{"id":"https://openalex.org/W3011817128","doi":"https://doi.org/10.1186/s13148-020-00835-3","title":"Crosstalk between DNA methylation and histone acetylation triggers GDNF high transcription in glioblastoma cells","display_name":"Crosstalk between DNA methylation and histone acetylation triggers GDNF high transcription in glioblastoma cells","publication_year":2020,"publication_date":"2020-03-17","ids":{"openalex":"https://openalex.org/W3011817128","doi":"https://doi.org/10.1186/s13148-020-00835-3","mag":"3011817128","pmid":"https://pubmed.ncbi.nlm.nih.gov/32183903","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7079383"},"language":"en","primary_location":{"id":"doi:10.1186/s13148-020-00835-3","doi":"https://doi.org/10.1186/s13148-020-00835-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13148-020-00835-3","pdf_url":"https://link.springer.com/content/pdf/10.1186/s13148-020-00835-3.pdf","source":{"id":"https://openalex.org/S200416800","display_name":"Clinical Epigenetics","issn_l":"1868-7075","issn":["1868-7075","1868-7083"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Epigenetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/s13148-020-00835-3.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108125924","display_name":"Baole Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Baole Zhang","raw_affiliation_strings":["Department of Neurobiology and Anatomy, Xuzhou Key Laboratory of Neurobiology, Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, 221004, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology and Anatomy, Xuzhou Key Laboratory of Neurobiology, Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, 221004, Jiangsu, China","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050683421","display_name":"Xiao-He Gu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaohe Gu","raw_affiliation_strings":["Department of Neurobiology and Anatomy, Xuzhou Key Laboratory of Neurobiology, Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, 221004, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology and Anatomy, Xuzhou Key Laboratory of Neurobiology, Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, 221004, Jiangsu, China","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100608368","display_name":"Xiao Han","orcid":"https://orcid.org/0000-0002-6024-6286","observed_orcids":["https://orcid.org/0000-0002-6024-6286"]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao Han","raw_affiliation_strings":["Department of Neurobiology and Anatomy, Xuzhou Key Laboratory of Neurobiology, Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, 221004, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology and Anatomy, Xuzhou Key Laboratory of Neurobiology, Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, 221004, Jiangsu, China","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101073272","display_name":"Qing Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qing Gao","raw_affiliation_strings":["Department of Neurobiology and Anatomy, Xuzhou Key Laboratory of Neurobiology, Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, 221004, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology and Anatomy, Xuzhou Key Laboratory of Neurobiology, Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, 221004, Jiangsu, China","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100454185","display_name":"Jie Liu","orcid":"https://orcid.org/0000-0003-1398-5411","observed_orcids":["https://orcid.org/0000-0003-1398-5411"]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Liu","raw_affiliation_strings":["Department of Neurobiology and Anatomy, Xuzhou Key Laboratory of Neurobiology, Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, 221004, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology and Anatomy, Xuzhou Key Laboratory of Neurobiology, Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, 221004, Jiangsu, China","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054618164","display_name":"Ting-Wen Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tingwen Guo","raw_affiliation_strings":["Department of Neurobiology and Anatomy, Xuzhou Key Laboratory of Neurobiology, Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, 221004, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology and Anatomy, Xuzhou Key Laboratory of Neurobiology, Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, 221004, Jiangsu, China","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100362393","display_name":"Dianshuai Gao","orcid":"https://orcid.org/0000-0001-8567-0238","observed_orcids":["https://orcid.org/0000-0001-8567-0238"]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Dianshuai Gao","raw_affiliation_strings":["Department of Neurobiology and Anatomy, Xuzhou Key Laboratory of Neurobiology, Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, 221004, Jiangsu, China. gds@xzhmu.edu.cn","Department of Neurobiology and Anatomy, Xuzhou Key Laboratory of Neurobiology, Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, 221004, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology and Anatomy, Xuzhou Key Laboratory of Neurobiology, Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, 221004, Jiangsu, China. gds@xzhmu.edu.cn","institution_ids":["https://openalex.org/I177388780"]},{"raw_affiliation_string":"Department of Neurobiology and Anatomy, Xuzhou Key Laboratory of Neurobiology, Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, 221004, Jiangsu, China","institution_ids":["https://openalex.org/I177388780"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100362393"],"corresponding_institution_ids":["https://openalex.org/I177388780"],"apc_list":{"value":3170,"currency":"USD","value_usd":3170},"apc_paid":{"value":3170,"currency":"USD","value_usd":3170},"fwci":2.3776,"has_fulltext":true,"cited_by_count":39,"citation_normalized_percentile":{"value":0.90823673,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"12","issue":"1","first_page":"47","last_page":"47"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.4036000072956085,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.4036000072956085,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.40209999680519104,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.17550000548362732,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.8489999771118164},{"id":"https://openalex.org/keywords/glial-cell-line-derived-neurotrophic-factor","display_name":"glial cell line-derived neurotrophic factor","score":0.972000002861023},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.8539999723434448},{"id":"https://openalex.org/keywords/histone-acetylation","display_name":"histone acetylation","score":0.984000027179718},{"id":"https://openalex.org/keywords/creb-phosphorylation","display_name":"CREB phosphorylation","score":0.9359999895095825},{"id":"https://openalex.org/keywords/creb-binding-protein","display_name":"CREB-binding protein","score":0.8799999952316284},{"id":"https://openalex.org/keywords/histone-h3-acetylation","display_name":"histone H3 acetylation","score":0.9210000038146973},{"id":"https://openalex.org/keywords/rna-polymerase-ii-recruitment","display_name":"RNA polymerase II recruitment","score":0.9359999895095825},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.5249999761581421},{"id":"https://openalex.org/keywords/epigenetic-crosstalk","display_name":"epigenetic crosstalk","score":0.9039999842643738}],"concepts":[{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.6938381195068359},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.6179062724113464},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6062765121459961},{"id":"https://openalex.org/C119157956","wikidata":"https://www.wikidata.org/wiki/Q796604","display_name":"Acetylation","level":3,"score":0.5678905248641968},{"id":"https://openalex.org/C47042493","wikidata":"https://www.wikidata.org/wiki/Q265799","display_name":"Human genetics","level":3,"score":0.528060257434845},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.5277669429779053},{"id":"https://openalex.org/C185856081","wikidata":"https://www.wikidata.org/wiki/Q14916286","display_name":"Glial cell line-derived neurotrophic factor","level":4,"score":0.4629583954811096},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.4257259964942932},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.419365793466568},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.41506555676460266},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40723419189453125},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40455982089042664},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.38807618618011475},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3711836338043213},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3421766757965088},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24770939350128174},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.12484651803970337},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.08874639868736267},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0671369731426239},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000107","descriptor_name":"Acetylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004742","descriptor_name":"Enhancer Elements, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012319","descriptor_name":"RNA Polymerase II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017362","descriptor_name":"Cyclic AMP Response Element-Binding Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017362","descriptor_name":"Cyclic AMP Response Element-Binding Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D037941","descriptor_name":"Silencer Elements, Transcriptional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051100","descriptor_name":"Glial Cell Line-Derived Neurotrophic Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051100","descriptor_name":"Glial Cell Line-Derived Neurotrophic Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1186/s13148-020-00835-3","doi":"https://doi.org/10.1186/s13148-020-00835-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13148-020-00835-3","pdf_url":"https://link.springer.com/content/pdf/10.1186/s13148-020-00835-3.pdf","source":{"id":"https://openalex.org/S200416800","display_name":"Clinical Epigenetics","issn_l":"1868-7075","issn":["1868-7075","1868-7083"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Epigenetics","raw_type":"journal-article"},{"id":"pmid:32183903","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32183903","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical epigenetics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7079383","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7079383/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Epigenetics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s13148-020-00835-3","doi":"https://doi.org/10.1186/s13148-020-00835-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13148-020-00835-3","pdf_url":"https://link.springer.com/content/pdf/10.1186/s13148-020-00835-3.pdf","source":{"id":"https://openalex.org/S200416800","display_name":"Clinical Epigenetics","issn_l":"1868-7075","issn":["1868-7075","1868-7083"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Epigenetics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G196445246","display_name":null,"funder_award_id":"1301068C","funder_id":"https://openalex.org/F4320335473","funder_display_name":"Postdoctoral Science Foundation of Jiangsu Province"},{"id":"https://openalex.org/G2400527493","display_name":null,"funder_award_id":"81372698","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2431859417","display_name":null,"funder_award_id":"81602464","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6225202288","display_name":null,"funder_award_id":"2013M540466","funder_id":"https://openalex.org/F4320335443","funder_display_name":"Postdoctoral Research Foundation of China"},{"id":"https://openalex.org/G6266152361","display_name":null,"funder_award_id":"SWYY-088","funder_id":"https://openalex.org/F4320326182","funder_display_name":"Six Talent Peaks Project in Jiangsu Province"},{"id":"https://openalex.org/G720937494","display_name":null,"funder_award_id":"BK20130212","funder_id":"https://openalex.org/F4320322769","funder_display_name":"Natural Science Foundation of Jiangsu Province"},{"id":"https://openalex.org/G8845996189","display_name":null,"funder_award_id":"81772688","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G915025772","display_name":null,"funder_award_id":"81772688 and 81372698","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321605","display_name":"Government of Jiangsu Province","ror":"https://ror.org/004svx814"},{"id":"https://openalex.org/F4320322769","display_name":"Natural Science Foundation of Jiangsu Province","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320326182","display_name":"Six Talent Peaks Project in Jiangsu Province","ror":null},{"id":"https://openalex.org/F4320327518","display_name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","ror":null},{"id":"https://openalex.org/F4320327794","display_name":"Qinglan Project of Jiangsu Province of China","ror":null},{"id":"https://openalex.org/F4320335443","display_name":"Postdoctoral Research Foundation of China","ror":null},{"id":"https://openalex.org/F4320335473","display_name":"Postdoctoral Science Foundation of Jiangsu Province","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3011817128.pdf","grobid_xml":"https://content.openalex.org/works/W3011817128.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1516589908","https://openalex.org/W1967342091","https://openalex.org/W1976805213","https://openalex.org/W1999206875","https://openalex.org/W2001973046","https://openalex.org/W2004995315","https://openalex.org/W2015197935","https://openalex.org/W2016637998","https://openalex.org/W2018805663","https://openalex.org/W2019726789","https://openalex.org/W2024703302","https://openalex.org/W2026206203","https://openalex.org/W2033355894","https://openalex.org/W2045794730","https://openalex.org/W2052937095","https://openalex.org/W2053544091","https://openalex.org/W2054810445","https://openalex.org/W2060208186","https://openalex.org/W2061586485","https://openalex.org/W2063346847","https://openalex.org/W2077278607","https://openalex.org/W2082668371","https://openalex.org/W2090574965","https://openalex.org/W2093203637","https://openalex.org/W2109572866","https://openalex.org/W2110673629","https://openalex.org/W2137385309","https://openalex.org/W2142746129","https://openalex.org/W2146809763","https://openalex.org/W2155635108","https://openalex.org/W2156101468","https://openalex.org/W2158656250","https://openalex.org/W2468233327","https://openalex.org/W2515005530","https://openalex.org/W2521337760","https://openalex.org/W2571314132","https://openalex.org/W2578822114","https://openalex.org/W2586422137","https://openalex.org/W2606250005","https://openalex.org/W2701712168","https://openalex.org/W2765683277","https://openalex.org/W2770550241","https://openalex.org/W2772242335","https://openalex.org/W2774359457","https://openalex.org/W2796681594","https://openalex.org/W2801961870","https://openalex.org/W2891372229","https://openalex.org/W2899224630","https://openalex.org/W2899511021","https://openalex.org/W2901152696","https://openalex.org/W2906086042","https://openalex.org/W2945671915"],"related_works":["https://openalex.org/W6939383486","https://openalex.org/W6901984657","https://openalex.org/W7220628030","https://openalex.org/W2951223916","https://openalex.org/W2090574965","https://openalex.org/W2468233327","https://openalex.org/W2004995315","https://openalex.org/W2410278764","https://openalex.org/W2016637998","https://openalex.org/W2360550008"],"abstract_inverted_index":{"BACKGROUND:":[0],"Glial":[1],"cell":[2,114],"line-derived":[3],"neurotrophic":[4],"factor":[5],"(GDNF)":[6],"is":[7,26],"highly":[8],"expressed":[9,124],"in":[10,45,58,64,69,90,108,145,167,171,234,249,260],"glioblastoma":[11],"(GBM)":[12],"and":[13,21,31,38,55,101,112,117,130,148,174,180,189,216,222,229,270,276,290],"blocking":[14],"its":[15],"expression":[16,100],"can":[17],"inhibit":[18],"the":[19,32,73,139,156,205,224,278,294],"initiation":[20],"development":[22],"of":[23,67,151,165,207,251],"GBM.":[24,91],"GDNF":[25,59,68,88,128,136,152,208,231,242,252,295,299],"a":[27,42,303],"dual":[28],"promoter":[29,33,60,131,153,296],"gene,":[30],"II":[34,61,132,147,150,169,188,219,254,273,297],"with":[35,200],"two":[36,39,157],"enhancers":[37],"silencers":[40],"plays":[41],"major":[43],"role":[44],"transcription":[46,66,89,129,137,225,233,243],"initiation.":[47],"We":[48],"had":[49],"previously":[50],"reported":[51],"that":[52,240,284],"histone":[53,201,213,267,291],"hyperacetylation":[54],"DNA":[56,247,288],"hypermethylation":[57,164,248],"region":[62],"result":[63],"high":[65,87,123,232,241,300],"GBM":[70,110,113,121,172,307],"cells,":[71,122],"but":[72],"mechanism":[74],"remains":[75],"unclear.":[76],"In":[77,119],"this":[78],"study,":[79],"we":[80],"investigated":[81],"whether":[82],"these":[83],"modifications":[84],"synergistically":[85],"regulate":[86],"RESULTS:":[92],"Cyclic":[93],"AMP":[94,141],"response":[95,142],"element":[96],"binding":[97,185,197,257],"protein":[98,198],"(CREB)":[99],"phosphorylation":[102],"at":[103,223,277,293],"S133":[104],"were":[105],"significantly":[106,126],"increased":[107,181],"human":[109],"tissues":[111,173],"lines":[115],"(U251":[116],"U343).":[118],"U251":[120,235],"CREB":[125,134,183,196],"enhanced":[127,264,298],"activity.":[133],"regulated":[135],"via":[138],"cyclic":[140],"elements":[143],"(CREs)":[144],"enhancer":[146,190,209,261],"silencer":[149,168,187,253],"II.":[154],"However,":[155],"CREs":[158],"played":[159],"opposite":[160],"regulatory":[161],"roles.":[162],"Interestingly,":[163],"CRE":[166,206,250,259],"occurred":[170],"cells":[175],"which":[176,263],"led":[177],"to":[178,186,204,246,258],"decreased":[179],"phosphorylated":[182],"(pCREB)":[184],"II,":[191,210,262],"respectively.":[192],"Moreover,":[193],"pCREB":[194,256],"recruited":[195],"(CBP)":[199],"acetylase":[202],"activity":[203],"thereby":[211],"increasing":[212,255],"H3":[214,268],"acetylation":[215,292],"RNA":[217,271],"polymerase":[218,272],"recruitment":[220,274],"there":[221,275],"start":[226],"site":[227],"(TSS),":[228],"promoted":[230],"cells.":[236],"The":[237],"results":[238,282],"indicated":[239],"was":[244],"attributable":[245],"CBP":[265],"recruitment,":[266],"acetylation,":[269],"TSS.":[279],"CONCLUSIONS:":[280],"Our":[281],"demonstrate":[283],"pCREB-induced":[285],"crosstalk":[286],"between":[287],"methylation":[289],"transcription,":[301],"providing":[302],"new":[304],"perspective":[305],"for":[306],"treatment.":[308]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-03-23T00:00:00"}
