{"id":"https://openalex.org/W301225940","doi":null,"title":"Venomic Characterization of the Terebridae and Novel Terebrid Neuropeptides","display_name":"Venomic Characterization of the Terebridae and Novel Terebrid Neuropeptides","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W301225940","mag":"301225940"},"language":"en","primary_location":{"id":"pmh:oai:academicworks.cuny.edu:gc_etds-1509","doi":null,"is_oa":true,"landing_page_url":"https://academicworks.cuny.edu/gc_etds/510","pdf_url":"https://academicworks.cuny.edu/cgi/viewcontent.cgi?article=1509&context=gc_etds","source":{"id":"https://openalex.org/S4377196304","display_name":"CUNY Academic Works (City University of New York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I174216632","host_organization_name":"City University of New York","host_organization_lineage":["https://openalex.org/I174216632"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations, Theses, and Capstone Projects","raw_type":"dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://academicworks.cuny.edu/cgi/viewcontent.cgi?article=1509&context=gc_etds","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109213128","display_name":"Mary Elizabeth Wright","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Mary E. Wright","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5109213128"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14028","display_name":"Healthcare and Venom Research","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12142","display_name":"Marine Invertebrate Physiology and Ecology","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/terebridae","display_name":"Terebridae","score":0.9449999928474426},{"id":"https://openalex.org/keywords/neuropeptides","display_name":"neuropeptides","score":0.8610000014305115},{"id":"https://openalex.org/keywords/terebra-subulata","display_name":"Terebra subulata","score":0.9990000128746033},{"id":"https://openalex.org/keywords/disulfide-rich-peptides","display_name":"disulfide-rich peptides","score":0.8539999723434448},{"id":"https://openalex.org/keywords/solid-phase-peptide-synthesis","display_name":"solid-phase peptide synthesis","score":0.8930000066757202},{"id":"https://openalex.org/keywords/ligand-gated-receptors","display_name":"ligand-gated receptors","score":0.9110000133514404},{"id":"https://openalex.org/keywords/venom-bioactivity","display_name":"venom bioactivity","score":0.5370000004768372}],"concepts":[{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.43150651454925537},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.30951225757598877},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1306072175502777},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:academicworks.cuny.edu:gc_etds-1509","doi":null,"is_oa":true,"landing_page_url":"https://academicworks.cuny.edu/gc_etds/510","pdf_url":"https://academicworks.cuny.edu/cgi/viewcontent.cgi?article=1509&context=gc_etds","source":{"id":"https://openalex.org/S4377196304","display_name":"CUNY Academic Works (City University of New York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I174216632","host_organization_name":"City University of New York","host_organization_lineage":["https://openalex.org/I174216632"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations, Theses, and Capstone Projects","raw_type":"dissertation"},{"id":"mag:301225940","doi":null,"is_oa":false,"landing_page_url":"https://academicworks.cuny.edu/cgi/viewcontent.cgi?article=1509&context=gc_etds","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:academicworks.cuny.edu:gc_etds-1509","doi":null,"is_oa":true,"landing_page_url":"https://academicworks.cuny.edu/gc_etds/510","pdf_url":"https://academicworks.cuny.edu/cgi/viewcontent.cgi?article=1509&context=gc_etds","source":{"id":"https://openalex.org/S4377196304","display_name":"CUNY Academic Works (City University of New York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I174216632","host_organization_name":"City University of New York","host_organization_lineage":["https://openalex.org/I174216632"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations, Theses, and Capstone Projects","raw_type":"dissertation"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W301225940.pdf","grobid_xml":"https://content.openalex.org/works/W301225940.grobid-xml"},"referenced_works_count":162,"referenced_works":["https://openalex.org/W75779669","https://openalex.org/W1479908568","https://openalex.org/W1482798859","https://openalex.org/W1550605202","https://openalex.org/W1719540896","https://openalex.org/W1860382351","https://openalex.org/W1931534490","https://openalex.org/W1965295046","https://openalex.org/W1966349755","https://openalex.org/W1966633447","https://openalex.org/W1967370885","https://openalex.org/W1970714631","https://openalex.org/W1970804271","https://openalex.org/W1971863224","https://openalex.org/W1971899779","https://openalex.org/W1971968167","https://openalex.org/W1972752128","https://openalex.org/W1972924519","https://openalex.org/W1976517254","https://openalex.org/W1980831688","https://openalex.org/W1981509058","https://openalex.org/W1982564744","https://openalex.org/W1983205605","https://openalex.org/W1983237645","https://openalex.org/W1984125269","https://openalex.org/W1987711608","https://openalex.org/W1989850193","https://openalex.org/W1991100710","https://openalex.org/W1992794539","https://openalex.org/W1993933755","https://openalex.org/W1993989403","https://openalex.org/W1994552948","https://openalex.org/W1995416346","https://openalex.org/W1996186559","https://openalex.org/W1997840216","https://openalex.org/W1999448894","https://openalex.org/W2000408299","https://openalex.org/W2001344194","https://openalex.org/W2003636430","https://openalex.org/W2003703108","https://openalex.org/W2009152806","https://openalex.org/W2010453349","https://openalex.org/W2011570269","https://openalex.org/W2011652502","https://openalex.org/W2011657487","https://openalex.org/W2012661100","https://openalex.org/W2012775033","https://openalex.org/W2015432354","https://openalex.org/W2016060560","https://openalex.org/W2016608967","https://openalex.org/W2018930308","https://openalex.org/W2019176374","https://openalex.org/W2023259110","https://openalex.org/W2023636464","https://openalex.org/W2024698360","https://openalex.org/W2028335226","https://openalex.org/W2029405062","https://openalex.org/W2030566998","https://openalex.org/W2030622814","https://openalex.org/W2031511867","https://openalex.org/W2032359283","https://openalex.org/W2034560907","https://openalex.org/W2036721436","https://openalex.org/W2037378018","https://openalex.org/W2037743006","https://openalex.org/W2038542572","https://openalex.org/W2040301159","https://openalex.org/W2040498602","https://openalex.org/W2041961404","https://openalex.org/W2046316286","https://openalex.org/W2048600395","https://openalex.org/W2049086270","https://openalex.org/W2049230134","https://openalex.org/W2049885807","https://openalex.org/W2050463685","https://openalex.org/W2050642686","https://openalex.org/W2051205246","https://openalex.org/W2051743378","https://openalex.org/W2052406788","https://openalex.org/W2052541667","https://openalex.org/W2052921411","https://openalex.org/W2052956415","https://openalex.org/W2060407010","https://openalex.org/W2060902393","https://openalex.org/W2061320844","https://openalex.org/W2066263439","https://openalex.org/W2066787103","https://openalex.org/W2067355487","https://openalex.org/W2068891967","https://openalex.org/W2069221946","https://openalex.org/W2070134886","https://openalex.org/W2071599396","https://openalex.org/W2071867073","https://openalex.org/W2072752990","https://openalex.org/W2073022226","https://openalex.org/W2075507642","https://openalex.org/W2077060302","https://openalex.org/W2079807285","https://openalex.org/W2079840693","https://openalex.org/W2080781079","https://openalex.org/W2082649104","https://openalex.org/W2083033039","https://openalex.org/W2083854815","https://openalex.org/W2086090153","https://openalex.org/W2091361727","https://openalex.org/W2092424786","https://openalex.org/W2093070099","https://openalex.org/W2094476648","https://openalex.org/W2095040458","https://openalex.org/W2100095444","https://openalex.org/W2101260051","https://openalex.org/W2101477035","https://openalex.org/W2105067980","https://openalex.org/W2105300484","https://openalex.org/W2106714479","https://openalex.org/W2108243132","https://openalex.org/W2110392562","https://openalex.org/W2112888168","https://openalex.org/W2115009764","https://openalex.org/W2118526609","https://openalex.org/W2118578832","https://openalex.org/W2119413355","https://openalex.org/W2119941822","https://openalex.org/W2126419817","https://openalex.org/W2127963635","https://openalex.org/W2128222086","https://openalex.org/W2128724117","https://openalex.org/W2130461923","https://openalex.org/W2131185103","https://openalex.org/W2133332425","https://openalex.org/W2133411387","https://openalex.org/W2134059510","https://openalex.org/W2134571618","https://openalex.org/W2136932575","https://openalex.org/W2137606590","https://openalex.org/W2138270253","https://openalex.org/W2138820253","https://openalex.org/W2142519284","https://openalex.org/W2147574203","https://openalex.org/W2147914469","https://openalex.org/W2150146437","https://openalex.org/W2150692694","https://openalex.org/W2152894709","https://openalex.org/W2158919227","https://openalex.org/W2159577812","https://openalex.org/W2159916941","https://openalex.org/W2160386479","https://openalex.org/W2160759749","https://openalex.org/W2160969485","https://openalex.org/W2163545771","https://openalex.org/W2163916590","https://openalex.org/W2166726458","https://openalex.org/W2168858154","https://openalex.org/W2171404422","https://openalex.org/W2320556745","https://openalex.org/W2414642016","https://openalex.org/W2414745891","https://openalex.org/W2583922755","https://openalex.org/W2800284038","https://openalex.org/W2950159416","https://openalex.org/W4211127304","https://openalex.org/W4367188979"],"related_works":["https://openalex.org/W2126355338","https://openalex.org/W2336622694","https://openalex.org/W2093070099","https://openalex.org/W7096869251","https://openalex.org/W2136932575","https://openalex.org/W2289385384","https://openalex.org/W1991100710","https://openalex.org/W1974189432","https://openalex.org/W2341770293","https://openalex.org/W1974437906"],"abstract_inverted_index":{"Unravelling":[0],"the":[1,8,13,24,28,36,48,52,71,84,89,117,123,130,164,203,244,266,299],"complex":[2],"mixture":[3],"of":[4,15,30,39,88,94,116,125,144,171,205,235,268,301,307],"neuropeptides":[5],"produced":[6,128,256],"by":[7,129,239],"terebrid":[9,90],"venom":[10,29,91,131],"duct":[11,92],"holds":[12],"promise":[14],"discovering":[16],"tomorrow's":[17],"therapeutics.":[18],"Cone":[19],"snails":[20],"have":[21,55,61,198],"already":[22],"demonstrated":[23],"potential":[25,308],"found":[26],"in":[27,70,80,159,183,231,259],"these":[31],"unusual":[32],"marine":[33],"organisms,":[34],"through":[35],"commercial":[37],"approval":[38],"drugs":[40],"for":[41,73,142,188,202,221,289,298],"pain":[42],"and":[43,99,105,114,147,193,271,278],"other":[44,279],"indications.":[45],"Terebrids,":[46],"as":[47],"sister":[49],"family":[50],"to":[51,121,180,186,216,293],"cone":[53],"snails,":[54],"been":[56,200],"much":[57],"less":[58],"investigated,":[59],"but":[60,154],"a":[62,139,168,178,210,218,305],"species":[63],"richness":[64],"that":[65],"makes":[66],"them":[67,151,182],"very":[68],"attractive":[69],"search":[72],"novel":[74,302],"neuropeptides.":[75],"The":[76],"venomics":[77],"research":[78],"described":[79],"this":[81,260],"work":[82],"encompasses":[83],"first":[85],"comprehensive":[86],"characterization":[87,234],"transcriptomes":[93],"two":[95],"species,":[96],"Cinguloterebra":[97],"anilis":[98],"Terebra":[100,252],"subulata.":[101],"De":[102],"novo":[103],"assembly":[104],"analysis":[106],"were":[107],"performed":[108,238],"using":[109,173],"next":[110,174],"generation":[111,175],"sequencing":[112,176],"technology":[113],"state":[115],"art":[118],"bioinformatics":[119],"tools":[120],"identify":[122],"cocktail":[124],"peptides,":[126],"teretoxins,":[127,208],"duct.":[132],"These":[133],"disulfide":[134,223],"rich":[135,224],"peptides":[136,225],"often":[137],"show":[138],"remarkable":[140],"specificity":[141],"subtypes":[143],"ion":[145],"channels":[146],"ligand-gated":[148],"receptors,":[149],"giving":[150],"therapeutic":[152],"potential,":[153],"they":[155],"are":[156],"only":[157],"available":[158],"vanishingly":[160],"small":[161],"amounts":[162],"from":[163,251],"natural":[165],"source.":[166],"As":[167],"result,":[169],"identification":[170],"teretoxins":[172,280],"is":[177],"prelude":[179],"synthesizing":[181,222],"sufficient":[184],"quantities":[185],"test":[187],"bioactivity.":[189],"Here":[190],"recombinant":[191,214],"expression":[192],"solid":[194],"phase":[195],"peptide":[196],"synthesis":[197,204,215],"both":[199],"utilized":[201],"four":[206],"different":[207],"with":[209,262,285,304],"special":[211],"focus":[212],"on":[213,276],"design":[217],"reproducible":[219],"strategy":[220],"greater":[226],"than":[227],"40":[228],"amino":[229],"acids":[230],"length.":[232],"Preliminary":[233],"bioactivity":[236],"was":[237],"injecting":[240],"synthesized":[241],"toxin":[242],"into":[243],"polychaete":[245],"N.":[246],"virens.":[247],"A":[248],"teretoxin":[249],"identified":[250],"guttata,":[253],"Tg77,":[254],"has":[255],"promising":[257],"results":[258],"assay,":[261],"repeated":[263],"trials":[264],"showing":[265],"effects":[267],"uncoordinated":[269],"movement":[270],"rigid":[272],"paralysis.":[273],"Further":[274],"testing":[275,300],"Tg77":[277],"will":[281],"be":[282],"carried":[283],"forward,":[284],"an":[286,295],"evident":[287],"need":[288],"high":[290],"throughput":[291],"assays":[292],"provide":[294],"efficient":[296],"means":[297],"compounds":[303],"variety":[306],"molecular":[309],"targets.":[310]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
