{"id":"https://openalex.org/W3011819632","doi":"https://doi.org/10.1146/annurev-cancerbio-030419-033428","title":"Regulatory T Cells in Cancer","display_name":"Regulatory T Cells in Cancer","publication_year":2020,"publication_date":"2020-03-09","ids":{"openalex":"https://openalex.org/W3011819632","doi":"https://doi.org/10.1146/annurev-cancerbio-030419-033428","mag":"3011819632"},"language":"en","primary_location":{"id":"doi:10.1146/annurev-cancerbio-030419-033428","doi":"https://doi.org/10.1146/annurev-cancerbio-030419-033428","is_oa":true,"landing_page_url":"https://doi.org/10.1146/annurev-cancerbio-030419-033428","pdf_url":"https://www.annualreviews.org/doi/pdf/10.1146/annurev-cancerbio-030419-033428","source":{"id":"https://openalex.org/S4210178937","display_name":"Annual Review of Cancer Biology","issn_l":"2472-3428","issn":["2472-3428"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Cancer Biology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.annualreviews.org/doi/pdf/10.1146/annurev-cancerbio-030419-033428","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089840300","display_name":"George Plitas","orcid":"https://orcid.org/0000-0002-8357-9534","observed_orcids":["https://orcid.org/0000-0002-8357-9534"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George Plitas","raw_affiliation_strings":["Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA","Immunology Program and Ludwig Center for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Immunology Program and Ludwig Center for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;,","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030125111","display_name":"Alexander Yu Rudensky","orcid":"https://orcid.org/0000-0003-1280-2898","observed_orcids":["https://orcid.org/0000-0003-1280-2898"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Y. Rudensky","raw_affiliation_strings":["Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA","Immunology Program and Ludwig Center for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I1344073410"]},{"raw_affiliation_string":"Immunology Program and Ludwig Center for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;,","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.9238,"has_fulltext":true,"cited_by_count":153,"citation_normalized_percentile":{"value":0.88927536,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"4","issue":"1","first_page":"459","last_page":"477"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.03880000114440918,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/foxp3","display_name":"Foxp3","score":0.875},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.781000018119812},{"id":"https://openalex.org/keywords/tumor-immunosuppression","display_name":"tumor immunosuppression","score":0.8259999752044678},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.859000027179718},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.6660000085830688},{"id":"https://openalex.org/keywords/tumor-associated-treg-cells","display_name":"tumor-associated Treg cells","score":0.652999997138977},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.5450000166893005},{"id":"https://openalex.org/keywords/cancer-associated-fibroblasts","display_name":"cancer-associated fibroblasts","score":0.6700000166893005},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.5429999828338623},{"id":"https://openalex.org/keywords/immune-homeostasis","display_name":"immune homeostasis","score":0.621999979019165}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7765617370605469},{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.6957891583442688},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.65977942943573},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.6549235582351685},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5368267893791199},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5316619873046875},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.514575183391571},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5037402510643005},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.478268027305603},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44126832485198975},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4204634130001068},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11673992872238159}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1146/annurev-cancerbio-030419-033428","doi":"https://doi.org/10.1146/annurev-cancerbio-030419-033428","is_oa":true,"landing_page_url":"https://doi.org/10.1146/annurev-cancerbio-030419-033428","pdf_url":"https://www.annualreviews.org/doi/pdf/10.1146/annurev-cancerbio-030419-033428","source":{"id":"https://openalex.org/S4210178937","display_name":"Annual Review of Cancer Biology","issn_l":"2472-3428","issn":["2472-3428"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Cancer Biology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1146/annurev-cancerbio-030419-033428","doi":"https://doi.org/10.1146/annurev-cancerbio-030419-033428","is_oa":true,"landing_page_url":"https://doi.org/10.1146/annurev-cancerbio-030419-033428","pdf_url":"https://www.annualreviews.org/doi/pdf/10.1146/annurev-cancerbio-030419-033428","source":{"id":"https://openalex.org/S4210178937","display_name":"Annual Review of Cancer Biology","issn_l":"2472-3428","issn":["2472-3428"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Cancer Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1735754663","display_name":null,"funder_award_id":"P30 CA008748","funder_id":"https://openalex.org/F4320333947","funder_display_name":"Ludwig Center at Harvard"},{"id":"https://openalex.org/G2051006376","display_name":null,"funder_award_id":"CA008748","funder_id":"https://openalex.org/F4320309468","funder_display_name":"Memorial Sloan-Kettering Cancer Center"},{"id":"https://openalex.org/G289723095","display_name":null,"funder_award_id":"P30\u00a0CA008748","funder_id":"https://openalex.org/F4320309468","funder_display_name":"Memorial Sloan-Kettering Cancer Center"},{"id":"https://openalex.org/G4874743251","display_name":"Self Peptides Bound to MHC Class II In T Cell Selection","funder_award_id":"R37AI034206","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8322667947","display_name":null,"funder_award_id":"Support Grant P30 CA008748","funder_id":"https://openalex.org/F4320309468","funder_display_name":"Memorial Sloan-Kettering Cancer Center"},{"id":"https://openalex.org/G9000098862","display_name":null,"funder_award_id":"AI034206","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000856728","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA008748","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G911969224","display_name":null,"funder_award_id":"AI034206","funder_id":"https://openalex.org/F4320333947","funder_display_name":"Ludwig Center at Harvard"}],"funders":[{"id":"https://openalex.org/F4320309468","display_name":"Memorial Sloan-Kettering Cancer Center","ror":"https://ror.org/02yrq0923"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333947","display_name":"Ludwig Center at Harvard","ror":null},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3011819632.pdf","grobid_xml":"https://content.openalex.org/works/W3011819632.grobid-xml"},"referenced_works_count":153,"referenced_works":["https://openalex.org/W1202139631","https://openalex.org/W1499151513","https://openalex.org/W1567647760","https://openalex.org/W1575585006","https://openalex.org/W1690266756","https://openalex.org/W1755415491","https://openalex.org/W1832928186","https://openalex.org/W1833987578","https://openalex.org/W1895474562","https://openalex.org/W1914215890","https://openalex.org/W1945156854","https://openalex.org/W1965671023","https://openalex.org/W1967215435","https://openalex.org/W1967521541","https://openalex.org/W1971949613","https://openalex.org/W1972187865","https://openalex.org/W1973647796","https://openalex.org/W1974140746","https://openalex.org/W1975566288","https://openalex.org/W1978073168","https://openalex.org/W1980296375","https://openalex.org/W1986497348","https://openalex.org/W1987128447","https://openalex.org/W1991344211","https://openalex.org/W1993211204","https://openalex.org/W2000971605","https://openalex.org/W2002726823","https://openalex.org/W2004409905","https://openalex.org/W2013043293","https://openalex.org/W2016983859","https://openalex.org/W2019214729","https://openalex.org/W2021249461","https://openalex.org/W2021603971","https://openalex.org/W2030150321","https://openalex.org/W2030284768","https://openalex.org/W2034621048","https://openalex.org/W2038381158","https://openalex.org/W2039769611","https://openalex.org/W2046609236","https://openalex.org/W2049504854","https://openalex.org/W2052386553","https://openalex.org/W2053737749","https://openalex.org/W2055264495","https://openalex.org/W2055901890","https://openalex.org/W2055923182","https://openalex.org/W2056535502","https://openalex.org/W2059409197","https://openalex.org/W2060878129","https://openalex.org/W2061071534","https://openalex.org/W2062142808","https://openalex.org/W2063264144","https://openalex.org/W2064084286","https://openalex.org/W2065948425","https://openalex.org/W2068155679","https://openalex.org/W2068639447","https://openalex.org/W2069095331","https://openalex.org/W2070213858","https://openalex.org/W2073310925","https://openalex.org/W2074888413","https://openalex.org/W2081693733","https://openalex.org/W2087482409","https://openalex.org/W2088017149","https://openalex.org/W2097811455","https://openalex.org/W2100228832","https://openalex.org/W2102650038","https://openalex.org/W2106190040","https://openalex.org/W2106605927","https://openalex.org/W2110228704","https://openalex.org/W2113030185","https://openalex.org/W2113325722","https://openalex.org/W2117692326","https://openalex.org/W2118546263","https://openalex.org/W2120644528","https://openalex.org/W2120897839","https://openalex.org/W2122285073","https://openalex.org/W2123363005","https://openalex.org/W2126072190","https://openalex.org/W2126538938","https://openalex.org/W2128334384","https://openalex.org/W2129534156","https://openalex.org/W2130364297","https://openalex.org/W2133739473","https://openalex.org/W2134435470","https://openalex.org/W2136749650","https://openalex.org/W2137049683","https://openalex.org/W2138116109","https://openalex.org/W2141363604","https://openalex.org/W2141649011","https://openalex.org/W2142081888","https://openalex.org/W2149123553","https://openalex.org/W2149915530","https://openalex.org/W2150678612","https://openalex.org/W2153008625","https://openalex.org/W2153389047","https://openalex.org/W2158123524","https://openalex.org/W2159945718","https://openalex.org/W2162819001","https://openalex.org/W2164701887","https://openalex.org/W2166438464","https://openalex.org/W2189381691","https://openalex.org/W2190558971","https://openalex.org/W2202295242","https://openalex.org/W2243760265","https://openalex.org/W2273004055","https://openalex.org/W2282962877","https://openalex.org/W2289068089","https://openalex.org/W2344037260","https://openalex.org/W2403400382","https://openalex.org/W2486595797","https://openalex.org/W2514649790","https://openalex.org/W2516298309","https://openalex.org/W2523687917","https://openalex.org/W2527833995","https://openalex.org/W2528083170","https://openalex.org/W2536331788","https://openalex.org/W2550291749","https://openalex.org/W2552653135","https://openalex.org/W2569297957","https://openalex.org/W2569549188","https://openalex.org/W2576663873","https://openalex.org/W2587363764","https://openalex.org/W2592133876","https://openalex.org/W2595324091","https://openalex.org/W2607103422","https://openalex.org/W2607137647","https://openalex.org/W2611694282","https://openalex.org/W2617691667","https://openalex.org/W2624341173","https://openalex.org/W2701487182","https://openalex.org/W2745455975","https://openalex.org/W2753140990","https://openalex.org/W2761681010","https://openalex.org/W2765354611","https://openalex.org/W2765728936","https://openalex.org/W2780430083","https://openalex.org/W2782893319","https://openalex.org/W2792557198","https://openalex.org/W2810097927","https://openalex.org/W2810786508","https://openalex.org/W2883725514","https://openalex.org/W2888235779","https://openalex.org/W2889824279","https://openalex.org/W2890274375","https://openalex.org/W2897925268","https://openalex.org/W2898394368","https://openalex.org/W2903147538","https://openalex.org/W2907885272","https://openalex.org/W2909809653","https://openalex.org/W2911285649","https://openalex.org/W2929109925","https://openalex.org/W4232939899","https://openalex.org/W4239710358","https://openalex.org/W4313324526"],"related_works":["https://openalex.org/W3159811519","https://openalex.org/W3125743629","https://openalex.org/W3024983705","https://openalex.org/W4410373738","https://openalex.org/W2382845618","https://openalex.org/W3030688653","https://openalex.org/W2896372714","https://openalex.org/W4250978799","https://openalex.org/W2052071472","https://openalex.org/W2793346580"],"abstract_inverted_index":{"The":[0],"immune":[1,66,128,188,193],"system":[2],"has":[3],"evolved":[4],"complex":[5],"effector":[6],"mechanisms":[7],"to":[8,69,94],"protect":[9],"the":[10,59,86,115,136,142,163,180],"host":[11],"against":[12],"a":[13,73],"diversity":[14],"of":[15,26,39,43,61,75,138,144,165,182,186],"pathogenic":[16],"organisms":[17],"and":[18,31,46,49,63,101,123,147,157],"regulatory":[19,80],"adaptations":[20],"that":[21,84],"can":[22,52,133],"curtail":[23],"pathological":[24],"sequelae":[25],"inflammatory":[27,103],"events,":[28],"prevent":[29,64],"autoimmunity,":[30],"assist":[32],"in":[33,98,105,114,152,177],"tissue":[34,44],"repair.":[35],"Cancers,":[36],"by":[37,125],"virtue":[38],"their":[40,65,95,174,184],"local":[41],"manifestations":[42],"dysfunction":[45],"destruction,":[47],"inflammation,":[48],"genomic":[50],"instability,":[51],"evoke":[53],"these":[54,70],"protective":[55],"mechanisms,":[56],"which":[57],"support":[58,135],"progression":[60,124],"tumors":[62,153],"eradication.":[67],"Central":[68],"processes":[71],"is":[72],"subset":[74],"CD4+T":[76],"cells,":[77,83],"known":[78],"as":[79,155],"T":[81],"(Treg)":[82],"express":[85],"X":[87],"chromosome\u2013linked":[88],"transcription":[89],"factor":[90],"FOXP3.":[91],"In":[92],"addition":[93],"critical":[96],"role":[97],"controlling":[99],"autoimmunity":[100],"suppressing":[102],"responses":[104,189],"diverse":[106],"biological":[107],"settings,":[108],"Treg":[109,131,167],"cells":[110,132,140,151,168],"are":[111],"ubiquitously":[112],"present":[113],"tumor":[116,121],"microenvironment":[117],"where":[118],"they":[119],"promote":[120],"development":[122],"dampening":[126],"antitumor":[127,187],"responses.":[129],"Furthermore,":[130],"directly":[134],"survival":[137],"transformed":[139],"through":[141],"elaboration":[143],"growth":[145],"factors":[146],"interacting":[148],"with":[149,179],"accessory":[150],"such":[154],"fibroblasts":[156],"endothelial":[158],"cells.":[159],"Current":[160],"insights":[161],"into":[162],"biology":[164],"tumor-associated":[166],"have":[169],"opened":[170],"up":[171],"opportunities":[172],"for":[173],"selective":[175],"targeting":[176],"cancer,":[178],"goal":[181],"alleviating":[183],"suppression":[185],"while":[190],"maintaining":[191],"overall":[192],"homeostasis.":[194]},"counts_by_year":[{"year":2026,"cited_by_count":20},{"year":2025,"cited_by_count":21},{"year":2024,"cited_by_count":30},{"year":2023,"cited_by_count":22},{"year":2022,"cited_by_count":27},{"year":2021,"cited_by_count":24},{"year":2020,"cited_by_count":8}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-03-23T00:00:00"}