{"id":"https://openalex.org/W3011803385","doi":null,"title":"Regulation of breast cancer biomarkers by intrinsic and extrinsic factors","display_name":"Regulation of breast cancer biomarkers by intrinsic and extrinsic factors","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W3011803385","mag":"3011803385"},"language":"en","primary_location":{"id":"pmh:oai:research.library.mun.ca:13753","doi":null,"is_oa":true,"landing_page_url":"https://research.library.mun.ca/13753/1/thesis.pdf","pdf_url":"https://research.library.mun.ca/13753/1/thesis.pdf","source":{"id":"https://openalex.org/S4306401319","display_name":"Memorial University Research Repository (Memorial University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I130438778","host_organization_name":"Memorial University of Newfoundland","host_organization_lineage":["https://openalex.org/I130438778"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://research.library.mun.ca/13753/1/thesis.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088188248","display_name":"Nikitha K. Pallegar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Nikitha K. Pallegar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5088188248"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9125999808311462,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9125999808311462,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.07090000063180923,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9739999771118164},{"id":"https://openalex.org/keywords/cd24","display_name":"CD24","score":0.9269999861717224},{"id":"https://openalex.org/keywords/breast-cancer-stem-cells","display_name":"breast cancer stem cells","score":0.9129999876022339},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.9509999752044678},{"id":"https://openalex.org/keywords/adipocytes","display_name":"adipocytes","score":0.7760000228881836},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8510000109672546},{"id":"https://openalex.org/keywords/mesenchymal-epithelial-transition","display_name":"mesenchymal-epithelial transition","score":0.9160000085830688},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.6370000243186951},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.7480000257492065},{"id":"https://openalex.org/keywords/three-dimensional-co-culture","display_name":"3D co-culture","score":0.7110000252723694},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.597000002861023},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.40700000524520874}],"concepts":[{"id":"https://openalex.org/C2779492189","wikidata":"https://www.wikidata.org/wiki/Q1190762","display_name":"CD24","level":4,"score":0.7933394908905029},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6962534785270691},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6552282571792603},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6123309135437012},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6047461628913879},{"id":"https://openalex.org/C2780110267","wikidata":"https://www.wikidata.org/wiki/Q7843332","display_name":"Triple-negative breast cancer","level":4,"score":0.5415473580360413},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.5375001430511475},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.5144574642181396},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49671608209609985},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.4886191487312317},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.46861180663108826},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.4570153057575226},{"id":"https://openalex.org/C2780932548","wikidata":"https://www.wikidata.org/wiki/Q1056532","display_name":"CD44","level":3,"score":0.43554019927978516},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.352647989988327},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3490756154060364},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2918885350227356},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2477504312992096},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1825011968612671},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16070684790611267}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:research.library.mun.ca:13753","doi":null,"is_oa":true,"landing_page_url":"https://research.library.mun.ca/13753/1/thesis.pdf","pdf_url":"https://research.library.mun.ca/13753/1/thesis.pdf","source":{"id":"https://openalex.org/S4306401319","display_name":"Memorial University Research Repository (Memorial University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I130438778","host_organization_name":"Memorial University of Newfoundland","host_organization_lineage":["https://openalex.org/I130438778"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"pmh:oai:memorial.scholaris.ca:20.500.14783/7482","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/20.500.14783/7482","pdf_url":null,"source":{"id":"https://openalex.org/S4306401319","display_name":"Memorial University Research Repository (Memorial University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I130438778","host_organization_name":"Memorial University of Newfoundland","host_organization_lineage":["https://openalex.org/I130438778"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Doctoral thesis"},{"id":"mag:3011803385","doi":null,"is_oa":false,"landing_page_url":"https://research.library.mun.ca/13753/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:research.library.mun.ca:13753","doi":null,"is_oa":true,"landing_page_url":"https://research.library.mun.ca/13753/1/thesis.pdf","pdf_url":"https://research.library.mun.ca/13753/1/thesis.pdf","source":{"id":"https://openalex.org/S4306401319","display_name":"Memorial University Research Repository (Memorial University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I130438778","host_organization_name":"Memorial University of Newfoundland","host_organization_lineage":["https://openalex.org/I130438778"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3011803385.pdf","grobid_xml":"https://content.openalex.org/works/W3011803385.grobid-xml"},"referenced_works_count":314,"referenced_works":["https://openalex.org/W125750803","https://openalex.org/W201784232","https://openalex.org/W1483247593","https://openalex.org/W1491779959","https://openalex.org/W1497109212","https://openalex.org/W1521056982","https://openalex.org/W1523439243","https://openalex.org/W1535075207","https://openalex.org/W1549372675","https://openalex.org/W1555009525","https://openalex.org/W1555772346","https://openalex.org/W1567785123","https://openalex.org/W1571499367","https://openalex.org/W1603960099","https://openalex.org/W1605655296","https://openalex.org/W1612967964","https://openalex.org/W1745053995","https://openalex.org/W1757562380","https://openalex.org/W1760215417","https://openalex.org/W1818943734","https://openalex.org/W1824075025","https://openalex.org/W1835915349","https://openalex.org/W1842994045","https://openalex.org/W1859037964","https://openalex.org/W1869629480","https://openalex.org/W1873642659","https://openalex.org/W1888612698","https://openalex.org/W1924119154","https://openalex.org/W1964081206","https://openalex.org/W1964733653","https://openalex.org/W1964847767","https://openalex.org/W1965820060","https://openalex.org/W1966526747","https://openalex.org/W1967113048","https://openalex.org/W1967407335","https://openalex.org/W1969224630","https://openalex.org/W1970446261","https://openalex.org/W1970527559","https://openalex.org/W1971303929","https://openalex.org/W1973403365","https://openalex.org/W1974196451","https://openalex.org/W1976736011","https://openalex.org/W1978507137","https://openalex.org/W1979512659","https://openalex.org/W1980039397","https://openalex.org/W1981018715","https://openalex.org/W1981898048","https://openalex.org/W1983051794","https://openalex.org/W1983364027","https://openalex.org/W1983733795","https://openalex.org/W1983991097","https://openalex.org/W1984921052","https://openalex.org/W1985084134","https://openalex.org/W1985339653","https://openalex.org/W1985714764","https://openalex.org/W1988197084","https://openalex.org/W1988838983","https://openalex.org/W1989696946","https://openalex.org/W1989801957","https://openalex.org/W1989882479","https://openalex.org/W1991321737","https://openalex.org/W1992142919","https://openalex.org/W1993031861","https://openalex.org/W1994809630","https://openalex.org/W1995699440","https://openalex.org/W1995976024","https://openalex.org/W1997316363","https://openalex.org/W2000241906","https://openalex.org/W2001306199","https://openalex.org/W2001935171","https://openalex.org/W2002158312","https://openalex.org/W2005764975","https://openalex.org/W2007446460","https://openalex.org/W2008922131","https://openalex.org/W2009640362","https://openalex.org/W2011912935","https://openalex.org/W2012312210","https://openalex.org/W2012594852","https://openalex.org/W2014691022","https://openalex.org/W2015939968","https://openalex.org/W2016298087","https://openalex.org/W2016360721","https://openalex.org/W2016970788","https://openalex.org/W2017075758","https://openalex.org/W2017950977","https://openalex.org/W2019513091","https://openalex.org/W2020541351","https://openalex.org/W2020733170","https://openalex.org/W2020815502","https://openalex.org/W2021765303","https://openalex.org/W2023316892","https://openalex.org/W2023427658","https://openalex.org/W2024829903","https://openalex.org/W2026591084","https://openalex.org/W2028356733","https://openalex.org/W2029965175","https://openalex.org/W2030815458","https://openalex.org/W2030966943","https://openalex.org/W2031770999","https://openalex.org/W2034435308","https://openalex.org/W2034855589","https://openalex.org/W2035811939","https://openalex.org/W2036236740","https://openalex.org/W2036496509","https://openalex.org/W2036836592","https://openalex.org/W2039021968","https://openalex.org/W2039356709","https://openalex.org/W2039392244","https://openalex.org/W2039694476","https://openalex.org/W2040207652","https://openalex.org/W2040512792","https://openalex.org/W2041237929","https://openalex.org/W2042665609","https://openalex.org/W2043376395","https://openalex.org/W2046406848","https://openalex.org/W2047231876","https://openalex.org/W2052051648","https://openalex.org/W2052750950","https://openalex.org/W2053832323","https://openalex.org/W2054564351","https://openalex.org/W2054658992","https://openalex.org/W2055880222","https://openalex.org/W2056046349","https://openalex.org/W2056793357","https://openalex.org/W2058935670","https://openalex.org/W2061385217","https://openalex.org/W2061915672","https://openalex.org/W2062409008","https://openalex.org/W2065461553","https://openalex.org/W2066518356","https://openalex.org/W2068038099","https://openalex.org/W2068842251","https://openalex.org/W2074333893","https://openalex.org/W2074820894","https://openalex.org/W2076669363","https://openalex.org/W2076891934","https://openalex.org/W2077231689","https://openalex.org/W2078714887","https://openalex.org/W2079613095","https://openalex.org/W2080232352","https://openalex.org/W2081427545","https://openalex.org/W2081743768","https://openalex.org/W2082225843","https://openalex.org/W2082239705","https://openalex.org/W2084308090","https://openalex.org/W2085183101","https://openalex.org/W2085659118","https://openalex.org/W2085907669","https://openalex.org/W2086077027","https://openalex.org/W2087208912","https://openalex.org/W2088293068","https://openalex.org/W2089171551","https://openalex.org/W2090722238","https://openalex.org/W2091720415","https://openalex.org/W2092335849","https://openalex.org/W2093585643","https://openalex.org/W2093921289","https://openalex.org/W2095592092","https://openalex.org/W2096027508","https://openalex.org/W2096353669","https://openalex.org/W2097208143","https://openalex.org/W2097642044","https://openalex.org/W2098503878","https://openalex.org/W2098647609","https://openalex.org/W2098804778","https://openalex.org/W2099540110","https://openalex.org/W2100303404","https://openalex.org/W2100676365","https://openalex.org/W2101121084","https://openalex.org/W2101142350","https://openalex.org/W2102424972","https://openalex.org/W2103213014","https://openalex.org/W2103488145","https://openalex.org/W2103959635","https://openalex.org/W2104546896","https://openalex.org/W2105916911","https://openalex.org/W2106195342","https://openalex.org/W2106292881","https://openalex.org/W2107277218","https://openalex.org/W2107994994","https://openalex.org/W2108296770","https://openalex.org/W2109995938","https://openalex.org/W2110656750","https://openalex.org/W2111304967","https://openalex.org/W2111689182","https://openalex.org/W2114004637","https://openalex.org/W2114505219","https://openalex.org/W2114895428","https://openalex.org/W2114906733","https://openalex.org/W2115124692","https://openalex.org/W2115521447","https://openalex.org/W2116287565","https://openalex.org/W2117640066","https://openalex.org/W2118821583","https://openalex.org/W2118969396","https://openalex.org/W2119067365","https://openalex.org/W2119964718","https://openalex.org/W2120622571","https://openalex.org/W2124673145","https://openalex.org/W2125022522","https://openalex.org/W2125025248","https://openalex.org/W2126931729","https://openalex.org/W2127190481","https://openalex.org/W2127362646","https://openalex.org/W2127469308","https://openalex.org/W2128016314","https://openalex.org/W2128721675","https://openalex.org/W2129209927","https://openalex.org/W2130521873","https://openalex.org/W2133799748","https://openalex.org/W2133998111","https://openalex.org/W2134539328","https://openalex.org/W2135736714","https://openalex.org/W2136101247","https://openalex.org/W2139151018","https://openalex.org/W2139213909","https://openalex.org/W2139517025","https://openalex.org/W2140765540","https://openalex.org/W2145355816","https://openalex.org/W2146527816","https://openalex.org/W2147526198","https://openalex.org/W2147720735","https://openalex.org/W2147807172","https://openalex.org/W2148388197","https://openalex.org/W2149771342","https://openalex.org/W2151352506","https://openalex.org/W2152207030","https://openalex.org/W2153864507","https://openalex.org/W2154589460","https://openalex.org/W2155052327","https://openalex.org/W2155348198","https://openalex.org/W2158997529","https://openalex.org/W2159732577","https://openalex.org/W2161415513","https://openalex.org/W2162470303","https://openalex.org/W2162647319","https://openalex.org/W2163013798","https://openalex.org/W2163149880","https://openalex.org/W2163292580","https://openalex.org/W2163635730","https://openalex.org/W2164207497","https://openalex.org/W2165286055","https://openalex.org/W2166779240","https://openalex.org/W2166910049","https://openalex.org/W2168647804","https://openalex.org/W2168887286","https://openalex.org/W2169272490","https://openalex.org/W2169726583","https://openalex.org/W2170009771","https://openalex.org/W2170602872","https://openalex.org/W2170984819","https://openalex.org/W2171313040","https://openalex.org/W2176658830","https://openalex.org/W2193682462","https://openalex.org/W2195365980","https://openalex.org/W2203051527","https://openalex.org/W2214230309","https://openalex.org/W2229366053","https://openalex.org/W2242735364","https://openalex.org/W2259161257","https://openalex.org/W2262500441","https://openalex.org/W2277711614","https://openalex.org/W2279663170","https://openalex.org/W2314027030","https://openalex.org/W2326384180","https://openalex.org/W2332912393","https://openalex.org/W2361659253","https://openalex.org/W2395396608","https://openalex.org/W2398516887","https://openalex.org/W2409685048","https://openalex.org/W2410340000","https://openalex.org/W2418468769","https://openalex.org/W2430731787","https://openalex.org/W2463504983","https://openalex.org/W2468554687","https://openalex.org/W2480325303","https://openalex.org/W2490606726","https://openalex.org/W2502655412","https://openalex.org/W2529254819","https://openalex.org/W2554787935","https://openalex.org/W2560396365","https://openalex.org/W2560836545","https://openalex.org/W2561806934","https://openalex.org/W2563599068","https://openalex.org/W2567639438","https://openalex.org/W2582743722","https://openalex.org/W2585253307","https://openalex.org/W2586407709","https://openalex.org/W2591644378","https://openalex.org/W2595342131","https://openalex.org/W2605870912","https://openalex.org/W2607217019","https://openalex.org/W2607618862","https://openalex.org/W2619978475","https://openalex.org/W2626725994","https://openalex.org/W2730739450","https://openalex.org/W2737125479","https://openalex.org/W2751247542","https://openalex.org/W2754823840","https://openalex.org/W2760900181","https://openalex.org/W2765486709","https://openalex.org/W2765633603","https://openalex.org/W2766270233","https://openalex.org/W2776719137","https://openalex.org/W2782811847","https://openalex.org/W2783337717","https://openalex.org/W2785880124","https://openalex.org/W2789200208","https://openalex.org/W2791090958","https://openalex.org/W2802022753","https://openalex.org/W2807915975","https://openalex.org/W4230266413","https://openalex.org/W4299676702","https://openalex.org/W4320578729"],"related_works":["https://openalex.org/W4322770779","https://openalex.org/W7095970208","https://openalex.org/W2065934262","https://openalex.org/W3037840179","https://openalex.org/W2582225602","https://openalex.org/W2892161739","https://openalex.org/W2566118279","https://openalex.org/W2909872940","https://openalex.org/W2201037268","https://openalex.org/W2912807695"],"abstract_inverted_index":{"Cancer":[0],"metastases":[1],"are":[2,70],"accountable":[3],"for":[4,259],"almost":[5],"90%":[6],"of":[7,111,117,125,127,153,184,212,225,245,261,339],"all":[8],"human":[9,52],"cancer-related":[10],"deaths":[11],"including":[12],"breast":[13,62],"cancer":[14,21,63,107,158],"(BC).":[15],"BC":[16,33,66,135,274,294,307],"is":[17,34,39,141,234,257],"the":[18,96,102,114,123,128,210,217,223,226,231,243,249,289,326,336],"most":[19],"common":[20],"among":[22],"Canadian":[23],"women,":[24],"with":[25],"one":[26],"in":[27,101,202,290,306,324,335],"four":[28],"women":[29],"diagnosed":[30],"per":[31],"year.":[32],"a":[35,143,189,283,303],"heterogenous":[36],"disease":[37],"and":[38,51,59,68,88,99,109,130,151,174,195,220,253,276,296,328],"broadly":[40],"classified":[41],"into":[42],"Luminal":[43,48],"A":[44],"(estrogen/progesterone":[45],"receptor":[46,55],"(ER/PR)\u207a),":[47],"B":[49],"(ER/PR\u207a":[50],"epidermal":[53],"growth":[54,87],"2\u207a":[56],"(HER2\u207a)),":[57],"HER2\u207a,":[58],"triple":[60],"negative":[61],"(TNBC,":[64],"ER-/PR-/HER2\u207b).":[65],"heterogeneity":[67],"progression":[69,108,275],"primarily":[71],"dependent":[72],"on":[73],"intrinsic":[74,129,139,327],"factors":[75,93,132,330],"such":[76,94,267],"as":[77,268],"genetic":[78],"or":[79],"epigenetic":[80],"changes":[81],"to":[82,106,121,193,207,273,287,343],"genes":[83],"that":[84,133,147,222,255,300,310,331],"regulate":[85,134,149],"cell":[86,155],"proliferation.":[89],"In":[90,205],"addition,":[91],"extrinsic":[92,131,329],"as,":[95],"extracellular":[97],"matrix":[98],"adipocytes":[100,301],"surrounding":[103],"microenvironment":[104],"contribute":[105,272],"initiation":[110],"metastasis.":[112,277],"Therefore,":[113],"main":[115],"aim":[116],"this":[118],"thesis":[119],"was":[120],"analyze":[122],"contribution":[124],"some":[126],"progression.":[136],"One":[137],"known":[138],"factor":[140],"CD24;":[142],"glycosylphosphatidylinositol-anchored":[144],"surface":[145,263],"glycoprotein":[146],"can":[148,163,187,270],"proliferation":[150],"apoptosis":[152],"various":[154],"types.":[156],"Breast":[157],"stem":[159],"cells":[160,295,308],"(BCSCs),":[161],"which":[162],"initiate":[164],"tumor":[165,168],"formation,":[166],"maintain":[167],"heterogeneity,":[169],"have":[170,177],"high":[171],"invasive":[172],"properties,":[173],"favor":[175],"metastasis,":[176],"low":[178],"CD24":[179,218,246,262],"expression.":[180,264],"Moreover,":[181],"drug":[182,200,341],"treatment":[183],"TNBC":[185],"tumors":[186],"cause":[188],"switch":[190],"from":[191],"CD24\u207a":[192],"CD24\u207b":[194],"vice":[196],"versa":[197],"exhibiting":[198],"differential":[199],"resistance":[201],"these":[203,320],"patients.":[204],"order":[206],"better":[208],"understand":[209],"role":[211],"CD24,":[213],"I":[214,241,281,298],"first":[215],"analyzed":[216],"gene,":[219],"found":[221,254,299],"sequence":[224],"mature":[227],"peptide,":[228],"but":[229],"not":[230],"genomic":[232],"structure":[233],"conserved":[235],"over":[236],"200":[237],"million":[238],"years.":[239],"Next,":[240],"studied":[242],"regulation":[244],"expression":[247],"by":[248,317],"oncogenic":[250],"Ras":[251,256],"pathway":[252],"essential":[258],"suppression":[260],"Extrinsic":[265],"factors,":[266],"adipocytes,":[269],"also":[271],"To":[278],"study":[279],"this,":[280],"developed":[282],"3-dimensional":[284],"co-culture":[285],"system":[286],"mimic":[288],"vivo":[291],"interactions":[292],"between":[293],"adipocytes.":[297,318],"promote":[302],"mesenchymal-to-epithelial-like":[304],"transition":[305],"suggesting":[309],"secondary":[311],"tumour":[312],"formation":[313],"might":[314],"be":[315,333],"promoted":[316],"Overall,":[319],"data":[321],"will":[322],"aid":[323],"understanding":[325],"should":[332],"considered":[334],"future":[337],"development":[338],"combination":[340],"treatments":[342],"successfully":[344],"cure":[345],"BC.":[346]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2020-03-23T00:00:00"}