{"id":"https://openalex.org/W3010791094","doi":"https://doi.org/10.1055/s-0039-1701016","title":"Temporal Changes in Fibrinolysis following Injury","display_name":"Temporal Changes in Fibrinolysis following Injury","publication_year":2020,"publication_date":"2020-03-01","ids":{"openalex":"https://openalex.org/W3010791094","doi":"https://doi.org/10.1055/s-0039-1701016","mag":"3010791094","pmid":"https://pubmed.ncbi.nlm.nih.gov/32160644"},"language":"en","primary_location":{"id":"doi:10.1055/s-0039-1701016","doi":"https://doi.org/10.1055/s-0039-1701016","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0039-1701016","pdf_url":null,"source":{"id":"https://openalex.org/S96726197","display_name":"Seminars in Thrombosis and Hemostasis","issn_l":"0094-6176","issn":["0094-6176","1098-9064"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Thrombosis and Hemostasis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008748881","display_name":"Hunter B. Moore","orcid":"https://orcid.org/0000-0002-5939-3828","observed_orcids":["https://orcid.org/0000-0002-5939-3828"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hunter B. Moore","raw_affiliation_strings":["Division of Transplant Surgery, Department of Surgery, University of Colorado School of Medicine, Aurora, Colorado"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Transplant Surgery, Department of Surgery, University of Colorado School of Medicine, Aurora, Colorado","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041612225","display_name":"Ernest Eugene Moore","orcid":"https://orcid.org/0000-0002-0419-4848","observed_orcids":["https://orcid.org/0000-0002-0419-4848"]},"institutions":[{"id":"https://openalex.org/I2801983979","display_name":"Denver Health Medical Center","ror":"https://ror.org/01fbz6h17","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801983979"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ernest E. Moore","raw_affiliation_strings":["Department of Surgery, Ernest E. Moore Shock and Trauma Center at Denver Health, Denver, Colorado","Division of Transplant Surgery, Department of Surgery, University of Colorado School of Medicine, Aurora, Colorado"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Ernest E. Moore Shock and Trauma Center at Denver Health, Denver, Colorado","institution_ids":["https://openalex.org/I2801983979"]},{"raw_affiliation_string":"Division of Transplant Surgery, Department of Surgery, University of Colorado School of Medicine, Aurora, Colorado","institution_ids":["https://openalex.org/I51713134"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5008748881"],"corresponding_institution_ids":["https://openalex.org/I51713134"],"apc_list":null,"apc_paid":null,"fwci":5.8643,"has_fulltext":false,"cited_by_count":49,"citation_normalized_percentile":{"value":0.96914843,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"46","issue":"02","first_page":"189","last_page":"198"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fibrinolysis","display_name":"fibrinolysis","score":0.9909999966621399},{"id":"https://openalex.org/keywords/trauma-physical-injury","display_name":"trauma (physical injury)","score":0.8880000114440918},{"id":"https://openalex.org/keywords/hemorrhagic-shock","display_name":"hemorrhagic shock","score":0.8450000286102295},{"id":"https://openalex.org/keywords/hyperfibrinolysis","display_name":"hyperfibrinolysis","score":0.9700000286102295},{"id":"https://openalex.org/keywords/hypofibrinolysis","display_name":"hypofibrinolysis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/plasminogen-activator-inhibitor-1","display_name":"plasminogen activator inhibitor-1","score":0.9860000014305115},{"id":"https://openalex.org/keywords/resuscitation","display_name":"resuscitation","score":0.6470000147819519},{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":0.7829999923706055},{"id":"https://openalex.org/keywords/organ-failure","display_name":"organ failure","score":0.8820000290870667},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6299999952316284}],"concepts":[{"id":"https://openalex.org/C2776825266","wikidata":"https://www.wikidata.org/wiki/Q1410794","display_name":"Fibrinolysis","level":2,"score":0.9371181130409241},{"id":"https://openalex.org/C2781219028","wikidata":"https://www.wikidata.org/wiki/Q5957994","display_name":"Hyperfibrinolysis","level":3,"score":0.9303112030029297},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.859599232673645},{"id":"https://openalex.org/C2778165595","wikidata":"https://www.wikidata.org/wiki/Q5491454","display_name":"Resuscitation","level":2,"score":0.6785152554512024},{"id":"https://openalex.org/C2776572282","wikidata":"https://www.wikidata.org/wiki/Q416351","display_name":"Tissue plasminogen activator","level":2,"score":0.5106001496315002},{"id":"https://openalex.org/C2781300812","wikidata":"https://www.wikidata.org/wiki/Q178061","display_name":"Shock (circulatory)","level":2,"score":0.4805458188056946},{"id":"https://openalex.org/C2779679481","wikidata":"https://www.wikidata.org/wiki/Q13581432","display_name":"Plasminogen activator","level":2,"score":0.4753256142139435},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3919908404350281},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.38676413893699646},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3338174521923065}],"mesh":[{"descriptor_ui":"D005342","descriptor_name":"Fibrinolysis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013916","descriptor_name":"Thrombelastography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D014947","descriptor_name":"Wounds and Injuries","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1055/s-0039-1701016","doi":"https://doi.org/10.1055/s-0039-1701016","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0039-1701016","pdf_url":null,"source":{"id":"https://openalex.org/S96726197","display_name":"Seminars in Thrombosis and Hemostasis","issn_l":"0094-6176","issn":["0094-6176","1098-9064"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Thrombosis and Hemostasis","raw_type":"journal-article"},{"id":"pmid:32160644","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32160644","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in thrombosis and hemostasis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7300000190734863,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8995988706","display_name":"Analysis and Characterization of Trauma-Induced Coagulopathy","funder_award_id":"UM1HL120877","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000913843","display_name":"Mechanisms of Trauma-Induced Coagulopathy","funder_award_id":"T32GM008315","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":77,"referenced_works":["https://openalex.org/W6233361","https://openalex.org/W1544166450","https://openalex.org/W1567129527","https://openalex.org/W1572037713","https://openalex.org/W1606842230","https://openalex.org/W1963983818","https://openalex.org/W1966420266","https://openalex.org/W1970362985","https://openalex.org/W1974377953","https://openalex.org/W1974693697","https://openalex.org/W1975459904","https://openalex.org/W1976665187","https://openalex.org/W1987823544","https://openalex.org/W1991409739","https://openalex.org/W1991600763","https://openalex.org/W1995123717","https://openalex.org/W1998083240","https://openalex.org/W2001971089","https://openalex.org/W2008748577","https://openalex.org/W2012191523","https://openalex.org/W2013893652","https://openalex.org/W2018568618","https://openalex.org/W2023895609","https://openalex.org/W2029829108","https://openalex.org/W2035959480","https://openalex.org/W2037526777","https://openalex.org/W2040767898","https://openalex.org/W2047076921","https://openalex.org/W2054878669","https://openalex.org/W2057673282","https://openalex.org/W2061643644","https://openalex.org/W2068324201","https://openalex.org/W2071676983","https://openalex.org/W2075182040","https://openalex.org/W2075840772","https://openalex.org/W2088266030","https://openalex.org/W2088319659","https://openalex.org/W2100095744","https://openalex.org/W2101322642","https://openalex.org/W2105453284","https://openalex.org/W2123578671","https://openalex.org/W2157097093","https://openalex.org/W2162573377","https://openalex.org/W2165358306","https://openalex.org/W2202341984","https://openalex.org/W2236491047","https://openalex.org/W2253151067","https://openalex.org/W2276154749","https://openalex.org/W2328890393","https://openalex.org/W2338859551","https://openalex.org/W2399350070","https://openalex.org/W2411105667","https://openalex.org/W2413193635","https://openalex.org/W2414257583","https://openalex.org/W2415488596","https://openalex.org/W2415675804","https://openalex.org/W2426433410","https://openalex.org/W2472224130","https://openalex.org/W2565160811","https://openalex.org/W2584930623","https://openalex.org/W2593982076","https://openalex.org/W2693139924","https://openalex.org/W2747099269","https://openalex.org/W2760821898","https://openalex.org/W2781922514","https://openalex.org/W2782507794","https://openalex.org/W2794072059","https://openalex.org/W2799403580","https://openalex.org/W2800355849","https://openalex.org/W2884757588","https://openalex.org/W2899038365","https://openalex.org/W2908695474","https://openalex.org/W2920820434","https://openalex.org/W2942549919","https://openalex.org/W2948313802","https://openalex.org/W2949290280","https://openalex.org/W3010146517"],"related_works":["https://openalex.org/W2893350814","https://openalex.org/W2593982076","https://openalex.org/W2418236595","https://openalex.org/W2899038365","https://openalex.org/W2760821898","https://openalex.org/W2974447587","https://openalex.org/W4307968976","https://openalex.org/W3093337042","https://openalex.org/W2046164777","https://openalex.org/W2061643644"],"abstract_inverted_index":{"Trauma":[0],"patients":[1,58,73,111,148],"present":[2],"to":[3,49,114,129,134,137,171],"the":[4,26,32,37,44,50,107,138,145,173,191],"emergency":[5],"department":[6],"with":[7,59,74,104],"a":[8,20,115,162],"spectrum":[9],"of":[10,28,34,43,67,86,98,109,140,167,176],"fibrinolytic":[11,41,61,76,116,155,177],"activity.":[12],"This":[13],"wide":[14],"variance":[15],"in":[16,144,190],"fibrinolysis":[17,99,132],"activity":[18,42,62,77,178],"is":[19,170],"complex":[21],"multifactorial":[22],"process":[23],"impacted":[24],"by":[25],"degree":[27],"hemorrhagic":[29],"shock":[30],"and":[31,54,106,181,189],"amount":[33],"tissue":[35],"injury":[36,92,102,160,180],"individual":[38],"sustains.":[39],"The":[40,123,165],"trauma":[45,110],"patient":[46],"at":[47,65,82],"presentation":[48],"hospital":[51],"has":[52],"prognostic":[53],"therapeutic":[55],"implications.":[56],"Those":[57,147],"high":[60],"(hyperfibrinolysis)":[63],"are":[64,81],"risk":[66,85],"mortality":[68,88],"from":[69,89,153],"hemorrhage,":[70],"whereas":[71],"those":[72],"low":[75],"(shutdown":[78],"or":[79,93],"hypofibrinolysis)":[80],"an":[83],"increased":[84],"delayed":[87],"traumatic":[90],"brain":[91],"organ":[94],"failure.":[95],"These":[96],"phenotypes":[97],"acutely":[100],"following":[101,179,187],"change":[103,184],"resuscitation,":[105],"majority":[108],"will":[112],"transition":[113,128],"resistant":[117],"state":[118,156],"several":[119],"hours":[120,158],"after":[121,159],"injury.":[122],"mechanism":[124],"for":[125],"this":[126,130,154,168],"near-global":[127],"acquired":[131],"appears":[133],"be":[135],"related":[136],"generation":[139],"plasminogen":[141],"activator":[142],"inhibitor-1":[143],"liver.":[146],"who":[149],"do":[150],"not":[151],"recover":[152],"24":[157],"have":[161],"poor":[163],"prognosis.":[164],"purpose":[166],"article":[169],"review":[172],"different":[174],"states":[175],"how":[182],"they":[183],"over":[185],"time":[186],"resuscitation":[188],"intensive":[192],"care":[193],"unit.":[194]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-03-23T00:00:00"}