{"id":"https://openalex.org/W3012012483","doi":"https://doi.org/10.1016/j.vaccine.2020.03.010","title":"Induction of cross-reactive HIV-1 specific antibody responses by engineered V1V2 immunogens with reduced conformational plasticity","display_name":"Induction of cross-reactive HIV-1 specific antibody responses by engineered V1V2 immunogens with reduced conformational plasticity","publication_year":2020,"publication_date":"2020-03-17","ids":{"openalex":"https://openalex.org/W3012012483","doi":"https://doi.org/10.1016/j.vaccine.2020.03.010","mag":"3012012483","pmid":"https://pubmed.ncbi.nlm.nih.gov/32192810","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7132531"},"language":"en","primary_location":{"id":"doi:10.1016/j.vaccine.2020.03.010","doi":"https://doi.org/10.1016/j.vaccine.2020.03.010","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.vaccine.2020.03.010","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0264410X20303546/pdf","source":{"id":"https://openalex.org/S27359860","display_name":"Vaccine","issn_l":"0264-410X","issn":["0264-410X","1873-2518"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S0264410X20303546/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109212696","display_name":"Jennifer I. Lai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer I. Lai","raw_affiliation_strings":["Thayer School of Engineering, Dartmouth College, Hanover, NH, USA"],"raw_orcid":"https://orcid.org/0000-0002-1741-8601","affiliations":[{"raw_affiliation_string":"Thayer School of Engineering, Dartmouth College, Hanover, NH, USA","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088926319","display_name":"Susan K. Eszterhas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan K. Eszterhas","raw_affiliation_strings":["Thayer School of Engineering, Dartmouth College, Hanover, NH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thayer School of Engineering, Dartmouth College, Hanover, NH, USA","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113671090","display_name":"Seth A. Brooks","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seth A. Brooks","raw_affiliation_strings":["Thayer School of Engineering, Dartmouth College, Hanover, NH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thayer School of Engineering, Dartmouth College, Hanover, NH, USA","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109453423","display_name":"Chengzi Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chengzi Guo","raw_affiliation_strings":["Thayer School of Engineering, Dartmouth College, Hanover, NH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thayer School of Engineering, Dartmouth College, Hanover, NH, USA","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041332295","display_name":"Susan Zolla\u2010Pazner","orcid":"https://orcid.org/0000-0002-0750-2666","observed_orcids":["https://orcid.org/0000-0002-0750-2666"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan Zolla-Pazner","raw_affiliation_strings":["Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080175927","display_name":"Michael S. Seaman","orcid":"https://orcid.org/0000-0001-6444-3562","observed_orcids":["https://orcid.org/0000-0001-6444-3562"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael S. Seaman","raw_affiliation_strings":["Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030579910","display_name":"Chris Bailey\u2010Kellogg","orcid":"https://orcid.org/0000-0003-1860-0912","observed_orcids":["https://orcid.org/0000-0003-1860-0912"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chris Bailey-Kellogg","raw_affiliation_strings":["Department of Computer Science, Dartmouth College, Hanover, NH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Dartmouth College, Hanover, NH, USA","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023327470","display_name":"Karl E. Griswold","orcid":"https://orcid.org/0000-0002-9835-3394","observed_orcids":["https://orcid.org/0000-0002-9835-3394"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karl E. Griswold","raw_affiliation_strings":["Thayer School of Engineering, Dartmouth College, Hanover, NH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thayer School of Engineering, Dartmouth College, Hanover, NH, USA","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071990559","display_name":"Margaret E. Ackerman","orcid":"https://orcid.org/0000-0002-4253-3476","observed_orcids":["https://orcid.org/0000-0002-4253-3476"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Margaret E. Ackerman","raw_affiliation_strings":["Thayer School of Engineering, Dartmouth College, Hanover, NH, USA; Department of Microbiology and Immunology, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA. Electronic address: Margaret.E.Ackerman@dartmouth.edu","Department of Microbiology and Immunology, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA","Thayer School of Engineering, Dartmouth College, Hanover, NH, USA"],"raw_orcid":"https://orcid.org/0000-0002-4253-3476","affiliations":[{"raw_affiliation_string":"Thayer School of Engineering, Dartmouth College, Hanover, NH, USA; Department of Microbiology and Immunology, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA. Electronic address: Margaret.E.Ackerman@dartmouth.edu","institution_ids":["https://openalex.org/I107672454"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA","institution_ids":["https://openalex.org/I107672454"]},{"raw_affiliation_string":"Thayer School of Engineering, Dartmouth College, Hanover, NH, USA","institution_ids":["https://openalex.org/I107672454"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5071990559"],"corresponding_institution_ids":["https://openalex.org/I107672454"],"apc_list":{"value":3620,"currency":"USD","value_usd":3620},"apc_paid":{"value":2619,"currency":"EUR","value_usd":2824},"fwci":0.6585,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.62482045,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"38","issue":"18","first_page":"3436","last_page":"3446"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cross-reactive-antibodies","display_name":"cross-reactive antibodies","score":0.8149999976158142},{"id":"https://openalex.org/keywords/conformational-plasticity","display_name":"conformational plasticity","score":0.8889999985694885},{"id":"https://openalex.org/keywords/gp120","display_name":"gp120","score":0.7749999761581421},{"id":"https://openalex.org/keywords/gp70","display_name":"gp70","score":0.8199999928474426},{"id":"https://openalex.org/keywords/antibody-breadth","display_name":"antibody breadth","score":0.44699999690055847},{"id":"https://openalex.org/keywords/hiv-1-vaccine-design","display_name":"HIV-1 vaccine design","score":0.7379999756813049},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.8330000042915344},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.4790000021457672}],"concepts":[{"id":"https://openalex.org/C2779909307","wikidata":"https://www.wikidata.org/wiki/Q1660181","display_name":"Immunogen","level":4,"score":0.854678750038147},{"id":"https://openalex.org/C179223381","wikidata":"https://www.wikidata.org/wiki/Q419425","display_name":"Avidity","level":3,"score":0.6863611936569214},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.6523376703262329},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6038677096366882},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.5977108478546143},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5224948525428772},{"id":"https://openalex.org/C2779026604","wikidata":"https://www.wikidata.org/wiki/Q4774742","display_name":"Antigenicity","level":3,"score":0.45137423276901245},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43969354033470154},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4252639412879944},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.359793484210968},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2567007839679718},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.13036638498306274},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000917","descriptor_name":"Antibody Formation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015483","descriptor_name":"HIV Antibodies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015699","descriptor_name":"HIV Envelope Protein gp120","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016915","descriptor_name":"AIDS Vaccines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.vaccine.2020.03.010","doi":"https://doi.org/10.1016/j.vaccine.2020.03.010","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.vaccine.2020.03.010","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0264410X20303546/pdf","source":{"id":"https://openalex.org/S27359860","display_name":"Vaccine","issn_l":"0264-410X","issn":["0264-410X","1873-2518"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7132531","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7132531","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccine","raw_type":"Text"},{"id":"pmid:32192810","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32192810","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.vaccine.2020.03.010","doi":"https://doi.org/10.1016/j.vaccine.2020.03.010","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.vaccine.2020.03.010","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0264410X20303546/pdf","source":{"id":"https://openalex.org/S27359860","display_name":"Vaccine","issn_l":"0264-410X","issn":["0264-410X","1873-2518"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8199999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2309091535","display_name":"Applying High-Performance Protein Engineering Tools to HIV Immunogen Design","funder_award_id":"R01AI102691","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2398693717","display_name":null,"funder_award_id":"OPP1146996","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3152060028","display_name":"Functional Deimmunization of Therapeutic Proteins","funder_award_id":"5r01gm098977-09","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5734038057","display_name":null,"funder_award_id":"R01-GM098977","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6526245115","display_name":null,"funder_award_id":"1F31AI45106","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000875328","display_name":"The Institute for Biomolecular Targeting","funder_award_id":"P20GM113132","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G995288493","display_name":null,"funder_award_id":"OPP1146996","funder_id":"https://openalex.org/F4320306137","funder_display_name":"Bill and Melinda Gates Foundation"}],"funders":[{"id":"https://openalex.org/F4320306137","display_name":"Bill and Melinda Gates Foundation","ror":"https://ror.org/0456r8d26"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3012012483.pdf","grobid_xml":"https://content.openalex.org/works/W3012012483.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1888747365","https://openalex.org/W1966607693","https://openalex.org/W1967050458","https://openalex.org/W1972341594","https://openalex.org/W1979058462","https://openalex.org/W1985145726","https://openalex.org/W1999554971","https://openalex.org/W2000885937","https://openalex.org/W2012923599","https://openalex.org/W2024287923","https://openalex.org/W2036741092","https://openalex.org/W2075163956","https://openalex.org/W2076188553","https://openalex.org/W2077247092","https://openalex.org/W2078990393","https://openalex.org/W2081291921","https://openalex.org/W2082019631","https://openalex.org/W2083002978","https://openalex.org/W2094750078","https://openalex.org/W2106372377","https://openalex.org/W2108096886","https://openalex.org/W2108823547","https://openalex.org/W2122617162","https://openalex.org/W2124058652","https://openalex.org/W2131896393","https://openalex.org/W2135151522","https://openalex.org/W2143421242","https://openalex.org/W2145002856","https://openalex.org/W2152048324","https://openalex.org/W2158439602","https://openalex.org/W2159923852","https://openalex.org/W2160672411","https://openalex.org/W2167867167","https://openalex.org/W2169367715","https://openalex.org/W2169908075","https://openalex.org/W2181008927","https://openalex.org/W2294997006","https://openalex.org/W2323929490","https://openalex.org/W2493518412","https://openalex.org/W2733120775","https://openalex.org/W2757998384","https://openalex.org/W2788651711","https://openalex.org/W2794191778","https://openalex.org/W2808405028","https://openalex.org/W2903937718","https://openalex.org/W2908773956","https://openalex.org/W2912400111","https://openalex.org/W2937155623","https://openalex.org/W2948248112","https://openalex.org/W2951936481","https://openalex.org/W2998115530","https://openalex.org/W6650600034","https://openalex.org/W6659584369","https://openalex.org/W6758078893","https://openalex.org/W6764931322"],"related_works":["https://openalex.org/W2529443898","https://openalex.org/W2076188553","https://openalex.org/W2080384624","https://openalex.org/W2315431344","https://openalex.org/W2082019631","https://openalex.org/W2077247092","https://openalex.org/W1985145726","https://openalex.org/W2037181410","https://openalex.org/W2049496803","https://openalex.org/W7095220861"],"abstract_inverted_index":{"Antibodies":[0],"against":[1],"the":[2,7,15,20,75,102,114,158,165,175,187,207,219],"HIV-1":[3,232],"V1V2":[4,21,30,64,89,108,132,171,209],"loops":[5,22,31],"were":[6,141],"only":[8],"correlate":[9],"of":[10,59,80,117,146,160,167,177,189,206,221,229],"reduced":[11],"infection":[12],"risk":[13],"in":[14,67,95,122,164,186,194,211],"RV144":[16],"vaccine":[17,27],"trial,":[18],"highlighting":[19],"as":[23],"promising":[24],"targets":[25],"for":[26],"design.":[28],"The":[29],"are":[32],"structurally":[33],"plastic,":[34],"exhibiting":[35],"either":[36],"an":[37,50,56,68],"\u03b1-helix-coil":[38],"or":[39],"\u03b2-strand":[40,103],"conformation.":[41,104],"V1V2-specific":[42],"antibodies":[43,100],"may":[44,70,214],"thus":[45,71,215],"recognize":[46],"distinct":[47],"conformations,":[48],"and":[49,61,78,119,149,172,180,198],"antibody's":[51],"conformational":[52,65,76],"specificity":[53,77],"can":[54],"be":[55,216,227],"important":[57],"determinant":[58],"breadth":[60],"function.":[62],"Restricting":[63],"plasticity":[66],"immunogen":[69],"provide":[72],"control":[73],"over":[74],"quality":[79],"a":[81,88,144,153,190,230],"vaccine-elicited":[82],"antibody":[83,138,200,223],"response.":[84],"Previously,":[85],"we":[86,106,156],"identified":[87],"sequence":[90],"variant":[91],"(K155M)":[92],"that":[93,140],"results":[94],"enhanced":[96],"recognition":[97],"by":[98,112],"cross-reactive":[99,142,199,222],"recognizing":[101],"Here,":[105],"relate":[107],"antigenicity":[109],"to":[110,143,226],"immunogenicity":[111,115,163],"comparing":[113],"profiles":[116],"wildtype":[118,136,203],"K155M":[120,133,161,183,212],"immunogens":[121,213],"two":[123],"mouse":[124],"models.":[125],"In":[126,152],"one":[127],"model,":[128,155],"immunization":[129,181],"with":[130,218],"gp70":[131,168],"but":[134],"not":[135],"elicited":[137],"responses":[139,201,224],"panel":[145],"heterologous":[147],"gp120":[148,191],"gp140":[150],"antigens.":[151],"second":[154],"compared":[157],"effect":[159],"on":[162],"context":[166,188],"V1V2,":[169],"gD":[170],"gp120,":[173],"examining":[174],"effects":[176],"scaffold,":[178],"epitope-focusing":[179],"regimen.":[182],"variants,":[184],"especially":[185],"immunogen,":[192],"resulted":[193],"more":[195],"robust,":[196],"durable":[197],"than":[202],"immunogens.":[204],"Restriction":[205],"\u03b2-stranded":[208],"conformation":[210],"associated":[217],"induction":[220],"thought":[225],"required":[228],"protective":[231],"vaccine.":[233]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-03-23T00:00:00"}