{"id":"https://openalex.org/W3011382181","doi":null,"title":"Using BXD mouse strains in vision research: A systems genetics approach.","display_name":"Using BXD mouse strains in vision research: A systems genetics approach.","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3011382181","mag":"3011382181","pmid":"https://pubmed.ncbi.nlm.nih.gov/32180682","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7058434"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7058434","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7058434","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7058434","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045113631","display_name":"Eldon E. Geisert","orcid":"https://orcid.org/0000-0003-0787-4416","observed_orcids":["https://orcid.org/0000-0003-0787-4416"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eldon E Geisert","raw_affiliation_strings":["Department of Ophthalmology, Emory University, 1365B Clifton Road NE Atlanta GA, 30322"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Emory University, 1365B Clifton Road NE Atlanta GA, 30322","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000103692","display_name":"Robert W. Williams","orcid":"https://orcid.org/0000-0001-8924-4447","observed_orcids":["https://orcid.org/0000-0001-8924-4447","https://orcid.org/0000-0002-6174-3209"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert W Williams","raw_affiliation_strings":["Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, 71 S Manassas St, Memphis TN 38163"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, 71 S Manassas St, Memphis TN 38163","institution_ids":["https://openalex.org/I160606119"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.7944,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.9035019,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"26","issue":null,"first_page":"173","last_page":"187"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bxd-mouse-strains","display_name":"BXD mouse strains","score":0.9779999852180481},{"id":"https://openalex.org/keywords/systems-genetics","display_name":"systems genetics","score":0.9340000152587891},{"id":"https://openalex.org/keywords/vision-research","display_name":"visual research","score":0.781000018119812},{"id":"https://openalex.org/keywords/glaucoma","display_name":"glaucoma","score":0.8650000095367432},{"id":"https://openalex.org/keywords/retinal-ganglion-cells","display_name":"retinal ganglion cells","score":0.890999972820282},{"id":"https://openalex.org/keywords/elevated-intraocular-pressure","display_name":"intraocular pressure elevation","score":0.8489999771118164},{"id":"https://openalex.org/keywords/genetic-variants","display_name":"genetic variants","score":0.6589999794960022},{"id":"https://openalex.org/keywords/susceptibility-genes","display_name":"susceptibility genes","score":0.39899998903274536}],"concepts":[{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5843058824539185},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5648192167282104},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4323465824127197},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.37766239047050476}],"mesh":[{"descriptor_ui":"D000444","descriptor_name":"Aldehyde Dehydrogenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000444","descriptor_name":"Aldehyde Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003315","descriptor_name":"Cornea","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D003315","descriptor_name":"Cornea","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003315","descriptor_name":"Cornea","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007429","descriptor_name":"Intraocular Pressure","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007429","descriptor_name":"Intraocular Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008811","descriptor_name":"Mice, Inbred DBA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012165","descriptor_name":"Retinal Ganglion Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050809","descriptor_name":"POU Domain Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050809","descriptor_name":"POU Domain Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:7058434","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7058434","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},{"id":"pmid:32180682","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32180682","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Journal Article"},{"id":"mag:3011382181","doi":null,"is_oa":true,"landing_page_url":"https://europepmc.org/article/MED/32180682","pdf_url":null,"source":{"id":"https://openalex.org/S182284546","display_name":"Molecular vision","issn_l":"1090-0535","issn":["1090-0535"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315722","host_organization_name":"Emory University","host_organization_lineage":["https://openalex.org/P4310315722"],"host_organization_lineage_names":["Emory University"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Molecular vision","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7058434","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7058434","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G170978301","display_name":"Overall NIDA Core \"Center of Excellence\" in Transcriptomics, Systems Genetics and the Addictome","funder_award_id":"P30DA044223","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G4579318641","display_name":"Modulators of Retinal Injury","funder_award_id":"R01EY017841","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G4603954669","display_name":"A Unified High Performance Web Service for Systems Genetics and Precision Medicine","funder_award_id":"R01GM123489","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000860143","display_name":"P30-Core Grant for Vision Research","funder_award_id":"P30EY006360","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":117,"referenced_works":["https://openalex.org/W93966645","https://openalex.org/W1129919997","https://openalex.org/W1562714951","https://openalex.org/W1574402411","https://openalex.org/W1575291820","https://openalex.org/W1595691218","https://openalex.org/W1599235209","https://openalex.org/W1653136022","https://openalex.org/W1861416728","https://openalex.org/W1939621514","https://openalex.org/W1960721561","https://openalex.org/W1964675499","https://openalex.org/W1964719402","https://openalex.org/W1969293572","https://openalex.org/W1971583765","https://openalex.org/W1974273434","https://openalex.org/W1977294643","https://openalex.org/W1983740408","https://openalex.org/W1983880505","https://openalex.org/W1988506908","https://openalex.org/W1989399186","https://openalex.org/W1991677561","https://openalex.org/W1999473458","https://openalex.org/W2001378198","https://openalex.org/W2002142934","https://openalex.org/W2013859310","https://openalex.org/W2017702277","https://openalex.org/W2019742519","https://openalex.org/W2022209206","https://openalex.org/W2024048826","https://openalex.org/W2027753607","https://openalex.org/W2032124492","https://openalex.org/W2037056548","https://openalex.org/W2040045236","https://openalex.org/W2042335805","https://openalex.org/W2044753638","https://openalex.org/W2049090757","https://openalex.org/W2052058687","https://openalex.org/W2058450943","https://openalex.org/W2064676287","https://openalex.org/W2066300602","https://openalex.org/W2075077772","https://openalex.org/W2077037485","https://openalex.org/W2085167343","https://openalex.org/W2086863589","https://openalex.org/W2091151219","https://openalex.org/W2092433966","https://openalex.org/W2093683922","https://openalex.org/W2100159037","https://openalex.org/W2105753034","https://openalex.org/W2106433994","https://openalex.org/W2106972194","https://openalex.org/W2109724812","https://openalex.org/W2117108791","https://openalex.org/W2118526609","https://openalex.org/W2120711134","https://openalex.org/W2126161265","https://openalex.org/W2132846716","https://openalex.org/W2136093811","https://openalex.org/W2138422160","https://openalex.org/W2139651996","https://openalex.org/W2145908472","https://openalex.org/W2147122728","https://openalex.org/W2147490548","https://openalex.org/W2151671159","https://openalex.org/W2155286781","https://openalex.org/W2161852106","https://openalex.org/W2165756541","https://openalex.org/W2203538494","https://openalex.org/W2257300821","https://openalex.org/W2265638154","https://openalex.org/W2294907207","https://openalex.org/W2295639051","https://openalex.org/W2313839883","https://openalex.org/W2321918144","https://openalex.org/W2412494787","https://openalex.org/W2430562598","https://openalex.org/W2503761780","https://openalex.org/W2524796157","https://openalex.org/W2558201052","https://openalex.org/W2560006298","https://openalex.org/W2560147609","https://openalex.org/W2560192623","https://openalex.org/W2560195165","https://openalex.org/W2560849088","https://openalex.org/W2568000928","https://openalex.org/W2573448684","https://openalex.org/W2578593822","https://openalex.org/W2585780878","https://openalex.org/W2593070567","https://openalex.org/W2609761914","https://openalex.org/W2616754551","https://openalex.org/W2618870156","https://openalex.org/W2623499978","https://openalex.org/W2625412183","https://openalex.org/W2740078953","https://openalex.org/W2744291640","https://openalex.org/W2753388315","https://openalex.org/W2765361998","https://openalex.org/W2769910208","https://openalex.org/W2771217310","https://openalex.org/W2774609083","https://openalex.org/W2775174939","https://openalex.org/W2788908583","https://openalex.org/W2796272779","https://openalex.org/W2801908338","https://openalex.org/W2803323905","https://openalex.org/W2807017062","https://openalex.org/W2884990155","https://openalex.org/W2890292817","https://openalex.org/W2922525825","https://openalex.org/W2949417290","https://openalex.org/W2949949104","https://openalex.org/W2952014132","https://openalex.org/W2954140492","https://openalex.org/W3000547714","https://openalex.org/W4241513017"],"related_works":["https://openalex.org/W2952014132","https://openalex.org/W2587909563","https://openalex.org/W2342156798","https://openalex.org/W7171434047","https://openalex.org/W2295639051","https://openalex.org/W1121710353","https://openalex.org/W3177808507","https://openalex.org/W3043041046","https://openalex.org/W2026733101","https://openalex.org/W2949949104"],"abstract_inverted_index":{"as":[0],"a":[1],"gene":[2,20],"that":[3],"modulates":[4],"the":[5,28,32],"susceptibility":[6],"of":[7,16,18],"RGCs":[8],"to":[9],"death":[10],"after":[11],"elevated":[12],"IOP.":[13],"The":[14],"role":[15],"three":[17],"these":[19],"variants":[21],"in":[22,31],"glaucoma":[23],"is":[24],"discussed,":[25],"along":[26],"with":[27],"pathways":[29],"activated":[30],"disease":[33],"process.":[34]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2020-03-23T00:00:00"}