{"id":"https://openalex.org/W3011452829","doi":"https://doi.org/10.1200/jco.2006.24.18_suppl.5529","title":"A Phase II study of axitinib (AG-013736), a potent inhibitor of VEGFRs, in patients with advanced thyroid cancer","display_name":"A Phase II study of axitinib (AG-013736), a potent inhibitor of VEGFRs, in patients with advanced thyroid cancer","publication_year":2006,"publication_date":"2006-06-20","ids":{"openalex":"https://openalex.org/W3011452829","doi":"https://doi.org/10.1200/jco.2006.24.18_suppl.5529","mag":"3011452829"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2006.24.18_suppl.5529","doi":"https://doi.org/10.1200/jco.2006.24.18_suppl.5529","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2006.24.18_suppl.5529","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028773499","display_name":"S. Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Kim","raw_affiliation_strings":["Pfizer Global Research and Development, San Diego, CA; Premiere Oncology, Santa Monica, CA; University of Chicago Medical Center, Chicago, IL; Fox Chase Cancer Center, Philadelphia, PA; Johns Hopkins Oncology Center, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Global Research and Development, San Diego, CA; Premiere Oncology, Santa Monica, CA; University of Chicago Medical Center, Chicago, IL; Fox Chase Cancer Center, Philadelphia, PA; Johns Hopkins Oncology Center, Baltimore, MD","institution_ids":["https://openalex.org/I1289437631","https://openalex.org/I145311948","https://openalex.org/I4210087865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037497042","display_name":"Lee S. Rosen","orcid":"https://orcid.org/0000-0003-2503-6133","observed_orcids":["https://orcid.org/0000-0003-2503-6133"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. S. Rosen","raw_affiliation_strings":["Pfizer Global Research and Development, San Diego, CA; Premiere Oncology, Santa Monica, CA; University of Chicago Medical Center, Chicago, IL; Fox Chase Cancer Center, Philadelphia, PA; Johns Hopkins Oncology Center, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Global Research and Development, San Diego, CA; Premiere Oncology, Santa Monica, CA; University of Chicago Medical Center, Chicago, IL; Fox Chase Cancer Center, Philadelphia, PA; Johns Hopkins Oncology Center, Baltimore, MD","institution_ids":["https://openalex.org/I1289437631","https://openalex.org/I145311948","https://openalex.org/I4210087865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001334189","display_name":"Ezra E.W. Cohen","orcid":"https://orcid.org/0000-0002-9872-6242","observed_orcids":["https://orcid.org/0000-0002-9872-6242"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. E. Cohen","raw_affiliation_strings":["Pfizer Global Research and Development, San Diego, CA; Premiere Oncology, Santa Monica, CA; University of Chicago Medical Center, Chicago, IL; Fox Chase Cancer Center, Philadelphia, PA; Johns Hopkins Oncology Center, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Global Research and Development, San Diego, CA; Premiere Oncology, Santa Monica, CA; University of Chicago Medical Center, Chicago, IL; Fox Chase Cancer Center, Philadelphia, PA; Johns Hopkins Oncology Center, Baltimore, MD","institution_ids":["https://openalex.org/I1289437631","https://openalex.org/I145311948","https://openalex.org/I4210087865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110382646","display_name":"Roger B. Cohen","orcid":"https://orcid.org/0009-0004-7423-2653","observed_orcids":["https://orcid.org/0009-0004-7423-2653"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. B. Cohen","raw_affiliation_strings":["Pfizer Global Research and Development, San Diego, CA; Premiere Oncology, Santa Monica, CA; University of Chicago Medical Center, Chicago, IL; Fox Chase Cancer Center, Philadelphia, PA; Johns Hopkins Oncology Center, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Global Research and Development, San Diego, CA; Premiere Oncology, Santa Monica, CA; University of Chicago Medical Center, Chicago, IL; Fox Chase Cancer Center, Philadelphia, PA; Johns Hopkins Oncology Center, Baltimore, MD","institution_ids":["https://openalex.org/I1289437631","https://openalex.org/I145311948","https://openalex.org/I4210087865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039206387","display_name":"A.A. Forastiere","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Forastiere","raw_affiliation_strings":["Pfizer Global Research and Development, San Diego, CA; Premiere Oncology, Santa Monica, CA; University of Chicago Medical Center, Chicago, IL; Fox Chase Cancer Center, Philadelphia, PA; Johns Hopkins Oncology Center, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Global Research and Development, San Diego, CA; Premiere Oncology, Santa Monica, CA; University of Chicago Medical Center, Chicago, IL; Fox Chase Cancer Center, Philadelphia, PA; Johns Hopkins Oncology Center, Baltimore, MD","institution_ids":["https://openalex.org/I1289437631","https://openalex.org/I145311948","https://openalex.org/I4210087865"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A. M. Silva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. M. Silva","raw_affiliation_strings":["Pfizer Global Research and Development, San Diego, CA; Premiere Oncology, Santa Monica, CA; University of Chicago Medical Center, Chicago, IL; Fox Chase Cancer Center, Philadelphia, PA; Johns Hopkins Oncology Center, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Global Research and Development, San Diego, CA; Premiere Oncology, Santa Monica, CA; University of Chicago Medical Center, Chicago, IL; Fox Chase Cancer Center, Philadelphia, PA; Johns Hopkins Oncology Center, Baltimore, MD","institution_ids":["https://openalex.org/I1289437631","https://openalex.org/I145311948","https://openalex.org/I4210087865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091509242","display_name":"Katherine Liau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. F. Liau","raw_affiliation_strings":["Pfizer Global Research and Development, San Diego, CA; Premiere Oncology, Santa Monica, CA; University of Chicago Medical Center, Chicago, IL; Fox Chase Cancer Center, Philadelphia, PA; Johns Hopkins Oncology Center, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Global Research and Development, San Diego, CA; Premiere Oncology, Santa Monica, CA; University of Chicago Medical Center, Chicago, IL; Fox Chase Cancer Center, Philadelphia, PA; Johns Hopkins Oncology Center, Baltimore, MD","institution_ids":["https://openalex.org/I1289437631","https://openalex.org/I145311948","https://openalex.org/I4210087865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111922117","display_name":"ROBERT L. ARCHER","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. L. Archer","raw_affiliation_strings":["Pfizer Global Research and Development, San Diego, CA; Premiere Oncology, Santa Monica, CA; University of Chicago Medical Center, Chicago, IL; Fox Chase Cancer Center, Philadelphia, PA; Johns Hopkins Oncology Center, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Global Research and Development, San Diego, CA; Premiere Oncology, Santa Monica, CA; University of Chicago Medical Center, Chicago, IL; Fox Chase Cancer Center, Philadelphia, PA; Johns Hopkins Oncology Center, Baltimore, MD","institution_ids":["https://openalex.org/I1289437631","https://openalex.org/I145311948","https://openalex.org/I4210087865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025882028","display_name":"Paul W. Bycott","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. Bycott","raw_affiliation_strings":["Pfizer Global Research and Development, San Diego, CA; Premiere Oncology, Santa Monica, CA; University of Chicago Medical Center, Chicago, IL; Fox Chase Cancer Center, Philadelphia, PA; Johns Hopkins Oncology Center, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Global Research and Development, San Diego, CA; Premiere Oncology, Santa Monica, CA; University of Chicago Medical Center, Chicago, IL; Fox Chase Cancer Center, Philadelphia, PA; Johns Hopkins Oncology Center, Baltimore, MD","institution_ids":["https://openalex.org/I1289437631","https://openalex.org/I145311948","https://openalex.org/I4210087865"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063904421","display_name":"Everett E. Vokes","orcid":"https://orcid.org/0000-0002-8645-8068","observed_orcids":["https://orcid.org/0000-0002-8645-8068"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. E. Vokes","raw_affiliation_strings":["Pfizer Global Research and Development, San Diego, CA; Premiere Oncology, Santa Monica, CA; University of Chicago Medical Center, Chicago, IL; Fox Chase Cancer Center, Philadelphia, PA; Johns Hopkins Oncology Center, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Global Research and Development, San Diego, CA; Premiere Oncology, Santa Monica, CA; University of Chicago Medical Center, Chicago, IL; Fox Chase Cancer Center, Philadelphia, PA; Johns Hopkins Oncology Center, Baltimore, MD","institution_ids":["https://openalex.org/I1289437631","https://openalex.org/I145311948","https://openalex.org/I4210087865"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"18_suppl","first_page":"5529","last_page":"5529"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/axitinib","display_name":"axitinib","score":0.9959999918937683},{"id":"https://openalex.org/keywords/vegfr-tyrosine-kinase-inhibitors","display_name":"VEGFR inhibitors","score":0.718999981880188},{"id":"https://openalex.org/keywords/advanced-thyroid-cancer","display_name":"advanced thyroid cancer","score":0.9879999756813049},{"id":"https://openalex.org/keywords/refractory-thyroid-cancer","display_name":"refractory thyroid cancer","score":0.8560000061988831},{"id":"https://openalex.org/keywords/papillary-thyroid-carcinoma","display_name":"papillary thyroid carcinoma","score":0.8650000095367432},{"id":"https://openalex.org/keywords/follicular-thyroid-carcinoma","display_name":"follicular thyroid carcinoma","score":0.9879999756813049},{"id":"https://openalex.org/keywords/medullary-thyroid-carcinoma","display_name":"medullary thyroid carcinoma","score":0.7960000038146973},{"id":"https://openalex.org/keywords/anaplastic-thyroid-carcinoma","display_name":"anaplastic thyroid carcinoma","score":0.9729999899864197},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.6909999847412109},{"id":"https://openalex.org/keywords/antitumor-efficacy","display_name":"antitumor efficacy","score":0.5419999957084656},{"id":"https://openalex.org/keywords/safety","display_name":"safety","score":0.46000000834465027},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.6919999718666077},{"id":"https://openalex.org/keywords/pdgfrbeta","display_name":"PDGFR\u03b2","score":0.550000011920929},{"id":"https://openalex.org/keywords/kit","display_name":"KIT","score":0.9760000109672546},{"id":"https://openalex.org/keywords/minimax-design","display_name":"minimax design","score":0.48899999260902405}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9120503664016724},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6393548250198364},{"id":"https://openalex.org/C2776539811","wikidata":"https://www.wikidata.org/wiki/Q4830631","display_name":"Axitinib","level":4,"score":0.6001842021942139},{"id":"https://openalex.org/C2779761222","wikidata":"https://www.wikidata.org/wiki/Q826522","display_name":"Thyroid cancer","level":3,"score":0.5992357730865479},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.548659086227417},{"id":"https://openalex.org/C2779341817","wikidata":"https://www.wikidata.org/wiki/Q5464665","display_name":"Follicular thyroid cancer","level":5,"score":0.5103279948234558},{"id":"https://openalex.org/C2780120053","wikidata":"https://www.wikidata.org/wiki/Q3493538","display_name":"Medullary thyroid cancer","level":4,"score":0.5025088787078857},{"id":"https://openalex.org/C187785154","wikidata":"https://www.wikidata.org/wiki/Q5464664","display_name":"Follicular phase","level":2,"score":0.4829082489013672},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.46925875544548035},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.44665876030921936},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4331231117248535},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.42318984866142273},{"id":"https://openalex.org/C2781461381","wikidata":"https://www.wikidata.org/wiki/Q2292945","display_name":"Papillary thyroid cancer","level":4,"score":0.4047560393810272},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.37559622526168823},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3330671191215515},{"id":"https://openalex.org/C2779490328","wikidata":"https://www.wikidata.org/wiki/Q417542","display_name":"Sunitinib","level":3,"score":0.2063642144203186},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2006.24.18_suppl.5529","doi":"https://doi.org/10.1200/jco.2006.24.18_suppl.5529","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2006.24.18_suppl.5529","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8500000238418579}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2252381540","https://openalex.org/W2010384685","https://openalex.org/W2069132726","https://openalex.org/W2106695112","https://openalex.org/W2312568845","https://openalex.org/W2086108795","https://openalex.org/W1996368888","https://openalex.org/W7097860576","https://openalex.org/W7075699784","https://openalex.org/W2133388512"],"abstract_inverted_index":{"5529":[0],"Background:":[1],"Elevated":[2],"levels":[3],"of":[4,25,77,91,130,162],"VEGF":[5],"have":[6,247,256],"been":[7,291],"found":[8],"in":[9,50,65,231,241,348,357,370],"thyroid":[10,97,359],"tumor":[11],"tissue":[12],"compared":[13],"to":[14,104],"normal":[15],"thyroid.":[16],"Axitinib":[17],"(AG-013736)":[18],"is":[19,229,281,362,373],"a":[20,73],"novel":[21],"small":[22],"molecule":[23],"inhibitor":[24],"the":[26,58,87],"receptor":[27],"tyrosine":[28],"kinases":[29],"with":[30,72,115,234,365],"picomolar":[31],"potency":[32,41],"against":[33,42],"VEGFR":[34],"1,":[35],"2":[36,136,190,344,349],"&":[37],"3":[38,232,242,262,267,319],"and":[39,44,89,125,193,237,266],"nanomolar":[40],"PDGFR-beta":[43],"KIT.":[45],"A":[46,61,134],"phase":[47,62],"I":[48],"study":[49,64,85,280],"solid":[51],"tumors":[52],"identified":[53],"5":[54,117],"mg":[55,118],"BID":[56],"as":[57,224,305],"therapeutic":[59],"dose.":[60],"II":[63],"renal":[66],"cell":[67],"cancer":[68],"demonstrated":[69],"significant":[70],"efficacy":[71,90],"response":[74,149,223],"rate":[75,150],"(RR)":[76,151],"46%":[78],"(Rini":[79],"et":[80],"al,":[81],"ASCO":[82],"2005).":[83],"This":[84],"examined":[86],"safety":[88,294],"AG-013736":[92,352],"(AG)":[93],"therapy":[94],"for":[95,109,277,296],"advanced":[96,358],"cancer.":[98,360],"Methods:":[99],"32":[100,163],"patients":[101,255],"(pts)":[102],"refractory":[103],"or":[105,132],"not":[106,290],"suitable":[107],"candidates":[108],"Iodine":[110],"(131I)":[111],"treatment":[112,302],"were":[113,172,176],"treated":[114],"AG":[116],"p.o.":[119],"BID.":[120],"Eligibility":[121],"included":[122],"measurable":[123],"disease":[124],"ECOG":[126],"performance":[127],"status":[128],"(PS)":[129],"0":[131],"1.":[133],"Simon":[135],"stage":[137],"minimax":[138],"design":[139],"was":[140,166,346],"used":[141],"(alpha":[142],"=":[143,146,152,156],"0.1;":[144,147],"beta":[145],"null":[148],"5%;":[153],"alternative":[154],"RR":[155],"20%).":[157],"Results:":[158],"The":[159,275],"median":[160],"age":[161],"enrolled":[164],"pts":[165,183,187,191,195,198,204,211,217,233,245,260,270,298],"63":[167],"yrs":[168],"(35\u201381),":[169],"20":[170],"(63%)":[171,271],"male,":[173],"12":[174,254],"(38%)":[175],"female.":[177],"Histological":[178],"subtypes":[179],"include":[180,321],"papillary:":[181],"19":[182,203],"(59%);":[184],"follicular-":[185],"9":[186],"(28%),":[188],"medullary-":[189],"(6%)":[192],"anaplastic-2":[194],"(6%).":[196],"25":[197],"(78%)":[199],"had":[200,206,213,219],"prior":[201,207,214,220],"surgery,":[202],"(59%)":[205],"131I":[208],"treatment,":[209],"15":[210],"(47%)":[212],"RT,":[215],"6":[216,259],"(19%)":[218],"Adriamycin.":[221],"Best":[222],"assessed":[225],"by":[226],"RECIST":[227],"criteria":[228],"PR":[230],"38%-48%":[235],"regression":[236],"additional":[238],"unconfirmed":[239],"PRs":[240],"pts.":[243,350],"Two":[244],"(follicular)":[246],"PR>12":[248],"mos.":[249],"Response":[250],"assessments":[251],"are":[252],"ongoing.":[253],"discontinued":[257],"treatment:":[258],"(19%)-progression,":[261],"pts-adverse":[263],"events":[264],"(AEs)":[265],"pts-other.":[268],"Twenty":[269],"remain":[272],"on":[273,279],"study.":[274],"range":[276],"time":[278],"(6,":[282],"469)":[283],"days.":[284],"Median":[285],"progression":[286],"free":[287],"survival":[288],"has":[289,353],"reached.":[292],"Preliminary":[293],"data":[295],"17":[297],"indicate":[299],"most":[300],"common":[301],"emergent":[303],"AEs":[304,320],"fatigue":[306,336],"(9":[307],"pts),":[308,311],"nausea":[309],"(5":[310],"proteinuria":[312,322],"(":[313,323],"5pts":[314],"),":[315,325],"dizziness":[316],"(4pts).":[317],"Gr.":[318,343],"2pts":[324],"cough":[326],"(1pt),":[327,333,335,337,340],"dyspnea":[328],"(1":[329],"pt),":[330],"abdominal":[331],"pain":[332],"dysphagia":[334],"muscle":[338],"weakness":[339],"anorexia":[341],"(1pt).":[342],"hypertension":[345],"observed":[347],"Conclusions:":[351],"substantial":[354],"anti-tumor":[355],"activity":[356],"Therapy":[361],"well":[363],"tolerated":[364],"manageable":[366],"toxicity.":[367],"Further":[368],"investigation":[369],"this":[371],"setting":[372],"warranted.":[374],"[Table:":[375],"see":[376],"text]":[377]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2020-03-23T00:00:00"}
