{"id":"https://openalex.org/W3011719476","doi":"https://doi.org/10.3390/pharmaceutics12030268","title":"Comparative Pharmacokinetics and Pharmacodynamics of a Novel Sodium-Glucose Cotransporter 2 Inhibitor, DWP16001, with Dapagliflozin and Ipragliflozin","display_name":"Comparative Pharmacokinetics and Pharmacodynamics of a Novel Sodium-Glucose Cotransporter 2 Inhibitor, DWP16001, with Dapagliflozin and Ipragliflozin","publication_year":2020,"publication_date":"2020-03-15","ids":{"openalex":"https://openalex.org/W3011719476","doi":"https://doi.org/10.3390/pharmaceutics12030268","mag":"3011719476","pmid":"https://pubmed.ncbi.nlm.nih.gov/32183468","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7151106"},"language":"en","primary_location":{"id":"doi:10.3390/pharmaceutics12030268","doi":"https://doi.org/10.3390/pharmaceutics12030268","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/pharmaceutics12030268","pdf_url":"https://www.mdpi.com/1999-4923/12/3/268/pdf?version=1584522177","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1999-4923/12/3/268/pdf?version=1584522177","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028334345","display_name":"Min\u2010Koo Choi","orcid":"https://orcid.org/0000-0003-0217-5042","observed_orcids":["https://orcid.org/0000-0003-0217-5042"]},"institutions":[{"id":"https://openalex.org/I89015989","display_name":"Dankook University","ror":"https://ror.org/058pdbn81","country_code":"KR","type":"education","lineage":["https://openalex.org/I89015989"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Min-Koo Choi","raw_affiliation_strings":["College of Pharmacy, Dankook University, Cheon-an 31116, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Dankook University, Cheon-an 31116, Korea","institution_ids":["https://openalex.org/I89015989"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110672287","display_name":"So Jeong Nam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31419693","display_name":"Kyungpook National University","ror":"https://ror.org/040c17130","country_code":"KR","type":"education","lineage":["https://openalex.org/I31419693"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"So Jeong Nam","raw_affiliation_strings":["College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 41566, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 41566, Korea","institution_ids":["https://openalex.org/I31419693"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052253482","display_name":"Hye\u2010Young Ji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47141704","display_name":"Daewoong Pharmaceutical (South Korea)","ror":"https://ror.org/05j0gfp71","country_code":"KR","type":"company","lineage":["https://openalex.org/I47141704"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hye-Young Ji","raw_affiliation_strings":["Life Science Institute, Daewoong Pharmaceutical, Yongin, Gyeonggido 17028, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Life Science Institute, Daewoong Pharmaceutical, Yongin, Gyeonggido 17028, Korea","institution_ids":["https://openalex.org/I47141704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083715736","display_name":"Mi Jie Park","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47141704","display_name":"Daewoong Pharmaceutical (South Korea)","ror":"https://ror.org/05j0gfp71","country_code":"KR","type":"company","lineage":["https://openalex.org/I47141704"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Mi Jie Park","raw_affiliation_strings":["Life Science Institute, Daewoong Pharmaceutical, Yongin, Gyeonggido 17028, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Life Science Institute, Daewoong Pharmaceutical, Yongin, Gyeonggido 17028, Korea","institution_ids":["https://openalex.org/I47141704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101056970","display_name":"Ji\u2010Soo Choi","orcid":"https://orcid.org/0009-0008-5535-4144","observed_orcids":["https://orcid.org/0009-0008-5535-4144"]},"institutions":[{"id":"https://openalex.org/I47141704","display_name":"Daewoong Pharmaceutical (South Korea)","ror":"https://ror.org/05j0gfp71","country_code":"KR","type":"company","lineage":["https://openalex.org/I47141704"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ji-Soo Choi","raw_affiliation_strings":["Life Science Institute, Daewoong Pharmaceutical, Yongin, Gyeonggido 17028, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Life Science Institute, Daewoong Pharmaceutical, Yongin, Gyeonggido 17028, Korea","institution_ids":["https://openalex.org/I47141704"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020233523","display_name":"Im\u2010Sook Song","orcid":"https://orcid.org/0000-0002-4564-709X","observed_orcids":["https://orcid.org/0000-0002-4564-709X"]},"institutions":[{"id":"https://openalex.org/I31419693","display_name":"Kyungpook National University","ror":"https://ror.org/040c17130","country_code":"KR","type":"education","lineage":["https://openalex.org/I31419693"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Im-Sook Song","raw_affiliation_strings":["College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 41566, Korea"],"raw_orcid":"https://orcid.org/0000-0002-4564-709X","affiliations":[{"raw_affiliation_string":"College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 41566, Korea","institution_ids":["https://openalex.org/I31419693"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5020233523"],"corresponding_institution_ids":["https://openalex.org/I31419693"],"apc_list":{"value":1800,"currency":"CHF","value_usd":1901},"apc_paid":{"value":1800,"currency":"CHF","value_usd":1901},"fwci":4.2916,"has_fulltext":true,"cited_by_count":49,"citation_normalized_percentile":{"value":0.95371616,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"12","issue":"3","first_page":"268","last_page":"268"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.007400000002235174,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sglt2-inhibitors","display_name":"SGLT2 inhibitors","score":0.9110000133514404},{"id":"https://openalex.org/keywords/dapagliflozin","display_name":"dapagliflozin","score":0.9710000157356262},{"id":"https://openalex.org/keywords/ipragliflozin","display_name":"ipragliflozin","score":1.0},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9789999723434448},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.9639999866485596},{"id":"https://openalex.org/keywords/organic-anion-transporters","display_name":"organic anion transporters","score":0.7720000147819519},{"id":"https://openalex.org/keywords/sglt2-inhibition","display_name":"SGLT2 inhibition","score":0.8870000243186951},{"id":"https://openalex.org/keywords/competitive-inhibition","display_name":"competitive inhibition","score":0.8769999742507935},{"id":"https://openalex.org/keywords/plasma-exposure","display_name":"plasma exposure","score":0.4259999990463257}],"concepts":[{"id":"https://openalex.org/C2777422806","wikidata":"https://www.wikidata.org/wiki/Q409898","display_name":"Dapagliflozin","level":4,"score":0.9835084676742554},{"id":"https://openalex.org/C90466245","wikidata":"https://www.wikidata.org/wiki/Q7312490","display_name":"Renal glucose reabsorption","level":4,"score":0.8144638538360596},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7106351852416992},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7002580165863037},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5229907035827637},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.49677830934524536},{"id":"https://openalex.org/C56906281","wikidata":"https://www.wikidata.org/wiki/Q4391435","display_name":"Reabsorption","level":3,"score":0.49274757504463196},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.48420098423957825},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.4493100643157959},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.32211124897003174},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3112831115722656},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21881559491157532},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15777498483657837},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.15713408589363098},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.09963753819465637},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/pharmaceutics12030268","doi":"https://doi.org/10.3390/pharmaceutics12030268","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/pharmaceutics12030268","pdf_url":"https://www.mdpi.com/1999-4923/12/3/268/pdf?version=1584522177","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},{"id":"pmid:32183468","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32183468","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7151106","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7151106/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:ebbea59424b440a8845e2bd0d8fe0638","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ebbea59424b440a8845e2bd0d8fe0638","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceutics, Vol 12, Iss 3, p 268 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/pharmaceutics12030268","doi":"https://doi.org/10.3390/pharmaceutics12030268","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/pharmaceutics12030268","pdf_url":"https://www.mdpi.com/1999-4923/12/3/268/pdf?version=1584522177","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3011719476.pdf","grobid_xml":"https://content.openalex.org/works/W3011719476.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W194823128","https://openalex.org/W1531245411","https://openalex.org/W1561949950","https://openalex.org/W1974115114","https://openalex.org/W1983241145","https://openalex.org/W1996042816","https://openalex.org/W2010145027","https://openalex.org/W2066912898","https://openalex.org/W2077028076","https://openalex.org/W2078992128","https://openalex.org/W2084514272","https://openalex.org/W2088226047","https://openalex.org/W2099802056","https://openalex.org/W2134855422","https://openalex.org/W2146177171","https://openalex.org/W2171680502","https://openalex.org/W2469884964","https://openalex.org/W2586590687","https://openalex.org/W2884961588","https://openalex.org/W2919894951","https://openalex.org/W2936273436","https://openalex.org/W2968067900","https://openalex.org/W3003288228","https://openalex.org/W3003871410"],"related_works":["https://openalex.org/W4224320974","https://openalex.org/W2031315153","https://openalex.org/W4311114247","https://openalex.org/W2287058651","https://openalex.org/W2906340657","https://openalex.org/W4309922062","https://openalex.org/W2075044961","https://openalex.org/W2036936011","https://openalex.org/W2134855422","https://openalex.org/W42427464"],"abstract_inverted_index":{"Since":[0],"sodium-glucose":[1],"cotransporter":[2],"2":[3],"(SGLT2)":[4],"inhibitors":[5,74,177],"reduced":[6],"blood":[7],"glucose":[8,14],"level":[9],"by":[10,17],"inhibiting":[11],"renal":[12],"tubular":[13],"reabsorption":[15],"mediated":[16],"SGLT2,":[18,131],"we":[19],"aimed":[20],"to":[21,35,86,116,130,225],"investigate":[22],"the":[23,67,117,124,166,169,173,190,207,214],"pharmacokinetics":[24],"and":[25,34,43,98,147,163,194,199,218,227],"kidney":[26,69,85,108,119,216],"distribution":[27,70,217],"of":[28,41,51,57,63,84,110,157,168,175,203,209,222],"DWP16001,":[29,92,140,186],"a":[30,132],"novel":[31],"SGLT2":[32,46,73,160,170,176,182,201,220],"inhibitor,":[33],"compare":[36],"these":[37],"properties":[38],"with":[39,55,185,192,213],"those":[40],"dapagliflozin":[42,97,193,226],"ipragliflozin,":[44],"representative":[45],"inhibitors.":[47],"The":[48,104,154],"plasma":[49,87],"exposure":[50],"DWP16001":[52,65,111,122,158,204,210,223],"was":[53,161,183],"comparable":[54],"that":[56,62],"ipragliflozin":[58],"but":[59,165],"higher":[60,215],"than":[61],"dapagliflozin.":[64],"showed":[66],"highest":[68,118],"among":[71],"three":[72],"when":[75],"expressed":[76],"as":[77],"an":[78],"area":[79],"under":[80],"curve":[81],"(AUC)":[82],"ratio":[83],"(85.0":[88],"\u00b1":[89,94,100,136,142,149],"16.1":[90],"for":[91,96,102,139,145,152],"64.6":[93],"31.8":[95],"38.4":[99],"5.3":[101],"ipragliflozin).":[103,153],"organic":[105],"anion":[106],"transporter-mediated":[107],"uptake":[109],"could":[112,205],"be":[113],"partly":[114],"attributed":[115],"uptake.":[120],"Additionally,":[121],"had":[123],"lowest":[125],"half-maximal":[126],"inhibitory":[127],"concentration":[128],"(IC50)":[129],"target":[133],"transporter":[134],"(0.8":[135],"0.3":[137,143],"nM":[138,144,151],"1.6":[141],"dapagliflozin,":[146],"8.9":[148],"1.7":[150],"inhibition":[155,171,202,221],"mode":[156],"on":[159],"reversible":[162],"competitive,":[164],"recovery":[167],"after":[172],"removal":[174],"in":[178,211],"CHO":[179],"cells":[180],"overexpressing":[181],"retained":[184,219],"which":[187],"is":[188],"not":[189],"case":[191],"ipragliflozin.":[195,228],"In":[196],"conclusion,":[197],"selective":[198],"competitive":[200],"potentiate":[206],"efficacy":[208],"coordination":[212],"relative":[224]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-03-23T00:00:00"}
