{"id":"https://openalex.org/W3012011944","doi":"https://doi.org/10.1158/1541-7786.mcr-19-1203","title":"Destruction of a Microtubule-Bound MYC Reservoir during Mitosis Contributes to Vincristine's Anticancer Activity","display_name":"Destruction of a Microtubule-Bound MYC Reservoir during Mitosis Contributes to Vincristine's Anticancer Activity","publication_year":2020,"publication_date":"2020-03-11","ids":{"openalex":"https://openalex.org/W3012011944","doi":"https://doi.org/10.1158/1541-7786.mcr-19-1203","mag":"3012011944","pmid":"https://pubmed.ncbi.nlm.nih.gov/32161139"},"language":"en","primary_location":{"id":"doi:10.1158/1541-7786.mcr-19-1203","doi":"https://doi.org/10.1158/1541-7786.mcr-19-1203","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1541-7786.mcr-19-1203","pdf_url":null,"source":{"id":"https://openalex.org/S192067876","display_name":"Molecular Cancer Research","issn_l":"1541-7786","issn":["1541-7786","1557-3125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://resolver.sub.uni-goettingen.de/purl?gro-2/136300","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Sabrina Becker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]},{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sabrina Becker","raw_affiliation_strings":["1Department of Hematology and Medical Oncology, University Medicine Goettingen, Goettingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Hematology and Medical Oncology, University Medicine Goettingen, Goettingen, Germany","institution_ids":["https://openalex.org/I4210116730","https://openalex.org/I74656192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018570681","display_name":"Christina Kiecke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]},{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christina Kiecke","raw_affiliation_strings":["1Department of Hematology and Medical Oncology, University Medicine Goettingen, Goettingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Hematology and Medical Oncology, University Medicine Goettingen, Goettingen, Germany","institution_ids":["https://openalex.org/I4210116730","https://openalex.org/I74656192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112531576","display_name":"Eva Sch\u00e4fer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]},{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Eva Sch\u00e4fer","raw_affiliation_strings":["1Department of Hematology and Medical Oncology, University Medicine Goettingen, Goettingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Hematology and Medical Oncology, University Medicine Goettingen, Goettingen, Germany","institution_ids":["https://openalex.org/I4210116730","https://openalex.org/I74656192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071464910","display_name":"Ursula Sinzig","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]},{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ursula Sinzig","raw_affiliation_strings":["1Department of Hematology and Medical Oncology, University Medicine Goettingen, Goettingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Hematology and Medical Oncology, University Medicine Goettingen, Goettingen, Germany","institution_ids":["https://openalex.org/I4210116730","https://openalex.org/I74656192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036813563","display_name":"Lena Deuper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]},{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lena Deuper","raw_affiliation_strings":["1Department of Hematology and Medical Oncology, University Medicine Goettingen, Goettingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Hematology and Medical Oncology, University Medicine Goettingen, Goettingen, Germany","institution_ids":["https://openalex.org/I4210116730","https://openalex.org/I74656192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006582372","display_name":"Pablo Trigo\u2010Mouri\u00f1o","orcid":"https://orcid.org/0000-0003-0822-882X","observed_orcids":["https://orcid.org/0000-0003-0822-882X"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]},{"id":"https://openalex.org/I4210131661","display_name":"Max Planck Institute for Biophysical Chemistry","ror":"https://ror.org/03e76ya46","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210131661","https://openalex.org/I4387154714"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Pablo Trigo-Mourino","raw_affiliation_strings":["2Max-Planck Institute for Biophysical Chemistry, Goettingen, Germany","3Analytical Research and Development, Merck & Co., Inc., Kenilworth, New Jersey","2Max-Planck Institute for Biophysical Chemistry, Goettingen, Germany.; 3Analytical Research and Development, Merck & Co., Inc., Kenilworth, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Max-Planck Institute for Biophysical Chemistry, Goettingen, Germany","institution_ids":["https://openalex.org/I4210131661"]},{"raw_affiliation_string":"3Analytical Research and Development, Merck & Co., Inc., Kenilworth, New Jersey","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"2Max-Planck Institute for Biophysical Chemistry, Goettingen, Germany.; 3Analytical Research and Development, Merck & Co., Inc., Kenilworth, New Jersey","institution_ids":["https://openalex.org/I1285764155","https://openalex.org/I4210131661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037375841","display_name":"Christian Griesinger","orcid":"https://orcid.org/0000-0002-1266-4344","observed_orcids":["https://orcid.org/0000-0002-1266-4344"]},"institutions":[{"id":"https://openalex.org/I4210131661","display_name":"Max Planck Institute for Biophysical Chemistry","ror":"https://ror.org/03e76ya46","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210131661","https://openalex.org/I4387154714"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Griesinger","raw_affiliation_strings":["2Max-Planck Institute for Biophysical Chemistry, Goettingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Max-Planck Institute for Biophysical Chemistry, Goettingen, Germany","institution_ids":["https://openalex.org/I4210131661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046212667","display_name":"Raphael Koch","orcid":"https://orcid.org/0000-0002-2018-5685","observed_orcids":["https://orcid.org/0000-0002-2018-5685"]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]},{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Raphael Koch","raw_affiliation_strings":["1Department of Hematology and Medical Oncology, University Medicine Goettingen, Goettingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Hematology and Medical Oncology, University Medicine Goettingen, Goettingen, Germany","institution_ids":["https://openalex.org/I4210116730","https://openalex.org/I74656192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046235587","display_name":"Zuzanna Rydzy\u0144ska","orcid":"https://orcid.org/0000-0002-4419-1641","observed_orcids":["https://orcid.org/0000-0002-4419-1641"]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]},{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Zuzanna Rydzynska","raw_affiliation_strings":["1Department of Hematology and Medical Oncology, University Medicine Goettingen, Goettingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Hematology and Medical Oncology, University Medicine Goettingen, Goettingen, Germany","institution_ids":["https://openalex.org/I4210116730","https://openalex.org/I74656192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074215180","display_name":"Bjoern Chapuy","orcid":"https://orcid.org/0000-0002-6485-8773","observed_orcids":["https://orcid.org/0000-0002-6485-8773","https://orcid.org/0000-0002-0886-9769"]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]},{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bjoern Chapuy","raw_affiliation_strings":["1Department of Hematology and Medical Oncology, University Medicine Goettingen, Goettingen, Germany"],"raw_orcid":"https://orcid.org/0000-0002-6485-8773","affiliations":[{"raw_affiliation_string":"1Department of Hematology and Medical Oncology, University Medicine Goettingen, Goettingen, Germany","institution_ids":["https://openalex.org/I4210116730","https://openalex.org/I74656192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111883476","display_name":"Frederike von Bonin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]},{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frederike von Bonin","raw_affiliation_strings":["1Department of Hematology and Medical Oncology, University Medicine Goettingen, Goettingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Hematology and Medical Oncology, University Medicine Goettingen, Goettingen, Germany","institution_ids":["https://openalex.org/I4210116730","https://openalex.org/I74656192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089489874","display_name":"Dieter Kube","orcid":"https://orcid.org/0000-0002-0974-9902","observed_orcids":["https://orcid.org/0000-0002-0974-9902","https://orcid.org/0000-0001-7760-525X"]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]},{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dieter Kube","raw_affiliation_strings":["1Department of Hematology and Medical Oncology, University Medicine Goettingen, Goettingen, Germany"],"raw_orcid":"https://orcid.org/0000-0002-0974-9902","affiliations":[{"raw_affiliation_string":"1Department of Hematology and Medical Oncology, University Medicine Goettingen, Goettingen, Germany","institution_ids":["https://openalex.org/I4210116730","https://openalex.org/I74656192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077734260","display_name":"Vivek Venkataramani","orcid":"https://orcid.org/0000-0002-6771-365X","observed_orcids":["https://orcid.org/0000-0002-6771-365X"]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]},{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Vivek Venkataramani","raw_affiliation_strings":["1Department of Hematology and Medical Oncology, University Medicine Goettingen, Goettingen, Germany"],"raw_orcid":"https://orcid.org/0000-0002-6771-365X","affiliations":[{"raw_affiliation_string":"1Department of Hematology and Medical Oncology, University Medicine Goettingen, Goettingen, Germany","institution_ids":["https://openalex.org/I4210116730","https://openalex.org/I74656192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019585492","display_name":"Hanibal Bohnenberger","orcid":"https://orcid.org/0000-0003-1038-1030","observed_orcids":["https://orcid.org/0000-0003-1038-1030"]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]},{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hanibal Bohnenberger","raw_affiliation_strings":["4Institute of Pathology, University Medicine Goettingen, Goettingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Institute of Pathology, University Medicine Goettingen, Goettingen, Germany","institution_ids":["https://openalex.org/I4210116730","https://openalex.org/I74656192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023940205","display_name":"Andreas Leha","orcid":"https://orcid.org/0000-0002-8072-1988","observed_orcids":["https://orcid.org/0000-0002-8072-1988"]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]},{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Leha","raw_affiliation_strings":["5Department of Medical Statistics, University Medicine Goettingen, Goettingen, Germany"],"raw_orcid":"https://orcid.org/0000-0002-8072-1988","affiliations":[{"raw_affiliation_string":"5Department of Medical Statistics, University Medicine Goettingen, Goettingen, Germany","institution_ids":["https://openalex.org/I4210116730","https://openalex.org/I74656192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056539867","display_name":"Johanna Flach","orcid":"https://orcid.org/0000-0001-6157-8357","observed_orcids":["https://orcid.org/0000-0001-6157-8357"]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]},{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Johanna Flach","raw_affiliation_strings":["1Department of Hematology and Medical Oncology, University Medicine Goettingen, Goettingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Hematology and Medical Oncology, University Medicine Goettingen, Goettingen, Germany","institution_ids":["https://openalex.org/I4210116730","https://openalex.org/I74656192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018807515","display_name":"Sascha Dierks","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]},{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sascha Dierks","raw_affiliation_strings":["1Department of Hematology and Medical Oncology, University Medicine Goettingen, Goettingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Hematology and Medical Oncology, University Medicine Goettingen, Goettingen, Germany","institution_ids":["https://openalex.org/I4210116730","https://openalex.org/I74656192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013651038","display_name":"Holger Bastians","orcid":"https://orcid.org/0000-0001-7915-3648","observed_orcids":["https://orcid.org/0000-0001-7915-3648"]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]},{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Holger Bastians","raw_affiliation_strings":["6Department of Experimental Oncology, University Medicine Goettingen, Goettingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Department of Experimental Oncology, University Medicine Goettingen, Goettingen, Germany","institution_ids":["https://openalex.org/I4210116730","https://openalex.org/I74656192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042618652","display_name":"Brigitte Maruschak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]},{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Brigitte Maruschak","raw_affiliation_strings":["7Institute for Neuropathology, University Medicine Goettingen, Goettingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Institute for Neuropathology, University Medicine Goettingen, Goettingen, Germany","institution_ids":["https://openalex.org/I4210116730","https://openalex.org/I74656192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031962066","display_name":"Kamil Bojarczuk","orcid":"https://orcid.org/0000-0002-6110-4060","observed_orcids":["https://orcid.org/0000-0002-6110-4060"]},"institutions":[{"id":"https://openalex.org/I4210090876","display_name":"Instytut Hematologii i Transfuzjologi","ror":"https://ror.org/00csw7971","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210090876"]},{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]},{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE","PL"],"is_corresponding":false,"raw_author_name":"Kamil Bojarczuk","raw_affiliation_strings":["1Department of Hematology and Medical Oncology, University Medicine Goettingen, Goettingen, Germany","8Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland","1Department of Hematology and Medical Oncology, University Medicine Goettingen, Goettingen, Germany.; 8Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland"],"raw_orcid":"https://orcid.org/0000-0002-6110-4060","affiliations":[{"raw_affiliation_string":"1Department of Hematology and Medical Oncology, University Medicine Goettingen, Goettingen, Germany","institution_ids":["https://openalex.org/I4210116730","https://openalex.org/I74656192"]},{"raw_affiliation_string":"8Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland","institution_ids":["https://openalex.org/I4210090876"]},{"raw_affiliation_string":"1Department of Hematology and Medical Oncology, University Medicine Goettingen, Goettingen, Germany.; 8Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland","institution_ids":["https://openalex.org/I4210090876","https://openalex.org/I4210116730","https://openalex.org/I74656192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059920152","display_name":"Mateus de Oliveira Taveira","orcid":"https://orcid.org/0000-0001-8091-6593","observed_orcids":["https://orcid.org/0000-0001-8091-6593"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mateus de Oliveira Taveira","raw_affiliation_strings":["9Department of Medicine, BIDMC/Harvard Medical School, Boston, Massachusetts"],"raw_orcid":"https://orcid.org/0000-0001-8091-6593","affiliations":[{"raw_affiliation_string":"9Department of Medicine, BIDMC/Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113894063","display_name":"Lorenz H. P. Tr\u00fcmper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]},{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lorenz Tr\u00fcmper","raw_affiliation_strings":["1Department of Hematology and Medical Oncology, University Medicine Goettingen, Goettingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Hematology and Medical Oncology, University Medicine Goettingen, Goettingen, Germany","institution_ids":["https://openalex.org/I4210116730","https://openalex.org/I74656192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018472888","display_name":"Gerburg M. Wulf","orcid":"https://orcid.org/0000-0001-7868-6231","observed_orcids":["https://orcid.org/0000-0001-7868-6231"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]},{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Gerburg M. Wulf","raw_affiliation_strings":["1Department of Hematology and Medical Oncology, University Medicine Goettingen, Goettingen, Germany","9Department of Medicine, BIDMC/Harvard Medical School, Boston, Massachusetts"],"raw_orcid":"https://orcid.org/0000-0002-7669-3785","affiliations":[{"raw_affiliation_string":"1Department of Hematology and Medical Oncology, University Medicine Goettingen, Goettingen, Germany","institution_ids":["https://openalex.org/I4210116730","https://openalex.org/I74656192"]},{"raw_affiliation_string":"9Department of Medicine, BIDMC/Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029448872","display_name":"Gerald Georg Wulf","orcid":"https://orcid.org/0000-0002-7669-3785","observed_orcids":["https://orcid.org/0000-0002-7669-3785"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]},{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Gerald G. Wulf","raw_affiliation_strings":["1Department of Hematology and Medical Oncology, University Medicine Goettingen, Goettingen, Germany","9Department of Medicine, BIDMC/Harvard Medical School, Boston, Massachusetts"],"raw_orcid":"https://orcid.org/0000-0002-7669-3785","affiliations":[{"raw_affiliation_string":"1Department of Hematology and Medical Oncology, University Medicine Goettingen, Goettingen, Germany","institution_ids":["https://openalex.org/I4210116730","https://openalex.org/I74656192"]},{"raw_affiliation_string":"9Department of Medicine, BIDMC/Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8004,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.62026932,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"18","issue":"6","first_page":"859","last_page":"872"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.9850000143051147},{"id":"https://openalex.org/keywords/vincristine","display_name":"vincristine","score":0.9129999876022339},{"id":"https://openalex.org/keywords/microtubules","display_name":"microtubules","score":0.7870000004768372},{"id":"https://openalex.org/keywords/mitotic-spindle","display_name":"mitotic spindle","score":0.9900000095367432},{"id":"https://openalex.org/keywords/myc-phosphorylation","display_name":"MYC phosphorylation","score":0.6940000057220459},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.7279999852180481},{"id":"https://openalex.org/keywords/proteasomal-degradation","display_name":"proteasomal degradation","score":0.9210000038146973},{"id":"https://openalex.org/keywords/microtubule-destabilization","display_name":"microtubule destabilization","score":0.6890000104904175},{"id":"https://openalex.org/keywords/vincristine-resistance","display_name":"vincristine resistance","score":0.7409999966621399},{"id":"https://openalex.org/keywords/polyploidy","display_name":"polyploidy","score":0.9919999837875366},{"id":"https://openalex.org/keywords/pi3k-inhibition","display_name":"PI3K inhibition","score":0.9919999837875366},{"id":"https://openalex.org/keywords/mitosis","display_name":"mitosis","score":0.4860000014305115},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.44999998807907104}],"concepts":[{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.7370389699935913},{"id":"https://openalex.org/C2779429289","wikidata":"https://www.wikidata.org/wiki/Q408977","display_name":"Vincristine","level":4,"score":0.71059650182724},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6659820675849915},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.5871164202690125},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38958078622817993},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3428536057472229},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.265627384185791},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.1986950933933258},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11321896314620972},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.05570116639137268}],"mesh":[{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014750","descriptor_name":"Vincristine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1158/1541-7786.mcr-19-1203","doi":"https://doi.org/10.1158/1541-7786.mcr-19-1203","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1541-7786.mcr-19-1203","pdf_url":null,"source":{"id":"https://openalex.org/S192067876","display_name":"Molecular Cancer Research","issn_l":"1541-7786","issn":["1541-7786","1557-3125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Research","raw_type":"journal-article"},{"id":"pmid:32161139","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32161139","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular cancer research : MCR","raw_type":"Journal Article"},{"id":"pmh:oai:publications.goettingen-research-online.de:2/136300","doi":null,"is_oa":true,"landing_page_url":"https://resolver.sub.uni-goettingen.de/purl?gro-2/136300","pdf_url":null,"source":{"id":"https://openalex.org/S4306401634","display_name":"GoeScholar  The Publication Server of the Georg-August-Universit\u00e4t G\u00f6ttingen (Georg-August-Universit\u00e4t G\u00f6ttingen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210122495","host_organization_name":"Asklepios Klinik St. Georg","host_organization_lineage":["https://openalex.org/I4210122495"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:publications.goettingen-research-online.de:2/136300","doi":null,"is_oa":true,"landing_page_url":"https://resolver.sub.uni-goettingen.de/purl?gro-2/136300","pdf_url":null,"source":{"id":"https://openalex.org/S4306401634","display_name":"GoeScholar  The Publication Server of the Georg-August-Universit\u00e4t G\u00f6ttingen (Georg-August-Universit\u00e4t G\u00f6ttingen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210122495","host_organization_name":"Asklepios Klinik St. Georg","host_organization_lineage":["https://openalex.org/I4210122495"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320318756","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W1538085254","https://openalex.org/W1560204041","https://openalex.org/W1690531714","https://openalex.org/W1781103050","https://openalex.org/W1825200556","https://openalex.org/W1847174723","https://openalex.org/W1956409007","https://openalex.org/W1963016133","https://openalex.org/W1964515703","https://openalex.org/W1964596502","https://openalex.org/W1977290507","https://openalex.org/W1982977272","https://openalex.org/W1984418041","https://openalex.org/W1988263368","https://openalex.org/W1992661182","https://openalex.org/W1994345832","https://openalex.org/W1999025078","https://openalex.org/W2021421164","https://openalex.org/W2032972450","https://openalex.org/W2035258932","https://openalex.org/W2036019787","https://openalex.org/W2036865475","https://openalex.org/W2042066283","https://openalex.org/W2044797731","https://openalex.org/W2051025473","https://openalex.org/W2052154365","https://openalex.org/W2072262157","https://openalex.org/W2074305355","https://openalex.org/W2078511240","https://openalex.org/W2079529944","https://openalex.org/W2081406767","https://openalex.org/W2092855542","https://openalex.org/W2093855538","https://openalex.org/W2106119346","https://openalex.org/W2108541596","https://openalex.org/W2109005919","https://openalex.org/W2118028844","https://openalex.org/W2122129877","https://openalex.org/W2126232974","https://openalex.org/W2130296076","https://openalex.org/W2135503594","https://openalex.org/W2136627573","https://openalex.org/W2139080752","https://openalex.org/W2141078839","https://openalex.org/W2147853500","https://openalex.org/W2155953052","https://openalex.org/W2159290008","https://openalex.org/W2161427213","https://openalex.org/W2163395716","https://openalex.org/W2164461769","https://openalex.org/W2254906934","https://openalex.org/W2314991324","https://openalex.org/W2319053438","https://openalex.org/W2346226705","https://openalex.org/W2411521589","https://openalex.org/W2552700328","https://openalex.org/W2571275916","https://openalex.org/W2734965995","https://openalex.org/W2762450632","https://openalex.org/W2763994374","https://openalex.org/W2791635405","https://openalex.org/W2922610698","https://openalex.org/W4236967220"],"related_works":["https://openalex.org/W2792057177","https://openalex.org/W2964724689","https://openalex.org/W4361011701","https://openalex.org/W2317367896","https://openalex.org/W2563899339","https://openalex.org/W2036200757","https://openalex.org/W2105214585","https://openalex.org/W2145846178","https://openalex.org/W2426078274","https://openalex.org/W4400657721"],"abstract_inverted_index":{"Tightly":[0],"regulated":[1],"activity":[2],"of":[3,28,37,54,61,86,99,117],"the":[4,38,59,62,66,96],"transcription":[5],"factor":[6],"MYC":[7,16,29,56,72,76,92,110],"is":[8,24,77],"essential":[9,26],"for":[10,109,123],"orderly":[11],"cell":[12],"proliferation.":[13],"Upon":[14],"deregulation,":[15],"elicits":[17],"and":[18,84,94],"promotes":[19],"cancer":[20,124],"progression.":[21],"Proteasomal":[22],"degradation":[23],"an":[25],"element":[27],"regulation,":[30],"initiated":[31],"by":[32],"phosphorylation":[33,46],"at":[34],"Serine62":[35],"(Ser62)":[36],"MB1":[39],"region.":[40],"Here,":[41],"we":[42],"found":[43],"that":[44,51],"Ser62":[45],"peaks":[47],"in":[48],"mitosis,":[49],"but":[50],"a":[52,106,115],"fraction":[53],"nonphosphorylated":[55],"binds":[57],"to":[58,81,120],"microtubules":[60],"mitotic":[63],"spindle.":[64],"Consequently,":[65],"microtubule-destabilizing":[67],"drug":[68],"vincristine":[69,82],"decreases":[70],"wild-type":[71],"stability,":[73],"whereas":[74],"phosphorylation-deficient":[75],"more":[78],"stable,":[79],"contributing":[80],"resistance":[83],"induction":[85],"polyploidy.":[87],"PI3K":[88],"inhibition":[89],"attenuates":[90],"postmitotic":[91],"formation":[93],"augments":[95],"cytotoxic":[97],"effect":[98],"vincristine.":[100],"IMPLICATIONS:":[101],"The":[102],"spindle's":[103],"function":[104],"as":[105],"docking":[107],"site":[108],"during":[111],"mitosis":[112],"may":[113],"constitute":[114],"window":[116],"specific":[118],"vulnerability":[119],"be":[121],"exploited":[122],"treatment.":[125]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2020-03-23T00:00:00"}