{"id":"https://openalex.org/W3012365685","doi":"https://doi.org/10.1089/jop.2019.0060","title":"The Immunological Basis of Dry Eye Disease and Current Topical Treatment Options","display_name":"The Immunological Basis of Dry Eye Disease and Current Topical Treatment Options","publication_year":2020,"publication_date":"2020-03-16","ids":{"openalex":"https://openalex.org/W3012365685","doi":"https://doi.org/10.1089/jop.2019.0060","mag":"3012365685","pmid":"https://pubmed.ncbi.nlm.nih.gov/32175799","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7175622"},"language":"en","primary_location":{"id":"doi:10.1089/jop.2019.0060","doi":"https://doi.org/10.1089/jop.2019.0060","is_oa":true,"landing_page_url":"https://doi.org/10.1089/jop.2019.0060","pdf_url":"https://www.liebertpub.com/doi/pdf/10.1089/jop.2019.0060","source":{"id":"https://openalex.org/S192126995","display_name":"Journal of Ocular Pharmacology and Therapeutics","issn_l":"1080-7683","issn":["1080-7683","1557-7732","8756-3320"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ocular Pharmacology and Therapeutics","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.liebertpub.com/doi/pdf/10.1089/jop.2019.0060","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015035411","display_name":"Laura M. Periman","orcid":"https://orcid.org/0000-0001-9036-5158","observed_orcids":["https://orcid.org/0000-0001-9036-5158"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Laura M. Periman","raw_affiliation_strings":["Periman Eye Center, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Periman Eye Center, Seattle, Washington","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100642343","display_name":"Victor L. Perez","orcid":"https://orcid.org/0000-0001-5872-5950","observed_orcids":["https://orcid.org/0000-0001-5872-5950"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victor L. Perez","raw_affiliation_strings":["Duke Eye Center, Duke University School of Medicine, Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke Eye Center, Duke University School of Medicine, Durham, North Carolina","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039527047","display_name":"Daniel R. Saban","orcid":"https://orcid.org/0000-0003-4177-8065","observed_orcids":["https://orcid.org/0000-0003-4177-8065"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel R. Saban","raw_affiliation_strings":["Duke Eye Center, Duke University School of Medicine, Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke Eye Center, Duke University School of Medicine, Durham, North Carolina","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018591572","display_name":"Meng C. Lin","orcid":"https://orcid.org/0000-0003-4301-0279","observed_orcids":["https://orcid.org/0000-0003-4301-0279"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meng C. Lin","raw_affiliation_strings":["School of Optometry, Clinical Research Center, University of California, Berkeley, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Optometry, Clinical Research Center, University of California, Berkeley, California","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044464477","display_name":"Piergiorgio Neri","orcid":"https://orcid.org/0000-0002-7673-4276","observed_orcids":["https://orcid.org/0000-0002-7673-4276"]},"institutions":[{"id":"https://openalex.org/I4405266839","display_name":"Cleveland Clinic Abu Dhabi","ror":"https://ror.org/00042rr39","country_code":"AE","type":"healthcare","lineage":["https://openalex.org/I4405266839"]}],"countries":["AE"],"is_corresponding":false,"raw_author_name":"Piergiorgio Neri","raw_affiliation_strings":["The Eye Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Eye Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates","institution_ids":["https://openalex.org/I4405266839"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5015035411"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.8795,"has_fulltext":true,"cited_by_count":174,"citation_normalized_percentile":{"value":0.93454686,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"36","issue":"3","first_page":"137","last_page":"146"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dry-eye-disease","display_name":"dry eye","score":1.0},{"id":"https://openalex.org/keywords/ocular-surface-inflammation","display_name":"ocular surface inflammation","score":0.8180000185966492},{"id":"https://openalex.org/keywords/tear-film-homeostasis","display_name":"tear film homeostasis","score":0.875},{"id":"https://openalex.org/keywords/ocular-immune-response","display_name":"ocular immune response","score":0.9049999713897705},{"id":"https://openalex.org/keywords/innate-and-adaptive-immunity","display_name":"innate and adaptive immunity","score":0.824999988079071},{"id":"https://openalex.org/keywords/immunosuppressive-therapy","display_name":"immunosuppressive therapy","score":0.75},{"id":"https://openalex.org/keywords/topical-corticosteroids","display_name":"topical corticosteroids","score":0.8379999995231628},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.9660000205039978},{"id":"https://openalex.org/keywords/lifitegrast","display_name":"lifitegrast","score":0.9990000128746033},{"id":"https://openalex.org/keywords/immunomodulators","display_name":"immunomodulators","score":0.8560000061988831},{"id":"https://openalex.org/keywords/immunopathology","display_name":"immunopathology","score":0.656000018119812}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7638753652572632},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6213439106941223},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6085084080696106},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6062967777252197},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5950235724449158},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.5309191346168518},{"id":"https://openalex.org/C2780648854","wikidata":"https://www.wikidata.org/wiki/Q2745824","display_name":"Immunopathology","level":2,"score":0.5061783194541931},{"id":"https://openalex.org/C2778837293","wikidata":"https://www.wikidata.org/wiki/Q3320636","display_name":"Artificial tears","level":2,"score":0.4520655572414398},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.41206198930740356},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.25643211603164673},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.22128725051879883},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14526060223579407}],"mesh":[{"descriptor_ui":"D000066491","descriptor_name":"Clinical Decision-Making","qualifier_ui":"Q000941","qualifier_name":"ethics","is_major_topic":false},{"descriptor_ui":"D000287","descriptor_name":"Administration, Topical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007765","descriptor_name":"Lacrimal Apparatus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010649","descriptor_name":"Phenylalanine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010649","descriptor_name":"Phenylalanine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D010649","descriptor_name":"Phenylalanine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013256","descriptor_name":"Steroids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013256","descriptor_name":"Steroids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013450","descriptor_name":"Sulfones","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013450","descriptor_name":"Sulfones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013666","descriptor_name":"Tears","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013666","descriptor_name":"Tears","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013666","descriptor_name":"Tears","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015352","descriptor_name":"Dry Eye Syndromes","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015352","descriptor_name":"Dry Eye Syndromes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015352","descriptor_name":"Dry Eye Syndromes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015352","descriptor_name":"Dry Eye Syndromes","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016169","descriptor_name":"Lymphocyte Function-Associated Antigen-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016572","descriptor_name":"Cyclosporine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D016572","descriptor_name":"Cyclosporine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018799","descriptor_name":"Intercellular Adhesion Molecule-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D020397","descriptor_name":"Goblet Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D020397","descriptor_name":"Goblet Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1089/jop.2019.0060","doi":"https://doi.org/10.1089/jop.2019.0060","is_oa":true,"landing_page_url":"https://doi.org/10.1089/jop.2019.0060","pdf_url":"https://www.liebertpub.com/doi/pdf/10.1089/jop.2019.0060","source":{"id":"https://openalex.org/S192126995","display_name":"Journal of Ocular Pharmacology and Therapeutics","issn_l":"1080-7683","issn":["1080-7683","1557-7732","8756-3320"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ocular Pharmacology and Therapeutics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7175622","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7175622","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Ocul Pharmacol Ther","raw_type":"Text"},{"id":"pmid:32175799","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32175799","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt7jj1k2kt","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/7jj1k2kt","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, vol 36, iss 3","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt7jj1k2kt","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/7jj1k2kt","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Ocular Pharmacology and Therapeutics, vol 36, iss 3","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1089/jop.2019.0060","doi":"https://doi.org/10.1089/jop.2019.0060","is_oa":true,"landing_page_url":"https://doi.org/10.1089/jop.2019.0060","pdf_url":"https://www.liebertpub.com/doi/pdf/10.1089/jop.2019.0060","source":{"id":"https://openalex.org/S192126995","display_name":"Journal of Ocular Pharmacology and Therapeutics","issn_l":"1080-7683","issn":["1080-7683","1557-7732","8756-3320"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ocular Pharmacology and Therapeutics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000910490","display_name":"Immune Mechanisms in Ocular Graft versus Host Disease","funder_award_id":"R01EY024484","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3012365685.pdf","grobid_xml":"https://content.openalex.org/works/W3012365685.grobid-xml"},"referenced_works_count":98,"referenced_works":["https://openalex.org/W263358538","https://openalex.org/W1492606441","https://openalex.org/W1523354060","https://openalex.org/W1585833237","https://openalex.org/W1593552847","https://openalex.org/W1616940749","https://openalex.org/W1782629442","https://openalex.org/W1834447795","https://openalex.org/W1858115123","https://openalex.org/W1966772950","https://openalex.org/W1971369241","https://openalex.org/W1971671391","https://openalex.org/W1976536758","https://openalex.org/W1976831998","https://openalex.org/W1980833693","https://openalex.org/W1984309285","https://openalex.org/W1990704371","https://openalex.org/W1992063412","https://openalex.org/W1998321598","https://openalex.org/W1999554027","https://openalex.org/W2001682689","https://openalex.org/W2001856828","https://openalex.org/W2001968948","https://openalex.org/W2002180108","https://openalex.org/W2008878337","https://openalex.org/W2011777137","https://openalex.org/W2015494251","https://openalex.org/W2018452537","https://openalex.org/W2021491704","https://openalex.org/W2022635325","https://openalex.org/W2025896394","https://openalex.org/W2031257608","https://openalex.org/W2032106050","https://openalex.org/W2036170000","https://openalex.org/W2037972678","https://openalex.org/W2049207532","https://openalex.org/W2049299771","https://openalex.org/W2049698725","https://openalex.org/W2052808939","https://openalex.org/W2057741044","https://openalex.org/W2057784785","https://openalex.org/W2058888578","https://openalex.org/W2066618391","https://openalex.org/W2067545345","https://openalex.org/W2070033983","https://openalex.org/W2070876163","https://openalex.org/W2073200435","https://openalex.org/W2075150730","https://openalex.org/W2080389273","https://openalex.org/W2081293304","https://openalex.org/W2081689799","https://openalex.org/W2091207705","https://openalex.org/W2093395242","https://openalex.org/W2095815384","https://openalex.org/W2099738114","https://openalex.org/W2106079454","https://openalex.org/W2107845315","https://openalex.org/W2115815608","https://openalex.org/W2124600315","https://openalex.org/W2127715753","https://openalex.org/W2131254168","https://openalex.org/W2135358480","https://openalex.org/W2138321161","https://openalex.org/W2142263640","https://openalex.org/W2144423756","https://openalex.org/W2149791045","https://openalex.org/W2163380226","https://openalex.org/W2163725373","https://openalex.org/W2169772679","https://openalex.org/W2176407061","https://openalex.org/W2193625867","https://openalex.org/W2218643654","https://openalex.org/W2293232340","https://openalex.org/W2313816167","https://openalex.org/W2314583443","https://openalex.org/W2340320857","https://openalex.org/W2343779963","https://openalex.org/W2398070174","https://openalex.org/W2514497641","https://openalex.org/W2541357500","https://openalex.org/W2560343879","https://openalex.org/W2611039653","https://openalex.org/W2737439597","https://openalex.org/W2737725878","https://openalex.org/W2737787547","https://openalex.org/W2738627012","https://openalex.org/W2739221391","https://openalex.org/W2739359388","https://openalex.org/W2739410682","https://openalex.org/W2765242879","https://openalex.org/W2783349375","https://openalex.org/W2791575019","https://openalex.org/W2794870319","https://openalex.org/W2810049703","https://openalex.org/W2883986429","https://openalex.org/W2885761574","https://openalex.org/W2902643770","https://openalex.org/W4251348407"],"related_works":["https://openalex.org/W4321018296","https://openalex.org/W4390701807","https://openalex.org/W1984309285","https://openalex.org/W4415718805","https://openalex.org/W3217297541","https://openalex.org/W7147510187","https://openalex.org/W4205835470","https://openalex.org/W2492082046","https://openalex.org/W3030717758","https://openalex.org/W4324095257"],"abstract_inverted_index":{"Homeostasis":[0],"of":[1,75,84,122,144,147,163,171],"the":[2,21,33,58,76,119,140,161,166],"lacrimal":[3],"functional":[4],"unit":[5],"is":[6,25,40,71,105,150],"needed":[7],"to":[8,50,57,110,117,176],"ensure":[9],"a":[10,72,106],"well-regulated":[11],"ocular":[12,22,44,77,88,96,101],"immune":[13,23,97],"response":[14],"comprising":[15],"innate":[16,36],"and":[17,37,42,61,82,92,124,128,134,137,165,168],"adaptive":[18,38],"phases.":[19],"When":[20],"system":[24],"excessively":[26],"stimulated":[27],"and/or":[28],"immunoregulatory":[29],"mechanisms":[30],"are":[31,115],"disrupted,":[32],"balance":[34],"between":[35],"phases":[39],"dysregulated":[41],"chronic":[43,51,126,141],"surface":[45,78,102],"inflammation":[46],"can":[47],"result,":[48],"leading":[49],"dry":[52],"eye":[53],"disease":[54,127],"(DED).":[55],"According":[56],"Tear":[59],"Film":[60],"Ocular":[62],"Surface":[63],"Society":[64],"Dry":[65],"Eye":[66],"Workshop":[67],"II":[68],"definition,":[69],"DED":[70,111,123,164,174],"multifactorial":[73],"disorder":[74],"characterized":[79],"by":[80],"impairment":[81],"loss":[83],"tear":[85],"homeostasis":[86],"(hyperosmolarity),":[87],"discomfort":[89],"or":[90],"pain,":[91],"neurosensory":[93],"abnormalities.":[94],"Dysregulated":[95],"responses":[98],"result":[99],"in":[100,153],"damage,":[103],"which":[104],"further":[107],"contributing":[108],"factor":[109],"pathology.":[112],"Several":[113],"therapeutics":[114,175],"available":[116],"break":[118],"vicious":[120],"circle":[121],"prevent":[125],"progression,":[129],"including":[130],"immunosuppressive":[131],"agents":[132,149],"(steroids)":[133],"immunomodulators":[135],"(cyclosporine":[136],"lifitegrast).":[138],"Given":[139],"inflammatory":[142],"nature":[143],"DED,":[145],"each":[146],"these":[148],"commonly":[151],"used":[152],"clinical":[154,178],"practice.":[155],"In":[156],"this":[157],"study,":[158],"we":[159],"review":[160],"immunopathology":[162],"molecular":[167],"cellular":[169],"actions":[170],"current":[172],"topical":[173],"inform":[177],"decision":[179],"making.":[180]},"counts_by_year":[{"year":2026,"cited_by_count":32},{"year":2025,"cited_by_count":34},{"year":2024,"cited_by_count":39},{"year":2023,"cited_by_count":29},{"year":2022,"cited_by_count":23},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-03-23T00:00:00"}