{"id":"https://openalex.org/W3011663197","doi":"https://doi.org/10.1038/s41598-020-61635-6","title":"Gut microbiota manipulation during the prepubertal period shapes behavioral abnormalities in a mouse neurodevelopmental disorder model","display_name":"Gut microbiota manipulation during the prepubertal period shapes behavioral abnormalities in a mouse neurodevelopmental disorder model","publication_year":2020,"publication_date":"2020-03-13","ids":{"openalex":"https://openalex.org/W3011663197","doi":"https://doi.org/10.1038/s41598-020-61635-6","mag":"3011663197","pmid":"https://pubmed.ncbi.nlm.nih.gov/32170216"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-020-61635-6","doi":"https://doi.org/10.1038/s41598-020-61635-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-020-61635-6","pdf_url":"https://www.nature.com/articles/s41598-020-61635-6.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-020-61635-6.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029883781","display_name":"Justin M. Saunders","orcid":"https://orcid.org/0000-0003-4131-9205","observed_orcids":["https://orcid.org/0000-0003-4131-9205"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Justin M. Saunders","raw_affiliation_strings":["Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, USA","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065089135","display_name":"Jos\u00e9 L. Moreno","orcid":"https://orcid.org/0000-0003-1851-925X","observed_orcids":["https://orcid.org/0000-0003-1851-925X"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 L. Moreno","raw_affiliation_strings":["Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, USA","VIVEbiotech S.L., E-20009, Donostia/San Sebasti\u00e1n, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, USA","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"VIVEbiotech S.L., E-20009, Donostia/San Sebasti\u00e1n, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023373285","display_name":"Daisuke Ibi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I96636082","display_name":"Meijo University","ror":"https://ror.org/04h42fc75","country_code":"JP","type":"education","lineage":["https://openalex.org/I96636082"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Daisuke Ibi","raw_affiliation_strings":["Department of Chemical Pharmacology, Meijo University, Nagoya, 468-8503, Japan","Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Pharmacology, Meijo University, Nagoya, 468-8503, Japan","institution_ids":["https://openalex.org/I96636082"]},{"raw_affiliation_string":"Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, USA","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083068675","display_name":"Masoumeh Sikaroodi","orcid":"https://orcid.org/0000-0002-8592-1145","observed_orcids":["https://orcid.org/0000-0002-8592-1145"]},"institutions":[{"id":"https://openalex.org/I162714631","display_name":"George Mason University","ror":"https://ror.org/02jqj7156","country_code":"US","type":"education","lineage":["https://openalex.org/I162714631"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masoumeh Sikaroodi","raw_affiliation_strings":["Center for Microbiome Analysis, George Mason University, Manassas, VA, 20110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Microbiome Analysis, George Mason University, Manassas, VA, 20110, USA","institution_ids":["https://openalex.org/I162714631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110525281","display_name":"Dae Joong Kang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I2801770128","display_name":"Hunter Holmes McGuire VA Medical Center","ror":"https://ror.org/04fp78s33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801770128","https://openalex.org/I4210159720"]},{"id":"https://openalex.org/I72019824","display_name":"Virginia Commonwealth University Medical Center","ror":"https://ror.org/057xmsr27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I72019824"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dae Joong Kang","raw_affiliation_strings":["Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA, 23298, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA, 23298, USA","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I2801770128","https://openalex.org/I72019824"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008298395","display_name":"Raquel Mu\u00f1oz-Moreno","orcid":"https://orcid.org/0000-0002-4521-0488","observed_orcids":["https://orcid.org/0000-0002-4521-0488"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raquel Mu\u00f1oz-Moreno","raw_affiliation_strings":["Department of Microbiology and Global Health & Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Global Health & Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082768394","display_name":"Swati S. Dalmet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162714631","display_name":"George Mason University","ror":"https://ror.org/02jqj7156","country_code":"US","type":"education","lineage":["https://openalex.org/I162714631"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Swati S. Dalmet","raw_affiliation_strings":["Center for Microbiome Analysis, George Mason University, Manassas, VA, 20110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Microbiome Analysis, George Mason University, Manassas, VA, 20110, USA","institution_ids":["https://openalex.org/I162714631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004889712","display_name":"Adolfo Garc\u00eda\u2010Sastre","orcid":"https://orcid.org/0000-0002-6551-1827","observed_orcids":["https://orcid.org/0000-0002-6551-1827"]},"institutions":[{"id":"https://openalex.org/I4390039328","display_name":"Tisch Cancer Institute","ror":"https://ror.org/0317dzj93","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I1320796813","https://openalex.org/I4390039328","https://openalex.org/I98704320"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adolfo Garc\u00eda-Sastre","raw_affiliation_strings":["Department of Medicine - Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA","Department of Microbiology and Global Health & Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA","The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA"],"raw_orcid":"https://orcid.org/0000-0002-6551-1827","affiliations":[{"raw_affiliation_string":"Department of Medicine - Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Department of Microbiology and Global Health & Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA","institution_ids":["https://openalex.org/I4390039328","https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024426792","display_name":"Patrick Martin Gillevet","orcid":"https://orcid.org/0000-0001-7734-5566","observed_orcids":["https://orcid.org/0000-0001-7734-5566"]},"institutions":[{"id":"https://openalex.org/I162714631","display_name":"George Mason University","ror":"https://ror.org/02jqj7156","country_code":"US","type":"education","lineage":["https://openalex.org/I162714631"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick M. Gillevet","raw_affiliation_strings":["Center for Microbiome Analysis, George Mason University, Manassas, VA, 20110, USA"],"raw_orcid":"https://orcid.org/0000-0001-7734-5566","affiliations":[{"raw_affiliation_string":"Center for Microbiome Analysis, George Mason University, Manassas, VA, 20110, USA","institution_ids":["https://openalex.org/I162714631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056470952","display_name":"Mikhail G. Dozmorov","orcid":"https://orcid.org/0000-0002-0086-8358","observed_orcids":["https://orcid.org/0000-0002-0086-8358"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mikhail G. Dozmorov","raw_affiliation_strings":["Department of Biostatistics, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, USA"],"raw_orcid":"https://orcid.org/0000-0002-0086-8358","affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, USA","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067770887","display_name":"Jasmohan Singh Bajaj","orcid":"https://orcid.org/0000-0003-4928-3681","observed_orcids":["https://orcid.org/0000-0003-4928-3681"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I2801770128","display_name":"Hunter Holmes McGuire VA Medical Center","ror":"https://ror.org/04fp78s33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801770128","https://openalex.org/I4210159720"]},{"id":"https://openalex.org/I72019824","display_name":"Virginia Commonwealth University Medical Center","ror":"https://ror.org/057xmsr27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I72019824"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jasmohan S. Bajaj","raw_affiliation_strings":["Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA, 23298, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA, 23298, USA","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I2801770128","https://openalex.org/I72019824"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047587284","display_name":"Javier Gonz\u00e1lez\u2010Maeso","orcid":"https://orcid.org/0000-0003-3105-3204","observed_orcids":["https://orcid.org/0000-0003-3105-3204","https://orcid.org/0000-0001-9029-5057"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Javier Gonz\u00e1lez-Maeso","raw_affiliation_strings":["Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, USA. javier.maeso@vcuhealth.org","Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, USA. javier.maeso@vcuhealth.org","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, USA","institution_ids":["https://openalex.org/I184840846"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5047587284"],"corresponding_institution_ids":["https://openalex.org/I184840846"],"apc_list":{"value":1870,"currency":"USD","value_usd":1870},"apc_paid":{"value":1870,"currency":"USD","value_usd":1870},"fwci":1.8657,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.86124329,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"10","issue":"1","first_page":"4697","last_page":"4697"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.6621000170707703,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.6621000170707703,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.29249998927116394,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9049999713897705},{"id":"https://openalex.org/keywords/maternal-immune-activation","display_name":"maternal immune activation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/prenatal-infection","display_name":"prenatal infection","score":0.6000000238418579},{"id":"https://openalex.org/keywords/influenza-virus","display_name":"influenza virus","score":0.9079999923706055},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.6499999761581421},{"id":"https://openalex.org/keywords/autism-spectrum-disorder","display_name":"autism spectrum disorder","score":0.9049999713897705},{"id":"https://openalex.org/keywords/neurodevelopmental-disorders","display_name":"neurodevelopmental disorders","score":0.890999972820282},{"id":"https://openalex.org/keywords/5-ht2a-receptor","display_name":"5-HT2A receptor","score":0.9419999718666077},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.6790000200271606},{"id":"https://openalex.org/keywords/novel-object-recognition","display_name":"novel object recognition","score":0.9319999814033508},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.8069999814033508},{"id":"https://openalex.org/keywords/antibiotic-therapy","display_name":"antibiotic therapy","score":0.6890000104904175},{"id":"https://openalex.org/keywords/microbiota-transplantation","display_name":"microbiota transplantation","score":0.7940000295639038},{"id":"https://openalex.org/keywords/ruminococcaceae","display_name":"Ruminococcaceae","score":0.9369999766349792},{"id":"https://openalex.org/keywords/gut-brain-axis","display_name":"gut-brain axis","score":0.9110000133514404},{"id":"https://openalex.org/keywords/prepubertal-period","display_name":"prepubertal period","score":0.8090000152587891},{"id":"https://openalex.org/keywords/frontal-cortex","display_name":"frontal cortex","score":0.6240000128746033}],"concepts":[{"id":"https://openalex.org/C2779388368","wikidata":"https://www.wikidata.org/wiki/Q3450985","display_name":"Neurodevelopmental disorder","level":3,"score":0.5984323024749756},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.5909532308578491},{"id":"https://openalex.org/C2781291010","wikidata":"https://www.wikidata.org/wiki/Q178580","display_name":"Period (music)","level":2,"score":0.570152997970581},{"id":"https://openalex.org/C177857423","wikidata":"https://www.wikidata.org/wiki/Q17077315","display_name":"Gut\u2013brain axis","level":3,"score":0.5128400921821594},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4382193088531494},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.376659631729126},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3722023367881775},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3718745708465576},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.32122603058815},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.18628492951393127},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.17463892698287964},{"id":"https://openalex.org/C205778803","wikidata":"https://www.wikidata.org/wiki/Q38404","display_name":"Autism","level":2,"score":0.11244922876358032},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000066553","descriptor_name":"Problem Behavior","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000066553","descriptor_name":"Problem Behavior","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000066553","descriptor_name":"Problem Behavior","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008568","descriptor_name":"Memory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008568","descriptor_name":"Memory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008568","descriptor_name":"Memory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D012741","descriptor_name":"Sexual Maturation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012741","descriptor_name":"Sexual Maturation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012741","descriptor_name":"Sexual Maturation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D021641","descriptor_name":"Recognition, Psychology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021641","descriptor_name":"Recognition, Psychology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021641","descriptor_name":"Recognition, Psychology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065886","descriptor_name":"Neurodevelopmental Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D065886","descriptor_name":"Neurodevelopmental Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D065886","descriptor_name":"Neurodevelopmental Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D065886","descriptor_name":"Neurodevelopmental Disorders","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D065886","descriptor_name":"Neurodevelopmental Disorders","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D065886","descriptor_name":"Neurodevelopmental Disorders","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41598-020-61635-6","doi":"https://doi.org/10.1038/s41598-020-61635-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-020-61635-6","pdf_url":"https://www.nature.com/articles/s41598-020-61635-6.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmid:32170216","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32170216","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:6036940","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7070045","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:7070045","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7070045","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sci Rep","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/s41598-020-61635-6","doi":"https://doi.org/10.1038/s41598-020-61635-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-020-61635-6","pdf_url":"https://www.nature.com/articles/s41598-020-61635-6.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8799999952316284,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G103575219","display_name":null,"funder_award_id":"HHSN272201400008C)","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G1423529922","display_name":null,"funder_award_id":"R21 TR002024","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G1544894325","display_name":"Involvement of serotonin 5-HT2A receptor in the antidepressant effect of ketamine","funder_award_id":"19K07332","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G2110691233","display_name":null,"funder_award_id":"R01MH111940","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G2155095335","display_name":"Preclinical role of HDAC2 in mGlu2-dependent schizophrenia treatment","funder_award_id":"R01MH111940","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G2709525598","display_name":null,"funder_award_id":"F30 MH116550","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G2899414965","display_name":null,"funder_award_id":"F30 MH116550","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G3028223774","display_name":null,"funder_award_id":"R01 MH084894","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G3621165171","display_name":null,"funder_award_id":"Grant-in-Aid 19K07332","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G3664559752","display_name":null,"funder_award_id":"Grant-in-Aid 19K07332","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4178338167","display_name":"Gut dysbiosis and 5-HT2A dysregulation in a preclinical schizophrenia model","funder_award_id":"5f30mh116550-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4786264864","display_name":"Structure and function of GPCR heteromeric complexes in brain","funder_award_id":"5r01mh084894-14","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5223602245","display_name":null,"funder_award_id":"Merit Review 2I0CX001076","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G548475077","display_name":null,"funder_award_id":"R01MH084894","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G5520316217","display_name":null,"funder_award_id":"NIH-R01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6769946440","display_name":null,"funder_award_id":"R01 MH084894","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7059131728","display_name":null,"funder_award_id":"HHSN272201400008C","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7992464556","display_name":"Modulation of Gut-Brain Axis Using Fecal Microbiome Transplant Capsules in Cirrhosis","funder_award_id":"R21TR002024","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8308204896","display_name":null,"funder_award_id":"MH111940","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G9000131702","display_name":null,"funder_award_id":"R01MH084894","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3011663197.pdf","grobid_xml":"https://content.openalex.org/works/W3011663197.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W609925145","https://openalex.org/W623506756","https://openalex.org/W797404807","https://openalex.org/W960051915","https://openalex.org/W1577274024","https://openalex.org/W1716352502","https://openalex.org/W1860290282","https://openalex.org/W1935310079","https://openalex.org/W1966407955","https://openalex.org/W1977884541","https://openalex.org/W1992595835","https://openalex.org/W1997058647","https://openalex.org/W1999072976","https://openalex.org/W2009134620","https://openalex.org/W2010055058","https://openalex.org/W2011375438","https://openalex.org/W2020626633","https://openalex.org/W2024546964","https://openalex.org/W2024942419","https://openalex.org/W2027917639","https://openalex.org/W2033386838","https://openalex.org/W2040789766","https://openalex.org/W2048184801","https://openalex.org/W2072740131","https://openalex.org/W2072898255","https://openalex.org/W2072970694","https://openalex.org/W2092533774","https://openalex.org/W2096400789","https://openalex.org/W2101357408","https://openalex.org/W2104890863","https://openalex.org/W2109884356","https://openalex.org/W2113207193","https://openalex.org/W2117029190","https://openalex.org/W2119799034","https://openalex.org/W2121366540","https://openalex.org/W2125244470","https://openalex.org/W2133856765","https://openalex.org/W2137216702","https://openalex.org/W2144133378","https://openalex.org/W2150381557","https://openalex.org/W2152885278","https://openalex.org/W2156512552","https://openalex.org/W2158463067","https://openalex.org/W2159030941","https://openalex.org/W2165189852","https://openalex.org/W2171016495","https://openalex.org/W2277411172","https://openalex.org/W2330498227","https://openalex.org/W2337492846","https://openalex.org/W2404566241","https://openalex.org/W2463836225","https://openalex.org/W2470154003","https://openalex.org/W2548933161","https://openalex.org/W2559826890","https://openalex.org/W2563720483","https://openalex.org/W2571989678","https://openalex.org/W2592627283","https://openalex.org/W2605381669","https://openalex.org/W2724933633","https://openalex.org/W2742660525","https://openalex.org/W2753100975","https://openalex.org/W2754172044","https://openalex.org/W2783481349","https://openalex.org/W2801116332","https://openalex.org/W2810627187","https://openalex.org/W2883948616","https://openalex.org/W2888504723","https://openalex.org/W2904339023","https://openalex.org/W2914809023","https://openalex.org/W2948003108","https://openalex.org/W4211171511","https://openalex.org/W4211211437","https://openalex.org/W4251169171"],"related_works":["https://openalex.org/W3012468462","https://openalex.org/W3088631478","https://openalex.org/W2006157649","https://openalex.org/W3095216271","https://openalex.org/W2519453916","https://openalex.org/W3107364628","https://openalex.org/W4308429779","https://openalex.org/W4360584858","https://openalex.org/W2360942211","https://openalex.org/W3033040644"],"abstract_inverted_index":{"Abstract":[0],"Previous":[1],"studies":[2],"demonstrate":[3,116],"an":[4,40],"association":[5],"between":[6],"activation":[7,55],"of":[8,18,69,89,128,174,177,196],"the":[9,28,36,78,105,178],"maternal":[10,53],"immune":[11,54],"system":[12],"during":[13,65],"pregnancy":[14,66],"and":[15,25,47,171,207],"increased":[16,137],"risk":[17],"neurodevelopmental":[19,218],"psychiatric":[20,219],"conditions,":[21],"such":[22],"as":[23,212],"schizophrenia":[24],"autism,":[26],"in":[27,43,77,85,99,122,146,160],"offspring.":[29,124,149],"Relatively":[30],"recent":[31],"findings":[32,191],"also":[33,97],"suggest":[34,208],"that":[35,52,117],"gut":[37,151,169,179],"microbiota":[38,152],"plays":[39],"important":[41],"role":[42],"shaping":[44],"brain":[45,205],"development":[46],"behavior.":[48],"Here":[49],"we":[50,115],"show":[51],"(MIA)":[56],"accomplished":[57],"by":[58,199],"infection":[59],"with":[60,184],"a":[61,81,193,213],"mouse-adapted":[62],"influenza":[63],"virus":[64],"induced":[67,119],"up-regulation":[68],"frontal":[70,87,138,185],"cortex":[71,88,139,186],"serotonin":[72],"5-HT2A":[73],"receptor":[74],"(5-HT2AR)":[75],"density":[76,141],"adult":[79,123,147],"offspring,":[80],"phenotype":[82],"previously":[83],"observed":[84],"postmortem":[86],"schizophrenic":[90],"subjects.":[91],"5-HT2AR":[92,140,187],"agonist-induced":[93],"head-twitch":[94,144],"behavior":[95,145],"was":[96],"augmented":[98],"this":[100,132],"preclinical":[101],"mouse":[102],"model.":[103],"Using":[104],"novel":[106],"object":[107],"recognition":[108],"(NOR)":[109],"test":[110],"to":[111],"evaluate":[112],"cognitive":[113,133],"performance,":[114],"MIA":[118,148,155,165],"NOR":[120],"deficits":[121,159],"Oral":[125],"antibiotic":[126],"treatment":[127],"prepubertal":[129],"mice":[130,156],"prevented":[131],"impairment,":[134],"but":[135],"not":[136],"or":[142],"psychedelic-induced":[143],"Additionally,":[150],"transplantation":[153],"from":[154],"produced":[157],"behavioral":[158],"antibiotic-treated":[161],"mock":[162],"mice.":[163],"Adult":[164],"offspring":[166,204],"displayed":[167],"altered":[168],"microbiota,":[170,180],"relative":[172],"abundance":[173],"specific":[175],"components":[176],"including":[181],"Ruminococcaceae,":[182],"correlated":[183],"density.":[188],"Together,":[189],"these":[190],"provide":[192],"better":[194],"understanding":[195],"basic":[197],"mechanisms":[198],"which":[200],"prenatal":[201],"insults":[202],"impact":[203],"function,":[206],"gut-brain":[209],"axis":[210],"manipulation":[211],"potential":[214],"therapeutic":[215],"approach":[216],"for":[217],"conditions.":[220]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":4}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
