{"id":"https://openalex.org/W3011750488","doi":"https://doi.org/10.1371/journal.pone.0230247","title":"Effects of human recombinant granulocyte-colony stimulating factor treatment during in vitro culture on porcine pre-implantation embryos","display_name":"Effects of human recombinant granulocyte-colony stimulating factor treatment during in vitro culture on porcine pre-implantation embryos","publication_year":2020,"publication_date":"2020-03-17","ids":{"openalex":"https://openalex.org/W3011750488","doi":"https://doi.org/10.1371/journal.pone.0230247","mag":"3011750488","pmid":"https://pubmed.ncbi.nlm.nih.gov/32182268","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7077850"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0230247","doi":"https://doi.org/10.1371/journal.pone.0230247","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0230247","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0230247&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0230247&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039285626","display_name":"Lian Cai","orcid":"https://orcid.org/0000-0002-1096-700X","observed_orcids":["https://orcid.org/0000-0002-1096-700X"]},"institutions":[{"id":"https://openalex.org/I163753206","display_name":"Chungbuk National University","ror":"https://ror.org/02wnxgj78","country_code":"KR","type":"education","lineage":["https://openalex.org/I163753206"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Lian Cai","raw_affiliation_strings":["Abu Dhabi Biotech Research Foundation, Seoul, Republic of Korea","College of Veterinary Medicine, Chungbuk National University, Cheongju, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abu Dhabi Biotech Research Foundation, Seoul, Republic of Korea","institution_ids":[]},{"raw_affiliation_string":"College of Veterinary Medicine, Chungbuk National University, Cheongju, South Korea","institution_ids":["https://openalex.org/I163753206"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091794833","display_name":"Yeonwoo Jeong","orcid":"https://orcid.org/0000-0002-4264-8134","observed_orcids":["https://orcid.org/0000-0002-4264-8134"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yeon-woo Jeong","raw_affiliation_strings":["Abu Dhabi Biotech Research Foundation, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abu Dhabi Biotech Research Foundation, Seoul, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112261478","display_name":"Yong-Xun Jin","orcid":"https://orcid.org/0000-0001-5120-4212","observed_orcids":["https://orcid.org/0000-0001-5120-4212","https://orcid.org/0009-0003-1033-1153"]},"institutions":[{"id":"https://openalex.org/I163753206","display_name":"Chungbuk National University","ror":"https://ror.org/02wnxgj78","country_code":"KR","type":"education","lineage":["https://openalex.org/I163753206"]},{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN","KR"],"is_corresponding":false,"raw_author_name":"Yong-xun Jin","raw_affiliation_strings":["Abu Dhabi Biotech Research Foundation, Seoul, Republic of Korea","College of Animal Science, Jilin University, Changchun, China","Department of Animal Science, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abu Dhabi Biotech Research Foundation, Seoul, Republic of Korea","institution_ids":[]},{"raw_affiliation_string":"College of Animal Science, Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716"]},{"raw_affiliation_string":"Department of Animal Science, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea","institution_ids":["https://openalex.org/I163753206"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020519646","display_name":"Jong-yun Lee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jong-yun Lee","raw_affiliation_strings":["Abu Dhabi Biotech Research Foundation, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abu Dhabi Biotech Research Foundation, Seoul, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112031718","display_name":"Yeon-ik Jeong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yeon-ik Jeong","raw_affiliation_strings":["Abu Dhabi Biotech Research Foundation, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abu Dhabi Biotech Research Foundation, Seoul, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103408375","display_name":"Kyu\u2010Chan Hwang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kyu-chan Hwang","raw_affiliation_strings":["Abu Dhabi Biotech Research Foundation, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abu Dhabi Biotech Research Foundation, Seoul, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110040817","display_name":"Sang\u2010Hwan Hyun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163753206","display_name":"Chungbuk National University","ror":"https://ror.org/02wnxgj78","country_code":"KR","type":"education","lineage":["https://openalex.org/I163753206"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Sang-hwan Hyun","raw_affiliation_strings":["Abu Dhabi Biotech Research Foundation, Seoul, Republic of Korea","College of Veterinary Medicine, Chungbuk National University, Cheongju, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abu Dhabi Biotech Research Foundation, Seoul, Republic of Korea","institution_ids":[]},{"raw_affiliation_string":"College of Veterinary Medicine, Chungbuk National University, Cheongju, South Korea","institution_ids":["https://openalex.org/I163753206"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049949988","display_name":"Woo Suk Hwang","orcid":"https://orcid.org/0000-0001-6304-8595","observed_orcids":["https://orcid.org/0000-0001-6304-8595"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Woo-suk Hwang","raw_affiliation_strings":["Abu Dhabi Biotech Research Foundation, Seoul, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0001-6304-8595","affiliations":[{"raw_affiliation_string":"Abu Dhabi Biotech Research Foundation, Seoul, Republic of Korea","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5049949988","https://openalex.org/A5110040817"],"corresponding_institution_ids":["https://openalex.org/I163753206"],"apc_list":{"value":1695,"currency":"USD","value_usd":1695},"apc_paid":{"value":1695,"currency":"USD","value_usd":1695},"fwci":2.0157,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.84615385,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"15","issue":"3","first_page":"e0230247","last_page":"e0230247"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.025499999523162842,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10584","display_name":"Reproductive Physiology in Livestock","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/granulocyte-colony-stimulating-factor","display_name":"granulocyte colony-stimulating factor","score":0.9660000205039978},{"id":"https://openalex.org/keywords/embryo-culture","display_name":"embryo culture","score":0.8019999861717224},{"id":"https://openalex.org/keywords/embryo-developmental-competence","display_name":"embryo developmental competence","score":0.8930000066757202},{"id":"https://openalex.org/keywords/somatic-cell-nuclear-transfer","display_name":"somatic cell nuclear transfer","score":0.7879999876022339},{"id":"https://openalex.org/keywords/parthenogenetic-activation","display_name":"parthenogenetic activation","score":0.9649999737739563},{"id":"https://openalex.org/keywords/blastocyst-development","display_name":"blastocyst development","score":0.7590000033378601},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8230000138282776},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.8970000147819519},{"id":"https://openalex.org/keywords/pcna","display_name":"PCNA","score":0.828000009059906},{"id":"https://openalex.org/keywords/oct4","display_name":"Oct4","score":0.9950000047683716},{"id":"https://openalex.org/keywords/fallopian-tube","display_name":"oviduct","score":0.6669999957084656},{"id":"https://openalex.org/keywords/uterus","display_name":"uterus","score":0.921999990940094},{"id":"https://openalex.org/keywords/cumulus-cells","display_name":"cumulus cells","score":0.8379999995231628},{"id":"https://openalex.org/keywords/cytokine-supplementation","display_name":"cytokine supplementation","score":0.5360000133514404}],"concepts":[{"id":"https://openalex.org/C2778177303","wikidata":"https://www.wikidata.org/wiki/Q227717","display_name":"Blastocyst","level":4,"score":0.84180748462677},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.6890931129455566},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6159579157829285},{"id":"https://openalex.org/C202438428","wikidata":"https://www.wikidata.org/wiki/Q1939923","display_name":"Somatic cell nuclear transfer","level":5,"score":0.6021630167961121},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.5871235728263855},{"id":"https://openalex.org/C2779335785","wikidata":"https://www.wikidata.org/wiki/Q5370217","display_name":"Embryo culture","level":4,"score":0.562121570110321},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.44850954413414},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.4422725439071655},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.428877055644989},{"id":"https://openalex.org/C512716672","wikidata":"https://www.wikidata.org/wiki/Q200117","display_name":"In vitro fertilisation","level":3,"score":0.41857925057411194},{"id":"https://openalex.org/C14814345","wikidata":"https://www.wikidata.org/wiki/Q589646","display_name":"Theriogenology","level":5,"score":0.4127037525177002},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3328116536140442},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32615047693252563},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.23410385847091675},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15930652618408203}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001755","descriptor_name":"Blastocyst","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005307","descriptor_name":"Fertilization in Vitro","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016179","descriptor_name":"Granulocyte Colony-Stimulating Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D046149","descriptor_name":"Embryo Culture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D047108","descriptor_name":"Embryonic Development","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053652","descriptor_name":"Nuclear Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054885","descriptor_name":"Cumulus Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pone.0230247","doi":"https://doi.org/10.1371/journal.pone.0230247","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0230247","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0230247&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmid:32182268","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32182268","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7077850","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7077850/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:cf600beb56fe4f70ae17369305f2476f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/cf600beb56fe4f70ae17369305f2476f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 15, Iss 3, p e0230247 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0230247","doi":"https://doi.org/10.1371/journal.pone.0230247","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0230247","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0230247&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2217629400","display_name":null,"funder_award_id":"318016-5","funder_id":"https://openalex.org/F4320322033","funder_display_name":"Ministry of Agriculture, Food and Rural Affairs"},{"id":"https://openalex.org/G3345765047","display_name":null,"funder_award_id":"318016-5","funder_id":"https://openalex.org/F4320322068","funder_display_name":"Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries"},{"id":"https://openalex.org/G3677774289","display_name":null,"funder_award_id":"819029-2","funder_id":"https://openalex.org/F4320322068","funder_display_name":"Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries"},{"id":"https://openalex.org/G5591841220","display_name":null,"funder_award_id":"2017K1A4A3014959","funder_id":"https://openalex.org/F4320322349","funder_display_name":"Ministry of Education, Science and Technology"},{"id":"https://openalex.org/G572112324","display_name":null,"funder_award_id":"819029-2","funder_id":"https://openalex.org/F4320322033","funder_display_name":"Ministry of Agriculture, Food and Rural Affairs"},{"id":"https://openalex.org/G6566423425","display_name":null,"funder_award_id":"2017K1A4A3014959","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320320420","display_name":"Grains Research and Development Corporation","ror":"https://ror.org/02xwr1996"},{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322033","display_name":"Ministry of Agriculture, Food and Rural Affairs","ror":"https://ror.org/009g8rq41"},{"id":"https://openalex.org/F4320322068","display_name":"Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries","ror":"https://ror.org/00c25dn03"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320322349","display_name":"Ministry of Education, Science and Technology","ror":"https://ror.org/01p262204"},{"id":"https://openalex.org/F4320322724","display_name":"Ministry of Education, India","ror":"https://ror.org/048xjjh50"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3011750488.pdf","grobid_xml":"https://content.openalex.org/works/W3011750488.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W1963559963","https://openalex.org/W1964371693","https://openalex.org/W1973312385","https://openalex.org/W1975835804","https://openalex.org/W1977057042","https://openalex.org/W1977373318","https://openalex.org/W1981088384","https://openalex.org/W1985737700","https://openalex.org/W1989071146","https://openalex.org/W1990284406","https://openalex.org/W1991512401","https://openalex.org/W1993073412","https://openalex.org/W1995437677","https://openalex.org/W2001233757","https://openalex.org/W2001562379","https://openalex.org/W2009778512","https://openalex.org/W2011409004","https://openalex.org/W2012206386","https://openalex.org/W2014141576","https://openalex.org/W2020564947","https://openalex.org/W2022199231","https://openalex.org/W2026692286","https://openalex.org/W2038340974","https://openalex.org/W2043218957","https://openalex.org/W2045709286","https://openalex.org/W2048113014","https://openalex.org/W2049639969","https://openalex.org/W2053021474","https://openalex.org/W2054964979","https://openalex.org/W2061036382","https://openalex.org/W2070690263","https://openalex.org/W2096167208","https://openalex.org/W2097317908","https://openalex.org/W2101197781","https://openalex.org/W2103639214","https://openalex.org/W2104183234","https://openalex.org/W2105142263","https://openalex.org/W2105672473","https://openalex.org/W2108023376","https://openalex.org/W2110098910","https://openalex.org/W2114081032","https://openalex.org/W2117875219","https://openalex.org/W2120615618","https://openalex.org/W2121497709","https://openalex.org/W2127134752","https://openalex.org/W2143935360","https://openalex.org/W2145358683","https://openalex.org/W2145945728","https://openalex.org/W2147177722","https://openalex.org/W2156851952","https://openalex.org/W2157935738","https://openalex.org/W2164387992","https://openalex.org/W2187956021","https://openalex.org/W2397811031","https://openalex.org/W2407234806","https://openalex.org/W2413861929","https://openalex.org/W2582801455","https://openalex.org/W2595664327","https://openalex.org/W4210653417"],"related_works":["https://openalex.org/W2559055961","https://openalex.org/W2065967978","https://openalex.org/W2145945728","https://openalex.org/W4389670671","https://openalex.org/W1971432269","https://openalex.org/W2053021474","https://openalex.org/W1968121586","https://openalex.org/W2346283559","https://openalex.org/W2030472887","https://openalex.org/W1975835804"],"abstract_inverted_index":{"Granulocyte-colony":[0],"stimulating":[1],"factor":[2,12],"(G-CSF),":[3],"a":[4,21],"pleiotropic":[5],"cytokine,":[6],"belongs":[7],"to":[8,38,61,110,238],"the":[9,63,77,112,190,196,213,223,241,260],"hematopoietic":[10],"growth":[11],"family.":[13],"Recent":[14],"studies":[15],"have":[16],"reported":[17],"that":[18,161,265,281],"G-CSF":[19,68],"is":[20],"predictive":[22],"biomarker":[23],"of":[24,34,65,80,142,149,157,198,209,217,227,244],"oocyte":[25],"and":[26,42,54,58,60,104,129,132,139,179,186,193,212,225,249,267,276],"embryo":[27],"developmental":[28,78,114],"competence":[29,79],"in":[30,48,72,100,153,166,176,199,233,271,289],"humans.":[31],"The":[32,155,207],"aim":[33],"our":[35,158],"study":[36,159],"was":[37,164,172],"determine":[39],"whether":[40],"CSF3":[41,162,266],"its":[43],"receptor":[44],"(CSF3R)":[45],"were":[46,189,219,230,254,269],"expressed":[47,270],"porcine":[49,272,285],"maternal":[50],"reproductive":[51,273],"tissues":[52],"(oviduct":[53],"uterus),":[55],"cumulus":[56,177],"cells,":[57,275],"embryos":[59],"investigate":[62],"effects":[64],"human":[66],"recombinant":[67],"(hrG-CSF)":[69],"supplementation":[70,118],"during":[71],"vitro":[73,101,200],"culture":[74],"(IVC)":[75],"on":[76,120],"pre-implantation":[81],"embryos.":[82,206,277],"To":[83],"do":[84],"this,":[85],"we":[86,95,145,169,263,279],"first":[87,261],"performed":[88,96],"reverse-transcription":[89],"polymerase":[90],"chain":[91],"reaction":[92],"(RT-PCR).":[93],"Second,":[94],"parthenogenetic":[97],"activation":[98],"(PA),":[99],"fertilization":[102],"(IVF),":[103],"somatic":[105],"cell":[106,215],"nuclear":[107],"transfer":[108],"(SCNT)":[109],"evaluate":[111],"embryonic":[113,201,286],"potential":[115],"after":[116],"hrG-CSF":[117,282],"based":[119],"various":[121],"concentrations":[122],"(0":[123],"ng/mL,":[124,126,128],"10":[125,184],"50":[127],"100":[130],"ng/mL)":[131],"durations":[133],"(Un-treated,":[134],"Days":[135,137,140,187],"0-3,":[136],"4-7,":[138],"0-7)":[141],"IVC.":[143],"Finally,":[144],"examined":[146],"transcriptional":[147,242],"levels":[148,243],"several":[150],"marker":[151],"genes":[152,253],"blastocysts.":[154],"results":[156],"showed":[160],"transcript":[163],"present":[165],"all":[167],"samples":[168],"assessed.":[170],"CSF3-R":[171],"also":[173],"detected,":[174],"except":[175],"cells":[178],"blastocysts":[180,218],"from":[181],"PA.":[182],"Furthermore,":[183],"ng/mL":[185],"0-7":[188],"optimal":[191,234],"concentration":[192],"duration":[194],"for":[195,204,259],"viability":[197],"development,":[202],"especially":[203],"SCNT-derived":[205],"rate":[208],"blastocyst":[210],"formation":[211],"total":[214],"number":[216,224],"significantly":[220,231],"enhanced,":[221],"while":[222],"index":[226],"apoptotic":[228],"nuclei":[229],"decreased":[232],"condition":[235],"groups":[236],"compared":[237],"others.":[239],"Moreover,":[240],"anti-apoptotis-":[245],"(BCL2),":[246],"proliferation-":[247],"(PCNA),":[248],"pluripotency-":[250],"(POU5F1)":[251],"related":[252],"dramatically":[255],"upregulated.":[256],"In":[257],"conclusion,":[258],"time,":[262],"demonstrated":[264],"CSF3R":[268],"organs,":[274],"Additionally,":[278],"determined":[280],"treatment":[283],"improved":[284],"development":[287],"capacity":[288],"vitro.":[290]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2020-03-23T00:00:00"}