{"id":"https://openalex.org/W3011290863","doi":"https://doi.org/10.1200/jco.2012.30.15_suppl.8066","title":"Dose- and time-intensified ABVD without radiotherapy (RT) for advanced-stage Hodgkin lymphoma (HL) with mediastinal bulky disease (MBD).","display_name":"Dose- and time-intensified ABVD without radiotherapy (RT) for advanced-stage Hodgkin lymphoma (HL) with mediastinal bulky disease (MBD).","publication_year":2012,"publication_date":"2012-05-20","ids":{"openalex":"https://openalex.org/W3011290863","doi":"https://doi.org/10.1200/jco.2012.30.15_suppl.8066","mag":"3011290863"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2012.30.15_suppl.8066","doi":"https://doi.org/10.1200/jco.2012.30.15_suppl.8066","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2012.30.15_suppl.8066","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087147482","display_name":"Gaetano Corazzelli","orcid":"https://orcid.org/0000-0002-9548-4807","observed_orcids":["https://orcid.org/0000-0002-9548-4807"]},"institutions":[{"id":"https://openalex.org/I4210141868","display_name":"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","ror":"https://ror.org/0506y2b23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141868","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gaetano Corazzelli","raw_affiliation_strings":["Hematology-Oncology and Stem Cell Transplantation Unit, Istituto Nazionale Tumori, Fondazione \"G.Pascale\", Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology-Oncology and Stem Cell Transplantation Unit, Istituto Nazionale Tumori, Fondazione \"G.Pascale\", Naples, Italy","institution_ids":["https://openalex.org/I4210141868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016024062","display_name":"Filippo Russo","orcid":"https://orcid.org/0000-0001-8128-9878","observed_orcids":["https://orcid.org/0000-0001-8128-9878"]},"institutions":[{"id":"https://openalex.org/I4210141868","display_name":"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","ror":"https://ror.org/0506y2b23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141868","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Filippo Russo","raw_affiliation_strings":["Hematology-Oncology and Stem Cell Transplantation Unit, Istituto Nazionale Tumori, Fondazione \"G.Pascale\", Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology-Oncology and Stem Cell Transplantation Unit, Istituto Nazionale Tumori, Fondazione \"G.Pascale\", Naples, Italy","institution_ids":["https://openalex.org/I4210141868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077919557","display_name":"Ferdinando Frigeri","orcid":"https://orcid.org/0000-0002-9818-3073","observed_orcids":["https://orcid.org/0000-0002-9818-3073"]},"institutions":[{"id":"https://openalex.org/I4210141868","display_name":"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","ror":"https://ror.org/0506y2b23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141868","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ferdinando Frigeri","raw_affiliation_strings":["Hematology-Oncology and Stem Cell Transplantation Unit, Istituto Nazionale Tumori, Fondazione \"G.Pascale\", Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology-Oncology and Stem Cell Transplantation Unit, Istituto Nazionale Tumori, Fondazione \"G.Pascale\", Naples, Italy","institution_ids":["https://openalex.org/I4210141868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073061488","display_name":"Francesco Volzone","orcid":"https://orcid.org/0000-0001-6509-0578","observed_orcids":["https://orcid.org/0000-0001-6509-0578"]},"institutions":[{"id":"https://openalex.org/I4210141868","display_name":"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","ror":"https://ror.org/0506y2b23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141868","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Volzone","raw_affiliation_strings":["Hematology-Oncology and Stem Cell Transplantation Unit, Istituto Nazionale Tumori, Fondazione \"G.Pascale\", Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology-Oncology and Stem Cell Transplantation Unit, Istituto Nazionale Tumori, Fondazione \"G.Pascale\", Naples, Italy","institution_ids":["https://openalex.org/I4210141868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103735331","display_name":"Gaetana Capobianco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141868","display_name":"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","ror":"https://ror.org/0506y2b23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141868","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gaetana Capobianco","raw_affiliation_strings":["Hematology-Oncology and Stem Cell Transplantation Unit, Istituto Nazionale Tumori, Fondazione \"G.Pascale\", Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology-Oncology and Stem Cell Transplantation Unit, Istituto Nazionale Tumori, Fondazione \"G.Pascale\", Naples, Italy","institution_ids":["https://openalex.org/I4210141868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024386803","display_name":"Manuela Arcamone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141868","display_name":"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","ror":"https://ror.org/0506y2b23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141868","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Manuela Arcamone","raw_affiliation_strings":["Hematology-Oncology and Stem Cell Transplantation Unit, Istituto Nazionale Tumori, Fondazione \"G.Pascale\", Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology-Oncology and Stem Cell Transplantation Unit, Istituto Nazionale Tumori, Fondazione \"G.Pascale\", Naples, Italy","institution_ids":["https://openalex.org/I4210141868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063945951","display_name":"Emanuela Morelli","orcid":"https://orcid.org/0000-0001-8704-9330","observed_orcids":["https://orcid.org/0000-0001-8704-9330"]},"institutions":[{"id":"https://openalex.org/I4210141868","display_name":"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","ror":"https://ror.org/0506y2b23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141868","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Emanuela Morelli","raw_affiliation_strings":["Hematology-Oncology and Stem Cell Transplantation Unit, Istituto Nazionale Tumori, Fondazione \"G.Pascale\", Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology-Oncology and Stem Cell Transplantation Unit, Istituto Nazionale Tumori, Fondazione \"G.Pascale\", Naples, Italy","institution_ids":["https://openalex.org/I4210141868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008520736","display_name":"Cristina Becchimanzi","orcid":"https://orcid.org/0000-0003-1299-6573","observed_orcids":["https://orcid.org/0000-0003-1299-6573"]},"institutions":[{"id":"https://openalex.org/I4210141868","display_name":"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","ror":"https://ror.org/0506y2b23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141868","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cristina Becchimanzi","raw_affiliation_strings":["Hematology-Oncology and Stem Cell Transplantation Unit, Istituto Nazionale Tumori, Fondazione \"G.Pascale\", Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology-Oncology and Stem Cell Transplantation Unit, Istituto Nazionale Tumori, Fondazione \"G.Pascale\", Naples, Italy","institution_ids":["https://openalex.org/I4210141868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087324886","display_name":"Giampaolo Marcacci","orcid":"https://orcid.org/0000-0002-4051-0756","observed_orcids":["https://orcid.org/0000-0002-4051-0756"]},"institutions":[{"id":"https://openalex.org/I4210141868","display_name":"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","ror":"https://ror.org/0506y2b23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141868","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giampaolo Marcacci","raw_affiliation_strings":["Hematology-Oncology and Stem Cell Transplantation Unit, Istituto Nazionale Tumori, Fondazione \"G.Pascale\", Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology-Oncology and Stem Cell Transplantation Unit, Istituto Nazionale Tumori, Fondazione \"G.Pascale\", Naples, Italy","institution_ids":["https://openalex.org/I4210141868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035514953","display_name":"Rosaria De Filippi","orcid":"https://orcid.org/0000-0001-7899-3071","observed_orcids":["https://orcid.org/0000-0001-7899-3071"]},"institutions":[{"id":"https://openalex.org/I4210141868","display_name":"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","ror":"https://ror.org/0506y2b23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141868","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rosaria De Filippi","raw_affiliation_strings":["Hematology-Oncology and Stem Cell Transplantation Unit, Istituto Nazionale Tumori, Fondazione \"G.Pascale\", Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology-Oncology and Stem Cell Transplantation Unit, Istituto Nazionale Tumori, Fondazione \"G.Pascale\", Naples, Italy","institution_ids":["https://openalex.org/I4210141868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058257085","display_name":"Mariangela Saggese","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141868","display_name":"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","ror":"https://ror.org/0506y2b23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141868","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mariangela Saggese","raw_affiliation_strings":["Hematology-Oncology and Stem Cell Transplantation Unit, Istituto Nazionale Tumori, Fondazione \"G.Pascale\", Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology-Oncology and Stem Cell Transplantation Unit, Istituto Nazionale Tumori, Fondazione \"G.Pascale\", Naples, Italy","institution_ids":["https://openalex.org/I4210141868"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033029228","display_name":"Antonio Pinto","orcid":"https://orcid.org/0000-0002-9425-9026","observed_orcids":["https://orcid.org/0000-0002-9425-9026"]},"institutions":[{"id":"https://openalex.org/I4210141868","display_name":"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","ror":"https://ror.org/0506y2b23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141868","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonio Pinto","raw_affiliation_strings":["Hematology-Oncology and Stem Cell Transplantation Unit, Istituto Nazionale Tumori, Fondazione \"G.Pascale\", Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology-Oncology and Stem Cell Transplantation Unit, Istituto Nazionale Tumori, Fondazione \"G.Pascale\", Naples, Italy","institution_ids":["https://openalex.org/I4210141868"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210141868"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"30","issue":"15_suppl","first_page":"8066","last_page":"8066"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hodgkin-lymphoma","display_name":"Hodgkin's disease","score":0.8519999980926514},{"id":"https://openalex.org/keywords/abvd","display_name":"ABVD chemotherapy","score":0.8849999904632568},{"id":"https://openalex.org/keywords/dose-intensification","display_name":"dose intensification","score":0.8130000233650208},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.8479999899864197},{"id":"https://openalex.org/keywords/granulocyte-colony-stimulating-factor","display_name":"granulocyte colony-stimulating factor","score":0.7789999842643738},{"id":"https://openalex.org/keywords/complete-response","display_name":"complete response","score":0.7170000076293945},{"id":"https://openalex.org/keywords/event-free-survival","display_name":"event-free survival","score":0.9259999990463257},{"id":"https://openalex.org/keywords/advanced-stage-hodgkin-lymphoma","display_name":"advanced-stage Hodgkin lymphoma","score":0.6710000038146973},{"id":"https://openalex.org/keywords/phase-ii-trial-results","display_name":"phase II trial results","score":0.4359999895095825}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9297770261764526},{"id":"https://openalex.org/C2776305933","wikidata":"https://www.wikidata.org/wiki/Q287631","display_name":"ABVD","level":5,"score":0.8869932889938354},{"id":"https://openalex.org/C2780964509","wikidata":"https://www.wikidata.org/wiki/Q416975","display_name":"Dacarbazine","level":3,"score":0.7203304171562195},{"id":"https://openalex.org/C2777132456","wikidata":"https://www.wikidata.org/wiki/Q282629","display_name":"Vinblastine","level":3,"score":0.7015733122825623},{"id":"https://openalex.org/C2776232574","wikidata":"https://www.wikidata.org/wiki/Q415571","display_name":"Bleomycin","level":3,"score":0.5103532671928406},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.48537957668304443},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.47040945291519165},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.44476258754730225},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41275784373283386},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3965751528739929},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.35083550214767456},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3226831555366516},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.30019456148147583},{"id":"https://openalex.org/C2779429289","wikidata":"https://www.wikidata.org/wiki/Q408977","display_name":"Vincristine","level":4,"score":0.23530858755111694},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2012.30.15_suppl.8066","doi":"https://doi.org/10.1200/jco.2012.30.15_suppl.8066","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2012.30.15_suppl.8066","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W6941047264","https://openalex.org/W1968882633","https://openalex.org/W2979884264","https://openalex.org/W1511199809","https://openalex.org/W2980176815","https://openalex.org/W3033665131","https://openalex.org/W2979357266","https://openalex.org/W3184827596","https://openalex.org/W2587302424","https://openalex.org/W2896398064"],"abstract_inverted_index":{"8066":[0],"Background:":[1],"The":[2,57],"role":[3],"of":[4,31,40,49,65,91,222,235,321],"consolidation":[5],"RT":[6,354],"on":[7,98,121,338],"MBD":[8,35,324,359],"after":[9,262],"upfront":[10],"chemotheraphy":[11],"for":[12,68,169,190,195],"advanced":[13,69],"HL":[14,70],"is":[15,362],"debated,":[16],"also":[17,109],"given":[18],"the":[19,25,29,62,104,162,183,196,342],"supradditive":[20],"iatrogenic":[21],"risk.":[22],"We":[23],"present":[24],"results":[26,335],"achieved":[27,202,363],"in":[28,44,203,212,302,316,348,358],"subset":[30],"patients":[32],"(pts)":[33],"with":[34,103,231,323,350],"(max":[36],"width":[37],">":[38],"1/3":[39],"thoracic":[41],"diameter)":[42],"accrued":[43,129],"a":[45,92,219,317,327,339],"phase":[46],"II":[47],"study":[48],"an":[50,232],"intensified":[51,163,365],"ABVD":[52,94,187,311],"program":[53],"without":[54,332],"RT.":[55,333],"Methods:":[56],"current":[58],"analysis":[59],"derives":[60],"from":[61,74],"final":[63],"evaluation":[64],"our":[66],"trial":[67],"(stage":[71],"IIXB-IV)":[72],"conducted":[73],"06/2004":[75],"to":[76,88],"03/2010":[77],"(Russo":[78],"et":[79],"al,":[80],"ASH":[81],"2009":[82],"abst":[83],"715).":[84],"Pts":[85],"were":[86,175,307],"scheduled":[87],"6":[89],"cycles":[90,107],"\u2018time-densified\u2019":[93],"(3-week":[95],"intercycle,":[96],"drugs":[97],"days":[99,115,122],"1":[100,116],"and":[101,117,119,124,173,179,192,257,286,325],"11)":[102],"first":[105],"4":[106],"being":[108],"\u2018dose-intensified\u2019:":[110],"doxorubicin":[111],"(ADM)":[112],"35":[113],"mg/m2,":[114],"11":[118],"G-CSF":[120],"6-8":[123],"17-19.":[125],"Results:":[126],"Of":[127],"82":[128],"pts,":[130],"39":[131],"had":[132,267],"BMD":[133],"at":[134,252],"presentation.":[135],"Median":[136,165],"age":[137],"was":[138,188,201],"29yrs":[139],"(r":[140,225],"16-58);":[141],"male":[142],"46%;":[143],"stage":[144],"IIB":[145],"48%,":[146],"III":[147],"8%,":[148],"IV":[149],"43%;":[150],"B-sympt":[151],"87%,":[152],"E-disease":[153],"53%;":[154],"IP":[155],"Score":[156],"\u22653":[157],"51%.":[158],"All":[159],"pts":[160,228,266,322],"completed":[161],"program.":[164],"actual":[166],"dose":[167],"intensities":[168],"ADM,":[170],"bleomycin,":[171],"vinblastine":[172],"dacarbazine":[174],"23.12,":[176],"6.69,":[177],"3.96":[178],"245":[180],"mg/week,":[181],"respectively;":[182],"increase":[184],"over":[185],"conventional":[186],"85%":[189],"ADM":[191],"averaged":[193],"32%":[194],"other":[197],"agents.":[198],"PET2":[199,314],"negativity":[200,315],"36/39":[204],"(92%;":[205],"95%":[206,215],"CI":[207,216],"79-98),":[208],"complete":[209],"responses":[210],"(CR)":[211],"37/39":[213],"[94%;":[214],"82-99].":[217],"At":[218],"median":[220],"f.u.":[221],"54":[223],"mo.s":[224],"20-91)":[226],"all":[227,264],"are":[229],"alive":[230],"event-free":[233],"survival":[234],"89%":[236],"(95%":[237],"CI,":[238],"80-98).":[239],"Events":[240],"were:":[241],"<CR":[242],"(n=1,":[243,247],"CS":[244,248],"IVB),":[245],"progression":[246],"IIIA),":[249],"relapse":[250],"[n=2;":[251],"10":[253],"(CS":[254,259],"IVA":[255],")":[256],"15":[258],"IIB)":[260],"months":[261],"treatment];":[263],"these":[265],"isolated":[268],"mediastinal":[269,344],"recurrence.":[270],"CTCAE":[271],"v3.0":[272],"toxicity:":[273],"Grade":[274],"(G)":[275],"2":[276],"nail":[277],"changes":[278],"(31%),":[279],"G2-G3":[280],"hemorrhoids":[281],"(12%-3%),":[282],"G3":[283],"infection":[284],"(13%)":[285],"constipation":[287],"(5%),":[288],"G3-G4":[289,296,300],"stomatitis":[290],"(7%-2%).":[291],"No":[292],"acute":[293],"or":[294],"delayed":[295],"cardiac":[297],"events,":[298],"nor":[299],"decline":[301],"pulmonary":[303],"function":[304],"(FEV1,":[305],"DLCO,FEF25-75)":[306],"seen.":[308],"Conclusions:":[309],"Intensified":[310],"can":[312],"achieve":[313],"very":[318],"high":[319],"proportion":[320],"ensure":[326],"long-term":[328],"disease-free":[329],"status":[330],"even":[331],"While":[334],"need":[336],"confirmation":[337],"randomized":[340],"basis,":[341],"low":[343],"failure":[345],"rate":[346],"seems":[347],"line":[349],"recent":[351],"suggestions":[352],"that":[353],"could":[355],"be":[356],"omitted":[357],"when":[360],"CR":[361],"upon":[364],"chemotheraphy.":[366]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2020-03-23T00:00:00"}