{"id":"https://openalex.org/W3010637972","doi":null,"title":"[The relationship between catechol O-methyltransferase and diseases].","display_name":"[The relationship between catechol O-methyltransferase and diseases].","publication_year":2016,"publication_date":"2016-04-01","ids":{"openalex":"https://openalex.org/W3010637972","mag":"3010637972","pmid":"https://pubmed.ncbi.nlm.nih.gov/29859522"},"language":"zh","primary_location":{"id":"pmid:29859522","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29859522","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Yao xue xue bao = Acta pharmaceutica Sinica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053303854","display_name":"Xing\u2010Kai Qian","orcid":"https://orcid.org/0000-0001-5310-1444","observed_orcids":["https://orcid.org/0000-0001-5310-1444"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xing-kai Qian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089164263","display_name":"Yangliu Xia","orcid":"https://orcid.org/0000-0002-5742-7182","observed_orcids":["https://orcid.org/0000-0002-5742-7182"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yang-liu Xia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050920786","display_name":"Tongyi Dou","orcid":"https://orcid.org/0000-0002-4252-5038","observed_orcids":["https://orcid.org/0000-0002-4252-5038"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tong-yi Dou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5118744018","display_name":"Jie Hou","orcid":"https://orcid.org/0000-0002-9339-1236","observed_orcids":["https://orcid.org/0000-0002-9339-1236"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jie Hou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102793746","display_name":"Hong Ma","orcid":"https://orcid.org/0000-0002-2805-3919","observed_orcids":["https://orcid.org/0000-0002-2805-3919"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hong Ma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043073852","display_name":"Guang\u2010Bo Ge","orcid":"https://orcid.org/0000-0002-9670-4349","observed_orcids":["https://orcid.org/0000-0002-9670-4349"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guang-bo Ge","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108009601","display_name":"Ling Yang","orcid":"https://orcid.org/0000-0001-7093-5926","observed_orcids":["https://orcid.org/0000-0001-7093-5926"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ling Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5062971735","display_name":"Xiaolin Bi","orcid":"https://orcid.org/0000-0002-7172-7851","observed_orcids":["https://orcid.org/0000-0002-7172-7851"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiao-lin Bi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"51","issue":"4","first_page":"543","last_page":"51"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.012400000356137753,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/catechol-o-methyltransferase","display_name":"catechol-O-methyltransferase","score":0.9959999918937683},{"id":"https://openalex.org/keywords/s-adenosylmethionine","display_name":"S-adenosylmethionine","score":0.8930000066757202},{"id":"https://openalex.org/keywords/catechol-metabolism","display_name":"catechol metabolism","score":0.9359999895095825},{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":0.5419999957084656},{"id":"https://openalex.org/keywords/epinephrine","display_name":"epinephrine","score":0.9900000095367432},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.9520000219345093},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.949999988079071},{"id":"https://openalex.org/keywords/xenobiotic-metabolism","display_name":"xenobiotic metabolism","score":0.9419999718666077},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.8610000014305115},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":1.0},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9940000176429749},{"id":"https://openalex.org/keywords/comt-polymorphism","display_name":"COMT gene polymorphism","score":0.49000000953674316},{"id":"https://openalex.org/keywords/disease-susceptibility","display_name":"disease susceptibility","score":0.47699999809265137}],"concepts":[{"id":"https://openalex.org/C185361966","wikidata":"https://www.wikidata.org/wiki/Q94291140","display_name":"Catechol-O-methyl transferase","level":4,"score":0.9438546299934387},{"id":"https://openalex.org/C91965660","wikidata":"https://www.wikidata.org/wiki/Q415875","display_name":"Methyltransferase","level":4,"score":0.5822015404701233},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4776904881000519},{"id":"https://openalex.org/C2777713698","wikidata":"https://www.wikidata.org/wiki/Q282440","display_name":"Catechol","level":2,"score":0.46132463216781616},{"id":"https://openalex.org/C2778524067","wikidata":"https://www.wikidata.org/wiki/Q17142059","display_name":"rs4680","level":5,"score":0.45327436923980713},{"id":"https://openalex.org/C89311334","wikidata":"https://www.wikidata.org/wiki/Q1124842","display_name":"Drug metabolism","level":3,"score":0.4250476658344269},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3806226849555969},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35768914222717285},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32651931047439575},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30454903841018677},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.19017615914344788},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08600369095802307},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.07385995984077454}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D002394","descriptor_name":"Catechol O-Methyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002396","descriptor_name":"Catechols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004837","descriptor_name":"Epinephrine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008658","descriptor_name":"Inactivation, Metabolic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D015262","descriptor_name":"Xenobiotics","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:29859522","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29859522","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Yao xue xue bao = Acta pharmaceutica Sinica","raw_type":"Journal Article"},{"id":"mag:3010637972","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29859522","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W1467572300","https://openalex.org/W1493305388","https://openalex.org/W1503791974","https://openalex.org/W1511481184","https://openalex.org/W1543624067","https://openalex.org/W1782271841","https://openalex.org/W1963740134","https://openalex.org/W1970544987","https://openalex.org/W1971120269","https://openalex.org/W1972799775","https://openalex.org/W1977138162","https://openalex.org/W1980380817","https://openalex.org/W1982616266","https://openalex.org/W1986059489","https://openalex.org/W1987248944","https://openalex.org/W1991305939","https://openalex.org/W1994593489","https://openalex.org/W1996395058","https://openalex.org/W1999676874","https://openalex.org/W2002715737","https://openalex.org/W2003694812","https://openalex.org/W2011464027","https://openalex.org/W2018410781","https://openalex.org/W2023205512","https://openalex.org/W2025642899","https://openalex.org/W2030119314","https://openalex.org/W2033881399","https://openalex.org/W2035295533","https://openalex.org/W2035682105","https://openalex.org/W2037921599","https://openalex.org/W2044665607","https://openalex.org/W2044774078","https://openalex.org/W2050764521","https://openalex.org/W2063007368","https://openalex.org/W2063619823","https://openalex.org/W2065094029","https://openalex.org/W2066266944","https://openalex.org/W2071555543","https://openalex.org/W2079424406","https://openalex.org/W2081747437","https://openalex.org/W2094597697","https://openalex.org/W2100896286","https://openalex.org/W2106350754","https://openalex.org/W2106481760","https://openalex.org/W2117224038","https://openalex.org/W2118958190","https://openalex.org/W2125652731","https://openalex.org/W2129676131","https://openalex.org/W2131721815","https://openalex.org/W2132881915","https://openalex.org/W2135812251","https://openalex.org/W2135835694","https://openalex.org/W2140815651","https://openalex.org/W2141496371","https://openalex.org/W2150242641","https://openalex.org/W2151204406","https://openalex.org/W2160108694","https://openalex.org/W2168605437","https://openalex.org/W2239722532","https://openalex.org/W2406858184","https://openalex.org/W4321429294"],"related_works":["https://openalex.org/W2086360865","https://openalex.org/W7099471643","https://openalex.org/W4386558198","https://openalex.org/W2609904336","https://openalex.org/W6941017240","https://openalex.org/W2070844108","https://openalex.org/W2008288225","https://openalex.org/W6989766077","https://openalex.org/W152709307","https://openalex.org/W2503774605"],"abstract_inverted_index":{"Catechol":[0],"O-methyltransferase":[1],"(COMT),":[2],"one":[3,32],"of":[4,19,33,42,61,76,80,90,106],"the":[5,17,34,40,59,74,104,115,130],"endogenous":[6],"phase":[7],"II":[8],"metabolizing":[9],"enzymes,":[10],"expressed":[11],"by":[12,114],"chromosome":[13],"22.":[14],"COMT":[15,37,53,68,81,107,116,131],"catalyzes":[16],"transfer":[18],"a":[20,70],"methyl":[21,25],"group":[22],"from":[23,64],"common":[24],"donor":[26],"S-adenosyl-L-methionine(Ado":[27],"Met":[28],"or":[29,86],"SAM)":[30],"to":[31],"catechol":[35],"hydroxyls.":[36],"participates":[38],"in":[39,45,58,73],"metabolism":[41,60,132],"many":[43,84],"catechols":[44,63],"vivo,":[46],"e.g.":[47,92],"dopamine,":[48],"epinephrine,":[49],"noradrenaline,":[50],"estradiol.":[51],"Furthermore":[52],"also":[54],"plays":[55],"important":[56],"roles":[57],"xenobiotic":[62],"food":[65],"and":[66,96,108],"drug.":[67],"play":[69],"critical":[71],"role":[72],"management":[75],"catechols.":[77],"Metabolism":[78],"disorders":[79],"can":[82],"cause":[83],"diseases":[85],"an":[87],"increased":[88],"risk":[89],"diseases,":[91,94],"Pakinson":[93],"schizophrenia,":[95],"breast":[97],"cancer.":[98],"In":[99],"this":[100],"review,":[101],"we":[102,120],"explains":[103],"relationship":[105],"related-diseases":[109],"through":[110],"expounding":[111],"disease":[112],"caused":[113],"metabolic":[117],"disorders.":[118],"Finally,":[119],"hope":[121],"that":[122],"there":[123],"will":[124],"be":[125],"more":[126],"effective":[127],"treatments":[128],"for":[129],"related":[133],"diseases.":[134]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-03-13T00:00:00"}
