{"id":"https://openalex.org/W3012015064","doi":null,"title":"Abstract #1514: BRCA1 orchestrates a novel molecular interplay at the BRCA1 and GADD153 promoters to regulate transcriptional responses to DNA damage","display_name":"Abstract #1514: BRCA1 orchestrates a novel molecular interplay at the BRCA1 and GADD153 promoters to regulate transcriptional responses to DNA damage","publication_year":2009,"publication_date":"2009-05-01","ids":{"openalex":"https://openalex.org/W3012015064","mag":"3012015064"},"language":"en","primary_location":{"id":"mag:3012015064","doi":null,"is_oa":false,"landing_page_url":"https://cancerres.aacrjournals.org/content/69/9_Supplement/1514","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research","raw_type":null},"volume":null,"type":"conference-abstract","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009533626","display_name":"Paola De Luca","orcid":"https://orcid.org/0000-0001-9810-8818","observed_orcids":["https://orcid.org/0000-0001-9810-8818","https://orcid.org/0009-0005-4079-7899","https://orcid.org/0000-0001-7212-1029"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paola De Luca","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9810-8818","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068896144","display_name":"Elba Susana Vazquez","orcid":"https://orcid.org/0000-0002-0460-0236","observed_orcids":["https://orcid.org/0000-0002-0460-0236"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elba S. V\u00e1zquez","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0460-0236","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089011260","display_name":"Cristian P. Moiola","orcid":"https://orcid.org/0000-0001-7218-0184","observed_orcids":["https://orcid.org/0000-0001-7218-0184"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cristian P. Moiola","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7218-0184","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016201080","display_name":"Geraldine Gueron","orcid":"https://orcid.org/0000-0002-9283-7451","observed_orcids":["https://orcid.org/0000-0002-9283-7451"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Geraldine Gueron","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9283-7451","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069223580","display_name":"Florencia Zalazar","orcid":"https://orcid.org/0000-0001-5358-2620","observed_orcids":["https://orcid.org/0000-0001-5358-2620"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Florencia Zalazar","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5358-2620","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Kevin H. Gardner","orcid":"https://orcid.org/0000-0002-8671-2556","observed_orcids":["https://orcid.org/0000-0002-8671-2556"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kevin H. Gardner","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8671-2556","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5059307829","display_name":"Adriana De Siervi","orcid":"https://orcid.org/0000-0002-1524-8063","observed_orcids":["https://orcid.org/0000-0002-1524-8063"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adriana De Siervi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1524-8063","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"69","issue":null,"first_page":"1514","last_page":"1514"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9042999744415283,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9042999744415283,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.07479999959468842,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brca1","display_name":"BRCA1","score":1.0},{"id":"https://openalex.org/keywords/gadd153","display_name":"GADD153","score":0.9959999918937683},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.8299999833106995},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6919999718666077},{"id":"https://openalex.org/keywords/e2f1","display_name":"E2F1","score":0.8610000014305115},{"id":"https://openalex.org/keywords/promoter-binding","display_name":"promoter binding","score":0.6340000033378601},{"id":"https://openalex.org/keywords/genotoxic-stress","display_name":"genotoxic stress","score":0.7360000014305115},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8220000267028809},{"id":"https://openalex.org/keywords/transcriptional-co-regulation","display_name":"transcriptional co-regulation","score":0.7829999923706055},{"id":"https://openalex.org/keywords/genomic-stability","display_name":"genome stability","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.7408450841903687},{"id":"https://openalex.org/C134320426","wikidata":"https://www.wikidata.org/wiki/Q901026","display_name":"Chromatin immunoprecipitation","level":5,"score":0.6605907082557678},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.6560268998146057},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6245768666267395},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.56479811668396},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.553047776222229},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.5390881896018982},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.5119353532791138},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4587647318840027},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.44330644607543945},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4284043312072754},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.39356529712677},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3895658254623413},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3510149121284485},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3012015064","doi":null,"is_oa":false,"landing_page_url":"https://cancerres.aacrjournals.org/content/69/9_Supplement/1514","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":"Cancer Research","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.7599999904632568,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1980110830","https://openalex.org/W2019602804","https://openalex.org/W1973049520","https://openalex.org/W2011137269","https://openalex.org/W2100747540","https://openalex.org/W874049513","https://openalex.org/W2316767106","https://openalex.org/W2099676698","https://openalex.org/W2966898099","https://openalex.org/W2963070813","https://openalex.org/W2092726292","https://openalex.org/W2990904963","https://openalex.org/W2051682149","https://openalex.org/W2074713677","https://openalex.org/W56949182","https://openalex.org/W2312397099","https://openalex.org/W2072264214","https://openalex.org/W2032232976","https://openalex.org/W2740941752","https://openalex.org/W3211901673"],"abstract_inverted_index":{"The":[0],"BRCA1":[1,24,48,54,63,70,110,117,151,159,166,171,184,195],"gene":[2],"product":[3],"plays":[4],"numerous":[5],"roles":[6],"in":[7,26,56,77,129,139,149,197],"regulating":[8],"genome":[9,40],"integrity.":[10],"It":[11],"interacts":[12],"with":[13,147],"crucial":[14],"proteins":[15],"and":[16,39,94,136,152,155,165,173,185],"is":[17,33,49,71,123,145],"considered":[18],"a":[19,126,179],"gene-specific":[20],"transcriptional":[21,28,143],"co-regulator;":[22],"however,":[23],"role":[25],"the":[27,53,107,113,133],"response":[29,198],"to":[30,67,79,82,199],"DNA":[31,88,95],"damage":[32,96],"poorly":[34],"understood.":[35],"By":[36],"chromatin":[37],"immunoprecipitation":[38],"arrays":[41],"technology":[42],"(ChIP-chip)":[43],"we":[44,104],"recently":[45],"determined":[46],"that":[47,106],"highly":[50],"enriched":[51],"at":[52,132],"promoter":[55,76,122,135,192],"cancer":[57],"cells":[58],"where":[59,183],"it":[60,74],"negative":[61],"influences":[62],"transcription.":[64,141],"Following":[65],"exposure":[66],"genotoxic":[68,200],"agents,":[69],"released":[72],"from":[73,119],"own":[75,121],"order":[78],"be":[80],"recruited":[81],"other":[83],"genes":[84],"or":[85],"sites":[86],"of":[87,194],"damage,":[89],"as":[90],"GADD153":[91,134,140,153,162,174,186],"(growth":[92],"arrest":[93],"gene).":[97],"In":[98],"this":[99],"study,":[100],"using":[101],"Tandem":[102],"ChIP,":[103],"show":[105,187],"mechanism":[108],"underlying":[109],"auto-regulation":[111],"involves":[112],"E2F1":[114],"transcription":[115,154,164,172],"factor.":[116],"release":[118],"its":[120,130],"accompanied":[124],"by":[125],"reciprocal":[127],"increase":[128,138],"occupancy":[131],"an":[137],"This":[142],"interplay":[144,182],"associated":[146],"increases":[148],"both":[150,169],"GADD153-mediated":[156],"apoptosis.":[157],"Enforced":[158],"expression":[160],"enhances":[161],"mediate":[163],"depletion":[167],"silences":[168],"active":[170],"expression.":[175],"These":[176],"results":[177],"describe":[178],"novel":[180],"molecular":[181],"coordinate":[188],"upregulation":[189],"through":[190],"rapid":[191],"exchange":[193],"protein":[196],"stress.":[201],"Citation":[203],"Information:":[204],"In:":[205],"Proc":[206],"Am":[207],"Assoc":[208],"Cancer":[209],"Res;":[210],"2009":[211],"Apr":[212],"18-22;":[213],"Denver,":[214],"CO.":[215],"Philadelphia":[216],"(PA):":[217],"AACR;":[218],"2009.":[219],"Abstract":[220],"nr":[221],"1514.":[222]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}