{"id":"https://openalex.org/W3010656341","doi":"https://doi.org/10.1021/acs.jmedchem.9b01846","title":"Rational Substitution of \u03b5-Lysine for \u03b1-Lysine Enhances the Cell and Membrane Selectivity of Pore-Forming Melittin","display_name":"Rational Substitution of \u03b5-Lysine for \u03b1-Lysine Enhances the Cell and Membrane Selectivity of Pore-Forming Melittin","publication_year":2020,"publication_date":"2020-03-16","ids":{"openalex":"https://openalex.org/W3010656341","doi":"https://doi.org/10.1021/acs.jmedchem.9b01846","mag":"3010656341","pmid":"https://pubmed.ncbi.nlm.nih.gov/32175733"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jmedchem.9b01846","doi":"https://doi.org/10.1021/acs.jmedchem.9b01846","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jmedchem.9b01846","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071182612","display_name":"Venkatesh Mayandi","orcid":"https://orcid.org/0000-0001-5547-8333","observed_orcids":["https://orcid.org/0000-0001-5547-8333"]},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]},{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Venkatesh Mayandi","raw_affiliation_strings":["Anti-Infectives Research Group, Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower, 169856, Singapore","School of Biological Sciences, Nanyang Technological University Singapore, 60 Nanyang Drive, 637551, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anti-Infectives Research Group, Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower, 169856, Singapore","institution_ids":["https://openalex.org/I4210116917"]},{"raw_affiliation_string":"School of Biological Sciences, Nanyang Technological University Singapore, 60 Nanyang Drive, 637551, Singapore","institution_ids":["https://openalex.org/I172675005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043420439","display_name":"Qingxiao Xi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Qingxiao Xi","raw_affiliation_strings":["Anti-Infectives Research Group, Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower, 169856, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anti-Infectives Research Group, Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower, 169856, Singapore","institution_ids":["https://openalex.org/I4210116917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049871126","display_name":"Eunice Tze Leng Goh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Eunice Tze Leng Goh","raw_affiliation_strings":["Anti-Infectives Research Group, Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower, 169856, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anti-Infectives Research Group, Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower, 169856, Singapore","institution_ids":["https://openalex.org/I4210116917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103462698","display_name":"Siew Kwan Koh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Siew Kwan Koh","raw_affiliation_strings":["Ocular Proteomics Laboratory, Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower, 169856, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ocular Proteomics Laboratory, Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower, 169856, Singapore","institution_ids":["https://openalex.org/I4210116917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066255787","display_name":"Thomas Yong Jie Toh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Thomas Yong Jie Toh","raw_affiliation_strings":["Anti-Infectives Research Group, Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower, 169856, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anti-Infectives Research Group, Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower, 169856, Singapore","institution_ids":["https://openalex.org/I4210116917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045929103","display_name":"Veluchamy A. Barathi","orcid":"https://orcid.org/0000-0002-6477-9784","observed_orcids":["https://orcid.org/0000-0002-6477-9784"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210097409","display_name":"SingHealth Duke-NUS Academic Medical Centre","ror":"https://ror.org/00xcwps97","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I157582758","https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210097409","https://openalex.org/I4210126319"]},{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]},{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Veluchamy Amutha Barathi","raw_affiliation_strings":["Anti-Infectives Research Group, Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower, 169856, Singapore","Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, 119077, Singapore","Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Graduate Medical School, 169857, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anti-Infectives Research Group, Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower, 169856, Singapore","institution_ids":["https://openalex.org/I4210116917"]},{"raw_affiliation_string":"Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, 119077, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Graduate Medical School, 169857, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210097409","https://openalex.org/I4210126319"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064283185","display_name":"Mobashar Hussain Urf Turabe Fazil","orcid":"https://orcid.org/0000-0002-4621-8625","observed_orcids":["https://orcid.org/0000-0002-4621-8625"]},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Mobashar Hussain Urf Turabe Fazil","raw_affiliation_strings":["Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Clinical Sciences Building, 308232, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Clinical Sciences Building, 308232, Singapore","institution_ids":["https://openalex.org/I172675005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012960322","display_name":"Madhavi Latha Somaraju Chalasani","orcid":"https://orcid.org/0000-0002-3883-8664","observed_orcids":["https://orcid.org/0000-0002-3883-8664"]},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Madhavi Latha Somaraju Chalasani","raw_affiliation_strings":["Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Clinical Sciences Building, 308232, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Clinical Sciences Building, 308232, Singapore","institution_ids":["https://openalex.org/I172675005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009799361","display_name":"Jayasudha Varadarajan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Jayasudha Varadarajan","raw_affiliation_strings":["Anti-Infectives Research Group, Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower, 169856, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anti-Infectives Research Group, Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower, 169856, Singapore","institution_ids":["https://openalex.org/I4210116917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010465757","display_name":"Darren Shu Jeng Ting","orcid":"https://orcid.org/0000-0003-1081-1141","observed_orcids":["https://orcid.org/0000-0003-1081-1141"]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]},{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]}],"countries":["GB","SG"],"is_corresponding":false,"raw_author_name":"Darren Shu Jeng Ting","raw_affiliation_strings":["Academic Ophthalmology, University of Nottingham, Nottingham NG7 2RD, U.K","Anti-Infectives Research Group, Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower, 169856, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academic Ophthalmology, University of Nottingham, Nottingham NG7 2RD, U.K","institution_ids":["https://openalex.org/I142263535"]},{"raw_affiliation_string":"Anti-Infectives Research Group, Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower, 169856, Singapore","institution_ids":["https://openalex.org/I4210116917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007551999","display_name":"Roger Wilmer Beuerman","orcid":"https://orcid.org/0000-0002-0725-9336","observed_orcids":["https://orcid.org/0000-0002-0725-9336"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210097409","display_name":"SingHealth Duke-NUS Academic Medical Centre","ror":"https://ror.org/00xcwps97","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I157582758","https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210097409","https://openalex.org/I4210126319"]},{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]},{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Roger W. Beuerman","raw_affiliation_strings":["Anti-Infectives Research Group, Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower, 169856, Singapore","Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Graduate Medical School, 169857, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anti-Infectives Research Group, Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower, 169856, Singapore","institution_ids":["https://openalex.org/I4210116917"]},{"raw_affiliation_string":"Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Graduate Medical School, 169857, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210097409","https://openalex.org/I4210126319"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050568819","display_name":"Lai Wah Chan","orcid":"https://orcid.org/0000-0003-2229-7784","observed_orcids":["https://orcid.org/0000-0003-2229-7784"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Lai Wah Chan","raw_affiliation_strings":["Department of Pharmacy, National University of Singapore, 18 Science Drive, 117543, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, National University of Singapore, 18 Science Drive, 117543, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052634452","display_name":"Rupesh V. Agrawal","orcid":"https://orcid.org/0000-0002-6662-5850","observed_orcids":["https://orcid.org/0000-0002-6662-5850"]},"institutions":[{"id":"https://openalex.org/I2802408685","display_name":"Tan Tock Seng Hospital","ror":"https://ror.org/032d59j24","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I2802408685"]},{"id":"https://openalex.org/I4405257834","display_name":"National Healthcare Group","ror":"https://ror.org/05qkemg93","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I4405257834"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Rupesh Agrawal","raw_affiliation_strings":["National Healthcare Group Eye Institute, Tan Tock Seng Hospital, 308433, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Healthcare Group Eye Institute, Tan Tock Seng Hospital, 308433, Singapore","institution_ids":["https://openalex.org/I2802408685","https://openalex.org/I4405257834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074928413","display_name":"Timothy Barkham","orcid":"https://orcid.org/0000-0003-0975-2244","observed_orcids":["https://orcid.org/0000-0003-0975-2244"]},"institutions":[{"id":"https://openalex.org/I2802408685","display_name":"Tan Tock Seng Hospital","ror":"https://ror.org/032d59j24","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I2802408685"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Timothy Mark Sebastian Barkham","raw_affiliation_strings":["Department of Laboratory Medicine, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, 308433, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, 308433, Singapore","institution_ids":["https://openalex.org/I2802408685"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100674991","display_name":"Lei Zhou","orcid":"https://orcid.org/0000-0001-5893-6002","observed_orcids":["https://orcid.org/0000-0001-5893-6002","https://orcid.org/0000-0001-8251-3974","https://orcid.org/0009-0007-9394-309X"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210097409","display_name":"SingHealth Duke-NUS Academic Medical Centre","ror":"https://ror.org/00xcwps97","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I157582758","https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210097409","https://openalex.org/I4210126319"]},{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]},{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Lei Zhou","raw_affiliation_strings":["Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, 119077, Singapore","Ocular Proteomics Laboratory, Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower, 169856, Singapore","Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Graduate Medical School, 169857, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, 119077, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Ocular Proteomics Laboratory, Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower, 169856, Singapore","institution_ids":["https://openalex.org/I4210116917"]},{"raw_affiliation_string":"Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Graduate Medical School, 169857, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210097409","https://openalex.org/I4210126319"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090151141","display_name":"Navin Kumar Verma","orcid":"https://orcid.org/0000-0002-5940-6633","observed_orcids":["https://orcid.org/0000-0002-5940-6633"]},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]},{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]},{"id":"https://openalex.org/I4405254580","display_name":"Skin Research Institute of Singapore","ror":"https://ror.org/01ztxwq91","country_code":"SG","type":"funder","lineage":["https://openalex.org/I4405254580"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Navin Kumar Verma","raw_affiliation_strings":["Anti-Infectives Research Group, Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower, 169856, Singapore","Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Clinical Sciences Building, 308232, Singapore","Skin Research Institute of Singapore, 11 Mandalay Road, Clinical Sciences Building, 308232, Singapore"],"raw_orcid":"https://orcid.org/0000-0002-5940-6633","affiliations":[{"raw_affiliation_string":"Anti-Infectives Research Group, Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower, 169856, Singapore","institution_ids":["https://openalex.org/I4210116917"]},{"raw_affiliation_string":"Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Clinical Sciences Building, 308232, Singapore","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"Skin Research Institute of Singapore, 11 Mandalay Road, Clinical Sciences Building, 308232, Singapore","institution_ids":["https://openalex.org/I4405254580"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035157534","display_name":"Rajamani Lakshminarayanan","orcid":"https://orcid.org/0000-0001-8214-5315","observed_orcids":["https://orcid.org/0000-0001-8214-5315"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210097409","display_name":"SingHealth Duke-NUS Academic Medical Centre","ror":"https://ror.org/00xcwps97","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I157582758","https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210097409","https://openalex.org/I4210126319"]},{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]},{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Rajamani Lakshminarayanan","raw_affiliation_strings":["Anti-Infectives Research Group, Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower, 169856, Singapore","Department of Pharmacy, National University of Singapore, 18 Science Drive, 117543, Singapore","Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Graduate Medical School, 169857, Singapore"],"raw_orcid":"https://orcid.org/0000-0001-8214-5315","affiliations":[{"raw_affiliation_string":"Anti-Infectives Research Group, Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower, 169856, Singapore","institution_ids":["https://openalex.org/I4210116917"]},{"raw_affiliation_string":"Department of Pharmacy, National University of Singapore, 18 Science Drive, 117543, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Graduate Medical School, 169857, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210097409","https://openalex.org/I4210126319"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5035157534","https://openalex.org/A5090151141"],"corresponding_institution_ids":["https://openalex.org/I165932596","https://openalex.org/I172675005","https://openalex.org/I4210097409","https://openalex.org/I4210116917","https://openalex.org/I4210126319","https://openalex.org/I4405254580"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":3.131,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.91458422,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"63","issue":"7","first_page":"3522","last_page":"3537"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.018799999728798866,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melittin","display_name":"melittin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/epsilon-polylysine","display_name":"\u03b5-polylysine","score":0.7879999876022339},{"id":"https://openalex.org/keywords/antimicrobial-peptides","display_name":"antimicrobial peptides","score":0.7710000276565552},{"id":"https://openalex.org/keywords/membrane-selectivity","display_name":"membrane selectivity","score":0.9259999990463257},{"id":"https://openalex.org/keywords/bacterial-membrane-disruption","display_name":"bacterial membrane disruption","score":0.5789999961853027},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7879999876022339},{"id":"https://openalex.org/keywords/antibiotic-resistant-bacteria","display_name":"antibiotic-resistant bacteria","score":0.8100000023841858},{"id":"https://openalex.org/keywords/nonspecific-immunity","display_name":"non-specific immunity","score":0.6259999871253967},{"id":"https://openalex.org/keywords/ocular-surface","display_name":"ocular surface","score":0.8460000157356262},{"id":"https://openalex.org/keywords/cationic-polymers","display_name":"cationic polymers","score":0.671999990940094}],"concepts":[{"id":"https://openalex.org/C2778001312","wikidata":"https://www.wikidata.org/wiki/Q424512","display_name":"Melittin","level":3,"score":0.9525084495544434},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8162885904312134},{"id":"https://openalex.org/C2776016237","wikidata":"https://www.wikidata.org/wiki/Q178430","display_name":"Lysine","level":3,"score":0.762958288192749},{"id":"https://openalex.org/C540938839","wikidata":"https://www.wikidata.org/wiki/Q1201508","display_name":"Antimicrobial peptides","level":3,"score":0.6551048755645752},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.6288132667541504},{"id":"https://openalex.org/C2780075363","wikidata":"https://www.wikidata.org/wiki/Q650157","display_name":"Polylysine","level":2,"score":0.587028980255127},{"id":"https://openalex.org/C118792377","wikidata":"https://www.wikidata.org/wiki/Q108584245","display_name":"Selectivity","level":3,"score":0.5206424593925476},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5040335059165955},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.4983198642730713},{"id":"https://openalex.org/C73588182","wikidata":"https://www.wikidata.org/wiki/Q2663023","display_name":"Cytolysis","level":4,"score":0.46621519327163696},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.4509791433811188},{"id":"https://openalex.org/C53105671","wikidata":"https://www.wikidata.org/wiki/Q14777816","display_name":"Rational design","level":2,"score":0.4390120804309845},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3922511339187622},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.3834555149078369},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3544062376022339},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2797337472438812},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.21202626824378967},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.12319540977478027},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10492071509361267},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000075082","descriptor_name":"Proof of Concept Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001516","descriptor_name":"Bees","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003315","descriptor_name":"Cornea","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D003315","descriptor_name":"Cornea","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007634","descriptor_name":"Keratitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007634","descriptor_name":"Keratitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008555","descriptor_name":"Melitten","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008555","descriptor_name":"Melitten","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008555","descriptor_name":"Melitten","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015818","descriptor_name":"Eye Infections, Bacterial","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015818","descriptor_name":"Eye Infections, Bacterial","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053835","descriptor_name":"Unilamellar Liposomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jmedchem.9b01846","doi":"https://doi.org/10.1021/acs.jmedchem.9b01846","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jmedchem.9b01846","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:32175733","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32175733","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.428600013256073,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2648731198","display_name":null,"funder_award_id":"SHF/FG663P/2017","funder_id":"https://openalex.org/F4320322552","funder_display_name":"SingHealth Foundation"},{"id":"https://openalex.org/G3752702994","display_name":null,"funder_award_id":"H17/01/a0/0K9","funder_id":"https://openalex.org/F4320320696","funder_display_name":"Agency for Science, Technology and Research"},{"id":"https://openalex.org/G4359114715","display_name":"Human Hybrid Antimicrobial Peptides for Corneal Infection: From Molecular Dynamic Simulation to In Vivo Animal Studies","funder_award_id":"MR/T001674/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G976044396","display_name":null,"funder_award_id":"(INCEPTOR)-NMRC/CG/M010/2017_SERI","funder_id":"https://openalex.org/F4320334737","funder_display_name":"National Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320320696","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09"},{"id":"https://openalex.org/F4320322552","display_name":"SingHealth Foundation","ror":"https://ror.org/04me94w47"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334737","display_name":"National Medical Research Council","ror":"https://ror.org/04x3cxs03"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W846546774","https://openalex.org/W1500386479","https://openalex.org/W1601605207","https://openalex.org/W1923009507","https://openalex.org/W1979355136","https://openalex.org/W1988228153","https://openalex.org/W1994239777","https://openalex.org/W1995762174","https://openalex.org/W1996772308","https://openalex.org/W1997152791","https://openalex.org/W2036087614","https://openalex.org/W2036206262","https://openalex.org/W2037492976","https://openalex.org/W2045956808","https://openalex.org/W2046830654","https://openalex.org/W2050996524","https://openalex.org/W2054602599","https://openalex.org/W2056013343","https://openalex.org/W2057198053","https://openalex.org/W2060682631","https://openalex.org/W2075694454","https://openalex.org/W2075892592","https://openalex.org/W2078169364","https://openalex.org/W2089685553","https://openalex.org/W2091549061","https://openalex.org/W2093354844","https://openalex.org/W2095416341","https://openalex.org/W2096998129","https://openalex.org/W2100969613","https://openalex.org/W2101273146","https://openalex.org/W2103599303","https://openalex.org/W2110232441","https://openalex.org/W2113493635","https://openalex.org/W2115486016","https://openalex.org/W2120061656","https://openalex.org/W2137475614","https://openalex.org/W2147652807","https://openalex.org/W2149812805","https://openalex.org/W2151084977","https://openalex.org/W2156854725","https://openalex.org/W2159861471","https://openalex.org/W2165457285","https://openalex.org/W2165496299","https://openalex.org/W2168519960","https://openalex.org/W2168674774","https://openalex.org/W2175270296","https://openalex.org/W2187871812","https://openalex.org/W2300011769","https://openalex.org/W2337957188","https://openalex.org/W2742863495","https://openalex.org/W2760425330","https://openalex.org/W2762803319","https://openalex.org/W2783785722","https://openalex.org/W2794510361","https://openalex.org/W2906960763","https://openalex.org/W2908494584","https://openalex.org/W2910766400","https://openalex.org/W2949619879","https://openalex.org/W2951329233","https://openalex.org/W4211190410","https://openalex.org/W4255310200"],"related_works":["https://openalex.org/W4403185702","https://openalex.org/W2095416341","https://openalex.org/W2074805920","https://openalex.org/W2036208478","https://openalex.org/W2149537721","https://openalex.org/W4401846695","https://openalex.org/W4389024807","https://openalex.org/W2236253062","https://openalex.org/W1995762174","https://openalex.org/W2056013343"],"abstract_inverted_index":{"Here,":[0],"we":[1],"present":[2],"a":[3,12,138],"rational":[4],"approach":[5],"that":[6,21,60,131,143],"enhances":[7],"the":[8,22,68,72,118,146],"membrane":[9,147],"selectivity":[10,148],"of":[11,71,117,132,149],"prolific":[13],"pore-forming":[14],"peptide,":[15],"melittin,":[16],"based":[17],"on":[18],"experimental":[19],"observations":[20],"cationic":[23],"polymer,":[24],"\u03b5-polylysine,":[25],"disrupts":[26],"bacterial":[27],"membranes":[28],"with":[29,53],"greater":[30],"affinity":[31],"over":[32],"mammalian":[33],"cells":[34],"when":[35],"compared":[36],"to":[37,130],"poly-":[38,42],"l":[39],"-lysine":[40],"and":[41,56,105,125,140],"d":[43],"-lysine.":[44],"We":[45,65],"systematically":[46],"replaced":[47],"three":[48,79],"\u03b1-lysine":[49],"residues":[50,55,59],"in":[51,108,113],"melittin":[52,84],"\u03b5-lysine":[54],"identified":[57],"key":[58],"are":[61],"important":[62],"for":[63,102,122],"cytotoxicity.":[64],"then":[66],"assessed":[67],"antimicrobial":[69,128],"properties":[70,89],"modified":[73,83],"peptides":[74,85,119,151],"which":[75],"carry":[76],"two":[77],"or":[78],"\u03b5-lysyl":[80],"residues.":[81],"Two":[82],"displayed":[86],"rapid":[87],"bactericidal":[88],"against":[90],"antibiotic-resistant":[91],"strains,":[92],"low":[93],"innate":[94],"resistance":[95],"development":[96],"by":[97,152],"pathogenic":[98],"bacteria,":[99],"remained":[100],"nonimmunogenic":[101],"T":[103],"lymphocytes,":[104],"increased":[106],"bioavailability":[107],"tear":[109],"fluids.":[110],"In":[111],"proof-of-concept":[112],"vivo":[114],"experiments,":[115],"one":[116],"was":[120],"noncytotoxic":[121],"ocular":[123],"surfaces":[124],"had":[126],"comparable":[127],"efficacy":[129],"fluoroquinolone":[133],"antibiotics.":[134],"The":[135],"results":[136],"uncover":[137],"simple":[139],"potential":[141],"strategy":[142],"can":[144],"enhance":[145],"cytolytic":[150],"\u03b5-lysylation.":[153]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-03-23T00:00:00"}