{"id":"https://openalex.org/W3010717847","doi":"https://doi.org/10.1038/s41409-020-0869-6","title":"Treosulfan\u2013fludarabine\u2013thiotepa-based conditioning treatment before allogeneic hematopoietic stem cell transplantation for pediatric patients with hematological malignancies","display_name":"Treosulfan\u2013fludarabine\u2013thiotepa-based conditioning treatment before allogeneic hematopoietic stem cell transplantation for pediatric patients with hematological malignancies","publication_year":2020,"publication_date":"2020-03-20","ids":{"openalex":"https://openalex.org/W3010717847","doi":"https://doi.org/10.1038/s41409-020-0869-6","mag":"3010717847","pmid":"https://pubmed.ncbi.nlm.nih.gov/32203268","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7515850"},"language":"en","primary_location":{"id":"doi:10.1038/s41409-020-0869-6","doi":"https://doi.org/10.1038/s41409-020-0869-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41409-020-0869-6","pdf_url":"https://www.nature.com/articles/s41409-020-0869-6.pdf","source":{"id":"https://openalex.org/S183182149","display_name":"Bone Marrow Transplantation","issn_l":"0268-3369","issn":["0268-3369","1476-5365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone Marrow Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/s41409-020-0869-6.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005040866","display_name":"Krzysztof Ka\u0142wak","orcid":"https://orcid.org/0000-0003-1174-5799","observed_orcids":["https://orcid.org/0000-0003-1174-5799"]},"institutions":[{"id":"https://openalex.org/I219388962","display_name":"University of Wroc\u0142aw","ror":"https://ror.org/00yae6e25","country_code":"PL","type":"education","lineage":["https://openalex.org/I219388962"]},{"id":"https://openalex.org/I385303915","display_name":"Wroclaw Medical University","ror":"https://ror.org/01qpw1b93","country_code":"PL","type":"education","lineage":["https://openalex.org/I385303915"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Krzysztof Kalwak","raw_affiliation_strings":["Department of Pediatric Hematology, Oncology and Bone Marrow Transplantation, Wroclaw Medical University, Wroclaw, Poland. krzysztof.kalwak@gmail.com","Department of Pediatric Hematology, Oncology and Bone Marrow Transplantation, Wroclaw Medical University, Wroclaw, Poland"],"raw_orcid":"https://orcid.org/0000-0003-1174-5799","affiliations":[{"raw_affiliation_string":"Department of Pediatric Hematology, Oncology and Bone Marrow Transplantation, Wroclaw Medical University, Wroclaw, Poland. krzysztof.kalwak@gmail.com","institution_ids":["https://openalex.org/I219388962","https://openalex.org/I385303915"]},{"raw_affiliation_string":"Department of Pediatric Hematology, Oncology and Bone Marrow Transplantation, Wroclaw Medical University, Wroclaw, Poland","institution_ids":["https://openalex.org/I385303915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024405301","display_name":"Monika Mielcarek\u2010Siedziuk","orcid":"https://orcid.org/0000-0003-2745-120X","observed_orcids":["https://orcid.org/0000-0003-2745-120X"]},"institutions":[{"id":"https://openalex.org/I385303915","display_name":"Wroclaw Medical University","ror":"https://ror.org/01qpw1b93","country_code":"PL","type":"education","lineage":["https://openalex.org/I385303915"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Monika Mielcarek","raw_affiliation_strings":["Department of Pediatric Hematology, Oncology and Bone Marrow Transplantation, Wroclaw Medical University, Wroclaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Hematology, Oncology and Bone Marrow Transplantation, Wroclaw Medical University, Wroclaw, Poland","institution_ids":["https://openalex.org/I385303915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108501495","display_name":"Katharine Patrick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210164839","display_name":"Sheffield Children's Hospital","ror":"https://ror.org/05mshxb09","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210121472","https://openalex.org/I4210164839"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Katharine Patrick","raw_affiliation_strings":["Sheffield Children's Hospital, Sheffield, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sheffield Children's Hospital, Sheffield, UK","institution_ids":["https://openalex.org/I4210164839"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085336702","display_name":"Jan Styczy\u0144ski","orcid":"https://orcid.org/0000-0002-3158-119X","observed_orcids":["https://orcid.org/0000-0002-3158-119X"]},"institutions":[{"id":"https://openalex.org/I3019271933","display_name":"Nicolaus Copernicus University","ror":"https://ror.org/0102mm775","country_code":"PL","type":"education","lineage":["https://openalex.org/I3019271933"]},{"id":"https://openalex.org/I4210148386","display_name":"Collegium Medicum in Bydgoszcz","ror":"https://ror.org/04c5jwj47","country_code":"PL","type":"education","lineage":["https://openalex.org/I3019271933","https://openalex.org/I4210148386"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Jan Styczynski","raw_affiliation_strings":["Department of Pediatric Hematology and Oncology, Collegium Medicum UMK Torun, Bydgoszcz, Poland"],"raw_orcid":"https://orcid.org/0000-0002-3158-119X","affiliations":[{"raw_affiliation_string":"Department of Pediatric Hematology and Oncology, Collegium Medicum UMK Torun, Bydgoszcz, Poland","institution_ids":["https://openalex.org/I3019271933","https://openalex.org/I4210148386"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029816641","display_name":"Peter Bader","orcid":"https://orcid.org/0000-0003-4554-0265","observed_orcids":["https://orcid.org/0000-0003-4554-0265","https://orcid.org/0009-0004-4345-4165"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Peter Bader","raw_affiliation_strings":["Department for Children and Adolescents, Division for Stem Cell Transplantation, Immunology and Intensive Care Medicine, Goethe University, Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Children and Adolescents, Division for Stem Cell Transplantation, Immunology and Intensive Care Medicine, Goethe University, Frankfurt, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078683084","display_name":"Selim Corbacioglu","orcid":"https://orcid.org/0000-0003-1070-8486","observed_orcids":["https://orcid.org/0000-0003-1070-8486"]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Selim Corbacioglu","raw_affiliation_strings":["University Hospital of Regensburg, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital of Regensburg, Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051824759","display_name":"Birgit Burkhardt","orcid":"https://orcid.org/0000-0002-1151-829X","observed_orcids":["https://orcid.org/0000-0002-1151-829X"]},"institutions":[{"id":"https://openalex.org/I4210103666","display_name":"University Hospital M\u00fcnster","ror":"https://ror.org/01856cw59","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210103666"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Birgit Burkhardt","raw_affiliation_strings":["Department of Pediatric Hematology, Oncology and BMT, University Hospital Muenster, Muenster, Germany"],"raw_orcid":"https://orcid.org/0000-0002-1151-829X","affiliations":[{"raw_affiliation_string":"Department of Pediatric Hematology, Oncology and BMT, University Hospital Muenster, Muenster, Germany","institution_ids":["https://openalex.org/I4210103666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110056623","display_name":"Karl Walter Sykora","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Karl Walter Sykora","raw_affiliation_strings":["Department of Pediatrics, Hannover Medical School, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Hannover Medical School, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016624880","display_name":"Katarzyna Anna Drabko","orcid":"https://orcid.org/0000-0002-7094-9129","observed_orcids":["https://orcid.org/0000-0002-7094-9129"]},"institutions":[{"id":"https://openalex.org/I121032520","display_name":"Medical University of Lublin","ror":"https://ror.org/016f61126","country_code":"PL","type":"education","lineage":["https://openalex.org/I121032520"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Katarzyna Drabko","raw_affiliation_strings":["Department of Pediatric Hematology, Oncology and Transplantology, Medical University of Lublin, Lublin, Poland"],"raw_orcid":"https://orcid.org/0000-0002-7094-9129","affiliations":[{"raw_affiliation_string":"Department of Pediatric Hematology, Oncology and Transplantology, Medical University of Lublin, Lublin, Poland","institution_ids":["https://openalex.org/I121032520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037313274","display_name":"Jolanta Go\u017adzik","orcid":"https://orcid.org/0000-0002-5449-0266","observed_orcids":["https://orcid.org/0000-0002-5449-0266"]},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]},{"id":"https://openalex.org/I4210090147","display_name":"Uniwersytecki Szpital Dzieci\u0119cy","ror":"https://ror.org/009x1kj44","country_code":"PL","type":"healthcare","lineage":["https://openalex.org/I126596746","https://openalex.org/I4210090147"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Jolanta Gozdzik","raw_affiliation_strings":["Medical College, University Children's Hospital in Cracow Jagiellonian University, Cracow, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College, University Children's Hospital in Cracow Jagiellonian University, Cracow, Poland","institution_ids":["https://openalex.org/I126596746","https://openalex.org/I4210090147"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073707704","display_name":"Franca Fagioli","orcid":"https://orcid.org/0000-0002-9257-900X","observed_orcids":["https://orcid.org/0000-0002-9257-900X"]},"institutions":[{"id":"https://openalex.org/I4210136185","display_name":"Ospedale Regina Margherita","ror":"https://ror.org/04e857469","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210136185"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Franca Fagioli","raw_affiliation_strings":["Children's Hospital Regina Margherita, University of Turin, Turin, Italy"],"raw_orcid":"https://orcid.org/0000-0002-9257-900X","affiliations":[{"raw_affiliation_string":"Children's Hospital Regina Margherita, University of Turin, Turin, Italy","institution_ids":["https://openalex.org/I4210136185","https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071278301","display_name":"Johann Greil","orcid":"https://orcid.org/0000-0003-1821-1183","observed_orcids":["https://orcid.org/0000-0003-1821-1183"]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Johann Greil","raw_affiliation_strings":["University Children's Hospital Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Children's Hospital Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022487135","display_name":"Bernd Gruhn","orcid":"https://orcid.org/0000-0003-1862-0075","observed_orcids":["https://orcid.org/0000-0003-1862-0075"]},"institutions":[{"id":"https://openalex.org/I4210134900","display_name":"Jena University Hospital","ror":"https://ror.org/035rzkx15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210134900"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bernd Gruhn","raw_affiliation_strings":["Department of Pediatrics, Jena University Hospital, Jena, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Jena University Hospital, Jena, Germany","institution_ids":["https://openalex.org/I4210134900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003067125","display_name":"Rita Beier","orcid":"https://orcid.org/0000-0002-7568-8749","observed_orcids":["https://orcid.org/0000-0002-7568-8749"]},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210119759"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rita Beier","raw_affiliation_strings":["Depertment of Pediatrics III, University Hospital of Essen, Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Depertment of Pediatrics III, University Hospital of Essen, Essen, Germany","institution_ids":["https://openalex.org/I4210119759"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022712318","display_name":"Franco Locatelli","orcid":"https://orcid.org/0000-0002-7976-3654","observed_orcids":["https://orcid.org/0000-0002-7976-3654"]},"institutions":[{"id":"https://openalex.org/I4210123352","display_name":"Bambino Ges\u00f9 Children's Hospital","ror":"https://ror.org/02sy42d13","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210123352","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Franco Locatelli","raw_affiliation_strings":["IRCCS Bambino Ges\u00fa Children's Hospital, Sapienza University of Rome, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Bambino Ges\u00fa Children's Hospital, Sapienza University of Rome, Rome, Italy","institution_ids":["https://openalex.org/I4210123352","https://openalex.org/I4210153126","https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015294864","display_name":"Ingo M\u00fcller","orcid":"https://orcid.org/0000-0002-7477-6632","observed_orcids":["https://orcid.org/0000-0002-7477-6632"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ingo M\u00fcller","raw_affiliation_strings":["University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-7477-6632","affiliations":[{"raw_affiliation_string":"University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110144396","display_name":"Paul Gerhard Schlegel","orcid":"https://orcid.org/0000-0003-1631-471X","observed_orcids":["https://orcid.org/0000-0003-1631-471X"]},"institutions":[{"id":"https://openalex.org/I4210126310","display_name":"Universit\u00e4tsklinikum W\u00fcrzburg","ror":"https://ror.org/03pvr2g57","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210126310"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Paul Gerhardt Schlegel","raw_affiliation_strings":["University Children's Hospital of Wuerzburg, Wuerzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Children's Hospital of Wuerzburg, Wuerzburg, Germany","institution_ids":["https://openalex.org/I4210126310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101774007","display_name":"Petr Sedl\u00e1\u010dek","orcid":"https://orcid.org/0000-0001-7895-2886","observed_orcids":["https://orcid.org/0000-0001-7895-2886"]},"institutions":[{"id":"https://openalex.org/I4210097985","display_name":"University Hospital in Motol","ror":"https://ror.org/0125yxn03","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210097985","https://openalex.org/I4405269046"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Petr Sedlacek","raw_affiliation_strings":["Department of Pediatric Hematology and Oncology, University Hospital Motol, Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Hematology and Oncology, University Hospital Motol, Prague, Czech Republic","institution_ids":["https://openalex.org/I4210097985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006327624","display_name":"Daniel Stachel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]},{"id":"https://openalex.org/I4210088053","display_name":"Universit\u00e4tsklinikum Erlangen","ror":"https://ror.org/0030f2a11","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210088053"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Klaus Daniel Stachel","raw_affiliation_strings":["Children's Hospital, University of Erlangen, Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital, University of Erlangen, Erlangen, Germany","institution_ids":["https://openalex.org/I181369854","https://openalex.org/I4210088053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082125898","display_name":"Claudia Hemmelmann","orcid":"https://orcid.org/0009-0006-6456-099X","observed_orcids":["https://orcid.org/0009-0006-6456-099X"]},"institutions":[{"id":"https://openalex.org/I4210165650","display_name":"Medac (Germany)","ror":"https://ror.org/05e0gzh77","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210165650"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Claudia Hemmelmann","raw_affiliation_strings":["medac GmbH, Wedel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"medac GmbH, Wedel, Germany","institution_ids":["https://openalex.org/I4210165650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040343829","display_name":"Ann-Kristin M\u00f6ller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165650","display_name":"Medac (Germany)","ror":"https://ror.org/05e0gzh77","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210165650"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ann-Kristin M\u00f6ller","raw_affiliation_strings":["medac GmbH, Wedel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"medac GmbH, Wedel, Germany","institution_ids":["https://openalex.org/I4210165650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048585584","display_name":"Joachim Baumgart","orcid":"https://orcid.org/0000-0003-4502-2847","observed_orcids":["https://orcid.org/0000-0003-4502-2847"]},"institutions":[{"id":"https://openalex.org/I4210165650","display_name":"Medac (Germany)","ror":"https://ror.org/05e0gzh77","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210165650"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Joachim Baumgart","raw_affiliation_strings":["medac GmbH, Wedel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"medac GmbH, Wedel, Germany","institution_ids":["https://openalex.org/I4210165650"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066319509","display_name":"Ajay J Vora","orcid":"https://orcid.org/0000-0002-2167-4368","observed_orcids":["https://orcid.org/0000-0002-2167-4368"]},"institutions":[{"id":"https://openalex.org/I2800129641","display_name":"Great Ormond Street Hospital","ror":"https://ror.org/00zn2c847","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800129641","https://openalex.org/I2800349819"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ajay Vora","raw_affiliation_strings":["Great Ormond Street Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Great Ormond Street Hospital, London, UK","institution_ids":["https://openalex.org/I2800129641"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":27,"corresponding_author_ids":["https://openalex.org/A5005040866"],"corresponding_institution_ids":["https://openalex.org/I219388962","https://openalex.org/I385303915"],"apc_list":{"value":3860,"currency":"USD","value_usd":3860},"apc_paid":{"value":3860,"currency":"USD","value_usd":3860},"fwci":3.4435,"has_fulltext":true,"cited_by_count":39,"citation_normalized_percentile":{"value":0.936492,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"55","issue":"10","first_page":"1996","last_page":"2007"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/treosulfan","display_name":"treosulfan","score":0.9980000257492065},{"id":"https://openalex.org/keywords/fludarabine","display_name":"fludarabine","score":0.984000027179718},{"id":"https://openalex.org/keywords/thiotepa","display_name":"thiotepa","score":1.0},{"id":"https://openalex.org/keywords/conditioning-regimen","display_name":"conditioning regimen","score":0.7179999947547913},{"id":"https://openalex.org/keywords/allogeneic-hematopoietic-stem-cell-transplantation","display_name":"allogeneic hematopoietic stem cell transplantation","score":0.9700000286102295},{"id":"https://openalex.org/keywords/pediatric-hematologic-malignancies","display_name":"pediatric hematologic malignancies","score":0.9269999861717224},{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.9779999852180481},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/myelodysplastic-syndrome","display_name":"myelodysplastic syndrome","score":0.9909999966621399},{"id":"https://openalex.org/keywords/juvenile-myelomonocytic-leukemia","display_name":"juvenile myelomonocytic leukemia","score":0.906000018119812},{"id":"https://openalex.org/keywords/graft-versus-host-disease","display_name":"graft-versus-host disease","score":0.8360000252723694},{"id":"https://openalex.org/keywords/treatment-related-mortality","display_name":"non-relapse mortality","score":0.8939999938011169},{"id":"https://openalex.org/keywords/donor-chimerism","display_name":"donor chimerism","score":0.8479999899864197},{"id":"https://openalex.org/keywords/graft-failure","display_name":"graft failure","score":0.6589999794960022},{"id":"https://openalex.org/keywords/relapse","display_name":"relapse","score":0.5870000123977661}],"concepts":[{"id":"https://openalex.org/C2779178397","wikidata":"https://www.wikidata.org/wiki/Q7838652","display_name":"Treosulfan","level":5,"score":0.9654465913772583},{"id":"https://openalex.org/C2779968505","wikidata":"https://www.wikidata.org/wiki/Q416507","display_name":"ThioTEPA","level":4,"score":0.9410995244979858},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9035298228263855},{"id":"https://openalex.org/C2779263901","wikidata":"https://www.wikidata.org/wiki/Q185916","display_name":"Fludarabine","level":4,"score":0.828021764755249},{"id":"https://openalex.org/C88879693","wikidata":"https://www.wikidata.org/wiki/Q217690","display_name":"Cumulative incidence","level":3,"score":0.633002519607544},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5924338102340698},{"id":"https://openalex.org/C2780611847","wikidata":"https://www.wikidata.org/wiki/Q348922","display_name":"Busulfan","level":4,"score":0.5397087335586548},{"id":"https://openalex.org/C2777408962","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Hematopoietic stem cell transplantation","level":3,"score":0.5261263847351074},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4637930989265442},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4328049123287201},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3220154643058777},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2095494270324707},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.16536197066307068}],"mesh":[{"descriptor_ui":"D002066","descriptor_name":"Busulfan","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006086","descriptor_name":"Graft vs Host Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013852","descriptor_name":"Thiotepa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014740","descriptor_name":"Vidarabine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D018380","descriptor_name":"Hematopoietic Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019172","descriptor_name":"Transplantation Conditioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":9,"locations":[{"id":"doi:10.1038/s41409-020-0869-6","doi":"https://doi.org/10.1038/s41409-020-0869-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41409-020-0869-6","pdf_url":"https://www.nature.com/articles/s41409-020-0869-6.pdf","source":{"id":"https://openalex.org/S183182149","display_name":"Bone Marrow Transplantation","issn_l":"0268-3369","issn":["0268-3369","1476-5365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone Marrow Transplantation","raw_type":"journal-article"},{"id":"pmid:32203268","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32203268","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone marrow transplantation","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7515850","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7515850/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone Marrow Transplant","raw_type":"Text"},{"id":"pmh:oai:ruj.uj.edu.pl:item/263469","doi":null,"is_oa":true,"landing_page_url":"https://ruj.uj.edu.pl/xmlui/handle/item/263469","pdf_url":"http://ruj.uj.edu.pl/bitstreams/3ade96e4-f7cf-473b-8667-3b1c6e4cd90e/download","source":{"id":"https://openalex.org/S4306400316","display_name":"Homo Politicus (Academy of Humanities and Economics in Lodz)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"artyku\u0142 w czasopi\u015bmie"},{"id":"pmh:oai:iris.uniroma1.it:11573/1480369","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11573/1480369","pdf_url":"https://iris.uniroma1.it/bitstream/11573/1480369/2/Kalwak_Treosulfan_2020.pdf","source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unito.it:2318/1757473","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2318/1757473","pdf_url":"https://iris.unito.it/bitstream/2318/1757473/1/2020%20Treosulfan-fludarabine-thiotepa-based_Kalwak.pdf","source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:epub.uni-regensburg.de:50185","doi":null,"is_oa":false,"landing_page_url":"https://epub.uni-regensburg.de/50185/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401229","display_name":"University of Regensburg Publication Server (University of Regensburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60668342","host_organization_name":"University of Regensburg","host_organization_lineage":["https://openalex.org/I60668342"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.uniroma1.it:11573/1479786","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11573/1479786","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:publicatt.unicatt.it:10807/229362","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10807/229362","pdf_url":null,"source":{"id":"https://openalex.org/S4306400564","display_name":"PubliCatt (Universit\u00e0 Cattolica del Sacro Cuore)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1038/s41409-020-0869-6","doi":"https://doi.org/10.1038/s41409-020-0869-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41409-020-0869-6","pdf_url":"https://www.nature.com/articles/s41409-020-0869-6.pdf","source":{"id":"https://openalex.org/S183182149","display_name":"Bone Marrow Transplantation","issn_l":"0268-3369","issn":["0268-3369","1476-5365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone Marrow Transplantation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320328692","display_name":"Medac","ror":"https://ror.org/05e0gzh77"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3010717847.pdf","grobid_xml":"https://content.openalex.org/works/W3010717847.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1194989569","https://openalex.org/W1559794160","https://openalex.org/W1905316647","https://openalex.org/W1954992673","https://openalex.org/W1963690117","https://openalex.org/W1966771497","https://openalex.org/W1972326283","https://openalex.org/W1983809785","https://openalex.org/W2008973770","https://openalex.org/W2009708076","https://openalex.org/W2035056593","https://openalex.org/W2063692775","https://openalex.org/W2097419847","https://openalex.org/W2109285747","https://openalex.org/W2128772846","https://openalex.org/W2139813696","https://openalex.org/W2169770774","https://openalex.org/W2265471938","https://openalex.org/W2395261873","https://openalex.org/W2403934281","https://openalex.org/W2532403292","https://openalex.org/W2558999668","https://openalex.org/W2588114258","https://openalex.org/W2602192248","https://openalex.org/W2623485996","https://openalex.org/W2766709436","https://openalex.org/W2769545549","https://openalex.org/W2772882570","https://openalex.org/W2793670020","https://openalex.org/W2802896371","https://openalex.org/W2947109453","https://openalex.org/W2979469227","https://openalex.org/W2986767939"],"related_works":["https://openalex.org/W2913240739","https://openalex.org/W1905316647","https://openalex.org/W1559794160","https://openalex.org/W4210833309","https://openalex.org/W2051443179","https://openalex.org/W78232097","https://openalex.org/W7130817709","https://openalex.org/W2585397044","https://openalex.org/W1969684548","https://openalex.org/W1996927670"],"abstract_inverted_index":{"Abstract":[0],"Treosulfan-based":[1],"conditioning":[2,35,173,187],"prior":[3],"to":[4,10,84],"allogeneic":[5],"transplantation":[6],"has":[7],"been":[8],"shown":[9],"have":[11],"myeloablative,":[12],"immunosuppressive,":[13],"and":[14,31,94,110,128,145,155,168],"antineoplastic":[15],"effects":[16],"associated":[17],"with":[18,38,49,92,107,177,190],"reduced":[19],"non-relapse":[20],"mortality":[21],"(NRM)":[22],"in":[23,36,41,90,174,188],"adults.":[24],"Therefore,":[25,180],"we":[26],"prospectively":[27],"evaluated":[28],"the":[29,166],"safety":[30],"efficacy":[32],"of":[33,72,98,136,171],"treosulfan-based":[34,172],"children":[37,48,189],"hematological":[39,178,191],"malignancies":[40],"this":[42],"phase":[43],"II":[44],"trial.":[45],"Overall,":[46],"65":[47],"acute":[50,54,137],"lymphoblastic":[51],"leukemia":[52,56,64],"(35.4%),":[53,78],"myeloid":[55],"(44.6%),":[57],"myelodysplastic":[58],"syndrome":[59],"(15.4%),":[60],"or":[61,79],"juvenile":[62],"myelomonocytic":[63],"(4.6%)":[65],"received":[66],"treosulfan":[67],"intravenously":[68],"at":[69,102],"a":[70],"dose":[71],"10":[73],"mg/m2/day":[74],"(7.7%),":[75],"12":[76],"g/m2/day":[77,81],"14":[80],"(56.9%)":[82],"according":[83],"their":[85],"individual":[86],"body":[87],"surface":[88],"area":[89],"combination":[91],"fludarabine":[93],"thiotepa.":[95],"The":[96,133],"incidence":[97,125,135],"complete":[99],"donor":[100],"chimerism":[101],"day":[103],"+28":[104],"was":[105,120,126,131,140],"98.4%":[106],"no":[108],"primary":[109],"only":[111,121],"one":[112],"secondary":[113],"graft":[114],"failure.":[115],"At":[116,150],"36":[117,151],"months,":[118,152],"NRM":[119],"3.1%,":[122],"while":[123],"relapse":[124],"21.7%,":[127],"overall":[129,154],"survival":[130],"83.0%.":[132],"cumulative":[134],"graft-vs.-host":[138,159],"disease":[139,160],"45.3%":[141],"for":[142,147,185],"grades":[143,148],"I\u2013IV":[144],"26.6%":[146],"II\u2013IV.":[149],"25.8%":[153],"19.4%":[156],"moderate/severe":[157],"chronic":[158],"were":[161],"reported.":[162],"These":[163],"data":[164],"confirm":[165],"safe":[167],"effective":[169],"use":[170],"pediatric":[175],"patients":[176],"malignancies.":[179,192],"treosulfan/fludarabine/thiotepa":[181],"can":[182],"be":[183],"recommended":[184],"myeloablative":[186]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2020-03-23T00:00:00"}