{"id":"https://openalex.org/W3012134165","doi":null,"title":"Depression and dementia : the effect of amyloid pathology and therapeutic interventions on affective and cognitive processes in mice","display_name":"Depression and dementia : the effect of amyloid pathology and therapeutic interventions on affective and cognitive processes in mice","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W3012134165","mag":"3012134165"},"language":"en","primary_location":{"id":"pmh:oai:https://orca.cardiff.ac.uk:129684","doi":null,"is_oa":true,"landing_page_url":"https://orca.cardiff.ac.uk/129684/2/2020brelsfordphd.pdf","pdf_url":"https://orca.cardiff.ac.uk/129684/2/2020brelsfordphd.pdf","source":{"id":"https://openalex.org/S4306401195","display_name":"ORCA Online Research @Cardiff (Cardiff University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79510175","host_organization_name":"Cardiff University","host_organization_lineage":["https://openalex.org/I79510175"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://orca.cardiff.ac.uk/129684/2/2020brelsfordphd.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038993556","display_name":"Adam Richard Brelsford","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Adam Richard Brelsford","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5038993556"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9229000210762024,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9229000210762024,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.04740000143647194,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.01140000019222498,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9259999990463257},{"id":"https://openalex.org/keywords/amyloid-beta-pathology","display_name":"amyloid-beta pathology","score":0.7689999938011169},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.8840000033378601},{"id":"https://openalex.org/keywords/anhedonia","display_name":"anhedonia","score":0.9769999980926514},{"id":"https://openalex.org/keywords/tg2576-mice","display_name":"Tg2576 mice","score":0.8849999904632568},{"id":"https://openalex.org/keywords/ketamine","display_name":"ketamine","score":0.7480000257492065},{"id":"https://openalex.org/keywords/spatial-memory","display_name":"spatial memory","score":0.5659999847412109},{"id":"https://openalex.org/keywords/novelty-preference","display_name":"novelty preference","score":0.6890000104904175},{"id":"https://openalex.org/keywords/opioid-system","display_name":"opioid system","score":0.7009999752044678},{"id":"https://openalex.org/keywords/kappa-opioid-receptor","display_name":"kappa opioid receptor","score":0.890999972820282},{"id":"https://openalex.org/keywords/mu-opioid-receptor","display_name":"mu-opioid receptor","score":0.996999979019165},{"id":"https://openalex.org/keywords/serotonin-transporter","display_name":"serotonin transporter","score":0.9679999947547913},{"id":"https://openalex.org/keywords/glutamate-signalling","display_name":"glutamate signalling","score":0.7450000047683716},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.6600000262260437},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.3619999885559082}],"concepts":[{"id":"https://openalex.org/C2778941446","wikidata":"https://www.wikidata.org/wiki/Q545365","display_name":"Anhedonia","level":3,"score":0.7688262462615967},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5525941848754883},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5216451287269592},{"id":"https://openalex.org/C2779484449","wikidata":"https://www.wikidata.org/wiki/Q412189","display_name":"Memantine","level":4,"score":0.5047823190689087},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.48542460799217224},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.47247880697250366},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.46746066212654114},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.44912150502204895},{"id":"https://openalex.org/C2780749935","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive deficit","level":4,"score":0.42844218015670776},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.4148412048816681},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33539891242980957},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3187180757522583},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.28675931692123413},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.12557151913642883},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:https://orca.cardiff.ac.uk:129684","doi":null,"is_oa":true,"landing_page_url":"https://orca.cardiff.ac.uk/129684/2/2020brelsfordphd.pdf","pdf_url":"https://orca.cardiff.ac.uk/129684/2/2020brelsfordphd.pdf","source":{"id":"https://openalex.org/S4306401195","display_name":"ORCA Online Research @Cardiff (Cardiff University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79510175","host_organization_name":"Cardiff University","host_organization_lineage":["https://openalex.org/I79510175"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:3012134165","doi":null,"is_oa":false,"landing_page_url":"https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.801968","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:https://orca.cardiff.ac.uk:129684","doi":null,"is_oa":true,"landing_page_url":"https://orca.cardiff.ac.uk/129684/2/2020brelsfordphd.pdf","pdf_url":"https://orca.cardiff.ac.uk/129684/2/2020brelsfordphd.pdf","source":{"id":"https://openalex.org/S4306401195","display_name":"ORCA Online Research @Cardiff (Cardiff University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79510175","host_organization_name":"Cardiff University","host_organization_lineage":["https://openalex.org/I79510175"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3012134165.pdf","grobid_xml":"https://content.openalex.org/works/W3012134165.grobid-xml"},"referenced_works_count":409,"referenced_works":["https://openalex.org/W6243660","https://openalex.org/W39182999","https://openalex.org/W72199885","https://openalex.org/W168333064","https://openalex.org/W201461438","https://openalex.org/W1481762643","https://openalex.org/W1511517753","https://openalex.org/W1534060220","https://openalex.org/W1536538075","https://openalex.org/W1552123779","https://openalex.org/W1556362327","https://openalex.org/W1558650798","https://openalex.org/W1561114541","https://openalex.org/W1561443084","https://openalex.org/W1586476523","https://openalex.org/W1603857261","https://openalex.org/W1621971853","https://openalex.org/W1631449371","https://openalex.org/W1637989849","https://openalex.org/W1762207349","https://openalex.org/W1841850981","https://openalex.org/W1886575365","https://openalex.org/W1893722936","https://openalex.org/W1895226538","https://openalex.org/W1904458203","https://openalex.org/W1906855128","https://openalex.org/W1923241552","https://openalex.org/W1930672392","https://openalex.org/W1951056124","https://openalex.org/W1962254068","https://openalex.org/W1964595024","https://openalex.org/W1964910428","https://openalex.org/W1965607096","https://openalex.org/W1966831629","https://openalex.org/W1968267010","https://openalex.org/W1968531410","https://openalex.org/W1969271586","https://openalex.org/W1970049338","https://openalex.org/W1970377013","https://openalex.org/W1970874743","https://openalex.org/W1971946214","https://openalex.org/W1972438875","https://openalex.org/W1974474435","https://openalex.org/W1974594322","https://openalex.org/W1975005780","https://openalex.org/W1975429473","https://openalex.org/W1976602187","https://openalex.org/W1977119881","https://openalex.org/W1977128117","https://openalex.org/W1978116973","https://openalex.org/W1978662219","https://openalex.org/W1979586675","https://openalex.org/W1979889191","https://openalex.org/W1980750700","https://openalex.org/W1980915383","https://openalex.org/W1980944036","https://openalex.org/W1981463613","https://openalex.org/W1982706802","https://openalex.org/W1983754627","https://openalex.org/W1984293506","https://openalex.org/W1984652813","https://openalex.org/W1984924722","https://openalex.org/W1985833916","https://openalex.org/W1987319516","https://openalex.org/W1988447288","https://openalex.org/W1988691690","https://openalex.org/W1989078413","https://openalex.org/W1989146486","https://openalex.org/W1989755760","https://openalex.org/W1990439642","https://openalex.org/W1990649294","https://openalex.org/W1990752558","https://openalex.org/W1991028076","https://openalex.org/W1991457465","https://openalex.org/W1993135690","https://openalex.org/W1993571512","https://openalex.org/W1993860176","https://openalex.org/W1994459847","https://openalex.org/W1995778163","https://openalex.org/W1996177755","https://openalex.org/W1999721747","https://openalex.org/W1999919402","https://openalex.org/W2001261203","https://openalex.org/W2001445086","https://openalex.org/W2002354852","https://openalex.org/W2002429324","https://openalex.org/W2003425352","https://openalex.org/W2004109806","https://openalex.org/W2004282523","https://openalex.org/W2004385393","https://openalex.org/W2005165316","https://openalex.org/W2005719973","https://openalex.org/W2005846380","https://openalex.org/W2009894997","https://openalex.org/W2010469304","https://openalex.org/W2010900435","https://openalex.org/W2011267762","https://openalex.org/W2011335492","https://openalex.org/W2011566601","https://openalex.org/W2012129255","https://openalex.org/W2012678641","https://openalex.org/W2012921227","https://openalex.org/W2013898280","https://openalex.org/W2013958954","https://openalex.org/W2014164931","https://openalex.org/W2014192652","https://openalex.org/W2014415524","https://openalex.org/W2015759485","https://openalex.org/W2015786514","https://openalex.org/W2015911699","https://openalex.org/W2015935700","https://openalex.org/W2016323146","https://openalex.org/W2016426141","https://openalex.org/W2016654175","https://openalex.org/W2017886789","https://openalex.org/W2017972820","https://openalex.org/W2018358250","https://openalex.org/W2018527534","https://openalex.org/W2021380055","https://openalex.org/W2021834069","https://openalex.org/W2022025213","https://openalex.org/W2022682998","https://openalex.org/W2023055592","https://openalex.org/W2024380057","https://openalex.org/W2025333158","https://openalex.org/W2025801062","https://openalex.org/W2027844417","https://openalex.org/W2028174194","https://openalex.org/W2028329342","https://openalex.org/W2028339791","https://openalex.org/W2029568863","https://openalex.org/W2030641075","https://openalex.org/W2031328682","https://openalex.org/W2032724700","https://openalex.org/W2034040607","https://openalex.org/W2034204213","https://openalex.org/W2034213169","https://openalex.org/W2035612688","https://openalex.org/W2036418428","https://openalex.org/W2036555834","https://openalex.org/W2036699165","https://openalex.org/W2037111632","https://openalex.org/W2037154303","https://openalex.org/W2037852973","https://openalex.org/W2038357517","https://openalex.org/W2039076728","https://openalex.org/W2039634087","https://openalex.org/W2040721710","https://openalex.org/W2041601072","https://openalex.org/W2043283741","https://openalex.org/W2043407651","https://openalex.org/W2043838674","https://openalex.org/W2044090829","https://openalex.org/W2045125289","https://openalex.org/W2047470842","https://openalex.org/W2047671957","https://openalex.org/W2048512926","https://openalex.org/W2049511526","https://openalex.org/W2049882268","https://openalex.org/W2050347424","https://openalex.org/W2051508159","https://openalex.org/W2051532765","https://openalex.org/W2052704430","https://openalex.org/W2052722557","https://openalex.org/W2052830386","https://openalex.org/W2053020615","https://openalex.org/W2053696585","https://openalex.org/W2053698751","https://openalex.org/W2053972194","https://openalex.org/W2056313099","https://openalex.org/W2056468240","https://openalex.org/W2056716542","https://openalex.org/W2057321407","https://openalex.org/W2057823239","https://openalex.org/W2059334396","https://openalex.org/W2060050678","https://openalex.org/W2060575765","https://openalex.org/W2061310823","https://openalex.org/W2061391028","https://openalex.org/W2061600370","https://openalex.org/W2062165094","https://openalex.org/W2063047220","https://openalex.org/W2063541383","https://openalex.org/W2063944875","https://openalex.org/W2064111585","https://openalex.org/W2065796254","https://openalex.org/W2067810163","https://openalex.org/W2068945622","https://openalex.org/W2069481882","https://openalex.org/W2070788071","https://openalex.org/W2070798484","https://openalex.org/W2071801806","https://openalex.org/W2072219714","https://openalex.org/W2072625029","https://openalex.org/W2073779547","https://openalex.org/W2074155946","https://openalex.org/W2075481535","https://openalex.org/W2076077022","https://openalex.org/W2078696245","https://openalex.org/W2079206376","https://openalex.org/W2079418286","https://openalex.org/W2079503245","https://openalex.org/W2079553153","https://openalex.org/W2079873627","https://openalex.org/W2080589549","https://openalex.org/W2080640632","https://openalex.org/W2081362241","https://openalex.org/W2081998222","https://openalex.org/W2082044837","https://openalex.org/W2082151254","https://openalex.org/W2082423614","https://openalex.org/W2085301512","https://openalex.org/W2085959837","https://openalex.org/W2087019986","https://openalex.org/W2087485448","https://openalex.org/W2088068432","https://openalex.org/W2088751222","https://openalex.org/W2088861514","https://openalex.org/W2089299823","https://openalex.org/W2089963291","https://openalex.org/W2090533412","https://openalex.org/W2090620788","https://openalex.org/W2090975324","https://openalex.org/W2091074778","https://openalex.org/W2091363925","https://openalex.org/W2091365059","https://openalex.org/W2091551200","https://openalex.org/W2092472726","https://openalex.org/W2092704615","https://openalex.org/W2093753108","https://openalex.org/W2094287576","https://openalex.org/W2094772434","https://openalex.org/W2095056606","https://openalex.org/W2095336250","https://openalex.org/W2096759154","https://openalex.org/W2097095684","https://openalex.org/W2097186958","https://openalex.org/W2097382546","https://openalex.org/W2098999434","https://openalex.org/W2099660163","https://openalex.org/W2101027386","https://openalex.org/W2101077392","https://openalex.org/W2101594326","https://openalex.org/W2102815754","https://openalex.org/W2102857043","https://openalex.org/W2104147494","https://openalex.org/W2105333746","https://openalex.org/W2106188323","https://openalex.org/W2106279983","https://openalex.org/W2106336538","https://openalex.org/W2106623141","https://openalex.org/W2108335346","https://openalex.org/W2109131632","https://openalex.org/W2109420899","https://openalex.org/W2109613116","https://openalex.org/W2109727228","https://openalex.org/W2113839148","https://openalex.org/W2116497718","https://openalex.org/W2118232797","https://openalex.org/W2118935254","https://openalex.org/W2120296399","https://openalex.org/W2121176561","https://openalex.org/W2121920106","https://openalex.org/W2122065036","https://openalex.org/W2123296304","https://openalex.org/W2124244312","https://openalex.org/W2124279119","https://openalex.org/W2126128851","https://openalex.org/W2126800086","https://openalex.org/W2126974689","https://openalex.org/W2127854743","https://openalex.org/W2128401893","https://openalex.org/W2128574573","https://openalex.org/W2128613449","https://openalex.org/W2128918664","https://openalex.org/W2129143684","https://openalex.org/W2130975721","https://openalex.org/W2131991903","https://openalex.org/W2132136308","https://openalex.org/W2132154794","https://openalex.org/W2132223509","https://openalex.org/W2132315817","https://openalex.org/W2133623572","https://openalex.org/W2133842711","https://openalex.org/W2135987299","https://openalex.org/W2136601432","https://openalex.org/W2136603773","https://openalex.org/W2136747326","https://openalex.org/W2136901555","https://openalex.org/W2136925113","https://openalex.org/W2138295551","https://openalex.org/W2140323904","https://openalex.org/W2140718540","https://openalex.org/W2140798832","https://openalex.org/W2141852448","https://openalex.org/W2142688387","https://openalex.org/W2142943752","https://openalex.org/W2143841415","https://openalex.org/W2144225695","https://openalex.org/W2144479616","https://openalex.org/W2144531560","https://openalex.org/W2145828601","https://openalex.org/W2145846347","https://openalex.org/W2146828973","https://openalex.org/W2149514160","https://openalex.org/W2149515427","https://openalex.org/W2150320931","https://openalex.org/W2150537415","https://openalex.org/W2150999725","https://openalex.org/W2151252981","https://openalex.org/W2151466405","https://openalex.org/W2151664809","https://openalex.org/W2151984407","https://openalex.org/W2152889673","https://openalex.org/W2154457867","https://openalex.org/W2154755614","https://openalex.org/W2154791985","https://openalex.org/W2154795125","https://openalex.org/W2155578288","https://openalex.org/W2156788921","https://openalex.org/W2157264662","https://openalex.org/W2157702984","https://openalex.org/W2158762199","https://openalex.org/W2161130389","https://openalex.org/W2161722802","https://openalex.org/W2162091209","https://openalex.org/W2162454135","https://openalex.org/W2162807572","https://openalex.org/W2163602955","https://openalex.org/W2164672521","https://openalex.org/W2164765564","https://openalex.org/W2165840219","https://openalex.org/W2167160506","https://openalex.org/W2167612537","https://openalex.org/W2167796542","https://openalex.org/W2167951079","https://openalex.org/W2168334242","https://openalex.org/W2169812612","https://openalex.org/W2170194206","https://openalex.org/W2170241219","https://openalex.org/W2170446709","https://openalex.org/W2173670840","https://openalex.org/W2185690353","https://openalex.org/W2196461303","https://openalex.org/W2208177230","https://openalex.org/W2235730659","https://openalex.org/W2258704607","https://openalex.org/W2284757052","https://openalex.org/W2291523072","https://openalex.org/W2329336071","https://openalex.org/W2336131134","https://openalex.org/W2336679328","https://openalex.org/W2337539519","https://openalex.org/W2342817525","https://openalex.org/W2346605869","https://openalex.org/W2400771625","https://openalex.org/W2401002261","https://openalex.org/W2407468727","https://openalex.org/W2407976149","https://openalex.org/W2410446460","https://openalex.org/W2421616427","https://openalex.org/W2461584436","https://openalex.org/W2472186754","https://openalex.org/W2516850319","https://openalex.org/W2521074193","https://openalex.org/W2528265397","https://openalex.org/W2534709063","https://openalex.org/W2562384805","https://openalex.org/W2574596077","https://openalex.org/W2590547542","https://openalex.org/W2596798372","https://openalex.org/W2604754546","https://openalex.org/W2612913686","https://openalex.org/W2624535799","https://openalex.org/W2724817424","https://openalex.org/W2740213823","https://openalex.org/W2750299285","https://openalex.org/W2762245031","https://openalex.org/W2764252694","https://openalex.org/W2772491648","https://openalex.org/W2772763207","https://openalex.org/W2776968073","https://openalex.org/W2782579702","https://openalex.org/W2785320292","https://openalex.org/W2795260584","https://openalex.org/W2799790315","https://openalex.org/W2799949353","https://openalex.org/W2810498355","https://openalex.org/W2810500650","https://openalex.org/W2883615957","https://openalex.org/W2892244808","https://openalex.org/W2898329077","https://openalex.org/W2899609037","https://openalex.org/W2900174582","https://openalex.org/W2901206011","https://openalex.org/W2936457924","https://openalex.org/W2939744089","https://openalex.org/W2941209113","https://openalex.org/W2943280373","https://openalex.org/W2949549185","https://openalex.org/W2962369126","https://openalex.org/W3214092816","https://openalex.org/W4211242662","https://openalex.org/W4230262818","https://openalex.org/W4247665917","https://openalex.org/W4298230857","https://openalex.org/W7074228914","https://openalex.org/W7099983525","https://openalex.org/W7100668674"],"related_works":["https://openalex.org/W2766127225","https://openalex.org/W2601219889","https://openalex.org/W2031260733","https://openalex.org/W2488148191","https://openalex.org/W2157314020","https://openalex.org/W1996177755","https://openalex.org/W7117114777","https://openalex.org/W2143648701","https://openalex.org/W2042751066","https://openalex.org/W1792545373"],"abstract_inverted_index":{"Preclinical":[0],"mouse":[1,29,65],"models":[2],"of":[3,24,44,49,58,67,72,93,168,197,215,224,256],"Alzheimer\u2019s":[4,68],"disease":[5],"capture":[6],"cognitive":[7,183],"impairments":[8,295],"which":[9],"can":[10,279],"be":[11,21],"attributed":[12],"to":[13,171,258,292],"\u03b2-amyloid":[14],"(A\u03b2)":[15],"pathology.":[16],"A\u03b2":[17,143,268],"pathology":[18],"may":[19,236],"also":[20,81,246],"an":[22,77,110,118,128,207,290],"antecedent":[23],"depressive":[25,47],"symptoms":[26,285],"in":[27,53,62,83,113,137,185,194,203,219,241,286],"these":[28,94,294],"models,":[30],"though":[31,253,289],"this":[32,257],"has":[33],"been":[34],"less":[35,262],"rigorously":[36],"investigated.":[37],"This":[38,264],"thesis":[39,265],"reports":[40],"a":[41,158,191],"longitudinal":[42],"investigation":[43],"both":[45,281],"the":[46,63,100,172,198,204,216,254,274],"symptom":[48],"anhedonia":[50],"(a":[51],"reduction":[52,112,193],"pleasurable":[54],"reactions),":[55],"and":[56,85,103,142,227,269,276,283],"memory":[57],"specific":[59],"object-location":[60],"associations,":[61],"Tg2576":[64,88,107,131,155,186,188,220,242,244,287],"model":[66],"disease.":[69],"The":[70],"effectiveness":[71],"sub-anaesthetic":[73],"ketamine,":[74],"largely":[75],"as":[76],"anti-depressant":[78],"treatment,":[79],"was":[80,261,296],"examined":[82],"anhedonic":[84],"cognitively":[86],"impaired":[87,135],"mice.":[89,187,243],"Possible":[90],"biochemical":[91],"underpinnings":[92],"deficits":[95,260],"were":[96,133],"then":[97],"investigated,":[98],"namely":[99],"glutamate,":[101],"serotonin":[102,250],"opioid":[104,217,234,277],"signalling":[105],"systems.":[106],"mice":[108,132,156,189,221,245],"displayed":[109,190,247],"age-dependent":[111,129],"hedonic":[114,181,239],"reactions,":[115],"consistent":[116,139],"with":[117,140],"A\u03b2-related":[119],"deficit.":[120,213],"While":[121],"object-in-place":[122,212],"testing":[123],"did":[124,178],"not":[125,179],"explicitly":[126],"reveal":[127],"dysfunction,":[130],"only":[134],"later":[136],"life,":[138],"aging":[141],"underlying":[144,210],"their":[145,211],"diminished":[146],"performance.":[147],"An":[148,232],"additional":[149],"T-maze":[150],"task":[151],"revealed":[152,222],"that":[153,267],"aged":[154],"retained":[157],"preference":[159],"for":[160],"spatial":[161],"novelty.":[162],"\\nWhile":[163],"ketamine":[164],"treatment":[165],"increased":[166],"expression":[167],"measures":[169],"relating":[170],"AMPA":[173],"receptor":[174,200,230],"GluR1":[175],"subunit,":[176],"it":[177],"improve":[180],"or":[182],"dysfunction":[184,209],"relative":[192],"Y1472":[195],"phosphorylation":[196],"NMDA":[199],"NR2B":[201],"subunit":[202],"hippocampus,":[205],"suggesting":[206],"NMDAR-mediated":[208],"Investigation":[214],"system":[218,235],"elevations":[223],"cortical":[225,249],"kappa":[226],"hippocampal":[228],"mu":[229],"expression.":[231],"unbalanced":[233],"therefore":[237],"diminish":[238],"tone":[240],"elevated":[248],"transporter":[251],"expression,":[252],"relation":[255],"behavioural":[259],"clear.":[263],"demonstrates":[266],"its":[270],"potential":[271],"effects":[272],"on":[273],"glutamate":[275],"systems":[278],"underlie":[280],"amnesic":[282],"affective":[284],"mice,":[288],"attempt":[291],"remedy":[293],"unsuccessful.":[297]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2020-03-23T00:00:00"}
