{"id":"https://openalex.org/W3011900284","doi":null,"title":"\ub2e4\ubc1c\uc131 \uace8\uc218\uc885\uc5d0 \ub300\ud55c Vincristine , Melphalan \ubc0f Prednisone ( VMP ) \ubcf5\ud569\ud654\ud559\uc694\ubc95\uc758 \uce58\ub8cc \ud6a8\uacfc","display_name":"\ub2e4\ubc1c\uc131 \uace8\uc218\uc885\uc5d0 \ub300\ud55c Vincristine , Melphalan \ubc0f Prednisone ( VMP ) \ubcf5\ud569\ud654\ud559\uc694\ubc95\uc758 \uce58\ub8cc \ud6a8\uacfc","publication_year":1993,"publication_date":"1993-01-01","ids":{"openalex":"https://openalex.org/W3011900284","mag":"3011900284"},"language":"ko","primary_location":{"id":"mag:3011900284","doi":null,"is_oa":true,"landing_page_url":"https://papersearch.net/google_link/fulltext.asp?file_name=42803392.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S162267923","display_name":"The Korean Journal of Internal Medicine","issn_l":"1226-3303","issn":["1226-3303","2005-6648"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","kci-registered","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320408","host_organization_name":"Korean Association of Internal Medicine","host_organization_lineage":["https://openalex.org/P4310320408"],"host_organization_lineage_names":["Korean Association of Internal Medicine"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":null,"is_accepted":false,"is_published":false,"raw_source_name":"The Korean Journal of Internal Medicine","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://papersearch.net/google_link/fulltext.asp?file_name=42803392.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009746824","display_name":"\uae40\ud0dc\uc720","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\uae40\ud0dc\uc720","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057655731","display_name":"\ud5c8\ub300\uc11d","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\ud5c8\ub300\uc11d","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091409681","display_name":"\ubc29\uc601\uc8fc","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\ubc29\uc601\uc8fc","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033396422","display_name":"\ubc15\uc120\uc591","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\ubc15\uc120\uc591","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004961866","display_name":"\uae40\ubcd1\uad6d","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\uae40\ubcd1\uad6d","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041522744","display_name":"\uae40\ub178\uacbd","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\uae40\ub178\uacbd","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5105834285","display_name":"\uae40\ud6a8\uc9c4","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\uae40\ud6a8\uc9c4","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":500,"currency":"USD","value_usd":500},"apc_paid":{"value":500,"currency":"USD","value_usd":500},"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.3822743,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"45","issue":"1","first_page":"1","last_page":"11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":1.0},{"id":"https://openalex.org/keywords/vincristine","display_name":"vincristine","score":0.9850000143051147},{"id":"https://openalex.org/keywords/melphalan","display_name":"melphalan","score":1.0},{"id":"https://openalex.org/keywords/prednisone","display_name":"prednisone","score":1.0},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.7919999957084656},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.8149999976158142},{"id":"https://openalex.org/keywords/induction-chemotherapy","display_name":"induction chemotherapy","score":0.7490000128746033},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.4449999928474426},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7540000081062317},{"id":"https://openalex.org/keywords/myelosuppression","display_name":"myelosuppression","score":0.6690000295639038},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.8870000243186951}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9371445775032043},{"id":"https://openalex.org/C2778684742","wikidata":"https://www.wikidata.org/wiki/Q2298283","display_name":"Melphalan","level":3,"score":0.9171746373176575},{"id":"https://openalex.org/C2779429289","wikidata":"https://www.wikidata.org/wiki/Q408977","display_name":"Vincristine","level":4,"score":0.8686076402664185},{"id":"https://openalex.org/C2778720950","wikidata":"https://www.wikidata.org/wiki/Q424972","display_name":"Prednisone","level":2,"score":0.7658330202102661},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.6865483522415161},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6165778636932373},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6149568557739258},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.5627329349517822},{"id":"https://openalex.org/C2780873365","wikidata":"https://www.wikidata.org/wiki/Q496812","display_name":"Leukopenia","level":3,"score":0.5298162698745728},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.46378788352012634},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3941793441772461},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.39255785942077637},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.22826838493347168}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3011900284","doi":null,"is_oa":true,"landing_page_url":"https://papersearch.net/google_link/fulltext.asp?file_name=42803392.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S162267923","display_name":"The Korean Journal of Internal Medicine","issn_l":"1226-3303","issn":["1226-3303","2005-6648"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","kci-registered","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320408","host_organization_name":"Korean Association of Internal Medicine","host_organization_lineage":["https://openalex.org/P4310320408"],"host_organization_lineage_names":["Korean Association of Internal Medicine"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":null,"is_accepted":false,"is_published":false,"raw_source_name":"The Korean Journal of Internal Medicine","raw_type":null}],"best_oa_location":{"id":"mag:3011900284","doi":null,"is_oa":true,"landing_page_url":"https://papersearch.net/google_link/fulltext.asp?file_name=42803392.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S162267923","display_name":"The Korean Journal of Internal Medicine","issn_l":"1226-3303","issn":["1226-3303","2005-6648"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","kci-registered","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320408","host_organization_name":"Korean Association of Internal Medicine","host_organization_lineage":["https://openalex.org/P4310320408"],"host_organization_lineage_names":["Korean Association of Internal Medicine"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":null,"is_accepted":false,"is_published":false,"raw_source_name":"The Korean Journal of Internal Medicine","raw_type":null},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2009143555","https://openalex.org/W2181033060","https://openalex.org/W1872098847","https://openalex.org/W90092677","https://openalex.org/W1803796409","https://openalex.org/W2412468341","https://openalex.org/W5731518","https://openalex.org/W2621353632","https://openalex.org/W2081001303","https://openalex.org/W2539417583"],"abstract_inverted_index":{"Background:":[0],"The":[1,67,106,114,125,136,143,181],"combination":[2,59,207],"of":[3,20,43,61,70,109,119,177],"melphalan":[4,63,77],"and":[5,64,83,132,165,191,200],"prednisone":[6,65,84],"has":[7],"been":[8],"the":[9,18,21,41,44,153,178],"standard":[10],"therapy":[11],"for":[12,214],"multiple":[13,53,215],"myeloma.":[14,216],"However,":[15],"owing":[16],"to":[17,36,39,46,117,155,171],"emergence":[19],"drug":[22],"resistance,":[23],"essentially":[24],"most":[25,145],"patients":[26,51,101,121],"have":[27],"relapse":[28],"or":[29],"progrssion":[30],"during":[31],"chemotherapy.":[32],"Vincristine":[33],"was":[34,90,111,122,140,152,161,173,184],"reported":[35],"be":[37],"albe":[38],"prevent":[40],"development":[42],"resistance":[45],"melphalan.":[47],"Methods:":[48],"Sixty":[49],"two":[50],"with":[52,57,149,186],"myeloma":[54],"were":[55,129],"treated":[56],"a":[58],"chemotherapy":[60,158,208],"vincristine,":[62],"(VMF).":[66],"regimen":[68,183,213],"consists":[69],"vincristine":[71,172],"0.03":[72],"mg/kg":[73,79],"i.v.":[74],"(day":[75,81,87],"1),":[76],"0,1":[78],"p.o.":[80,86],"1-7)":[82],"1mg/kg":[85],"1-7),":[88],"which":[89],"repeated":[91],"every":[92],"four":[93],"weeks.":[94],"Results:":[95],"Among":[96],"51":[97],"evaluable":[98],"patients,":[99],"29":[100],"(56%)":[102],"achieved":[103],"objective":[104],"responses.":[105],"median":[107,115,138],"duration":[108],"response":[110,128,189],"15":[112],"months.":[113,124,142],"time":[116],"progression":[118],"overall":[120,137],"11":[123],"factors":[126],"influencing":[127],"age":[130],"(p<0.04)":[131],"performance":[133],"status":[134],"(p<0.03).":[135],"surivival":[139],"36":[141],"single":[144],"important":[146],"factor":[147],"associated":[148,185],"prolonged":[150],"survival":[151],"responsiveness":[154],"remission":[156],"induction":[157],"(p<0.001).":[159],"Leukopenia":[160],"observed":[162],"in":[163,167,175],"42%":[164],"thrombocytopenia":[166],"2%.":[168],"Neurotoxicity":[169],"due":[170],"found":[174],"5.2%":[176],"patients.":[179],"Conclusions:":[180],"VMP":[182,206],"relatively":[187],"high":[188],"rate":[190],"well":[192],"tolerted,":[193],"producing":[194],"only":[195],"mild":[196],"bone":[197],"marrow":[198],"suppression":[199],"neuratoxicity.":[201],"This":[202],"result":[203],"shows":[204],"that":[205],"is":[209],"an":[210],"effective":[211],"treatment":[212]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2020-03-23T00:00:00"}