{"id":"https://openalex.org/W3010844304","doi":"https://doi.org/10.3389/fphys.2020.00107","title":"Modifications of Sarcoplasmic Reticulum Function Prevent Progression of Sarcomere-Linked Hypertrophic Cardiomyopathy Despite a Persistent Increase in Myofilament Calcium Response","display_name":"Modifications of Sarcoplasmic Reticulum Function Prevent Progression of Sarcomere-Linked Hypertrophic Cardiomyopathy Despite a Persistent Increase in Myofilament Calcium Response","publication_year":2020,"publication_date":"2020-03-10","ids":{"openalex":"https://openalex.org/W3010844304","doi":"https://doi.org/10.3389/fphys.2020.00107","mag":"3010844304","pmid":"https://pubmed.ncbi.nlm.nih.gov/32210830","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7075858"},"language":"en","primary_location":{"id":"doi:10.3389/fphys.2020.00107","doi":"https://doi.org/10.3389/fphys.2020.00107","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2020.00107","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphys.2020.00107/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fphys.2020.00107/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109165479","display_name":"Shamim A. K. Chowdhury","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shamim A. K. Chowdhury","raw_affiliation_strings":["Department of Physiology and Biophysics and the Center for Cardiovascular Research, College of Medicine, University of Illinois at Chicago, Chicago, IL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics and the Center for Cardiovascular Research, College of Medicine, University of Illinois at Chicago, Chicago, IL, United States","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024090322","display_name":"Chad M. Warren","orcid":"https://orcid.org/0000-0003-3958-0682","observed_orcids":["https://orcid.org/0000-0003-3958-0682"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chad M. Warren","raw_affiliation_strings":["Department of Physiology and Biophysics and the Center for Cardiovascular Research, College of Medicine, University of Illinois at Chicago, Chicago, IL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics and the Center for Cardiovascular Research, College of Medicine, University of Illinois at Chicago, Chicago, IL, United States","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012229696","display_name":"Jillian N. Simon","orcid":"https://orcid.org/0000-0001-8140-7782","observed_orcids":["https://orcid.org/0000-0001-8140-7782"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jillian N. Simon","raw_affiliation_strings":["Department of Physiology and Biophysics and the Center for Cardiovascular Research, College of Medicine, University of Illinois at Chicago, Chicago, IL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics and the Center for Cardiovascular Research, College of Medicine, University of Illinois at Chicago, Chicago, IL, United States","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068434071","display_name":"David M. Ryba","orcid":"https://orcid.org/0009-0007-3210-767X","observed_orcids":["https://orcid.org/0009-0007-3210-767X","https://orcid.org/0000-0002-5994-5581"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David M. Ryba","raw_affiliation_strings":["Department of Physiology and Biophysics and the Center for Cardiovascular Research, College of Medicine, University of Illinois at Chicago, Chicago, IL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics and the Center for Cardiovascular Research, College of Medicine, University of Illinois at Chicago, Chicago, IL, United States","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088970485","display_name":"Ashley Batra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashley Batra","raw_affiliation_strings":["Department of Physiology and Biophysics and the Center for Cardiovascular Research, College of Medicine, University of Illinois at Chicago, Chicago, IL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics and the Center for Cardiovascular Research, College of Medicine, University of Illinois at Chicago, Chicago, IL, United States","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Peter Varga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Varga","raw_affiliation_strings":["Department of Pediatrics, Section of Cardiology, University of Illinois at Chicago, Chicago, IL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Section of Cardiology, University of Illinois at Chicago, Chicago, IL, United States","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080329479","display_name":"Evangelia Galani Kranias","orcid":"https://orcid.org/0000-0002-4621-6179","observed_orcids":["https://orcid.org/0000-0002-4621-6179"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Evangelia G. Kranias","raw_affiliation_strings":["Department of Pharmacology and Systems Physiology, University of Cincinnati, Cincinnati, OH, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Systems Physiology, University of Cincinnati, Cincinnati, OH, United States","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072803970","display_name":"Jil C. Tardiff","orcid":"https://orcid.org/0000-0003-4291-4882","observed_orcids":["https://orcid.org/0000-0003-4291-4882"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jil C. Tardiff","raw_affiliation_strings":["Department of Medicine, Division of Cardiology, The University of Arizona, Tucson, AZ, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Cardiology, The University of Arizona, Tucson, AZ, United States","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109085884","display_name":"Ross John Solaro","orcid":"https://orcid.org/0000-0002-4196-0353","observed_orcids":["https://orcid.org/0000-0002-4196-0353"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. John Solaro","raw_affiliation_strings":["Department of Physiology and Biophysics and the Center for Cardiovascular Research, College of Medicine, University of Illinois at Chicago, Chicago, IL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics and the Center for Cardiovascular Research, College of Medicine, University of Illinois at Chicago, Chicago, IL, United States","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086108615","display_name":"Beata Maria Wolska","orcid":"https://orcid.org/0000-0003-1519-2896","observed_orcids":["https://orcid.org/0000-0003-1519-2896"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Beata M. Wolska","raw_affiliation_strings":["Department of Medicine, Division of Cardiology, University of Illinois at Chicago, Chicago, IL, United States","Department of Physiology and Biophysics and the Center for Cardiovascular Research, College of Medicine, University of Illinois at Chicago, Chicago, IL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Cardiology, University of Illinois at Chicago, Chicago, IL, United States","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Department of Physiology and Biophysics and the Center for Cardiovascular Research, College of Medicine, University of Illinois at Chicago, Chicago, IL, United States","institution_ids":["https://openalex.org/I39422238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5086108615"],"corresponding_institution_ids":["https://openalex.org/I39422238"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":1.547,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.8473466,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"11","issue":null,"first_page":"107","last_page":"107"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypertrophic-cardiomyopathy","display_name":"hypertrophic cardiomyopathy","score":0.9900000095367432},{"id":"https://openalex.org/keywords/sarcomere","display_name":"sarcomere","score":0.8149999976158142},{"id":"https://openalex.org/keywords/diastolic-dysfunction","display_name":"diastolic dysfunction","score":0.8889999985694885},{"id":"https://openalex.org/keywords/myofilament-calcium-sensitivity","display_name":"myofilament calcium sensitivity","score":0.9470000267028809},{"id":"https://openalex.org/keywords/sarcoplasmic-reticulum-calcium-handling","display_name":"sarcoplasmic reticulum calcium handling","score":0.8019999861717224},{"id":"https://openalex.org/keywords/camkii-phosphorylation","display_name":"CaMKII phosphorylation","score":0.8769999742507935},{"id":"https://openalex.org/keywords/speckle-tracking-strain","display_name":"speckle tracking strain","score":0.8149999976158142},{"id":"https://openalex.org/keywords/transgenic-mouse-model","display_name":"transgenic mouse model","score":0.7590000033378601},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.39800000190734863},{"id":"https://openalex.org/keywords/collagen-deposition","display_name":"collagen deposition","score":0.5590000152587891},{"id":"https://openalex.org/keywords/myocyte-disarray","display_name":"myocyte disarray","score":0.8320000171661377},{"id":"https://openalex.org/keywords/calcium-flux","display_name":"calcium flux","score":0.5009999871253967}],"concepts":[{"id":"https://openalex.org/C68731436","wikidata":"https://www.wikidata.org/wiki/Q1337087","display_name":"Sarcomere","level":3,"score":0.7701733708381653},{"id":"https://openalex.org/C174054327","wikidata":"https://www.wikidata.org/wiki/Q6947920","display_name":"Myofilament","level":3,"score":0.7660479545593262},{"id":"https://openalex.org/C17137333","wikidata":"https://www.wikidata.org/wiki/Q410105","display_name":"Phospholamban","level":3,"score":0.7479546070098877},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.6125941872596741},{"id":"https://openalex.org/C2780185194","wikidata":"https://www.wikidata.org/wiki/Q1364270","display_name":"Hypertrophic cardiomyopathy","level":2,"score":0.5829726457595825},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.570705235004425},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5177673101425171},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.5157661437988281},{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.49573859572410583},{"id":"https://openalex.org/C144469398","wikidata":"https://www.wikidata.org/wiki/Q24785650","display_name":"Troponin T","level":3,"score":0.46840307116508484},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4522576332092285},{"id":"https://openalex.org/C8880881","wikidata":"https://www.wikidata.org/wiki/Q7846262","display_name":"Troponin complex","level":4,"score":0.4457385241985321},{"id":"https://openalex.org/C36036425","wikidata":"https://www.wikidata.org/wiki/Q7846262","display_name":"Troponin","level":3,"score":0.4290289282798767},{"id":"https://openalex.org/C207583985","wikidata":"https://www.wikidata.org/wiki/Q128723","display_name":"Wild type","level":4,"score":0.42813533544540405},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42296379804611206},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.4220472574234009},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4100872874259949},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3854108154773712},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36311542987823486},{"id":"https://openalex.org/C6997183","wikidata":"https://www.wikidata.org/wiki/Q271727","display_name":"Myosin","level":2,"score":0.3482353091239929},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.34758251905441284},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.33862537145614624},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2444581389427185},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1897357702255249},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.1477350890636444},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fphys.2020.00107","doi":"https://doi.org/10.3389/fphys.2020.00107","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2020.00107","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphys.2020.00107/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7075858","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7075858","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Physiol","raw_type":"Text"},{"id":"pmid:32210830","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32210830","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in physiology","raw_type":"Journal Article"},{"id":"pmh:oai:repository.arizona.edu:10150/641547","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10150/641547","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Switzerland","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:4f5f102bf0564eda9c95446b3789c405","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4f5f102bf0564eda9c95446b3789c405","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Physiology, Vol 11 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphys.2020.00107","doi":"https://doi.org/10.3389/fphys.2020.00107","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2020.00107","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphys.2020.00107/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5973772321","display_name":"Myofilament signaling and cardiac disorders","funder_award_id":"R01HL128468","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G891108873","display_name":"Integrated Mechanisms of Cardiac Maladaptation","funder_award_id":"P01HL062426","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000120429","display_name":null,"funder_award_id":"HL062426","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000885063","display_name":"Integrative Approach to Divergent Remodeling in Thin Filament Cardiomyopathies","funder_award_id":"R01HL075619","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320320890","display_name":"Fondation Leducq","ror":"https://ror.org/01czwga19"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3010844304.pdf","grobid_xml":"https://content.openalex.org/works/W3010844304.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W1518597768","https://openalex.org/W1606524341","https://openalex.org/W1932052686","https://openalex.org/W1974714435","https://openalex.org/W1976018567","https://openalex.org/W1984606352","https://openalex.org/W1988077099","https://openalex.org/W1995218317","https://openalex.org/W1999251970","https://openalex.org/W2001160771","https://openalex.org/W2002479494","https://openalex.org/W2027178882","https://openalex.org/W2029396634","https://openalex.org/W2060151654","https://openalex.org/W2070031931","https://openalex.org/W2072625807","https://openalex.org/W2082838239","https://openalex.org/W2084136804","https://openalex.org/W2085529735","https://openalex.org/W2095487467","https://openalex.org/W2109101320","https://openalex.org/W2120600360","https://openalex.org/W2123552783","https://openalex.org/W2129985885","https://openalex.org/W2132374854","https://openalex.org/W2133397439","https://openalex.org/W2155922317","https://openalex.org/W2157048650","https://openalex.org/W2160416495","https://openalex.org/W2161240082","https://openalex.org/W2163363089","https://openalex.org/W2164641172","https://openalex.org/W2166877777","https://openalex.org/W2170268034","https://openalex.org/W2177721873","https://openalex.org/W2180458501","https://openalex.org/W2202285110","https://openalex.org/W2277697424","https://openalex.org/W2283806402","https://openalex.org/W2311875137","https://openalex.org/W2557663987","https://openalex.org/W2579484052","https://openalex.org/W2594034827","https://openalex.org/W2616302857","https://openalex.org/W2618728300","https://openalex.org/W2738545992","https://openalex.org/W2752348618","https://openalex.org/W2756203218","https://openalex.org/W2809430106","https://openalex.org/W2888439606","https://openalex.org/W2899182703","https://openalex.org/W2903132424","https://openalex.org/W2922176301","https://openalex.org/W2938448662","https://openalex.org/W2985262897","https://openalex.org/W4240337538","https://openalex.org/W4244420109","https://openalex.org/W4245028961"],"related_works":["https://openalex.org/W2901484055","https://openalex.org/W4410700387","https://openalex.org/W4362518645","https://openalex.org/W2155922317","https://openalex.org/W2029396634","https://openalex.org/W2903132424","https://openalex.org/W2789825017","https://openalex.org/W4240066567","https://openalex.org/W3005251013","https://openalex.org/W2060874562"],"abstract_inverted_index":{"Hypertrophic":[0],"cardiomyopathy":[1],"(HCM)":[2],"is":[3,102],"a":[4,20,94,294,341],"genetic":[5],"disorder":[6],"caused":[7],"by":[8,126],"mutations":[9,31],"in":[10,110,140,149,221,226,240,250,255,269,303,322],"different":[11,57],"genes":[12],"mainly":[13],"encoding":[14],"myofilament":[15,111,270,323],"proteins":[16],"and":[17,53,74,106,114,154,164,175,183,193,205,216,235,275,336],"therefore":[18],"called":[19],"\u201cdisease":[21],"of":[22,28,46,85,122,136,147,167,186,233,260,332],"the":[23,26,39,44,82,86,98,123,134,137,261,333],"sarcomere\u201d.":[24],"Despite":[25],"discovery":[27],"sarcomere":[29],"protein":[30],"linked":[32,103],"to":[33,63,79,104,132,280,298,325,329],"HCM":[34,105,138,262,334,346],"almost":[35],"30":[36],"years":[37],"ago,":[38],"cellular":[40,83],"mechanisms":[41,84],"responsible":[42],"for":[43,67,156,345],"development":[45,135,331],"this":[47],"disease":[48],"are":[49,77],"not":[50,254,265],"completely":[51],"understood":[52],"likely":[54],"vary":[55],"among":[56],"mutations.":[58],"Moreover,":[59,278],"despite":[60],"many":[61],"efforts":[62],"develop":[64],"effective":[65],"treatments":[66],"HCM,":[68],"these":[69],"have":[70],"largely":[71],"been":[72],"unsuccessful,":[73],"more":[75,295],"studies":[76],"needed":[78],"better":[80],"understand":[81],"disease.":[87],"In":[88,306],"experiments":[89],"reported":[90],"here,":[91],"we":[92],"investigated":[93],"mouse":[95],"model":[96],"expressing":[97],"mutant":[99],"cTnT-R92Q,":[100],"which":[101,160,171,180,190],"induces":[107],"an":[108],"increase":[109],"Ca2+":[112,271,317,326],"sensitivity":[113,272],"diastolic":[115,124,217,313],"dysfunction.":[116],"We":[117,210,243],"found":[118,211],"that":[119,212,311],"early":[120,300],"correction":[121],"dysfunction":[125,302,314],"phospholamban":[127],"knockout":[128],"(PLNKO)":[129],"was":[130,198,264,327],"able":[131,328],"prevent":[133,330],"phenotype":[139,263,335],"TnT-R92Q":[141,182,192],"transgenic":[142],"(TG)":[143],"mice.":[144,228,277,305],"Four":[145],"groups":[146],"mice":[148],"FVBN":[150],"background":[151],"were":[152,219],"generated":[153],"used":[155],"experiments:":[157],"1)":[158],"NTG/PLN,":[159],"express":[161,172,181,191],"wild-type":[162,173],"TnT":[163,174],"normal":[165,184,225],"level":[166,185],"PLN;":[168,177,187],"2)":[169],"NTG/PLNKO;":[170],"no":[176,194,320],"3)":[178],"TG/PLN;":[179],"4)":[188],"TG/PLNKO;":[189],"PLN.":[195],"Cardiac":[196],"function":[197,218],"determined":[199],"using":[200],"both":[201,213],"standard":[202,281],"echocardiographic":[203],"parameters":[204,284],"speckle":[206,290],"tracking":[207],"strain":[208,291],"measurements.":[209],"atrial":[214],"morphology":[215],"altered":[220],"TG-PLN":[222,241,251,274,304],"mice,":[223],"but":[224,253],"TG-PLNKO":[227,256,276],"Histological":[229],"analysis":[230],"showed":[231],"disarray":[232],"myocytes":[234],"increased":[236,246],"collagen":[237],"deposition":[238],"only":[239,249],"hearts.":[242,257],"also":[244],"observed":[245],"CaMKII":[247],"phosphorylation":[248],"hearts,":[252],"The":[258],"rescue":[259],"associated":[266],"with":[267,319],"differences":[268],"between":[273],"compared":[279],"systolic":[282,301],"echo":[283],"such":[285],"as":[286,340],"ejection":[287],"fraction":[288],"(EF),":[289],"measurements":[292],"provided":[293],"sensitive":[296],"approach":[297],"detect":[299],"summary,":[307],"our":[308],"results":[309],"indicate":[310],"targeting":[312],"through":[315],"altering":[316],"fluxes":[318],"change":[321],"response":[324],"should":[337],"be":[338],"considered":[339],"potential":[342],"additional":[343],"treatment":[344],"patients.":[347]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2020-03-23T00:00:00"}