{"id":"https://openalex.org/W3012317697","doi":"https://doi.org/10.1242/jcs.241455","title":"The ubiquitin hydrolase Doa4 directly binds Snf7 to inhibit recruitment of ESCRT-III remodeling factors in S. cerevisiae","display_name":"The ubiquitin hydrolase Doa4 directly binds Snf7 to inhibit recruitment of ESCRT-III remodeling factors in S. cerevisiae","publication_year":2020,"publication_date":"2020-03-17","ids":{"openalex":"https://openalex.org/W3012317697","doi":"https://doi.org/10.1242/jcs.241455","mag":"3012317697","pmid":"https://pubmed.ncbi.nlm.nih.gov/32184262","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7197871"},"language":"en","primary_location":{"id":"doi:10.1242/jcs.241455","doi":"https://doi.org/10.1242/jcs.241455","is_oa":false,"landing_page_url":"https://doi.org/10.1242/jcs.241455","pdf_url":null,"source":{"id":"https://openalex.org/S5677253","display_name":"Journal of Cell Science","issn_l":"0021-9533","issn":["0021-9533","1477-9137"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7197871","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000770134","display_name":"Dalton Buysse","orcid":"https://orcid.org/0000-0003-0218-7414","observed_orcids":["https://orcid.org/0000-0003-0218-7414"]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dalton Buysse","raw_affiliation_strings":["University of Colorado 1 Department of Molecular, Cellular, and Developmental Biology , , Boulder, CO 80309, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado 1 Department of Molecular, Cellular, and Developmental Biology , , Boulder, CO 80309, USA","institution_ids":["https://openalex.org/I188538660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053389864","display_name":"Anna-Katharina Pfitzner","orcid":"https://orcid.org/0000-0001-9952-5525","observed_orcids":["https://orcid.org/0000-0001-9952-5525"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Anna-Katharina Pfitzner","raw_affiliation_strings":["University of Geneva 2 Department of Biochemistry , , Geneva CH-1211 , Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-9952-5525","affiliations":[{"raw_affiliation_string":"University of Geneva 2 Department of Biochemistry , , Geneva CH-1211 , Switzerland","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113333197","display_name":"Matt West","orcid":"https://orcid.org/0000-0002-4710-9252","observed_orcids":["https://orcid.org/0000-0002-4710-9252"]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matt West","raw_affiliation_strings":["University of Colorado 1 Department of Molecular, Cellular, and Developmental Biology , , Boulder, CO 80309, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado 1 Department of Molecular, Cellular, and Developmental Biology , , Boulder, CO 80309, USA","institution_ids":["https://openalex.org/I188538660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017325892","display_name":"Aur\u00e9lien Roux","orcid":"https://orcid.org/0000-0002-6088-0711","observed_orcids":["https://orcid.org/0000-0002-6088-0711","https://orcid.org/0000-0001-7333-0738"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Aur\u00e9lien Roux","raw_affiliation_strings":["Swiss National Centre for Competence in Research Program Chemical Biology 3 , Geneva CH-1211 , Switzerland","University of Geneva 2 Department of Biochemistry , , Geneva CH-1211 , Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-6088-0711","affiliations":[{"raw_affiliation_string":"Swiss National Centre for Competence in Research Program Chemical Biology 3 , Geneva CH-1211 , Switzerland","institution_ids":[]},{"raw_affiliation_string":"University of Geneva 2 Department of Biochemistry , , Geneva CH-1211 , Switzerland","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084440501","display_name":"Greg Odorizzi","orcid":"https://orcid.org/0000-0002-1143-1098","observed_orcids":["https://orcid.org/0000-0002-1143-1098"]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Greg Odorizzi","raw_affiliation_strings":["University of Colorado 1 Department of Molecular, Cellular, and Developmental Biology , , Boulder, CO 80309, USA"],"raw_orcid":"https://orcid.org/0000-0002-1143-1098","affiliations":[{"raw_affiliation_string":"University of Colorado 1 Department of Molecular, Cellular, and Developmental Biology , , Boulder, CO 80309, USA","institution_ids":["https://openalex.org/I188538660"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5084440501"],"corresponding_institution_ids":["https://openalex.org/I188538660"],"apc_list":null,"apc_paid":null,"fwci":0.8893,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.64783968,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"133","issue":"8","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.013199999928474426,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/snf7","display_name":"Snf7","score":0.8920000195503235},{"id":"https://openalex.org/keywords/escrt-iii","display_name":"ESCRT-III","score":0.9750000238418579},{"id":"https://openalex.org/keywords/ubiquitin-hydrolase","display_name":"ubiquitin hydrolase","score":0.8510000109672546},{"id":"https://openalex.org/keywords/deubiquitination","display_name":"deubiquitination","score":0.9739999771118164},{"id":"https://openalex.org/keywords/membrane-fission","display_name":"membrane fission","score":0.8949999809265137},{"id":"https://openalex.org/keywords/endosomal-sorting","display_name":"endosomal sorting","score":0.5569999814033508},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.8960000276565552}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9436228275299072},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.7095773816108704},{"id":"https://openalex.org/C143876685","wikidata":"https://www.wikidata.org/wiki/Q22327705","display_name":"ESCRT","level":4,"score":0.6881346702575684},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6086317300796509},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.4577476382255554},{"id":"https://openalex.org/C2780120296","wikidata":"https://www.wikidata.org/wiki/Q96286","display_name":"Hydrolase","level":3,"score":0.4419745206832886},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.32066071033477783},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31070584058761597},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.3023574948310852},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.27166664600372314},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.25335952639579773},{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.12578070163726807},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000251","descriptor_name":"Adenosine Triphosphatases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000251","descriptor_name":"Adenosine Triphosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006867","descriptor_name":"Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010450","descriptor_name":"Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011992","descriptor_name":"Endosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025801","descriptor_name":"Ubiquitin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D043222","descriptor_name":"Ubiquitin Thiolesterase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D056827","descriptor_name":"Endosomal Sorting Complexes Required for Transport","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056827","descriptor_name":"Endosomal Sorting Complexes Required for Transport","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1242/jcs.241455","doi":"https://doi.org/10.1242/jcs.241455","is_oa":false,"landing_page_url":"https://doi.org/10.1242/jcs.241455","pdf_url":null,"source":{"id":"https://openalex.org/S5677253","display_name":"Journal of Cell Science","issn_l":"0021-9533","issn":["0021-9533","1477-9137"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7197871","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7197871","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Sci","raw_type":"Text"},{"id":"pmid:32184262","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32184262","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cell science","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:joces:133/8/jcs241455","doi":null,"is_oa":false,"landing_page_url":"http://jcs.biologists.org/cgi/content/short/133/8/jcs241455","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7197871","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7197871","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Sci","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5914000513","display_name":null,"funder_award_id":"311536","funder_id":"https://openalex.org/F4320338335","funder_display_name":"H2020 European Research Council"},{"id":"https://openalex.org/G6748220986","display_name":"Regulation of ESCRT-III activity in yeast","funder_award_id":"R01GM111335","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320338335","display_name":"H2020 European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W1568990285","https://openalex.org/W1813298809","https://openalex.org/W1838684492","https://openalex.org/W1966072209","https://openalex.org/W1970773887","https://openalex.org/W1973214920","https://openalex.org/W1975227291","https://openalex.org/W1993871755","https://openalex.org/W1994256471","https://openalex.org/W2003979167","https://openalex.org/W2010542476","https://openalex.org/W2018973985","https://openalex.org/W2019215631","https://openalex.org/W2025029519","https://openalex.org/W2029101220","https://openalex.org/W2035178600","https://openalex.org/W2039937164","https://openalex.org/W2041174140","https://openalex.org/W2043409309","https://openalex.org/W2045715086","https://openalex.org/W2045968066","https://openalex.org/W2047809194","https://openalex.org/W2051459755","https://openalex.org/W2074577396","https://openalex.org/W2078211289","https://openalex.org/W2083087230","https://openalex.org/W2083480759","https://openalex.org/W2084983790","https://openalex.org/W2089867788","https://openalex.org/W2089916390","https://openalex.org/W2099674108","https://openalex.org/W2104165543","https://openalex.org/W2122730639","https://openalex.org/W2123730624","https://openalex.org/W2126382240","https://openalex.org/W2127943293","https://openalex.org/W2128786395","https://openalex.org/W2145625720","https://openalex.org/W2149579871","https://openalex.org/W2150091336","https://openalex.org/W2155705945","https://openalex.org/W2161112640","https://openalex.org/W2166456692","https://openalex.org/W2170283917","https://openalex.org/W2338497250","https://openalex.org/W2527818273","https://openalex.org/W2568539670","https://openalex.org/W2625652273","https://openalex.org/W2796334734","https://openalex.org/W2804399884","https://openalex.org/W2809186646","https://openalex.org/W2954640757","https://openalex.org/W2966640838"],"related_works":["https://openalex.org/W4200290543","https://openalex.org/W2752475308","https://openalex.org/W2568539670","https://openalex.org/W1970773887","https://openalex.org/W2155705945","https://openalex.org/W2341116104","https://openalex.org/W2338497250","https://openalex.org/W7220967392","https://openalex.org/W1992721127","https://openalex.org/W96091585"],"abstract_inverted_index":{"ABSTRACT":[0],"The":[1,9],"ESCRT-III":[2,20,28,39,73,137,159],"protein":[3],"complex":[4],"executes":[5],"reverse-topology":[6],"membrane":[7,24,87],"scission.":[8,88],"scission":[10],"mechanism":[11,48,147],"is":[12,15,43,129],"unclear":[13],"but":[14],"linked":[16],"to":[17,104,135],"remodeling":[18],"of":[19,32,67,96],"complexes":[21,138],"at":[22,41],"the":[23,30,64,71,91,125,150],"surface.":[25],"At":[26],"endosomes,":[27],"mediates":[29],"budding":[31],"intralumenal":[33],"vesicles":[34],"(ILVs).":[35],"In":[36,89,113],"Saccharomyces":[37],"cerevisiae,":[38],"activity":[40],"endosomes":[42],"regulated":[44],"through":[45],"an":[46,51],"unknown":[47],"by":[49,131,139,148,156],"Doa4,":[50],"ubiquitin":[52],"hydrolase":[53],"that":[54,63],"deubiquitylates":[55],"transmembrane":[56],"proteins":[57],"sorted":[58],"into":[59],"ILVs.":[60],"We":[61],"report":[62],"non-catalytic":[65],"N-terminus":[66,93],"Doa4":[68,78,92,115],"binds":[69],"Snf7,":[70],"predominant":[72],"subunit.":[74],"Through":[75],"this":[76],"interaction,":[77],"overexpression":[79,116],"alters":[80],"Snf7":[81,97,106,110,118],"assembly":[82],"status":[83],"and":[84,108,122,133],"inhibits":[85,94,117],"ILV":[86,154],"vitro,":[90],"association":[95],"with":[98,102,120,124,158],"Vps2,":[99],"which":[100,128,149],"functions":[101],"Vps24":[103,134],"arrest":[105],"polymerization":[107],"remodel":[109,136],"polymer":[111],"structure.":[112],"vivo,":[114],"interaction":[119],"Vps2":[121,132],"also":[123],"ATPase":[126],"Vps4,":[127],"recruited":[130],"catalyzing":[140],"subunit":[141],"turnover.":[142],"Our":[143],"data":[144],"suggest":[145],"a":[146],"deubiquitylation":[151],"machinery":[152],"regulates":[153],"biogenesis":[155],"interfering":[157],"remodeling.":[160]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2020-03-23T00:00:00"}