{"id":"https://openalex.org/W3011663469","doi":"https://doi.org/10.1128/iai.00906-19","title":"Illuminating Macrophage Contributions to Host-Pathogen Interactions In Vivo : the Power of Zebrafish","display_name":"Illuminating Macrophage Contributions to Host-Pathogen Interactions In Vivo : the Power of Zebrafish","publication_year":2020,"publication_date":"2020-03-16","ids":{"openalex":"https://openalex.org/W3011663469","doi":"https://doi.org/10.1128/iai.00906-19","mag":"3011663469","pmid":"https://pubmed.ncbi.nlm.nih.gov/32179583","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7309627"},"language":"en","primary_location":{"id":"doi:10.1128/iai.00906-19","doi":"https://doi.org/10.1128/iai.00906-19","is_oa":false,"landing_page_url":"https://doi.org/10.1128/iai.00906-19","pdf_url":null,"source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7309627","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040862836","display_name":"Emily E. Rosowski","orcid":"https://orcid.org/0000-0002-6761-1098","observed_orcids":["https://orcid.org/0000-0002-6761-1098"]},"institutions":[{"id":"https://openalex.org/I8078737","display_name":"Clemson University","ror":"https://ror.org/037s24f05","country_code":"US","type":"education","lineage":["https://openalex.org/I8078737"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Emily E. Rosowski","raw_affiliation_strings":["Department of Biological Sciences, Clemson University, Clemson, South Carolina, USA"],"raw_orcid":"https://orcid.org/0000-0002-6761-1098","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Clemson University, Clemson, South Carolina, USA","institution_ids":["https://openalex.org/I8078737"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5040862836"],"corresponding_institution_ids":["https://openalex.org/I8078737"],"apc_list":null,"apc_paid":null,"fwci":0.3186,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.26666667,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"88","issue":"7","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.8525000214576721,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.8525000214576721,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11403","display_name":"Invertebrate Immune Response Mechanisms","score":0.06620000302791595,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.057500001043081284,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":1.0},{"id":"https://openalex.org/keywords/host-pathogen-interaction","display_name":"host-pathogen interaction","score":0.9369999766349792},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.9670000076293945},{"id":"https://openalex.org/keywords/zebrafish","display_name":"zebrafish","score":0.8640000224113464},{"id":"https://openalex.org/keywords/zebrafish-larvae","display_name":"zebrafish larvae","score":0.8650000095367432},{"id":"https://openalex.org/keywords/in-vivo-immune-response","display_name":"in vivo immune response","score":0.7549999952316284},{"id":"https://openalex.org/keywords/pathogen-effectors","display_name":"pathogen effectors","score":0.8479999899864197}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9002573490142822},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.8934258222579956},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.7565228939056396},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.6939590573310852},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.6687849760055542},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5954539775848389},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.5884875655174255},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5464249849319458},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.5043002367019653},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.456606388092041},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.41558822989463806},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.38825690746307373},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34438273310661316},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3394263684749603},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1297730803489685},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07191652059555054},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008262","descriptor_name":"Macrophage Activation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008262","descriptor_name":"Macrophage Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D057054","descriptor_name":"Molecular Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1128/iai.00906-19","doi":"https://doi.org/10.1128/iai.00906-19","is_oa":false,"landing_page_url":"https://doi.org/10.1128/iai.00906-19","pdf_url":null,"source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7309627","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7309627","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infect Immun","raw_type":"Text"},{"id":"pmid:32179583","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32179583","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and immunity","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7309627","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7309627","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infect Immun","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2703272509","display_name":"Defining and harnessing macrophage pathways for Aspergillus clearance in vivo","funder_award_id":"K22AI134677","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":84,"referenced_works":["https://openalex.org/W1490800150","https://openalex.org/W1891961100","https://openalex.org/W1957642752","https://openalex.org/W1976353903","https://openalex.org/W1977138279","https://openalex.org/W1986514504","https://openalex.org/W2017762021","https://openalex.org/W2019997079","https://openalex.org/W2028889783","https://openalex.org/W2036903343","https://openalex.org/W2039830769","https://openalex.org/W2048630989","https://openalex.org/W2050195517","https://openalex.org/W2050697866","https://openalex.org/W2055224823","https://openalex.org/W2058507546","https://openalex.org/W2064964564","https://openalex.org/W2074401088","https://openalex.org/W2075400586","https://openalex.org/W2085432374","https://openalex.org/W2086181643","https://openalex.org/W2093178459","https://openalex.org/W2095953605","https://openalex.org/W2100088019","https://openalex.org/W2102122111","https://openalex.org/W2102467166","https://openalex.org/W2103101461","https://openalex.org/W2104048810","https://openalex.org/W2104058719","https://openalex.org/W2116059196","https://openalex.org/W2118636734","https://openalex.org/W2123679840","https://openalex.org/W2128471563","https://openalex.org/W2129443010","https://openalex.org/W2131056555","https://openalex.org/W2145663614","https://openalex.org/W2154315671","https://openalex.org/W2154335274","https://openalex.org/W2156420692","https://openalex.org/W2158014788","https://openalex.org/W2163078748","https://openalex.org/W2163573140","https://openalex.org/W2164474259","https://openalex.org/W2169415226","https://openalex.org/W2193921588","https://openalex.org/W2262858406","https://openalex.org/W2278506590","https://openalex.org/W2359912528","https://openalex.org/W2402107045","https://openalex.org/W2404703480","https://openalex.org/W2479197761","https://openalex.org/W2479881538","https://openalex.org/W2487251532","https://openalex.org/W2512092116","https://openalex.org/W2532005031","https://openalex.org/W2547347442","https://openalex.org/W2560320387","https://openalex.org/W2612773113","https://openalex.org/W2674875376","https://openalex.org/W2734046086","https://openalex.org/W2746586093","https://openalex.org/W2747986502","https://openalex.org/W2763257724","https://openalex.org/W2805100691","https://openalex.org/W2805372449","https://openalex.org/W2880439530","https://openalex.org/W2887055255","https://openalex.org/W2904631392","https://openalex.org/W2912544720","https://openalex.org/W2912883422","https://openalex.org/W2913689157","https://openalex.org/W2917669362","https://openalex.org/W2921127352","https://openalex.org/W2945953423","https://openalex.org/W2949468942","https://openalex.org/W2950794265","https://openalex.org/W2968052468","https://openalex.org/W2971118426","https://openalex.org/W2971865815","https://openalex.org/W2971963475","https://openalex.org/W2979586952","https://openalex.org/W2982851021","https://openalex.org/W3106798016","https://openalex.org/W4211056322"],"related_works":["https://openalex.org/W2143540026","https://openalex.org/W2768560506","https://openalex.org/W2766862411","https://openalex.org/W4392663279","https://openalex.org/W2410272608","https://openalex.org/W2099452097","https://openalex.org/W2383632954","https://openalex.org/W2561230361","https://openalex.org/W2999229314","https://openalex.org/W1499664235"],"abstract_inverted_index":{"Macrophages":[0],"are":[1],"a":[2],"key":[3],"cell":[4,13,35,58,81],"type":[5],"in":[6,11,33,53],"innate":[7,50,71],"immunity.":[8],"Years":[9],"of":[10,48,70],"vitro":[12,34],"culture":[14,36,82],"studies":[15,37,83],"have":[16,64],"unraveled":[17],"myriad":[18],"macrophage":[19],"pathways":[20],"that":[21],"combat":[22],"pathogens":[23],"and":[24,60,73,84],"demonstrated":[25],"how":[26,42],"pathogen":[27],"effectors":[28],"subvert":[29],"these":[30],"mechanisms.":[31],"However,":[32],"may":[38],"not":[39],"accurately":[40],"reflect":[41],"macrophages":[43],"fit":[44],"into":[45],"the":[46,78],"context":[47],"an":[49,67],"immune":[51],"response":[52],"whole":[54],"animals":[55],"with":[56],"multiple":[57],"types":[59],"tissues.":[61],"Larval":[62],"zebrafish":[63],"emerged":[65],"as":[66],"intermediate":[68],"model":[69],"immunity":[72],"host-pathogen":[74],"interactions":[75],"to":[76],"bridge":[77],"gap":[79],"between":[80],"mammalian":[85],"models.":[86]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-03-23T00:00:00"}
