{"id":"https://openalex.org/W3011215664","doi":"https://doi.org/10.1016/j.tibs.2020.02.009","title":"Binge Drinking: Macropinocytosis Promotes Tumorigenic Growth of RAS-Mutant Cancers","display_name":"Binge Drinking: Macropinocytosis Promotes Tumorigenic Growth of RAS-Mutant Cancers","publication_year":2020,"publication_date":"2020-03-09","ids":{"openalex":"https://openalex.org/W3011215664","doi":"https://doi.org/10.1016/j.tibs.2020.02.009","mag":"3011215664","pmid":"https://pubmed.ncbi.nlm.nih.gov/32413322"},"language":"en","primary_location":{"id":"doi:10.1016/j.tibs.2020.02.009","doi":"https://doi.org/10.1016/j.tibs.2020.02.009","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tibs.2020.02.009","pdf_url":null,"source":{"id":"https://openalex.org/S136233269","display_name":"Trends in Biochemical Sciences","issn_l":"0968-0004","issn":["0968-0004","1362-4326"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Biochemical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.17615/q4be-5f02","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068312423","display_name":"G. Aaron Hobbs","orcid":"https://orcid.org/0000-0002-4751-9681","observed_orcids":["https://orcid.org/0000-0002-4751-9681"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Aaron Hobbs","raw_affiliation_strings":["University of North Carolina at Chapel Hill, Department of Pharmacology, Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill, Department of Pharmacology, Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599, USA","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064063895","display_name":"Channing J. Der","orcid":"https://orcid.org/0000-0002-7751-2747","observed_orcids":["https://orcid.org/0000-0002-7751-2747"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Channing J. Der","raw_affiliation_strings":["University of North Carolina at Chapel Hill, Department of Pharmacology, Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599, USA. Electronic address: cjder@med.unc.educjder@med.unc.edu(@cjder23)","University of North Carolina at Chapel Hill, Department of Pharmacology, Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill, Department of Pharmacology, Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599, USA. Electronic address: cjder@med.unc.educjder@med.unc.edu(@cjder23)","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]},{"raw_affiliation_string":"University of North Carolina at Chapel Hill, Department of Pharmacology, Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599, USA","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5064063895"],"corresponding_institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"],"apc_list":{"value":4000,"currency":"USD","value_usd":4000},"apc_paid":null,"fwci":0.5818,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.57311106,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"45","issue":"6","first_page":"459","last_page":"461"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.4336000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.4336000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.4259999990463257,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.01600000075995922,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/macropinocytosis","display_name":"macropinocytosis","score":0.9559999704360962},{"id":"https://openalex.org/keywords/ras-mutations","display_name":"RAS mutations","score":0.7279999852180481},{"id":"https://openalex.org/keywords/rac1-gtpase","display_name":"Rac1 GTPase","score":0.8349999785423279},{"id":"https://openalex.org/keywords/v-atpase","display_name":"V-ATPase","score":0.9919999837875366},{"id":"https://openalex.org/keywords/plasma-membrane-association","display_name":"plasma membrane association","score":0.8050000071525574},{"id":"https://openalex.org/keywords/nutrient-acquisition","display_name":"nutrient acquisition","score":0.7760000228881836},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.7440000176429749},{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.8069999814033508},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.4740000069141388}],"concepts":[{"id":"https://openalex.org/C40017333","wikidata":"https://www.wikidata.org/wiki/Q321362","display_name":"Pinocytosis","level":4,"score":0.8496522903442383},{"id":"https://openalex.org/C207332259","wikidata":"https://www.wikidata.org/wiki/Q769143","display_name":"GTPase","level":2,"score":0.7461686134338379},{"id":"https://openalex.org/C2779717556","wikidata":"https://www.wikidata.org/wiki/Q15325735","display_name":"RAC1","level":3,"score":0.7280046939849854},{"id":"https://openalex.org/C2780298669","wikidata":"https://www.wikidata.org/wiki/Q415071","display_name":"Small GTPase","level":3,"score":0.690470814704895},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6016993522644043},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5358772277832031},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.49166780710220337},{"id":"https://openalex.org/C23265538","wikidata":"https://www.wikidata.org/wiki/Q300033","display_name":"ATPase","level":3,"score":0.47098585963249207},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.31779709458351135},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29404765367507935},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.1685357391834259},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11775606870651245},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.11675247550010681},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09479963779449463}],"mesh":[{"descriptor_ui":"D000251","descriptor_name":"Adenosine Triphosphatases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010873","descriptor_name":"Pinocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063425","descriptor_name":"Binge Drinking","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.tibs.2020.02.009","doi":"https://doi.org/10.1016/j.tibs.2020.02.009","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tibs.2020.02.009","pdf_url":null,"source":{"id":"https://openalex.org/S136233269","display_name":"Trends in Biochemical Sciences","issn_l":"0968-0004","issn":["0968-0004","1362-4326"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Biochemical Sciences","raw_type":"journal-article"},{"id":"pmid:32413322","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32413322","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in biochemical sciences","raw_type":"Journal Article"},{"id":"pmh:cdr.lib.unc.edu:hh63t7561","doi":null,"is_oa":true,"landing_page_url":"https://cdr.lib.unc.edu/downloads/z316qd21z","pdf_url":"https://doi.org/10.17615/q4be-5f02","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Trends in Biochemical Sciences, 45(6)","raw_type":"Article"},{"id":"doi:10.17615/q4be-5f02","doi":"https://doi.org/10.17615/q4be-5f02","is_oa":true,"landing_page_url":"https://doi.org/10.17615/q4be-5f02","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"pmh:cdr.lib.unc.edu:hh63t7561","doi":null,"is_oa":true,"landing_page_url":"https://cdr.lib.unc.edu/downloads/z316qd21z","pdf_url":"https://doi.org/10.17615/q4be-5f02","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Trends in Biochemical Sciences, 45(6)","raw_type":"Article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7246000170707703}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3052603789","display_name":"Defining RAS isoform- and mutation-specific roles in oncogenesis","funder_award_id":"P01CA203657","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4126989831","display_name":"Targeting undruggable RAS for cancer treatment","funder_award_id":"R35CA232113","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4339777089","display_name":"Integrated Training in Cancer Model Systems","funder_award_id":"T32CA009156","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7537052817","display_name":null,"funder_award_id":"F32CA200303","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7816896342","display_name":"Identification of synthetic lethal interactors in pancreatic cancer","funder_award_id":"U01CA199235","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3011215664.pdf","grobid_xml":"https://content.openalex.org/works/W3011215664.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W2011911021","https://openalex.org/W2061772840","https://openalex.org/W2093226717","https://openalex.org/W2129917557","https://openalex.org/W2234115940","https://openalex.org/W2759290374","https://openalex.org/W2925187261","https://openalex.org/W2981746321","https://openalex.org/W2995084623","https://openalex.org/W3193270327"],"related_works":["https://openalex.org/W2995084623","https://openalex.org/W4252939362","https://openalex.org/W2080717317","https://openalex.org/W3212020801","https://openalex.org/W2045357431","https://openalex.org/W2085513503","https://openalex.org/W2019631358","https://openalex.org/W2180283538","https://openalex.org/W2129917557","https://openalex.org/W3121931506"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-03-23T00:00:00"}