{"id":"https://openalex.org/W3012397650","doi":"https://doi.org/10.1161/str.51.suppl_1.tp433","title":"Abstract TP433: Effect of Vitamin D and Marine Omega-3 Fatty Acid Supplements on Stroke Outcomes","display_name":"Abstract TP433: Effect of Vitamin D and Marine Omega-3 Fatty Acid Supplements on Stroke Outcomes","publication_year":2020,"publication_date":"2020-02-01","ids":{"openalex":"https://openalex.org/W3012397650","doi":"https://doi.org/10.1161/str.51.suppl_1.tp433","mag":"3012397650"},"language":"en","primary_location":{"id":"doi:10.1161/str.51.suppl_1.tp433","doi":"https://doi.org/10.1161/str.51.suppl_1.tp433","is_oa":false,"landing_page_url":"https://doi.org/10.1161/str.51.suppl_1.tp433","pdf_url":null,"source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005759523","display_name":"Pamela M. Rist","orcid":"https://orcid.org/0000-0003-3543-045X","observed_orcids":["https://orcid.org/0000-0003-3543-045X"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pamela M Rist","raw_affiliation_strings":["Brigham and Women\u2019s Hosp, Boston, MA","Pamela M Rist"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women\u2019s Hosp, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Pamela M Rist","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084857746","display_name":"Nancy R. Cook","orcid":"https://orcid.org/0000-0002-9705-0842","observed_orcids":["https://orcid.org/0000-0002-9705-0842"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy R Cook","raw_affiliation_strings":["Brigham and Women\u2019s Hosp, Boston, MA","Nancy R Cook"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women\u2019s Hosp, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Nancy R Cook","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049411008","display_name":"JoAnn E. Manson","orcid":"https://orcid.org/0000-0002-9426-7595","observed_orcids":["https://orcid.org/0000-0002-9426-7595"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JoAnn E Manson","raw_affiliation_strings":["Harvard Med Sch, Brigham and Women\u2019s Hosp, Boston, MA","JoAnn E Manson"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Med Sch, Brigham and Women\u2019s Hosp, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"JoAnn E Manson","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090744975","display_name":"Julie E. Buring","orcid":"https://orcid.org/0000-0003-2648-8692","observed_orcids":["https://orcid.org/0000-0003-2648-8692"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie E Buring","raw_affiliation_strings":["Brigham and Women\u2019s Hosp, Boston, MA","Julie E Buring"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women\u2019s Hosp, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Julie E Buring","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051820798","display_name":"Kathryn M. Rexrode","orcid":"https://orcid.org/0000-0003-3387-8429","observed_orcids":["https://orcid.org/0000-0003-3387-8429"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathryn M Rexrode","raw_affiliation_strings":["Harvard Schl of Med, Brigham and Women\u2019s Hosp, Boston, MA","Kathryn M Rexrode"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Schl of Med, Brigham and Women\u2019s Hosp, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Kathryn M Rexrode","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"51","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.6747999787330627,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.6747999787330627,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.2808000147342682,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.012199999764561653,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-d-supplementation","display_name":"vitamin D supplementation","score":0.9819999933242798},{"id":"https://openalex.org/keywords/marine-omega-3-fatty-acids","display_name":"marine omega-3 fatty acids","score":0.8600000143051147},{"id":"https://openalex.org/keywords/epa-and-dha","display_name":"EPA and DHA","score":0.6859999895095825},{"id":"https://openalex.org/keywords/functional-disability","display_name":"functional disability","score":0.7419999837875366},{"id":"https://openalex.org/keywords/physical-disability","display_name":"physical disability","score":0.7059999704360962},{"id":"https://openalex.org/keywords/stroke-outcome","display_name":"stroke outcome","score":0.6019999980926514},{"id":"https://openalex.org/keywords/vital-trial","display_name":"VITAL trial","score":0.6039999723434448},{"id":"https://openalex.org/keywords/vitamin-d3","display_name":"vitamin D3","score":0.796999990940094},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.6420000195503235},{"id":"https://openalex.org/keywords/activities-of-daily-living","display_name":"activities of daily living","score":0.7310000061988831},{"id":"https://openalex.org/keywords/stroke-recovery","display_name":"stroke recovery","score":0.5720000267028809},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.4659999907016754},{"id":"https://openalex.org/keywords/functional-limitations","display_name":"functional limitations","score":0.3190000057220459},{"id":"https://openalex.org/keywords/physical-performance","display_name":"physical performance","score":0.4659999907016754}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9347240924835205},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.814265787601471},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.7475513219833374},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.6090900897979736},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5934815406799316},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5332982540130615},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.5216472744941711},{"id":"https://openalex.org/C3017514745","wikidata":"https://www.wikidata.org/wiki/Q191756","display_name":"Omega 3 fatty acid","level":5,"score":0.5006294250488281},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.46340394020080566},{"id":"https://openalex.org/C2777171753","wikidata":"https://www.wikidata.org/wiki/Q423345","display_name":"Docosahexaenoic acid","level":4,"score":0.19806933403015137},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.19571945071220398},{"id":"https://openalex.org/C19038510","wikidata":"https://www.wikidata.org/wiki/Q2005087","display_name":"Polyunsaturated fatty acid","level":3,"score":0.14843878149986267},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08025217056274414},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.06456750631332397},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/str.51.suppl_1.tp433","doi":"https://doi.org/10.1161/str.51.suppl_1.tp433","is_oa":false,"landing_page_url":"https://doi.org/10.1161/str.51.suppl_1.tp433","pdf_url":null,"source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Life below water","id":"https://metadata.un.org/sdg/14","score":0.8100000023841858}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3097929805","https://openalex.org/W3193895272","https://openalex.org/W4220722763","https://openalex.org/W4311061098","https://openalex.org/W4376131823","https://openalex.org/W2792263283","https://openalex.org/W2513160881","https://openalex.org/W2512122450","https://openalex.org/W2591353406","https://openalex.org/W4408296031"],"abstract_inverted_index":{"Introduction:":[0],"Low":[1],"serum":[2,27],"25-hydroxyvitamin":[3],"D":[4,57,69,109,232,310],"(25(OH)D)":[5],"and":[6,34,110,121,133,162,173,189,233,283],"low":[7,26],"marine":[8],"omega-3":[9,312],"fatty":[10,313],"acid":[11],"(n-3)":[12],"intake":[13,41],"are":[14],"associated":[15],"with":[16,308],"increased":[17],"stroke":[18,24,62,86,97,145,200,209,213,317,326],"risk":[19,89,274],"in":[20,46,321],"observational":[21],"studies.":[22],"Among":[23],"patients,":[25],"25(OH)D":[28],"at":[29,131],"admission":[30],"predicts":[31],"poor":[32],"outcomes":[33,214,324],"animal":[35],"studies":[36,51],"suggest":[37],"that":[38,67],"higher":[39],"n-3":[40,59,74,271],"may":[42],"diminish":[43],"brain":[44],"damage":[45],"ischemic":[47],"stroke.":[48],"However,":[49],"few":[50],"have":[52],"examined":[53],"effects":[54],"of":[55,77,80,90,170,218,275],"vitamin":[56,68,231,309],"or":[58,73,93,129,245,256,311],"supplements":[60],"on":[61,191,248,286,297],"outcomes.":[63],"Hypothesis:":[64],"We":[65,102,178,223],"hypothesized":[66],"(cholecalciferol,":[70],"2,000":[71],"IU/day)":[72],"(840":[75],"mg/day":[76],"EPA/DHA":[78],"[ratio":[79],"1.3:1])":[81],"supplementation":[82],"initiated":[83],"prior":[84,315],"to":[85,99,150,182,230,270,316],"would":[87],"reduce":[88],"functional":[91,152,234,276],"limitations":[92,153,190,235,277],"physical":[94,156,163,246,284],"disability":[95,164,247,285],"after":[96,221,325],"compared":[98],"placebo.":[100],"Methods:":[101],"used":[103,179],"data":[104],"from":[105,160],"the":[106,155,166,202,212,249,287,298],"completed":[107,211],"VITamin":[108],"OmegA-3":[111],"TriaL":[112],"(VITAL)":[113],"which":[114],"randomized":[115,186,228,269],"25,871":[116],"men":[117],"aged":[118,123],"\u226550":[119],"years":[120,125,220],"women":[122],"\u226555":[124],"without":[126],"cardiovascular":[127],"disease":[128],"cancer":[130],"baseline":[132],"followed":[134],"them":[135],"for":[136],"incident":[137],"events":[138],"over":[139],"5.3":[140],"years.":[141],"Individuals":[142],"experiencing":[143],"a":[144,148,216],"were":[146],"mailed":[147],"questionnaire":[149,215],"assess":[151],"(with":[154,165],"performance":[157],"scale":[158,289,300],"adapted":[159],"Nagi)":[161],"modified":[167],"Katz":[168,257,288],"Activities":[169],"Daily":[171],"Living":[172],"Rosow-Breslau":[174,250,299],"Functional":[175],"Health":[176],"scales).":[177],"logistic":[180],"regression":[181],"analyze":[183],"associations":[184,226],"between":[185,227],"treatment":[187,229],"assignments":[188],"each":[192],"scale.":[193],"Results:":[194],"290":[195],"individuals":[196],"experienced":[197],"their":[198],"first":[199],"during":[201],"trial":[203],"(including":[204],"42":[205],"fatal":[206],"strokes).":[207],"197":[208],"survivors":[210],"mean":[217],"1.6":[219],"diagnosis.":[222],"observed":[224],"no":[225],"(odds":[236],"ratio":[237],"(OR)=1.01,":[238],"95%":[239,252,259,279,291,302],"confidence":[240],"interval":[241],"(CI):":[242],"0.52,":[243],"1.97)":[244],"(OR=1.03,":[251,301],"CI:":[253,260,280,292,303],"0.31,":[254,304],"3.42)":[255],"(OR=0.92,":[258],"0.50,":[261,293],"1.67)":[262,294],"scales.":[263],"Although":[264],"not":[265,296,319],"statistically":[266],"significant,":[267],"those":[268],"had":[272],"lower":[273],"(OR=0.55,":[278],"0.28,":[281],"1.09)":[282],"(OR=0.32,":[290],"but":[295],"3.42).":[305],"Conclusion:":[306],"Supplementation":[307],"acids":[314],"did":[318],"result":[320],"significantly":[322],"improved":[323],"among":[327],"older":[328],"individuals.":[329]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2020-03-23T00:00:00"}