{"id":"https://openalex.org/W3010892282","doi":"https://doi.org/10.1016/j.tiv.2020.104831","title":"Skin sensitisation testing in practice: Applying a stacking meta model to cosmetic ingredients","display_name":"Skin sensitisation testing in practice: Applying a stacking meta model to cosmetic ingredients","publication_year":2020,"publication_date":"2020-03-18","ids":{"openalex":"https://openalex.org/W3010892282","doi":"https://doi.org/10.1016/j.tiv.2020.104831","mag":"3010892282","pmid":"https://pubmed.ncbi.nlm.nih.gov/32198056"},"language":"en","primary_location":{"id":"doi:10.1016/j.tiv.2020.104831","doi":"https://doi.org/10.1016/j.tiv.2020.104831","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tiv.2020.104831","pdf_url":null,"source":{"id":"https://openalex.org/S39580544","display_name":"Toxicology in Vitro","issn_l":"0887-2333","issn":["0887-2333","1879-3177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology in Vitro","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W3010892282"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034398465","display_name":"Fleur Tourneix","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I14285755","display_name":"L'Or\u00e9al (France)","ror":"https://ror.org/00nb3j622","country_code":"FR","type":"company","lineage":["https://openalex.org/I14285755"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Fleur Tourneix","raw_affiliation_strings":["L'Or\u00e9al R&I, Aulnay-sous-Bois, France. Electronic address: fleur.tourneix@rd.loreal.com","L'Or\u00e9al R&I, Aulnay-sous-Bois, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"L'Or\u00e9al R&I, Aulnay-sous-Bois, France. Electronic address: fleur.tourneix@rd.loreal.com","institution_ids":["https://openalex.org/I14285755"]},{"raw_affiliation_string":"L'Or\u00e9al R&I, Aulnay-sous-Bois, France","institution_ids":["https://openalex.org/I14285755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023026500","display_name":"Nathalie Al\u00e9p\u00e9e","orcid":"https://orcid.org/0000-0002-2181-4308","observed_orcids":["https://orcid.org/0000-0002-2181-4308"]},"institutions":[{"id":"https://openalex.org/I14285755","display_name":"L'Or\u00e9al (France)","ror":"https://ror.org/00nb3j622","country_code":"FR","type":"company","lineage":["https://openalex.org/I14285755"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nathalie Al\u00e9p\u00e9e","raw_affiliation_strings":["L'Or\u00e9al R&I, Aulnay-sous-Bois, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"L'Or\u00e9al R&I, Aulnay-sous-Bois, France","institution_ids":["https://openalex.org/I14285755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064669439","display_name":"Ann Detroyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I14285755","display_name":"L'Or\u00e9al (France)","ror":"https://ror.org/00nb3j622","country_code":"FR","type":"company","lineage":["https://openalex.org/I14285755"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ann Detroyer","raw_affiliation_strings":["L'Or\u00e9al R&I, Aulnay-sous-Bois, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"L'Or\u00e9al R&I, Aulnay-sous-Bois, France","institution_ids":["https://openalex.org/I14285755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014509954","display_name":"Joan Eilstein","orcid":"https://orcid.org/0000-0002-9695-847X","observed_orcids":["https://orcid.org/0000-0002-9695-847X"]},"institutions":[{"id":"https://openalex.org/I4210161494","display_name":"L'Or\u00e9al (India)","ror":"https://ror.org/059vyyn23","country_code":"IN","type":"company","lineage":["https://openalex.org/I14285755","https://openalex.org/I4210161494"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Joan Eilstein","raw_affiliation_strings":["L'Or\u00e9al R&I, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"L'Or\u00e9al R&I, Bangalore, India","institution_ids":["https://openalex.org/I4210161494"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009816872","display_name":"Mehdi Ez\u2010Zoubir","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I14285755","display_name":"L'Or\u00e9al (France)","ror":"https://ror.org/00nb3j622","country_code":"FR","type":"company","lineage":["https://openalex.org/I14285755"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Mehdi Ez-Zoubir","raw_affiliation_strings":["L'Or\u00e9al R&I, Aulnay-sous-Bois, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"L'Or\u00e9al R&I, Aulnay-sous-Bois, France","institution_ids":["https://openalex.org/I14285755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040221120","display_name":"Silvia Martinozzi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I14285755","display_name":"L'Or\u00e9al (France)","ror":"https://ror.org/00nb3j622","country_code":"FR","type":"company","lineage":["https://openalex.org/I14285755"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Silvia Martinozzi Teissier","raw_affiliation_strings":["L'Or\u00e9al R&I, Aulnay-sous-Bois, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"L'Or\u00e9al R&I, Aulnay-sous-Bois, France","institution_ids":["https://openalex.org/I14285755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055122936","display_name":"Hicham No\u00e7airi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I14285755","display_name":"L'Or\u00e9al (France)","ror":"https://ror.org/00nb3j622","country_code":"FR","type":"company","lineage":["https://openalex.org/I14285755"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Hicham No\u00e7airi","raw_affiliation_strings":["L'Or\u00e9al R&I, Aulnay-sous-Bois, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"L'Or\u00e9al R&I, Aulnay-sous-Bois, France","institution_ids":["https://openalex.org/I14285755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028636049","display_name":"C\u00e9cile Piroird","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I14285755","display_name":"L'Or\u00e9al (France)","ror":"https://ror.org/00nb3j622","country_code":"FR","type":"company","lineage":["https://openalex.org/I14285755"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C\u00e9cile Piroird","raw_affiliation_strings":["L'Or\u00e9al R&I, Aulnay-sous-Bois, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"L'Or\u00e9al R&I, Aulnay-sous-Bois, France","institution_ids":["https://openalex.org/I14285755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102825573","display_name":"David Arthur Basketter","orcid":"https://orcid.org/0000-0002-8239-0721","observed_orcids":["https://orcid.org/0000-0002-8239-0721"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Basketter","raw_affiliation_strings":["DABMEB Consultancy Ltd, Sharnbrook, Bedfordshire, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DABMEB Consultancy Ltd, Sharnbrook, Bedfordshire, UK","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074954877","display_name":"Aur\u00e9lia Del Bufalo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I14285755","display_name":"L'Or\u00e9al (France)","ror":"https://ror.org/00nb3j622","country_code":"FR","type":"company","lineage":["https://openalex.org/I14285755"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Aur\u00e9lia Del Bufalo","raw_affiliation_strings":["L'Or\u00e9al R&I, Aulnay-sous-Bois, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"L'Or\u00e9al R&I, Aulnay-sous-Bois, France","institution_ids":["https://openalex.org/I14285755"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5034398465"],"corresponding_institution_ids":["https://openalex.org/I14285755"],"apc_list":{"value":2900,"currency":"USD","value_usd":2900},"apc_paid":null,"fwci":0.9817,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.75193859,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"66","issue":null,"first_page":"104831","last_page":"104831"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11033","display_name":"Contact Dermatitis and Allergies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11033","display_name":"Contact Dermatitis and Allergies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/skin-sensitization","display_name":"skin sensitization","score":0.9850000143051147},{"id":"https://openalex.org/keywords/cosmetic-ingredients","display_name":"cosmetic ingredients","score":0.9020000100135803},{"id":"https://openalex.org/keywords/non-animal-testing","display_name":"non-animal testing","score":0.7490000128746033},{"id":"https://openalex.org/keywords/local-lymph-node-assay","display_name":"local lymph node assay","score":0.8299999833106995},{"id":"https://openalex.org/keywords/direct-peptide-reactivity-assay","display_name":"direct peptide reactivity assay","score":0.9359999895095825},{"id":"https://openalex.org/keywords/toxtree","display_name":"Toxtree","score":0.9200000166893005},{"id":"https://openalex.org/keywords/in-silico-prediction","display_name":"in silico prediction","score":0.7910000085830688},{"id":"https://openalex.org/keywords/risk-assessment","display_name":"risk assessment","score":0.47699999809265137},{"id":"https://openalex.org/keywords/dyes","display_name":"dyes","score":0.5440000295639038},{"id":"https://openalex.org/keywords/preservatives","display_name":"preservatives","score":0.9829999804496765},{"id":"https://openalex.org/keywords/fragrance","display_name":"fragrance","score":0.9169999957084656},{"id":"https://openalex.org/keywords/physicochemical-parameters","display_name":"physicochemical parameters","score":0.6179999709129333}],"concepts":[{"id":"https://openalex.org/C2780614586","wikidata":"https://www.wikidata.org/wiki/Q6664446","display_name":"Local lymph node assay","level":4,"score":0.9418389797210693},{"id":"https://openalex.org/C2779717098","wikidata":"https://www.wikidata.org/wiki/Q131207","display_name":"Cosmetics","level":2,"score":0.7511079907417297},{"id":"https://openalex.org/C33347731","wikidata":"https://www.wikidata.org/wiki/Q285210","display_name":"Stacking","level":2,"score":0.6754332780838013},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.6306411623954773},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.49861812591552734},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.4004942774772644},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.36498773097991943},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3467155992984772},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.34439992904663086},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.34340304136276245},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.20181262493133545},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1716284155845642},{"id":"https://openalex.org/C3018346242","wikidata":"https://www.wikidata.org/wiki/Q4826986","display_name":"Skin sensitization","level":3,"score":0.09174162149429321},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09121888875961304},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.09098237752914429},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C2776217527","wikidata":"https://www.wikidata.org/wiki/Q944828","display_name":"Sensitization","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003358","descriptor_name":"Cosmetics","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D006241","descriptor_name":"Haptens","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012882","descriptor_name":"Skin Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017449","descriptor_name":"Dermatitis, Allergic Contact","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.tiv.2020.104831","doi":"https://doi.org/10.1016/j.tiv.2020.104831","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tiv.2020.104831","pdf_url":null,"source":{"id":"https://openalex.org/S39580544","display_name":"Toxicology in Vitro","issn_l":"0887-2333","issn":["0887-2333","1879-3177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology in Vitro","raw_type":"journal-article"},{"id":"pmid:32198056","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32198056","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology in vitro : an international journal published in association with BIBRA","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.766700029373169,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W28412257","https://openalex.org/W1541066427","https://openalex.org/W1963598807","https://openalex.org/W1966405873","https://openalex.org/W1974797859","https://openalex.org/W1976477992","https://openalex.org/W1986162358","https://openalex.org/W1998549010","https://openalex.org/W1998816898","https://openalex.org/W2021031776","https://openalex.org/W2157971131","https://openalex.org/W2169548777","https://openalex.org/W2170822660","https://openalex.org/W2216121083","https://openalex.org/W2271802269","https://openalex.org/W2564146927","https://openalex.org/W2564535590","https://openalex.org/W2571007314","https://openalex.org/W2587349574","https://openalex.org/W2588487321","https://openalex.org/W2725869602","https://openalex.org/W2740638834","https://openalex.org/W2759426193","https://openalex.org/W2770248284","https://openalex.org/W2781974637","https://openalex.org/W2790898262","https://openalex.org/W2792505613","https://openalex.org/W2809278402","https://openalex.org/W2884837038","https://openalex.org/W2904225550","https://openalex.org/W2914369697","https://openalex.org/W2919214572","https://openalex.org/W2946795893","https://openalex.org/W2969196079","https://openalex.org/W2977382755"],"related_works":["https://openalex.org/W2781974637","https://openalex.org/W2946795893","https://openalex.org/W7008175155","https://openalex.org/W2495307734","https://openalex.org/W2792505613","https://openalex.org/W2124700474","https://openalex.org/W3039209319","https://openalex.org/W2089842537","https://openalex.org/W2753075176","https://openalex.org/W4362670995"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-03-23T00:00:00"}