{"id":"https://openalex.org/W3010855265","doi":"https://doi.org/10.1111/imr.12849","title":"Obesity and CD8 T cell metabolism: Implications for anti\u2010tumor immunity and cancer immunotherapy outcomes","display_name":"Obesity and CD8 T cell metabolism: Implications for anti\u2010tumor immunity and cancer immunotherapy outcomes","publication_year":2020,"publication_date":"2020-03-10","ids":{"openalex":"https://openalex.org/W3010855265","doi":"https://doi.org/10.1111/imr.12849","mag":"3010855265","pmid":"https://pubmed.ncbi.nlm.nih.gov/32157710","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7416819"},"language":"en","primary_location":{"id":"doi:10.1111/imr.12849","doi":"https://doi.org/10.1111/imr.12849","is_oa":false,"landing_page_url":"https://doi.org/10.1111/imr.12849","pdf_url":null,"source":{"id":"https://openalex.org/S133112385","display_name":"Immunological Reviews","issn_l":"0105-2896","issn":["0105-2896","1600-065X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunological Reviews","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7416819","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051197598","display_name":"William J. Turbitt","orcid":"https://orcid.org/0000-0002-7584-3307","observed_orcids":["https://orcid.org/0000-0002-7584-3307"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William J. Turbitt","raw_affiliation_strings":["Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama"],"raw_orcid":"https://orcid.org/0000-0002-7584-3307","affiliations":[{"raw_affiliation_string":"Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003531433","display_name":"Claire Buchta Rosean","orcid":"https://orcid.org/0000-0002-3347-3168","observed_orcids":["https://orcid.org/0000-0002-3347-3168"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claire Buchta Rosean","raw_affiliation_strings":["Department of Urology, The University of Iowa, Iowa City, Iowa"],"raw_orcid":"https://orcid.org/0000-0002-3347-3168","affiliations":[{"raw_affiliation_string":"Department of Urology, The University of Iowa, Iowa City, Iowa","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051560040","display_name":"K. Scott Weber","orcid":"https://orcid.org/0000-0003-3688-2191","observed_orcids":["https://orcid.org/0000-0003-3688-2191"]},"institutions":[{"id":"https://openalex.org/I100005738","display_name":"Brigham Young University","ror":"https://ror.org/047rhhm47","country_code":"US","type":"education","lineage":["https://openalex.org/I100005738"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Scott Weber","raw_affiliation_strings":["Department of Microbiology and Molecular Biology, Brigham Young University, Provo, Utah"],"raw_orcid":"https://orcid.org/0000-0003-3688-2191","affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Biology, Brigham Young University, Provo, Utah","institution_ids":["https://openalex.org/I100005738"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004594443","display_name":"Lyse A. Norian","orcid":"https://orcid.org/0000-0003-1016-313X","observed_orcids":["https://orcid.org/0000-0003-1016-313X"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039376","display_name":"O'Neal Comprehensive Cancer Center","ror":"https://ror.org/03j18km61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250","https://openalex.org/I4390039376"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lyse A. Norian","raw_affiliation_strings":["Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama","Nutrition Obesity Research Center, University of Alabama at Birmingham, Birmingham, Alabama","O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama"],"raw_orcid":"https://orcid.org/0000-0003-1016-313X","affiliations":[{"raw_affiliation_string":"Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"Nutrition Obesity Research Center, University of Alabama at Birmingham, Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039376"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5004594443"],"corresponding_institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039376"],"apc_list":{"value":4300,"currency":"USD","value_usd":4300},"apc_paid":null,"fwci":0.8128,"has_fulltext":false,"cited_by_count":60,"citation_normalized_percentile":{"value":0.69359862,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"295","issue":"1","first_page":"203","last_page":"219"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.03139999881386757,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.01590000092983246,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":1.0},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9539999961853027},{"id":"https://openalex.org/keywords/t-cell-metabolism","display_name":"T cell metabolism","score":0.9330000281333923},{"id":"https://openalex.org/keywords/immunometabolism","display_name":"immunometabolism","score":0.9470000267028809},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.8920000195503235},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.9710000157356262},{"id":"https://openalex.org/keywords/t-cell-function","display_name":"T cell function","score":0.6389999985694885},{"id":"https://openalex.org/keywords/immunotherapy-resistance","display_name":"immunotherapy resistance","score":0.4449999928474426},{"id":"https://openalex.org/keywords/metabolic-regulators","display_name":"metabolic modulators","score":0.34599998593330383}],"concepts":[{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.7394828796386719},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.6549703478813171},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.591472327709198},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5740254521369934},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5704065561294556},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5566469430923462},{"id":"https://openalex.org/C2991704936","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Cell metabolism","level":3,"score":0.5527533292770386},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5320953130722046},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5194922685623169},{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.49175670742988586},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.43165484070777893},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.41984444856643677},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4054489731788635},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.29522159695625305},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.25145864486694336},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.16004103422164917},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006019","descriptor_name":"Glycolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007111","descriptor_name":"Immunity, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016246","descriptor_name":"Lymphocytes, Tumor-Infiltrating","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016246","descriptor_name":"Lymphocytes, Tumor-Infiltrating","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016246","descriptor_name":"Lymphocytes, Tumor-Infiltrating","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019468","descriptor_name":"Disease Management","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/imr.12849","doi":"https://doi.org/10.1111/imr.12849","is_oa":false,"landing_page_url":"https://doi.org/10.1111/imr.12849","pdf_url":null,"source":{"id":"https://openalex.org/S133112385","display_name":"Immunological Reviews","issn_l":"0105-2896","issn":["0105-2896","1600-065X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunological Reviews","raw_type":"journal-article"},{"id":"pmid:32157710","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32157710","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunological reviews","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7416819","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7416819","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Immunol Rev","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7416819","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7416819","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Immunol Rev","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2203409294","display_name":"Research Training Program in Basic and Translational Oncology","funder_award_id":"T32CA183926","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2543987075","display_name":"Obesity Affects Immunity to Kidney Cancer","funder_award_id":"R01CA181088","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3501820973","display_name":"Identifying outcome mediators of calorie restriction mimetic use in renal cancer","funder_award_id":"R21CA223126","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000897483","display_name":"UAB Nutrition Obesity Research Center (NORC)","funder_award_id":"P30DK056336","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000911678","display_name":"UAB Diabetes Research Center","funder_award_id":"P30DK079626","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":189,"referenced_works":["https://openalex.org/W900373682","https://openalex.org/W1483193127","https://openalex.org/W1487731794","https://openalex.org/W1578283200","https://openalex.org/W1590709474","https://openalex.org/W1608509077","https://openalex.org/W1850292730","https://openalex.org/W1853287186","https://openalex.org/W1859037964","https://openalex.org/W1944753949","https://openalex.org/W1964598084","https://openalex.org/W1966122087","https://openalex.org/W1972825083","https://openalex.org/W1973407294","https://openalex.org/W1975566288","https://openalex.org/W1976028023","https://openalex.org/W1976124684","https://openalex.org/W1976555781","https://openalex.org/W1976714959","https://openalex.org/W1982484787","https://openalex.org/W1986935067","https://openalex.org/W1993686673","https://openalex.org/W1996175687","https://openalex.org/W1998664010","https://openalex.org/W2000725338","https://openalex.org/W2008381613","https://openalex.org/W2013388724","https://openalex.org/W2016662511","https://openalex.org/W2026161601","https://openalex.org/W2034269086","https://openalex.org/W2037707039","https://openalex.org/W2038918212","https://openalex.org/W2043416239","https://openalex.org/W2044798581","https://openalex.org/W2044835625","https://openalex.org/W2049345643","https://openalex.org/W2049553585","https://openalex.org/W2049702842","https://openalex.org/W2050216284","https://openalex.org/W2051051060","https://openalex.org/W2051582909","https://openalex.org/W2052543023","https://openalex.org/W2060070314","https://openalex.org/W2060878129","https://openalex.org/W2061172198","https://openalex.org/W2066671159","https://openalex.org/W2068175785","https://openalex.org/W2068994108","https://openalex.org/W2069663698","https://openalex.org/W2075901463","https://openalex.org/W2077508806","https://openalex.org/W2079431196","https://openalex.org/W2080154792","https://openalex.org/W2094558708","https://openalex.org/W2095695954","https://openalex.org/W2096322385","https://openalex.org/W2097259163","https://openalex.org/W2100039832","https://openalex.org/W2100373006","https://openalex.org/W2100412095","https://openalex.org/W2100866502","https://openalex.org/W2103456976","https://openalex.org/W2104750134","https://openalex.org/W2105665764","https://openalex.org/W2105697998","https://openalex.org/W2110271242","https://openalex.org/W2110603890","https://openalex.org/W2113845760","https://openalex.org/W2116676186","https://openalex.org/W2117692326","https://openalex.org/W2117971406","https://openalex.org/W2119313330","https://openalex.org/W2122653113","https://openalex.org/W2123105952","https://openalex.org/W2129205142","https://openalex.org/W2129424071","https://openalex.org/W2131591460","https://openalex.org/W2135730659","https://openalex.org/W2142431039","https://openalex.org/W2144211575","https://openalex.org/W2145697808","https://openalex.org/W2156145814","https://openalex.org/W2157369555","https://openalex.org/W2157559566","https://openalex.org/W2157739158","https://openalex.org/W2158082259","https://openalex.org/W2160571820","https://openalex.org/W2160915024","https://openalex.org/W2164164239","https://openalex.org/W2165334726","https://openalex.org/W2168631000","https://openalex.org/W2209812019","https://openalex.org/W2223535266","https://openalex.org/W2234115940","https://openalex.org/W2239996937","https://openalex.org/W2285239684","https://openalex.org/W2301131921","https://openalex.org/W2336409096","https://openalex.org/W2340890831","https://openalex.org/W2344873770","https://openalex.org/W2395444360","https://openalex.org/W2401536218","https://openalex.org/W2407131888","https://openalex.org/W2415557067","https://openalex.org/W2468925656","https://openalex.org/W2469758901","https://openalex.org/W2472539201","https://openalex.org/W2503407514","https://openalex.org/W2507163473","https://openalex.org/W2510411424","https://openalex.org/W2517357121","https://openalex.org/W2519020116","https://openalex.org/W2519181983","https://openalex.org/W2524413044","https://openalex.org/W2529393815","https://openalex.org/W2530067632","https://openalex.org/W2548313353","https://openalex.org/W2560185130","https://openalex.org/W2560367415","https://openalex.org/W2560396365","https://openalex.org/W2564004030","https://openalex.org/W2580449060","https://openalex.org/W2586506766","https://openalex.org/W2589066097","https://openalex.org/W2593483995","https://openalex.org/W2606475335","https://openalex.org/W2606939149","https://openalex.org/W2620406790","https://openalex.org/W2626638947","https://openalex.org/W2724106870","https://openalex.org/W2727838564","https://openalex.org/W2735267600","https://openalex.org/W2737206084","https://openalex.org/W2740616896","https://openalex.org/W2743010525","https://openalex.org/W2743408091","https://openalex.org/W2755181857","https://openalex.org/W2755321719","https://openalex.org/W2767159687","https://openalex.org/W2773550242","https://openalex.org/W2774935690","https://openalex.org/W2775167938","https://openalex.org/W2780852610","https://openalex.org/W2783439615","https://openalex.org/W2784374589","https://openalex.org/W2786396800","https://openalex.org/W2789660401","https://openalex.org/W2789892520","https://openalex.org/W2791591091","https://openalex.org/W2792178736","https://openalex.org/W2795423981","https://openalex.org/W2795915709","https://openalex.org/W2796643083","https://openalex.org/W2801082810","https://openalex.org/W2801309958","https://openalex.org/W2802554884","https://openalex.org/W2810532319","https://openalex.org/W2853912962","https://openalex.org/W2885288866","https://openalex.org/W2887577080","https://openalex.org/W2890653858","https://openalex.org/W2894324859","https://openalex.org/W2896283264","https://openalex.org/W2898946138","https://openalex.org/W2899984019","https://openalex.org/W2900980862","https://openalex.org/W2902146996","https://openalex.org/W2904410891","https://openalex.org/W2913400417","https://openalex.org/W2940904702","https://openalex.org/W2943677497","https://openalex.org/W2943781197","https://openalex.org/W2944462720","https://openalex.org/W2950397173","https://openalex.org/W2951296513","https://openalex.org/W2953813865","https://openalex.org/W2960739610","https://openalex.org/W2962176576","https://openalex.org/W2966041852","https://openalex.org/W2967093625","https://openalex.org/W2970427296","https://openalex.org/W2973127038","https://openalex.org/W2977508467","https://openalex.org/W2981884208","https://openalex.org/W2985623197","https://openalex.org/W2991118872","https://openalex.org/W3147238672","https://openalex.org/W3152169041","https://openalex.org/W4294138012"],"related_works":["https://openalex.org/W2797368159","https://openalex.org/W4205596805","https://openalex.org/W4389241815","https://openalex.org/W4385685463","https://openalex.org/W3112898749","https://openalex.org/W4210512619","https://openalex.org/W4205350805","https://openalex.org/W4283371335","https://openalex.org/W7160420779","https://openalex.org/W2967985263"],"abstract_inverted_index":{"Obesity":[0],"is":[1,35,44],"an":[2],"established":[3],"risk":[4],"factor":[5],"for":[6,150],"many":[7],"cancers":[8],"and":[9,71,74,92,98,109,127,159],"has":[10],"recently":[11],"been":[12],"found":[13],"to":[14,47,60,117,153],"alter":[15,68],"the":[16,24,38,65,69,90,118],"efficacy":[17],"of":[18,26,85,94,120,167],"T":[19,41,55,86,106,133,156],"cell-based":[20],"immunotherapies.":[21],"Currently,":[22],"however,":[23],"effects":[25],"obesity":[27,122,169],"on":[28,123],"immunometabolism":[29],"remain":[30],"unclear.":[31],"Understanding":[32],"these":[33],"associations":[34],"critical,":[36],"given":[37],"fact":[39],"that":[40,146],"cell":[42,56,87,107,134,157],"metabolism":[43,88,135,158],"tightly":[45],"linked":[46],"effector":[48],"function.":[49],"Thus,":[50],"any":[51],"obesity-associated":[52,103],"changes":[53,63,104],"in":[54,89,105,164],"bioenergetics":[57],"are":[58,147],"likely":[59],"drive":[61],"functional":[62],"at":[64],"cellular":[66],"level,":[67],"metabolome":[70],"cytokine/chemokine":[72],"milieu,":[73],"impact":[75,119],"cancer":[76,124,161],"immunotherapy":[77,125,162],"outcomes.":[78],"Here,":[79],"we":[80,141],"provide":[81],"a":[82],"brief":[83],"overview":[84],"presence":[91],"absence":[93],"solid":[95],"tumor":[96],"growth":[97],"summarize":[99],"current":[100],"literature":[101],"regarding":[102],"function":[108],"bioenergetics.":[110],"We":[111],"also":[112],"discuss":[113],"recent":[114],"findings":[115],"related":[116],"host":[121],"outcomes":[126,163],"present":[128],"potential":[129],"mechanisms":[130],"by":[131],"which":[132],"may":[136],"influence":[137],"therapeutic":[138],"efficacy.":[139],"Finally,":[140],"describe":[142],"promising":[143],"pharmaceutical":[144],"therapies":[145],"being":[148],"investigated":[149],"their":[151,168],"ability":[152],"improve":[154],"CD8":[155],"enhance":[160],"patients,":[165],"regardless":[166],"status.":[170]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":10}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-03-23T00:00:00"}