{"id":"https://openalex.org/W3010707783","doi":"https://doi.org/10.1111/1759-7714.13342","title":"Molecular mechanism of acquired drug resistance in the EGFR\u2010TKI resistant cell line HCC827\u2010TR","display_name":"Molecular mechanism of acquired drug resistance in the EGFR\u2010TKI resistant cell line HCC827\u2010TR","publication_year":2020,"publication_date":"2020-03-12","ids":{"openalex":"https://openalex.org/W3010707783","doi":"https://doi.org/10.1111/1759-7714.13342","mag":"3010707783","pmid":"https://pubmed.ncbi.nlm.nih.gov/32163227","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7180561"},"language":"en","primary_location":{"id":"doi:10.1111/1759-7714.13342","doi":"https://doi.org/10.1111/1759-7714.13342","is_oa":true,"landing_page_url":"https://doi.org/10.1111/1759-7714.13342","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1759-7714.13342","source":{"id":"https://openalex.org/S37904752","display_name":"Thoracic Cancer","issn_l":"1759-7706","issn":["1759-7706","1759-7714"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","medline","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thoracic Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1759-7714.13342","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100601812","display_name":"Tao Yu","orcid":"https://orcid.org/0000-0002-1000-8861","observed_orcids":["https://orcid.org/0000-0002-1000-8861"]},"institutions":[{"id":"https://openalex.org/I2802534033","display_name":"Tianjin Medical University General Hospital","ror":"https://ror.org/003sav965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802534033"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tao Yu","raw_affiliation_strings":["Department of Medical Oncology, Tianjin Medical University General Hospital, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Tianjin Medical University General Hospital, Tianjin, China","institution_ids":["https://openalex.org/I2802534033"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100764862","display_name":"Xia Qian","orcid":"https://orcid.org/0009-0008-4931-2124","observed_orcids":["https://orcid.org/0009-0008-4931-2124","https://orcid.org/0009-0009-8168-8428","https://orcid.org/0000-0002-6226-4840"]},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qian Xia","raw_affiliation_strings":["Tianjin Medical University, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin Medical University, Tianjin, China","institution_ids":["https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100766852","display_name":"Ting Gong","orcid":"https://orcid.org/0000-0003-4844-0227","observed_orcids":["https://orcid.org/0000-0003-4844-0227"]},"institutions":[{"id":"https://openalex.org/I2802534033","display_name":"Tianjin Medical University General Hospital","ror":"https://ror.org/003sav965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802534033"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ting Gong","raw_affiliation_strings":["Department of Medical Oncology, Tianjin Medical University General Hospital, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Tianjin Medical University General Hospital, Tianjin, China","institution_ids":["https://openalex.org/I2802534033"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100378537","display_name":"Jing Wang","orcid":"https://orcid.org/0000-0002-5398-0802","observed_orcids":["https://orcid.org/0000-0002-5398-0802","https://orcid.org/0000-0001-5412-9860"]},"institutions":[{"id":"https://openalex.org/I2802534033","display_name":"Tianjin Medical University General Hospital","ror":"https://ror.org/003sav965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802534033"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Wang","raw_affiliation_strings":["Department of Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin, China","institution_ids":["https://openalex.org/I2802534033"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019840134","display_name":"Diansheng Zhong","orcid":"https://orcid.org/0000-0001-6483-8134","observed_orcids":["https://orcid.org/0000-0001-6483-8134","https://orcid.org/0000-0002-2685-2442","https://orcid.org/0000-0002-0644-6543"]},"institutions":[{"id":"https://openalex.org/I2802534033","display_name":"Tianjin Medical University General Hospital","ror":"https://ror.org/003sav965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802534033"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"DianSheng Zhong","raw_affiliation_strings":["Department of Medical Oncology, Tianjin Medical University General Hospital, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Tianjin Medical University General Hospital, Tianjin, China","institution_ids":["https://openalex.org/I2802534033"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5019840134"],"corresponding_institution_ids":["https://openalex.org/I2802534033"],"apc_list":{"value":2420,"currency":"USD","value_usd":2420},"apc_paid":{"value":2420,"currency":"USD","value_usd":2420},"fwci":0.8435,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.74980695,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"11","issue":"5","first_page":"1129","last_page":"1138"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/egfr-tki-resistance","display_name":"EGFR tyrosine kinase inhibitor resistance","score":0.878000020980835},{"id":"https://openalex.org/keywords/erlotinib-resistance","display_name":"erlotinib resistance","score":0.8299999833106995},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9300000071525574},{"id":"https://openalex.org/keywords/azd4547","display_name":"AZD4547","score":0.9049999713897705},{"id":"https://openalex.org/keywords/fgfr-inhibitors","display_name":"FGFR inhibitors","score":0.9279999732971191},{"id":"https://openalex.org/keywords/drug-resistance-mechanisms","display_name":"drug resistance mechanisms","score":0.4580000042915344},{"id":"https://openalex.org/keywords/egfr-mutation","display_name":"EGFR mutation","score":0.3869999945163727}],"concepts":[{"id":"https://openalex.org/C2778087573","wikidata":"https://www.wikidata.org/wiki/Q418369","display_name":"Erlotinib","level":4,"score":0.8088453412055969},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7206615209579468},{"id":"https://openalex.org/C2777930144","wikidata":"https://www.wikidata.org/wiki/Q25100112","display_name":"T790M","level":5,"score":0.5867513418197632},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5818192362785339},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4669573903083801},{"id":"https://openalex.org/C2777626846","wikidata":"https://www.wikidata.org/wiki/Q21506464","display_name":"Osimertinib","level":5,"score":0.44839513301849365},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.41788846254348755},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.26741284132003784},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2560707926750183},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.19879546761512756},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.1686006784439087},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15932747721672058},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14294779300689697},{"id":"https://openalex.org/C2780580887","wikidata":"https://www.wikidata.org/wiki/Q417824","display_name":"Gefitinib","level":4,"score":0.13773781061172485},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12524530291557312}],"mesh":[{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/1759-7714.13342","doi":"https://doi.org/10.1111/1759-7714.13342","is_oa":true,"landing_page_url":"https://doi.org/10.1111/1759-7714.13342","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1759-7714.13342","source":{"id":"https://openalex.org/S37904752","display_name":"Thoracic Cancer","issn_l":"1759-7706","issn":["1759-7706","1759-7714"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","medline","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thoracic Cancer","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7180561","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7180561","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thorac Cancer","raw_type":"Text"},{"id":"pmid:32163227","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32163227","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thoracic cancer","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:8cd815e445c246f9afc554e14ef0539b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8cd815e445c246f9afc554e14ef0539b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Thoracic Cancer, Vol 11, Iss 5, Pp 1129-1138 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1111/1759-7714.13342","doi":"https://doi.org/10.1111/1759-7714.13342","is_oa":true,"landing_page_url":"https://doi.org/10.1111/1759-7714.13342","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1759-7714.13342","source":{"id":"https://openalex.org/S37904752","display_name":"Thoracic Cancer","issn_l":"1759-7706","issn":["1759-7706","1759-7714"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","medline","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thoracic Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3010707783.pdf","grobid_xml":"https://content.openalex.org/works/W3010707783.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W950232622","https://openalex.org/W1228651778","https://openalex.org/W1846586690","https://openalex.org/W1990626198","https://openalex.org/W1990938833","https://openalex.org/W1994075309","https://openalex.org/W2005890747","https://openalex.org/W2010065353","https://openalex.org/W2023781626","https://openalex.org/W2081855695","https://openalex.org/W2096019143","https://openalex.org/W2099530756","https://openalex.org/W2102748761","https://openalex.org/W2111662961","https://openalex.org/W2129360604","https://openalex.org/W2133149289","https://openalex.org/W2154662831","https://openalex.org/W2210071992","https://openalex.org/W2260880079","https://openalex.org/W2272984102","https://openalex.org/W2280957887","https://openalex.org/W2399188169","https://openalex.org/W2600348349","https://openalex.org/W2763344034","https://openalex.org/W2791187138"],"related_works":["https://openalex.org/W3011810823","https://openalex.org/W2340521092","https://openalex.org/W1997133017","https://openalex.org/W7097853967","https://openalex.org/W2049076276","https://openalex.org/W2792821195","https://openalex.org/W2335120462","https://openalex.org/W1979481233","https://openalex.org/W2011657586","https://openalex.org/W3014942598"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"first-line":[2],"standard":[3],"treatment":[4,45,181,240,273],"of":[5,35,191,219,229,251,274],"non-small":[6],"cell":[7,57,64,107,199],"lung":[8],"cancer":[9],"(NSCLC)":[10],"with":[11,113,152,182],"EGFR":[12,93],"mutation":[13,156,163],"is":[14,178],"EGFR-tyrosine":[15],"kinase":[16],"inhibitors":[17],"(TKIs).":[18],"However,":[19],"most":[20],"patients":[21],"will":[22],"develop":[23],"acquired":[24,36,261],"resistance":[25,37,82,210],"after":[26],"9-13":[27],"months.":[28],"This":[29],"study":[30],"investigated":[31],"novel":[32,239,256,269],"molecular":[33,124,257],"mechanisms":[34,83],"to":[38,40,78,174,194,233],"EGFR-TKIs":[39],"identify":[41],"a":[42,148,153,238,255],"potential":[43,268],"new":[44],"for":[46,242,259,271],"EGFR-TKI":[47,55,209,243,260,275],"resistant":[48,56,231,244,276],"NSCLC":[49,245,277],"patients.":[50,246,278],"METHODS:":[51],"We":[52,70,120],"established":[53],"an":[54],"line":[58,65,200],"(HCC827-TR)":[59],"by":[60],"culturing":[61],"the":[62,111,123,183,189,208,213,220,227,230,252,272],"HCC827-P":[63],"through":[66],"continuous":[67],"erlotinib":[68],"culture.":[69],"used":[71],"Sanger":[72],"sequencing,":[73],"RT-PCR,":[74],"and":[75,89,100,109,115,128,131,140,165,205],"western":[76],"blot":[77],"rule":[79],"out":[80],"known":[81],"in":[84,126,157],"HCC827-TR":[85,158,168,201],"cells,":[86],"including":[87],"EGFR-T790M":[88],"MET,":[90],"PTEN,":[91],"or":[92],"expression":[94],"changes.":[95],"Next-generation":[96],"sequencing":[97],"was":[98,202],"performed":[99,132],"identified":[101,145,207],"differentially":[102,149],"expressed":[103,150],"genes":[104,112],"between":[105],"two":[106],"lines":[108],"examined":[110,122],"GO":[114],"KEGG":[116],"pathway":[117,223],"database":[118],"analyses.":[119],"also":[121],"alterations":[125],"COSMIC":[127],"GDSC":[129],"databases":[130],"hazard":[133,166],"predictions":[134],"using":[135],"SIFT,":[136],"PolyPhen-2,":[137],"Mutation":[138],"Taster,":[139],"CADD.":[141],"RESULTS:":[142],"Our":[143],"results":[144,236],"FGF2":[146,172,214],"as":[147],"gene":[151,215],"G101T":[154],"point":[155],"cells":[159,169,193,232],"that":[160,180],"showed":[161,170],"high":[162],"frequency":[164],"score.":[167],"elevated":[171],"compared":[173],"parental":[175],"cells.":[176],"It":[177],"noteworthy":[179],"FGFR":[184],"inhibitor":[185],"AZD4547":[186],"could":[187],"restore":[188,226],"sensitivity":[190,228],"HCC872-TR":[192],"erlotinib.":[195,234],"CONCLUSIONS:":[196],"An":[197],"erlotinib-resistant":[198],"successfully":[203],"constructed":[204],"we":[206],"mechanism":[211,258],"involving":[212],"mutation.":[216],"Targeted":[217],"inhibition":[218],"FGF2/FGFR":[221],"signaling":[222],"may":[224],"effectively":[225],"These":[235],"suggest":[237],"strategy":[241,270],"KEY":[247],"POINTS:":[248],"Significant":[249],"findings":[250],"study:":[253],"Identifies":[254],"resistance.":[262],"WHAT":[263],"THIS":[264],"STUDY":[265],"ADDS:":[266],"A":[267]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-03-23T00:00:00"}
