{"id":"https://openalex.org/W3011968641","doi":"https://doi.org/10.1007/s11426-019-9673-4","title":"A triple-combination nanotechnology platform based on multifunctional RNA hydrogel for lung cancer therapy","display_name":"A triple-combination nanotechnology platform based on multifunctional RNA hydrogel for lung cancer therapy","publication_year":2020,"publication_date":"2020-03-13","ids":{"openalex":"https://openalex.org/W3011968641","doi":"https://doi.org/10.1007/s11426-019-9673-4","mag":"3011968641"},"language":"en","primary_location":{"id":"doi:10.1007/s11426-019-9673-4","doi":"https://doi.org/10.1007/s11426-019-9673-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11426-019-9673-4","pdf_url":null,"source":{"id":"https://openalex.org/S147836164","display_name":"Science China Chemistry","issn_l":"1001-652X","issn":["1001-652X","1006-9291","1674-7291","1862-2771","1869-1870"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science China Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100374879","display_name":"Junwei Li","orcid":"https://orcid.org/0009-0009-2806-1511","observed_orcids":["https://orcid.org/0009-0009-2806-1511","https://orcid.org/0009-0000-0919-2289"]},"institutions":[{"id":"https://openalex.org/I15823474","display_name":"Linyi University","ror":"https://ror.org/01knv0402","country_code":"CN","type":"education","lineage":["https://openalex.org/I15823474"]},{"id":"https://openalex.org/I28006308","display_name":"Shandong Normal University","ror":"https://ror.org/01wy3h363","country_code":"CN","type":"education","lineage":["https://openalex.org/I28006308"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junwei Li","raw_affiliation_strings":["Collaborative Innovation Center of Tumor Marker Detection Technology, Equipment and Diagnosis-Therapy Integration in Universities of Shandong, Shandong Province Key Laboratory of Detection Technology for Tumor Makers, School of Chemistry and Chemical Engineering, Linyi University, Linyi, 276005, China","College of Chemistry, Chemical Engineering and Materials Science, Cooperative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Shandong Normal University, Jinan, 250014, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Collaborative Innovation Center of Tumor Marker Detection Technology, Equipment and Diagnosis-Therapy Integration in Universities of Shandong, Shandong Province Key Laboratory of Detection Technology for Tumor Makers, School of Chemistry and Chemical Engineering, Linyi University, Linyi, 276005, China","institution_ids":["https://openalex.org/I15823474"]},{"raw_affiliation_string":"College of Chemistry, Chemical Engineering and Materials Science, Cooperative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Shandong Normal University, Jinan, 250014, China","institution_ids":["https://openalex.org/I28006308"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101979239","display_name":"Dandan Yuan","orcid":"https://orcid.org/0000-0003-1027-7751","observed_orcids":["https://orcid.org/0000-0003-1027-7751"]},"institutions":[{"id":"https://openalex.org/I15823474","display_name":"Linyi University","ror":"https://ror.org/01knv0402","country_code":"CN","type":"education","lineage":["https://openalex.org/I15823474"]},{"id":"https://openalex.org/I28006308","display_name":"Shandong Normal University","ror":"https://ror.org/01wy3h363","country_code":"CN","type":"education","lineage":["https://openalex.org/I28006308"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dandan Yuan","raw_affiliation_strings":["Collaborative Innovation Center of Tumor Marker Detection Technology, Equipment and Diagnosis-Therapy Integration in Universities of Shandong, Shandong Province Key Laboratory of Detection Technology for Tumor Makers, School of Chemistry and Chemical Engineering, Linyi University, Linyi, 276005, China","College of Chemistry, Chemical Engineering and Materials Science, Cooperative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Shandong Normal University, Jinan, 250014, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Collaborative Innovation Center of Tumor Marker Detection Technology, Equipment and Diagnosis-Therapy Integration in Universities of Shandong, Shandong Province Key Laboratory of Detection Technology for Tumor Makers, School of Chemistry and Chemical Engineering, Linyi University, Linyi, 276005, China","institution_ids":["https://openalex.org/I15823474"]},{"raw_affiliation_string":"College of Chemistry, Chemical Engineering and Materials Science, Cooperative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Shandong Normal University, Jinan, 250014, China","institution_ids":["https://openalex.org/I28006308"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103116375","display_name":"Xiangjiang Zheng","orcid":"https://orcid.org/0000-0001-9670-2514","observed_orcids":["https://orcid.org/0000-0001-9670-2514"]},"institutions":[{"id":"https://openalex.org/I15823474","display_name":"Linyi University","ror":"https://ror.org/01knv0402","country_code":"CN","type":"education","lineage":["https://openalex.org/I15823474"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiangjiang Zheng","raw_affiliation_strings":["Collaborative Innovation Center of Tumor Marker Detection Technology, Equipment and Diagnosis-Therapy Integration in Universities of Shandong, Shandong Province Key Laboratory of Detection Technology for Tumor Makers, School of Chemistry and Chemical Engineering, Linyi University, Linyi, 276005, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Collaborative Innovation Center of Tumor Marker Detection Technology, Equipment and Diagnosis-Therapy Integration in Universities of Shandong, Shandong Province Key Laboratory of Detection Technology for Tumor Makers, School of Chemistry and Chemical Engineering, Linyi University, Linyi, 276005, China","institution_ids":["https://openalex.org/I15823474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100319966","display_name":"Xinyue Zhang","orcid":"https://orcid.org/0000-0002-5908-4478","observed_orcids":["https://orcid.org/0000-0002-5908-4478"]},"institutions":[{"id":"https://openalex.org/I15823474","display_name":"Linyi University","ror":"https://ror.org/01knv0402","country_code":"CN","type":"education","lineage":["https://openalex.org/I15823474"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyue Zhang","raw_affiliation_strings":["Collaborative Innovation Center of Tumor Marker Detection Technology, Equipment and Diagnosis-Therapy Integration in Universities of Shandong, Shandong Province Key Laboratory of Detection Technology for Tumor Makers, School of Chemistry and Chemical Engineering, Linyi University, Linyi, 276005, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Collaborative Innovation Center of Tumor Marker Detection Technology, Equipment and Diagnosis-Therapy Integration in Universities of Shandong, Shandong Province Key Laboratory of Detection Technology for Tumor Makers, School of Chemistry and Chemical Engineering, Linyi University, Linyi, 276005, China","institution_ids":["https://openalex.org/I15823474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100420289","display_name":"Xuemei Li","orcid":"https://orcid.org/0000-0002-8303-8121","observed_orcids":["https://orcid.org/0000-0002-8303-8121","https://orcid.org/0009-0008-8978-7757","https://orcid.org/0009-0001-0242-0696"]},"institutions":[{"id":"https://openalex.org/I15823474","display_name":"Linyi University","ror":"https://ror.org/01knv0402","country_code":"CN","type":"education","lineage":["https://openalex.org/I15823474"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xuemei Li","raw_affiliation_strings":["Collaborative Innovation Center of Tumor Marker Detection Technology, Equipment and Diagnosis-Therapy Integration in Universities of Shandong, Shandong Province Key Laboratory of Detection Technology for Tumor Makers, School of Chemistry and Chemical Engineering, Linyi University, Linyi, 276005, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Collaborative Innovation Center of Tumor Marker Detection Technology, Equipment and Diagnosis-Therapy Integration in Universities of Shandong, Shandong Province Key Laboratory of Detection Technology for Tumor Makers, School of Chemistry and Chemical Engineering, Linyi University, Linyi, 276005, China","institution_ids":["https://openalex.org/I15823474"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100610307","display_name":"Shusheng Zhang","orcid":"https://orcid.org/0000-0002-8416-8331","observed_orcids":["https://orcid.org/0000-0002-8416-8331"]},"institutions":[{"id":"https://openalex.org/I15823474","display_name":"Linyi University","ror":"https://ror.org/01knv0402","country_code":"CN","type":"education","lineage":["https://openalex.org/I15823474"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shusheng Zhang","raw_affiliation_strings":["Collaborative Innovation Center of Tumor Marker Detection Technology, Equipment and Diagnosis-Therapy Integration in Universities of Shandong, Shandong Province Key Laboratory of Detection Technology for Tumor Makers, School of Chemistry and Chemical Engineering, Linyi University, Linyi, 276005, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Collaborative Innovation Center of Tumor Marker Detection Technology, Equipment and Diagnosis-Therapy Integration in Universities of Shandong, Shandong Province Key Laboratory of Detection Technology for Tumor Makers, School of Chemistry and Chemical Engineering, Linyi University, Linyi, 276005, China","institution_ids":["https://openalex.org/I15823474"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100420289","https://openalex.org/A5100610307"],"corresponding_institution_ids":["https://openalex.org/I15823474"],"apc_list":{"value":3260,"currency":"USD","value_usd":3260},"apc_paid":null,"fwci":1.213,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.76338179,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"63","issue":"4","first_page":"546","last_page":"553"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.8539999723434448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.8539999723434448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.09449999779462814,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.03669999912381172,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.8659999966621399},{"id":"https://openalex.org/keywords/triple-combination-therapy","display_name":"triple combination therapy","score":0.7379999756813049},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.8399999737739563},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.9010000228881836},{"id":"https://openalex.org/keywords/phototherapy","display_name":"phototherapy","score":0.9120000004768372},{"id":"https://openalex.org/keywords/let-7a","display_name":"let-7a","score":0.9459999799728394},{"id":"https://openalex.org/keywords/mir-34a","display_name":"miR-34a","score":0.9169999957084656},{"id":"https://openalex.org/keywords/mir-145","display_name":"miR-145","score":0.9990000128746033},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.9210000038146973},{"id":"https://openalex.org/keywords/tmpyp4","display_name":"TMPyP4","score":0.8579999804496765},{"id":"https://openalex.org/keywords/photosensitizers","display_name":"photosensitizers","score":0.8349999785423279},{"id":"https://openalex.org/keywords/rolling-circle-transcription","display_name":"rolling circle transcription","score":0.8870000243186951},{"id":"https://openalex.org/keywords/dna-nanotechnology","display_name":"DNA nanotechnology","score":0.8410000205039978},{"id":"https://openalex.org/keywords/aptamer-targeting","display_name":"aptamer targeting","score":0.6769999861717224},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.871999979019165},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"drug delivery","score":0.4339999854564667}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5482838153839111},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5421475172042847},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.5235952138900757},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.5219333171844482},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5192546844482422},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5150825381278992},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.501117467880249},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.48391062021255493},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.4754635691642761},{"id":"https://openalex.org/C2781469039","wikidata":"https://www.wikidata.org/wiki/Q18388377","display_name":"Photosensitizer","level":2,"score":0.4412800669670105},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.4337392747402191},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.42986780405044556},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.42976123094558716},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.41263440251350403},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.41240373253822327},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.350334107875824},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3189256191253662},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2218843698501587},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17449504137039185},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.12165749073028564},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09739759564399719},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09196978807449341},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/s11426-019-9673-4","doi":"https://doi.org/10.1007/s11426-019-9673-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11426-019-9673-4","pdf_url":null,"source":{"id":"https://openalex.org/S147836164","display_name":"Science China Chemistry","issn_l":"1001-652X","issn":["1001-652X","1006-9291","1674-7291","1862-2771","1869-1870"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science China Chemistry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1525478498","https://openalex.org/W1903419358","https://openalex.org/W1996517412","https://openalex.org/W2010693773","https://openalex.org/W2019880556","https://openalex.org/W2028204215","https://openalex.org/W2053527763","https://openalex.org/W2095509038","https://openalex.org/W2119505328","https://openalex.org/W2131487381","https://openalex.org/W2132194692","https://openalex.org/W2165323887","https://openalex.org/W2236332245","https://openalex.org/W2256492013","https://openalex.org/W2272984102","https://openalex.org/W2282587270","https://openalex.org/W2289266827","https://openalex.org/W2315109539","https://openalex.org/W2389554188","https://openalex.org/W2404671794","https://openalex.org/W2518119257","https://openalex.org/W2521996233","https://openalex.org/W2549125766","https://openalex.org/W2582355584","https://openalex.org/W2584318012","https://openalex.org/W2612076232","https://openalex.org/W2748688966","https://openalex.org/W2767427905","https://openalex.org/W2768741450","https://openalex.org/W2771639621","https://openalex.org/W2780546491","https://openalex.org/W2794122963","https://openalex.org/W2800924700","https://openalex.org/W2885913751","https://openalex.org/W2902674912","https://openalex.org/W2905522695","https://openalex.org/W2914296406","https://openalex.org/W2914431697","https://openalex.org/W2922199398","https://openalex.org/W2971872568","https://openalex.org/W2980954221"],"related_works":["https://openalex.org/W2512910972","https://openalex.org/W4200621548","https://openalex.org/W4242187806","https://openalex.org/W2989196175","https://openalex.org/W4367400097","https://openalex.org/W2478443708","https://openalex.org/W2791439031","https://openalex.org/W2761920910","https://openalex.org/W3154012099","https://openalex.org/W2568902392"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":7}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-03-23T00:00:00"}