{"id":"https://openalex.org/W3012016445","doi":"https://doi.org/10.1038/s41587-020-0455-x","title":"Prime genome editing in rice and wheat","display_name":"Prime genome editing in rice and wheat","publication_year":2020,"publication_date":"2020-03-16","ids":{"openalex":"https://openalex.org/W3012016445","doi":"https://doi.org/10.1038/s41587-020-0455-x","mag":"3012016445","pmid":"https://pubmed.ncbi.nlm.nih.gov/32393904"},"language":"en","primary_location":{"id":"doi:10.1038/s41587-020-0455-x","doi":"https://doi.org/10.1038/s41587-020-0455-x","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41587-020-0455-x","pdf_url":null,"source":{"id":"https://openalex.org/S106963461","display_name":"Nature Biotechnology","issn_l":"0733-222X","issn":["0733-222X","1087-0156","1546-1696","2331-3684"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Biotechnology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025933056","display_name":"Qiupeng Lin","orcid":"https://orcid.org/0000-0002-7944-6683","observed_orcids":["https://orcid.org/0000-0002-7944-6683"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210124606","display_name":"Institute of Genetics and Developmental Biology","ror":"https://ror.org/02aee5m12","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210124606"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"id":"https://openalex.org/I4391767732","display_name":"State Key Laboratory of Plant Cell and Chromosome Engineering","ror":"https://ror.org/05mqa4073","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210124606","https://openalex.org/I4391767732"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiupeng Lin","raw_affiliation_strings":["College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing, China","State Key Laboratory of Plant Cell and Chromosome Engineering, Center for Genome Editing, Institute of Genetics and Developmental Biology, Innovation Academy for Seed Design, Chinese Academy of Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I4210165038"]},{"raw_affiliation_string":"State Key Laboratory of Plant Cell and Chromosome Engineering, Center for Genome Editing, Institute of Genetics and Developmental Biology, Innovation Academy for Seed Design, Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210124606","https://openalex.org/I4391767732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048833569","display_name":"Yuan Zong","orcid":"https://orcid.org/0000-0003-0576-6614","observed_orcids":["https://orcid.org/0000-0003-0576-6614"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210124606","display_name":"Institute of Genetics and Developmental Biology","ror":"https://ror.org/02aee5m12","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210124606"]},{"id":"https://openalex.org/I4391767732","display_name":"State Key Laboratory of Plant Cell and Chromosome Engineering","ror":"https://ror.org/05mqa4073","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210124606","https://openalex.org/I4391767732"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan Zong","raw_affiliation_strings":["State Key Laboratory of Plant Cell and Chromosome Engineering, Center for Genome Editing, Institute of Genetics and Developmental Biology, Innovation Academy for Seed Design, Chinese Academy of Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Plant Cell and Chromosome Engineering, Center for Genome Editing, Institute of Genetics and Developmental Biology, Innovation Academy for Seed Design, Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210124606","https://openalex.org/I4391767732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090316892","display_name":"Chenxiao Xue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210124606","display_name":"Institute of Genetics and Developmental Biology","ror":"https://ror.org/02aee5m12","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210124606"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"id":"https://openalex.org/I4391767732","display_name":"State Key Laboratory of Plant Cell and Chromosome Engineering","ror":"https://ror.org/05mqa4073","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210124606","https://openalex.org/I4391767732"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenxiao Xue","raw_affiliation_strings":["College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing, China","State Key Laboratory of Plant Cell and Chromosome Engineering, Center for Genome Editing, Institute of Genetics and Developmental Biology, Innovation Academy for Seed Design, Chinese Academy of Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I4210165038"]},{"raw_affiliation_string":"State Key Laboratory of Plant Cell and Chromosome Engineering, Center for Genome Editing, Institute of Genetics and Developmental Biology, Innovation Academy for Seed Design, Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210124606","https://openalex.org/I4391767732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019781839","display_name":"Shengxing Wang","orcid":"https://orcid.org/0000-0003-0446-8914","observed_orcids":["https://orcid.org/0000-0003-0446-8914"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210124606","display_name":"Institute of Genetics and Developmental Biology","ror":"https://ror.org/02aee5m12","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210124606"]},{"id":"https://openalex.org/I4391767732","display_name":"State Key Laboratory of Plant Cell and Chromosome Engineering","ror":"https://ror.org/05mqa4073","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210124606","https://openalex.org/I4391767732"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shengxing Wang","raw_affiliation_strings":["State Key Laboratory of Plant Cell and Chromosome Engineering, Center for Genome Editing, Institute of Genetics and Developmental Biology, Innovation Academy for Seed Design, Chinese Academy of Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Plant Cell and Chromosome Engineering, Center for Genome Editing, Institute of Genetics and Developmental Biology, Innovation Academy for Seed Design, Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210124606","https://openalex.org/I4391767732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041935436","display_name":"Shuai Jin","orcid":"https://orcid.org/0000-0003-4314-1834","observed_orcids":["https://orcid.org/0000-0003-4314-1834"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210124606","display_name":"Institute of Genetics and Developmental Biology","ror":"https://ror.org/02aee5m12","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210124606"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"id":"https://openalex.org/I4391767732","display_name":"State Key Laboratory of Plant Cell and Chromosome Engineering","ror":"https://ror.org/05mqa4073","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210124606","https://openalex.org/I4391767732"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuai Jin","raw_affiliation_strings":["College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing, China","State Key Laboratory of Plant Cell and Chromosome Engineering, Center for Genome Editing, Institute of Genetics and Developmental Biology, Innovation Academy for Seed Design, Chinese Academy of Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I4210165038"]},{"raw_affiliation_string":"State Key Laboratory of Plant Cell and Chromosome Engineering, Center for Genome Editing, Institute of Genetics and Developmental Biology, Innovation Academy for Seed Design, Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210124606","https://openalex.org/I4391767732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061011522","display_name":"Zixu Zhu","orcid":"https://orcid.org/0000-0003-4068-0082","observed_orcids":["https://orcid.org/0000-0003-4068-0082"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210124606","display_name":"Institute of Genetics and Developmental Biology","ror":"https://ror.org/02aee5m12","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210124606"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"id":"https://openalex.org/I4391767732","display_name":"State Key Laboratory of Plant Cell and Chromosome Engineering","ror":"https://ror.org/05mqa4073","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210124606","https://openalex.org/I4391767732"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zixu Zhu","raw_affiliation_strings":["College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing, China","State Key Laboratory of Plant Cell and Chromosome Engineering, Center for Genome Editing, Institute of Genetics and Developmental Biology, Innovation Academy for Seed Design, Chinese Academy of Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I4210165038"]},{"raw_affiliation_string":"State Key Laboratory of Plant Cell and Chromosome Engineering, Center for Genome Editing, Institute of Genetics and Developmental Biology, Innovation Academy for Seed Design, Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210124606","https://openalex.org/I4391767732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100697795","display_name":"Yanpeng Wang","orcid":"https://orcid.org/0000-0003-1577-6883","observed_orcids":["https://orcid.org/0000-0003-1577-6883"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210124606","display_name":"Institute of Genetics and Developmental Biology","ror":"https://ror.org/02aee5m12","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210124606"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"id":"https://openalex.org/I4391767732","display_name":"State Key Laboratory of Plant Cell and Chromosome Engineering","ror":"https://ror.org/05mqa4073","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210124606","https://openalex.org/I4391767732"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanpeng Wang","raw_affiliation_strings":["College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing, China","State Key Laboratory of Plant Cell and Chromosome Engineering, Center for Genome Editing, Institute of Genetics and Developmental Biology, Innovation Academy for Seed Design, Chinese Academy of Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I4210165038"]},{"raw_affiliation_string":"State Key Laboratory of Plant Cell and Chromosome Engineering, Center for Genome Editing, Institute of Genetics and Developmental Biology, Innovation Academy for Seed Design, Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210124606","https://openalex.org/I4391767732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045186411","display_name":"Andrew V. Anzalone","orcid":"https://orcid.org/0000-0003-2531-5589","observed_orcids":["https://orcid.org/0000-0003-2531-5589"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew V. Anzalone","raw_affiliation_strings":["Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA","Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA","Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA, USA","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006014007","display_name":"Aditya Raguram","orcid":"https://orcid.org/0000-0002-5749-7308","observed_orcids":["https://orcid.org/0000-0002-5749-7308"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aditya Raguram","raw_affiliation_strings":["Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA","Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA","Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA, USA","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068982340","display_name":"Jordan L. Doman","orcid":"https://orcid.org/0000-0002-9887-0391","observed_orcids":["https://orcid.org/0000-0002-9887-0391"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jordan L. Doman","raw_affiliation_strings":["Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA","Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA","Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA, USA"],"raw_orcid":"https://orcid.org/0000-0002-9887-0391","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA, USA","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065535610","display_name":"David R. Liu","orcid":"https://orcid.org/0000-0002-9943-7557","observed_orcids":["https://orcid.org/0000-0002-9943-7557","https://orcid.org/0000-0003-0346-5033","https://orcid.org/0000-0002-6078-6506"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David R. Liu","raw_affiliation_strings":["Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA","Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA","Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA, USA"],"raw_orcid":"https://orcid.org/0000-0002-9943-7557","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA, USA","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077799932","display_name":"Caixia Gao","orcid":"https://orcid.org/0000-0003-3169-8248","observed_orcids":["https://orcid.org/0000-0003-3169-8248"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210124606","display_name":"Institute of Genetics and Developmental Biology","ror":"https://ror.org/02aee5m12","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210124606"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"id":"https://openalex.org/I4391767732","display_name":"State Key Laboratory of Plant Cell and Chromosome Engineering","ror":"https://ror.org/05mqa4073","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210124606","https://openalex.org/I4391767732"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Caixia Gao","raw_affiliation_strings":["College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing, China. cxgao@genetics.ac.cn","State Key Laboratory of Plant Cell and Chromosome Engineering, Center for Genome Editing, Institute of Genetics and Developmental Biology, Innovation Academy for Seed Design, Chinese Academy of Sciences, Beijing, China. cxgao@genetics.ac.cn","College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0003-3169-8248","affiliations":[{"raw_affiliation_string":"College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing, China. cxgao@genetics.ac.cn","institution_ids":["https://openalex.org/I4210165038"]},{"raw_affiliation_string":"State Key Laboratory of Plant Cell and Chromosome Engineering, Center for Genome Editing, Institute of Genetics and Developmental Biology, Innovation Academy for Seed Design, Chinese Academy of Sciences, Beijing, China. cxgao@genetics.ac.cn","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210124606","https://openalex.org/I4391767732"]},{"raw_affiliation_string":"College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I4210165038"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5077799932"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210124606","https://openalex.org/I4210165038","https://openalex.org/I4391767732"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":44.6489,"has_fulltext":false,"cited_by_count":877,"citation_normalized_percentile":{"value":0.99948082,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"38","issue":"5","first_page":"582","last_page":"585"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12828","display_name":"Plant Genetic and Mutation Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12856","display_name":"Transgenic Plants and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prime-editing","display_name":"prime editing","score":0.9679999947547913},{"id":"https://openalex.org/keywords/crispr-cas9-nickase","display_name":"CRISPR/Cas9 nickase","score":0.9169999957084656},{"id":"https://openalex.org/keywords/reverse-transcriptase","display_name":"reverse transcriptase","score":0.7089999914169312},{"id":"https://openalex.org/keywords/pegrna","display_name":"pegRNA","score":0.6769999861717224},{"id":"https://openalex.org/keywords/plant-genome-editing","display_name":"plant genome editing","score":0.8190000057220459},{"id":"https://openalex.org/keywords/rice","display_name":"rice","score":0.9430000185966492},{"id":"https://openalex.org/keywords/wheat","display_name":"wheat","score":1.0},{"id":"https://openalex.org/keywords/protoplast-transformation","display_name":"protoplast transformation","score":0.9240000247955322},{"id":"https://openalex.org/keywords/point-mutations","display_name":"point mutations","score":0.7080000042915344},{"id":"https://openalex.org/keywords/indels","display_name":"indels","score":0.9909999966621399},{"id":"https://openalex.org/keywords/codon-optimization","display_name":"codon optimization","score":0.8700000047683716},{"id":"https://openalex.org/keywords/promoter-optimization","display_name":"promoter optimization","score":0.9350000023841858},{"id":"https://openalex.org/keywords/plant-regeneration","display_name":"plant regeneration","score":0.49000000953674316}],"concepts":[{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5813708305358887},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5276252627372742},{"id":"https://openalex.org/C144501496","wikidata":"https://www.wikidata.org/wiki/Q5533489","display_name":"Genome editing","level":4,"score":0.5087726712226868},{"id":"https://openalex.org/C184992742","wikidata":"https://www.wikidata.org/wiki/Q7243229","display_name":"Prime (order theory)","level":2,"score":0.430191308259964},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.3979884684085846},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.378303200006485},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3778080940246582},{"id":"https://openalex.org/C6557445","wikidata":"https://www.wikidata.org/wiki/Q173113","display_name":"Agronomy","level":1,"score":0.3218645453453064},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.28861725330352783},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.11059707403182983},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072669","descriptor_name":"Gene Editing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D003850","descriptor_name":"Deoxyribonuclease I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012275","descriptor_name":"Oryza","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012275","descriptor_name":"Oryza","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D014908","descriptor_name":"Triticum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014908","descriptor_name":"Triticum","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D018745","descriptor_name":"Genome, Plant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064113","descriptor_name":"CRISPR-Cas Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/s41587-020-0455-x","doi":"https://doi.org/10.1038/s41587-020-0455-x","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41587-020-0455-x","pdf_url":null,"source":{"id":"https://openalex.org/S106963461","display_name":"Nature Biotechnology","issn_l":"0733-222X","issn":["0733-222X","1087-0156","1546-1696","2331-3684"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Biotechnology","raw_type":"journal-article"},{"id":"pmid:32393904","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32393904","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature biotechnology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/2","score":0.6735000014305115,"display_name":"Zero hunger"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4237274230","display_name":"Expanding the Scope of Base Editing","funder_award_id":"U01AI142756","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7514249068","display_name":"Continuous Evolution of Proteins with Novel Therapeutic Potential","funder_award_id":"R01EB022376","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G9000908732","display_name":"Integrating Chemistry and Evolution to Illuminate Biology and Enable Novel Therapeutics","funder_award_id":"R35GM118062","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000912514","display_name":"Center for Genomic Editing and Recording: Development and Application of Next-Generation Genome and Epigenome Editing Methods to Advance the Study and Treatment of Human Disease","funder_award_id":"RM1HG009490","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1731173485","https://openalex.org/W1971295892","https://openalex.org/W1973673212","https://openalex.org/W1980201684","https://openalex.org/W1991769596","https://openalex.org/W2001845502","https://openalex.org/W2027404506","https://openalex.org/W2095331545","https://openalex.org/W2116041063","https://openalex.org/W2165016943","https://openalex.org/W2336828812","https://openalex.org/W2480829753","https://openalex.org/W2513796658","https://openalex.org/W2588556918","https://openalex.org/W2594683972","https://openalex.org/W2616302079","https://openalex.org/W2616839861","https://openalex.org/W2766599608","https://openalex.org/W2800434159","https://openalex.org/W2806478486","https://openalex.org/W2893791662","https://openalex.org/W2918418208","https://openalex.org/W2981137429"],"related_works":["https://openalex.org/W4293723920","https://openalex.org/W4200020209","https://openalex.org/W4288045976","https://openalex.org/W3021113268","https://openalex.org/W3189516790","https://openalex.org/W3145870363","https://openalex.org/W4410873687","https://openalex.org/W7001178693","https://openalex.org/W7117243280","https://openalex.org/W3016002413"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":109},{"year":2025,"cited_by_count":118},{"year":2024,"cited_by_count":106},{"year":2023,"cited_by_count":135},{"year":2022,"cited_by_count":146},{"year":2021,"cited_by_count":175},{"year":2020,"cited_by_count":86}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2020-03-23T00:00:00"}