{"id":"https://openalex.org/W3011066871","doi":"https://doi.org/10.1146/annurev-cancerbio-030419-033436","title":"Immune-Based Approaches for the Treatment of Pediatric Malignancies","display_name":"Immune-Based Approaches for the Treatment of Pediatric Malignancies","publication_year":2020,"publication_date":"2020-03-09","ids":{"openalex":"https://openalex.org/W3011066871","doi":"https://doi.org/10.1146/annurev-cancerbio-030419-033436","mag":"3011066871","pmid":"https://pubmed.ncbi.nlm.nih.gov/34113750","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8189419"},"language":"en","primary_location":{"id":"doi:10.1146/annurev-cancerbio-030419-033436","doi":"https://doi.org/10.1146/annurev-cancerbio-030419-033436","is_oa":true,"landing_page_url":"https://doi.org/10.1146/annurev-cancerbio-030419-033436","pdf_url":null,"source":{"id":"https://openalex.org/S4210178937","display_name":"Annual Review of Cancer Biology","issn_l":"2472-3428","issn":["2472-3428"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Cancer Biology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1146/annurev-cancerbio-030419-033436","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019056686","display_name":"Kristopher R. Bosse","orcid":"https://orcid.org/0000-0002-1424-2858","observed_orcids":["https://orcid.org/0000-0002-1424-2858"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristopher R. Bosse","raw_affiliation_strings":["Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA","Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA;","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033972749","display_name":"Robbie G. Majzner","orcid":"https://orcid.org/0000-0001-6969-8011","observed_orcids":["https://orcid.org/0000-0001-6969-8011"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I4390039303","display_name":"Stanford Cancer Institute","ror":"https://ror.org/014qe3j22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I4390039303","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robbie G. Majzner","raw_affiliation_strings":["Department of Pediatrics and Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California 94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics and Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California 94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I4390039303","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087779758","display_name":"Crystal Lee Mackall","orcid":"https://orcid.org/0000-0003-0359-9023","observed_orcids":["https://orcid.org/0000-0003-0359-9023","https://orcid.org/0000-0001-6323-4304"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I4390039303","display_name":"Stanford Cancer Institute","ror":"https://ror.org/014qe3j22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I4390039303","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Crystal L. Mackall","raw_affiliation_strings":["Department of Pediatrics and Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California 94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics and Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California 94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I4390039303","https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005797590","display_name":"John M. Maris","orcid":"https://orcid.org/0000-0002-8088-7929","observed_orcids":["https://orcid.org/0000-0002-8088-7929"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John M. Maris","raw_affiliation_strings":["Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA","Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA;","institution_ids":["https://openalex.org/I1335321130"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1879,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.23202218,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"4","issue":"1","first_page":"353","last_page":"370"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.7172999978065491,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.7172999978065491,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.20669999718666077,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.06369999796152115,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pediatric-cancer","display_name":"childhood cancer","score":0.6349999904632568},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.7210000157356262},{"id":"https://openalex.org/keywords/chimeric-antigen-receptor-t-cells","display_name":"chimeric antigen receptor T cells","score":0.8009999990463257},{"id":"https://openalex.org/keywords/b-cell-acute-lymphoblastic-leukemia","display_name":"B-cell acute lymphoblastic leukemia","score":0.9509999752044678},{"id":"https://openalex.org/keywords/antibody-drug-conjugates","display_name":"antibody-drug conjugates","score":0.9309999942779541},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.9470000267028809},{"id":"https://openalex.org/keywords/tumor-immunogenicity","display_name":"tumor immunogenicity","score":0.9179999828338623},{"id":"https://openalex.org/keywords/pediatric-malignancies","display_name":"pediatric malignancies","score":0.5960000157356262}],"concepts":[{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.7627046704292297},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6964617967605591},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6698833703994751},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6502835750579834},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.6262763738632202},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5322954654693604},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.47509968280792236},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4690326452255249},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4603087902069092},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.4472910165786743},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12831458449363708}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1146/annurev-cancerbio-030419-033436","doi":"https://doi.org/10.1146/annurev-cancerbio-030419-033436","is_oa":true,"landing_page_url":"https://doi.org/10.1146/annurev-cancerbio-030419-033436","pdf_url":null,"source":{"id":"https://openalex.org/S4210178937","display_name":"Annual Review of Cancer Biology","issn_l":"2472-3428","issn":["2472-3428"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Cancer Biology","raw_type":"journal-article"},{"id":"pmid:34113750","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34113750","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual review of cancer biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8189419","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8189419","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Annu Rev Cancer Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1146/annurev-cancerbio-030419-033436","doi":"https://doi.org/10.1146/annurev-cancerbio-030419-033436","is_oa":true,"landing_page_url":"https://doi.org/10.1146/annurev-cancerbio-030419-033436","pdf_url":null,"source":{"id":"https://openalex.org/S4210178937","display_name":"Annual Review of Cancer Biology","issn_l":"2472-3428","issn":["2472-3428"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Cancer Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5827870131","display_name":"Targeting the GPC2 oncoprotein with immune-based therapies in neuroblastoma","funder_award_id":"K08CA230223","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8577699080","display_name":"Discovery and Development of Optimal Immunotherapeutic Strategies for Childhood Cancers","funder_award_id":"U54CA232568","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000902435","display_name":"Discovering mechanisms of neuroblastoma tumorigenesis to improve patient outcomes","funder_award_id":"R35CA220500","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":140,"referenced_works":["https://openalex.org/W1485169915","https://openalex.org/W1491888133","https://openalex.org/W1532769922","https://openalex.org/W1547298604","https://openalex.org/W1548883740","https://openalex.org/W1560058309","https://openalex.org/W1931737153","https://openalex.org/W1938243302","https://openalex.org/W1943300686","https://openalex.org/W1967512987","https://openalex.org/W1967517831","https://openalex.org/W1972725743","https://openalex.org/W1973745263","https://openalex.org/W1982488143","https://openalex.org/W1986354050","https://openalex.org/W1987633400","https://openalex.org/W2010978319","https://openalex.org/W2011118089","https://openalex.org/W2011795445","https://openalex.org/W2012833296","https://openalex.org/W2015758016","https://openalex.org/W2017277108","https://openalex.org/W2018486897","https://openalex.org/W2027399451","https://openalex.org/W2027863358","https://openalex.org/W2037100222","https://openalex.org/W2039484130","https://openalex.org/W2044313879","https://openalex.org/W2044890596","https://openalex.org/W2045770496","https://openalex.org/W2049790267","https://openalex.org/W2062062519","https://openalex.org/W2064505748","https://openalex.org/W2064510700","https://openalex.org/W2066508515","https://openalex.org/W2068512864","https://openalex.org/W2078069330","https://openalex.org/W2087055812","https://openalex.org/W2093297340","https://openalex.org/W2094945699","https://openalex.org/W2099044540","https://openalex.org/W2099653461","https://openalex.org/W2099742439","https://openalex.org/W2104885590","https://openalex.org/W2107968021","https://openalex.org/W2110305039","https://openalex.org/W2118796952","https://openalex.org/W2121027155","https://openalex.org/W2125616358","https://openalex.org/W2129702476","https://openalex.org/W2130465135","https://openalex.org/W2138654358","https://openalex.org/W2141410122","https://openalex.org/W2143562524","https://openalex.org/W2143772132","https://openalex.org/W2146862320","https://openalex.org/W2147486937","https://openalex.org/W2155118053","https://openalex.org/W2155977618","https://openalex.org/W2157003991","https://openalex.org/W2162999406","https://openalex.org/W2169923083","https://openalex.org/W2171741398","https://openalex.org/W2173303337","https://openalex.org/W2179454156","https://openalex.org/W2191511762","https://openalex.org/W2195425332","https://openalex.org/W2222086386","https://openalex.org/W2259369970","https://openalex.org/W2277505199","https://openalex.org/W2284799323","https://openalex.org/W2292587137","https://openalex.org/W2299654235","https://openalex.org/W2300626718","https://openalex.org/W2303158491","https://openalex.org/W2318605753","https://openalex.org/W2341089209","https://openalex.org/W2387397851","https://openalex.org/W2407062242","https://openalex.org/W2417798589","https://openalex.org/W2419639370","https://openalex.org/W2431004354","https://openalex.org/W2460088816","https://openalex.org/W2471150274","https://openalex.org/W2496398835","https://openalex.org/W2524515200","https://openalex.org/W2529226476","https://openalex.org/W2539686048","https://openalex.org/W2551609581","https://openalex.org/W2561771531","https://openalex.org/W2592467398","https://openalex.org/W2598988196","https://openalex.org/W2604003809","https://openalex.org/W2605626471","https://openalex.org/W2606495925","https://openalex.org/W2606786998","https://openalex.org/W2607870782","https://openalex.org/W2609835530","https://openalex.org/W2609973112","https://openalex.org/W2611189127","https://openalex.org/W2614019261","https://openalex.org/W2615777511","https://openalex.org/W2616637874","https://openalex.org/W2618869560","https://openalex.org/W2624700430","https://openalex.org/W2659232377","https://openalex.org/W2662598785","https://openalex.org/W2724638186","https://openalex.org/W2731673561","https://openalex.org/W2750328162","https://openalex.org/W2754294524","https://openalex.org/W2767034994","https://openalex.org/W2768823259","https://openalex.org/W2770704851","https://openalex.org/W2775803967","https://openalex.org/W2787301955","https://openalex.org/W2789869568","https://openalex.org/W2789924919","https://openalex.org/W2793744535","https://openalex.org/W2796163387","https://openalex.org/W2796436502","https://openalex.org/W2797865989","https://openalex.org/W2803040262","https://openalex.org/W2807110328","https://openalex.org/W2807603420","https://openalex.org/W2808090012","https://openalex.org/W2885192969","https://openalex.org/W2885227878","https://openalex.org/W2888063816","https://openalex.org/W2888107969","https://openalex.org/W2891253541","https://openalex.org/W2893765519","https://openalex.org/W2895691142","https://openalex.org/W2895919137","https://openalex.org/W2895922290","https://openalex.org/W2905313158","https://openalex.org/W2905654445","https://openalex.org/W2912626997","https://openalex.org/W2916249195","https://openalex.org/W2922363031"],"related_works":["https://openalex.org/W2114484791","https://openalex.org/W2067839517","https://openalex.org/W2002331044","https://openalex.org/W2087599286","https://openalex.org/W7124447680","https://openalex.org/W4206496671","https://openalex.org/W4400647726","https://openalex.org/W1988266744","https://openalex.org/W7154457768","https://openalex.org/W7099854415"],"abstract_inverted_index":{"Immune-based":[0],"therapies":[1,63,89,113],"have":[2],"now":[3],"been":[4,101],"credentialed":[5],"for":[6,20,34,61,114,122],"pediatric":[7,21,55,130],"cancers":[8,56],"with":[9,36],"the":[10,67,85,108],"robust":[11],"efficacy":[12,86],"of":[13,31,53,70,87,111,129],"chimeric":[14],"antigen":[15],"receptor":[16],"(CAR)":[17],"T":[18,82],"cells":[19],"B":[22],"cell":[23,72],"acute":[24],"lymphocytic":[25],"leukemia":[26],"(ALL),":[27],"offering":[28],"a":[29,32,41],"chance":[30],"cure":[33],"children":[35],"previously":[37],"lethal":[38],"disease":[39],"and":[40,125,133],"potentially":[42],"more":[43],"targeted":[44],"therapy":[45],"to":[46,103,119],"limit":[47],"treatment-related":[48],"morbidities.":[49],"The":[50],"developmental":[51],"origins":[52],"most":[54],"make":[57],"them":[58],"ideal":[59],"targets":[60],"immune-based":[62,112],"that":[64,90],"capitalize":[65],"on":[66,92],"differential":[68],"expression":[69],"lineage-specific":[71],"surface":[73],"molecules":[74],"such":[75,95],"as":[76,96],"antibodies,":[77],"antibody-drug":[78],"conjugates,":[79],"or":[80],"CAR":[81],"cells,":[83],"while":[84],"other":[88],"depend":[91],"tumor":[93],"immunogenicity":[94],"immune":[97],"checkpoint":[98],"inhibitors":[99],"has":[100],"limited":[102],"date.":[104],"Here":[105],"we":[106],"review":[107],"current":[109],"status":[110],"childhood":[115],"cancers,":[116],"discuss":[117],"challenges":[118],"developing":[120],"immunotherapeutics":[121],"these":[123],"diseases,":[124],"outline":[126],"future":[127],"directions":[128],"immunotherapy":[131],"discovery":[132],"development.":[134]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2020-03-23T00:00:00"}