{"id":"https://openalex.org/W3011555804","doi":"https://doi.org/10.3760/cma.j.issn.1001-0939.2020.03.019","title":"[Detection of tuberculosis genes associated with drug-resistance in paraffin-embedded tissue specimens using next generation sequencing technology].","display_name":"[Detection of tuberculosis genes associated with drug-resistance in paraffin-embedded tissue specimens using next generation sequencing technology].","publication_year":2020,"publication_date":"2020-03-12","ids":{"openalex":"https://openalex.org/W3011555804","doi":"https://doi.org/10.3760/cma.j.issn.1001-0939.2020.03.019","mag":"3011555804","pmid":"https://pubmed.ncbi.nlm.nih.gov/32164095"},"language":"zh","primary_location":{"id":"pmid:32164095","doi":"https://doi.org/10.3760/cma.j.issn.1001-0939.2020.03.019","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32164095","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101994147","display_name":"Jing Song","orcid":"https://orcid.org/0000-0001-7146-7917","observed_orcids":["https://orcid.org/0000-0001-7146-7917"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210107581","display_name":"Beijing Chest Hospital","ror":"https://ror.org/01espdw89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210107581"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"J Song","raw_affiliation_strings":["Department of Pathology, Beijing Key Laboratory for Drug Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Beijing Key Laboratory for Drug Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210107581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083778564","display_name":"Zhiguo Zhang","orcid":"https://orcid.org/0000-0002-4501-6423","observed_orcids":["https://orcid.org/0000-0002-4501-6423"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Z G Zhang","raw_affiliation_strings":["Changping District Center for Tuberculosis Prevention and Treatment, Beijing 102200, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Changping District Center for Tuberculosis Prevention and Treatment, Beijing 102200, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101758452","display_name":"Yujie Dong","orcid":"https://orcid.org/0000-0002-2000-0484","observed_orcids":["https://orcid.org/0000-0002-2000-0484"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210107581","display_name":"Beijing Chest Hospital","ror":"https://ror.org/01espdw89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210107581"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Y J Dong","raw_affiliation_strings":["Department of Pathology, Beijing Key Laboratory for Drug Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Beijing Key Laboratory for Drug Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210107581"]}]},{"author_position":"middle","author":{"id":null,"display_name":"W L Du","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210107581","display_name":"Beijing Chest Hospital","ror":"https://ror.org/01espdw89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210107581"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"W L Du","raw_affiliation_strings":["Department of Pathology, Beijing Key Laboratory for Drug Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Beijing Key Laboratory for Drug Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210107581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100375999","display_name":"Yuxuan Wang","orcid":"https://orcid.org/0009-0009-8384-9918","observed_orcids":["https://orcid.org/0009-0009-8384-9918"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210107581","display_name":"Beijing Chest Hospital","ror":"https://ror.org/01espdw89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210107581"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Y X Wang","raw_affiliation_strings":["Department of Pathology, Beijing Key Laboratory for Drug Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Beijing Key Laboratory for Drug Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210107581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101818310","display_name":"Zichen Liu","orcid":"https://orcid.org/0000-0003-0807-9801","observed_orcids":["https://orcid.org/0000-0003-0807-9801","https://orcid.org/0009-0007-1137-3565"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210107581","display_name":"Beijing Chest Hospital","ror":"https://ror.org/01espdw89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210107581"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Z C Liu","raw_affiliation_strings":["Department of Pathology, Beijing Key Laboratory for Drug Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Beijing Key Laboratory for Drug Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210107581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002977955","display_name":"Kun Li","orcid":"https://orcid.org/0000-0003-0210-5167","observed_orcids":["https://orcid.org/0000-0003-0210-5167"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210107581","display_name":"Beijing Chest Hospital","ror":"https://ror.org/01espdw89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210107581"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"K Li","raw_affiliation_strings":["Department of Pathology, Beijing Key Laboratory for Drug Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Beijing Key Laboratory for Drug Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210107581"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Q Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Q Zhang","raw_affiliation_strings":["Changping District Center for Tuberculosis Prevention and Treatment, Beijing 102200, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Changping District Center for Tuberculosis Prevention and Treatment, Beijing 102200, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Q Sun","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Q Sun","raw_affiliation_strings":["Changping District Center for Tuberculosis Prevention and Treatment, Beijing 102200, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Changping District Center for Tuberculosis Prevention and Treatment, Beijing 102200, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035695385","display_name":"Nanying Che","orcid":"https://orcid.org/0000-0003-4179-1737","observed_orcids":["https://orcid.org/0000-0003-4179-1737"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210107581","display_name":"Beijing Chest Hospital","ror":"https://ror.org/01espdw89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210107581"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"N Y Che","raw_affiliation_strings":["Department of Pathology, Beijing Key Laboratory for Drug Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Beijing Key Laboratory for Drug Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210107581"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0366,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.41566853,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"43","issue":"3","first_page":"234","last_page":"241"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11316","display_name":"Mycobacterium research and diagnosis","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-resistant-tuberculosis","display_name":"drug-resistant tuberculosis","score":0.9800000190734863},{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.968999981880188},{"id":"https://openalex.org/keywords/drug-resistance-genes","display_name":"drug resistance genes","score":0.7850000262260437},{"id":"https://openalex.org/keywords/mutation","display_name":"genetic mutations","score":0.8140000104904175},{"id":"https://openalex.org/keywords/paraffin-embedded-tissue","display_name":"paraffin-embedded tissue","score":0.9580000042915344},{"id":"https://openalex.org/keywords/multiplex-pcr","display_name":"multiplex PCR","score":0.7099999785423279},{"id":"https://openalex.org/keywords/next-generation-sequencing","display_name":"next-generation sequencing","score":0.7459999918937683},{"id":"https://openalex.org/keywords/molecular-pathology","display_name":"molecular pathology","score":0.7200000286102295},{"id":"https://openalex.org/keywords/tuberculosis-diagnosis","display_name":"tuberculosis diagnosis","score":0.7599999904632568}],"concepts":[{"id":"https://openalex.org/C2776228421","wikidata":"https://www.wikidata.org/wiki/Q412318","display_name":"Ethambutol","level":4,"score":0.9219729900360107},{"id":"https://openalex.org/C2778607973","wikidata":"https://www.wikidata.org/wiki/Q422652","display_name":"Rifampicin","level":3,"score":0.7123615741729736},{"id":"https://openalex.org/C2776967927","wikidata":"https://www.wikidata.org/wiki/Q423169","display_name":"Isoniazid","level":3,"score":0.7020857930183411},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.6489325165748596},{"id":"https://openalex.org/C2775843808","wikidata":"https://www.wikidata.org/wiki/Q192717","display_name":"Streptomycin","level":3,"score":0.6289370059967041},{"id":"https://openalex.org/C2781019175","wikidata":"https://www.wikidata.org/wiki/Q415909","display_name":"Capreomycin","level":5,"score":0.6255877614021301},{"id":"https://openalex.org/C2777427914","wikidata":"https://www.wikidata.org/wiki/Q408529","display_name":"Amikacin","level":3,"score":0.624789297580719},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.6121360063552856},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.6091659069061279},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5320051312446594},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3885965049266815},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34986412525177},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.34302982687950134},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.2345174252986908},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.20831197500228882}],"mesh":[{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005798","descriptor_name":"Genes, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016612","descriptor_name":"Paraffin Embedding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018088","descriptor_name":"Tuberculosis, Multidrug-Resistant","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D024901","descriptor_name":"Drug Resistance, Multiple, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:32164095","doi":"https://doi.org/10.3760/cma.j.issn.1001-0939.2020.03.019","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32164095","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases","raw_type":"Journal Article"},{"id":"mag:3011555804","doi":"https://doi.org/10.3760/cma.j.issn.1001-0939.2020.03.019","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32164095","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4411182042","https://openalex.org/W4295027400","https://openalex.org/W2912771453","https://openalex.org/W7136034999","https://openalex.org/W3096014681","https://openalex.org/W4382602118","https://openalex.org/W4392353724","https://openalex.org/W3201655698","https://openalex.org/W4403503638","https://openalex.org/W7127366050"],"abstract_inverted_index":{"mPCR-NGS":[0,20],"showed":[1],"good":[2],"sensitivities":[3],"and":[4,16,28],"specificities":[5],"in":[6,12],"detecting":[7],"drug-resistant":[8,36],"gene":[9],"mutations":[10],"both":[11],"clinical":[13],"MTB":[14],"isolates":[15],"paraffin-embedded":[17],"tissue":[18],"specimens.":[19],"has":[21],"the":[22],"potential":[23],"to":[24],"be":[25],"an":[26],"accurate":[27],"rapid":[29],"molecular":[30],"pathological":[31],"technology":[32],"for":[33],"diagnosis":[34],"of":[35],"tuberculosis.":[37]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2020-03-23T00:00:00"}
