356],"from":[88],"UK":[90,297],"Republic":[92],"Ireland":[94],"subject":[98],"my":[100],"two":[101],"year":[102],"project.":[103],"I":[105,136,188,213,291,386],"performed":[106,215],"initial":[108,360],"review":[109,141],"existing":[111],"global":[112],"centres":[113],"establish":[115],"what":[116],"was":[117,131,173,301],"already":[118],"available,":[119],"which":[120,315],"techniques":[121,420],"were":[122],"being":[123],"used":[124],"confirm":[127],"that":[128,229],"required":[132],"UK.":[135],"also":[137],"conducted":[138],"systematic":[140],"into":[142],"maternal":[143,162,368],"other":[148,195],"surgery,":[150,309],"appeared":[153],"be":[155,176,374],"neglected":[157],"area.":[158],"This":[159],"demonstrated":[160],"morbidity":[163],"associated":[164],"surgery;":[167,226],"severe":[171],"complications":[172],"found":[174,299],"approximately":[177],"4.5%":[178],"open":[180],"1.7%":[183],"fetoscopic":[185],"surgery.":[186,450],"have,":[189],"help":[192],"many":[194],"people,":[196],"new":[200,286],"clinical":[201],"service":[202,408],"have":[204,214,317,336,357,362,387,397,429],"developed":[205],"local":[206],"pathways":[207],"protocols":[209],"facilitate":[211],"this.":[212],"cost-analysis":[217],"study":[218],"evaluate":[220],"cost":[222,258,275],"implications":[223],"showed":[228],"itself":[231],"roughly":[233],"equal":[234],"to,":[235],"if":[236],"slightly":[238],"cheaper":[239],"than,":[240],"than":[241],"standard":[243],"postnatal":[244],"at":[246,340],"point":[248],"operation.":[250],"Prematurity":[251],"(if":[252],"it":[253],"occurs)":[254],"will":[255,373],"bring":[256,273],"up,":[259],"but":[260,310],"expected":[262],"reduced":[263],"healthcare":[264,293],"utilisation":[265],"these":[267,355],"children":[268],"over":[269],"their":[270],"lifetime":[271],"should":[272,413],"down.":[276],"Acceptability":[278],"important":[281],"consideration":[282],"when":[283],"introducing":[284],"potentially":[288],"controversial":[289],"technique.":[290],"surveyed":[292],"workers":[294],"throughout":[295],"there":[300],"general":[302],"support":[303],"concept":[306],"concern":[311],"about":[312],"long-term":[313,382,416],"outcomes,":[314,418],"we":[316,335,396,428],"mindful":[319],"our":[322,434],"planning.":[323],"began":[326],"seeing":[327],"January":[330],"2018":[331],"date":[334],"evaluated":[337],"27":[338],"operated":[343],"on":[344],"13":[345],"them,":[347],"either":[348],"London":[350],"or":[351,369],"Leuven.":[352],"Eight":[353],"delivered":[358],"good,":[364],"no":[366],"major":[367],"fetal/neonatal":[370],"morbidity.":[371],"following":[375],"very":[377],"closely":[378],"monitor":[380],"data":[383],"complications.":[385],"assessed":[388],"patient":[389,417],"experience":[390],"acceptability":[392],"all":[394],"women":[395],"seen,":[398],"extremely":[403],"positive.":[404],"Now":[406],"established,":[410],"future":[411],"work":[412],"include":[414],"monitoring":[415],"developing":[419],"earlier":[422],"detection":[423],"spina":[425],"(which":[427],"attempted":[430],"do":[432],"department,":[435],"described":[438],"chapter":[440],"5.1)":[441],"evaluating":[443],"emerging":[444],"evidence":[445],"regarding":[446],"less-invasive":[447],"methods":[448]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-03-23T00:00:00"}
