{"id":"https://openalex.org/W3011176147","doi":"https://doi.org/10.21037/atm.2020.03.26","title":"Biological variation of metabolic cardiovascular risk factors in haemodialysis patients and healthy individuals","display_name":"Biological variation of metabolic cardiovascular risk factors in haemodialysis patients and healthy individuals","publication_year":2020,"publication_date":"2020-03-01","ids":{"openalex":"https://openalex.org/W3011176147","doi":"https://doi.org/10.21037/atm.2020.03.26","mag":"3011176147","pmid":"https://pubmed.ncbi.nlm.nih.gov/32355725","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7186598"},"language":"en","primary_location":{"id":"doi:10.21037/atm.2020.03.26","doi":"https://doi.org/10.21037/atm.2020.03.26","is_oa":true,"landing_page_url":"https://doi.org/10.21037/atm.2020.03.26","pdf_url":"https://atm.amegroups.com/article/viewFile/38309/pdf","source":{"id":"https://openalex.org/S2755174949","display_name":"Annals of Translational Medicine","issn_l":"2305-5839","issn":["2305-5839","2305-5847"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Translational Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://atm.amegroups.com/article/viewFile/38309/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084558704","display_name":"Zoraida Corte","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087461","display_name":"Hospital Universitario San Agust\u00edn","ror":"https://ror.org/003zecf96","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2800212897","https://openalex.org/I4210087461","https://openalex.org/I4405258403"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Zoraida Corte","raw_affiliation_strings":["Clinical Biochemistry Service, San Agust\u00edn University Hospital, Avil\u00e9s, Asturias, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Biochemistry Service, San Agust\u00edn University Hospital, Avil\u00e9s, Asturias, Spain","institution_ids":["https://openalex.org/I4210087461"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071231443","display_name":"Rafael Venta","orcid":"https://orcid.org/0000-0003-0750-6517","observed_orcids":["https://orcid.org/0000-0003-0750-6517"]},"institutions":[{"id":"https://openalex.org/I165339363","display_name":"Universidad de Oviedo","ror":"https://ror.org/006gksa02","country_code":"ES","type":"education","lineage":["https://openalex.org/I165339363"]},{"id":"https://openalex.org/I4210087461","display_name":"Hospital Universitario San Agust\u00edn","ror":"https://ror.org/003zecf96","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2800212897","https://openalex.org/I4210087461","https://openalex.org/I4405258403"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Rafael Venta","raw_affiliation_strings":["Biochemistry and Molecular Biology Department, Oviedo University, Asturias, Spain","Clinical Biochemistry Service, San Agust\u00edn University Hospital, Avil\u00e9s, Asturias, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology Department, Oviedo University, Asturias, Spain","institution_ids":["https://openalex.org/I165339363"]},{"raw_affiliation_string":"Clinical Biochemistry Service, San Agust\u00edn University Hospital, Avil\u00e9s, Asturias, Spain","institution_ids":["https://openalex.org/I4210087461"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5071231443"],"corresponding_institution_ids":["https://openalex.org/I165339363","https://openalex.org/I4210087461"],"apc_list":null,"apc_paid":null,"fwci":1.2652,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.758159,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"8","issue":"6","first_page":"281","last_page":"281"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.9282000064849854,"subfield":{"id":"https://openalex.org/subfields/3607","display_name":"Medical Laboratory Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.9282000064849854,"subfield":{"id":"https://openalex.org/subfields/3607","display_name":"Medical Laboratory Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.03530000150203705,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.029600000008940697,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biological-variation","display_name":"biological variation","score":0.8519999980926514},{"id":"https://openalex.org/keywords/maintenance-hemodialysis","display_name":"maintenance hemodialysis","score":0.8799999952316284},{"id":"https://openalex.org/keywords/cardiovascular-risk-factors","display_name":"cardiovascular risk factors","score":0.9779999852180481},{"id":"https://openalex.org/keywords/reference-change-value","display_name":"reference change value","score":0.8080000281333923},{"id":"https://openalex.org/keywords/serum-calcium","display_name":"serum calcium","score":0.7039999961853027},{"id":"https://openalex.org/keywords/inorganic-phosphorus","display_name":"inorganic phosphorus","score":0.996999979019165},{"id":"https://openalex.org/keywords/intact-parathyroid-hormone","display_name":"intact parathyroid hormone","score":0.9829999804496765},{"id":"https://openalex.org/keywords/vitamin-d","display_name":"vitamin D","score":0.7070000171661377},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9950000047683716},{"id":"https://openalex.org/keywords/homocysteine","display_name":"homocysteine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/serum-lipids","display_name":"serum lipids","score":0.7329999804496765},{"id":"https://openalex.org/keywords/homeostatic-set-point","display_name":"homeostatic set point","score":0.8600000143051147}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.679206132888794},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.6547479033470154},{"id":"https://openalex.org/C2781208988","wikidata":"https://www.wikidata.org/wiki/Q202476","display_name":"Parathyroid hormone","level":3,"score":0.5921714901924133},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5836015343666077},{"id":"https://openalex.org/C2777090595","wikidata":"https://www.wikidata.org/wiki/Q192466","display_name":"Homocysteine","level":2,"score":0.46767956018447876},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.4395044147968292},{"id":"https://openalex.org/C510538283","wikidata":"https://www.wikidata.org/wiki/Q674","display_name":"Phosphorus","level":2,"score":0.4256996512413025},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4243384003639221},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3302779495716095},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0962391197681427},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.21037/atm.2020.03.26","doi":"https://doi.org/10.21037/atm.2020.03.26","is_oa":true,"landing_page_url":"https://doi.org/10.21037/atm.2020.03.26","pdf_url":"https://atm.amegroups.com/article/viewFile/38309/pdf","source":{"id":"https://openalex.org/S2755174949","display_name":"Annals of Translational Medicine","issn_l":"2305-5839","issn":["2305-5839","2305-5847"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Translational Medicine","raw_type":"journal-article"},{"id":"pmid:32355725","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32355725","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of translational medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7186598","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7186598/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ann Transl Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.21037/atm.2020.03.26","doi":"https://doi.org/10.21037/atm.2020.03.26","is_oa":true,"landing_page_url":"https://doi.org/10.21037/atm.2020.03.26","pdf_url":"https://atm.amegroups.com/article/viewFile/38309/pdf","source":{"id":"https://openalex.org/S2755174949","display_name":"Annals of Translational Medicine","issn_l":"2305-5839","issn":["2305-5839","2305-5847"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Translational Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3011176147.pdf","grobid_xml":"https://content.openalex.org/works/W3011176147.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1978359035","https://openalex.org/W2072548623","https://openalex.org/W2117872000","https://openalex.org/W2121957610","https://openalex.org/W2133499388","https://openalex.org/W2149997127","https://openalex.org/W2159042875","https://openalex.org/W2167670747","https://openalex.org/W2275547636","https://openalex.org/W2309609927","https://openalex.org/W2315464387","https://openalex.org/W2337868668","https://openalex.org/W2339429504","https://openalex.org/W2402599050","https://openalex.org/W2442032894","https://openalex.org/W2526018201","https://openalex.org/W2775695442","https://openalex.org/W2790398892","https://openalex.org/W2801744186","https://openalex.org/W2810859406","https://openalex.org/W2884182966","https://openalex.org/W2898259005","https://openalex.org/W2920817146","https://openalex.org/W2956360033","https://openalex.org/W2967790209","https://openalex.org/W3021842026","https://openalex.org/W4211140718"],"related_works":["https://openalex.org/W2377411473","https://openalex.org/W2368613282","https://openalex.org/W2121957610","https://openalex.org/W2168257678","https://openalex.org/W7096387438","https://openalex.org/W3030439964","https://openalex.org/W2785376899","https://openalex.org/W1591314436","https://openalex.org/W4285250395","https://openalex.org/W2726451015"],"abstract_inverted_index":{"Background:":[0],"Maintenance":[1],"haemodialysis":[2],"(HD)":[3],"is":[4,20,172],"associated":[5],"with":[6],"a":[7],"very":[8],"high":[9],"cardiovascular":[10,17,187],"risk":[11,18,188],"and":[12,26,52,58,90,113,149,163],"the":[13,31,37,66,175,184,190],"assessment":[14],"of":[15,30,41,69,110,177,186,192],"metabolic":[16],"factors":[19],"essential":[21],"for":[22,130,174],"an":[23],"adequate":[24],"diagnosis":[25],"management.":[27],"The":[28],"aim":[29],"study":[32],"has":[33],"been":[34],"to":[35,61],"estimate":[36],"biological":[38],"variation":[39,111],"(BV)":[40],"serum":[42],"lipids,":[43],"calcium,":[44,160],"inorganic":[45,140,161],"phosphorus,":[46],"25-OH":[47],"vitamin":[48],"D,":[49],"C-reactive":[50],"protein":[51],"plasma":[53],"intact":[54],"parathyroid":[55],"hormone":[56],"(PTHi)":[57],"total":[59],"homocysteine,":[60],"evaluate":[62],"whether":[63],"HD":[64,79,121,181],"alter":[65],"homeostatic":[67],"set-point":[68],"these":[70],"magnitudes.":[71],"Methods:":[72],"Blood":[73],"samples":[74],"were":[75,103,123],"collected":[76],"from":[77,91,167,195],"18":[78],"patients":[80,122],"in":[81,120,127,180],"steady-state":[82],"conditions,":[83],"one":[84],"per":[85],"month":[86],"during":[87],"6":[88],"months,":[89],"11":[92],"healthy":[93,128,196],"volunteers":[94],"at":[95],"weekly":[96],"intervals":[97],"over":[98],"5":[99],"weeks.":[100],"BV":[101,170],"data":[102,171],"derived":[104,114,166,194],"using":[105],"CV-ANOVA.":[106],"Results:":[107],"Within-subject":[108],"coefficients":[109],"(CVI)":[112],"reference":[115],"change":[116],"values":[117],"(RCV)":[118],"estimated":[119],"significantly":[124],"higher":[125],"than":[126],"individuals":[129,197],"calcium":[131],"(CVI":[132],"=3.8%":[133],"vs.":[134,138,143,147,152,156],"2.3%)":[135],"(RCV":[136,145,154],"=12.6%":[137],"7.6%),":[139],"phosphorus":[141,162],"(13.1%":[142],"8.0%)":[144],"=38.7%":[146],"30.1%)":[148],"PTHi":[150],"(20.3%":[151],"11.3%)":[153],"=57.5%":[155],"34.0%).":[157],"Conclusions:":[158],"For":[159,183],"PTHi,":[164],"RCV":[165,193],"advanced":[168],"disease-specific":[169],"recommended":[173],"management":[176],"bone-mineral":[178],"disturbances":[179],"patients.":[182],"rest":[185],"factors,":[189],"use":[191],"could":[198],"be":[199],"appropriate.":[200]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-03-23T00:00:00"}