{"id":"https://openalex.org/W3010552499","doi":"https://doi.org/10.1111/bph.15036","title":"Idiopathic pulmonary fibrosis and pulmonary hypertension: Heracles meets the Hydra","display_name":"Idiopathic pulmonary fibrosis and pulmonary hypertension: Heracles meets the Hydra","publication_year":2020,"publication_date":"2020-03-04","ids":{"openalex":"https://openalex.org/W3010552499","doi":"https://doi.org/10.1111/bph.15036","mag":"3010552499","pmid":"https://pubmed.ncbi.nlm.nih.gov/32128790","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7910027"},"language":"en","primary_location":{"id":"doi:10.1111/bph.15036","doi":"https://doi.org/10.1111/bph.15036","is_oa":false,"landing_page_url":"https://doi.org/10.1111/bph.15036","pdf_url":null,"source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7910027","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026030297","display_name":"Keshava Rajagopal","orcid":"https://orcid.org/0000-0001-7017-7459","observed_orcids":["https://orcid.org/0000-0001-7017-7459"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keshava Rajagopal","raw_affiliation_strings":["Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055370303","display_name":"Andrew J. Bryant","orcid":"https://orcid.org/0000-0001-9433-3049","observed_orcids":["https://orcid.org/0000-0001-9433-3049"]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew J. Bryant","raw_affiliation_strings":["Division of Pulmonology, Department of Medicine, University of Florida, Gainesville, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonology, Department of Medicine, University of Florida, Gainesville, Florida","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061867976","display_name":"Sandeep Sahay","orcid":"https://orcid.org/0000-0002-0672-1680","observed_orcids":["https://orcid.org/0000-0002-0672-1680"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandeep Sahay","raw_affiliation_strings":["Houston Methodist Lung Center, Division of Pulmonary Medicine, Department of Internal Medicine, Houston Methodist Hospital, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Houston Methodist Lung Center, Division of Pulmonary Medicine, Department of Internal Medicine, Houston Methodist Hospital, Houston, Texas","institution_ids":["https://openalex.org/I1295876152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025473050","display_name":"Nancy E. Wareing","orcid":"https://orcid.org/0000-0001-5149-3966","observed_orcids":["https://orcid.org/0000-0001-5149-3966"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy Wareing","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston, Houston, Texas","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029083062","display_name":"Yang Zhou","orcid":"https://orcid.org/0000-0001-6867-6443","observed_orcids":["https://orcid.org/0000-0001-6867-6443"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yang Zhou","raw_affiliation_strings":["Division of Biology and Medicine, Brown University, Providence, Rhode Island"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biology and Medicine, Brown University, Providence, Rhode Island","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002559677","display_name":"Lavannya M. Pandit","orcid":"https://orcid.org/0000-0001-5071-5184","observed_orcids":["https://orcid.org/0000-0001-5071-5184"]},"institutions":[{"id":"https://openalex.org/I1299501804","display_name":"Michael E. DeBakey VA Medical Center","ror":"https://ror.org/052qqbc08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299501804","https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210138636"]},{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lavannya M. Pandit","raw_affiliation_strings":["Department of Medicine, Pulmonary, Critical Care and Sleep Medicine Baylor College of Medicine\u2013Michael E. DeBakey Veterans Affairs Medical Center  Houston Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Pulmonary, Critical Care and Sleep Medicine Baylor College of Medicine\u2013Michael E. DeBakey Veterans Affairs Medical Center  Houston Texas","institution_ids":["https://openalex.org/I1299501804","https://openalex.org/I181547552"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058022497","display_name":"Harry Karmouty\u2010Quintana","orcid":"https://orcid.org/0000-0003-4753-9823","observed_orcids":["https://orcid.org/0000-0003-4753-9823"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Harry Karmouty\u2010Quintana","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston, Houston, Texas"],"raw_orcid":"https://orcid.org/0000-0003-4753-9823","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston, Houston, Texas","institution_ids":["https://openalex.org/I919571938"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5058022497"],"corresponding_institution_ids":["https://openalex.org/I919571938"],"apc_list":{"value":4000,"currency":"USD","value_usd":4000},"apc_paid":null,"fwci":0.7033,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.66925363,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"178","issue":"1","first_page":"172","last_page":"186"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.798799991607666,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.798799991607666,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.19429999589920044,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/idiopathic-pulmonary-fibrosis","display_name":"idiopathic pulmonary fibrosis","score":1.0},{"id":"https://openalex.org/keywords/pulmonary-hypertension","display_name":"pulmonary hypertension","score":0.9879999756813049},{"id":"https://openalex.org/keywords/pulmonary-vascular-disease","display_name":"pulmonary vascular disease","score":0.8029999732971191},{"id":"https://openalex.org/keywords/pulmonary-fibrosis","display_name":"pulmonary fibrosis","score":0.8539999723434448},{"id":"https://openalex.org/keywords/vasoconstriction","display_name":"vasoconstriction","score":0.9020000100135803},{"id":"https://openalex.org/keywords/vascular-remodeling","display_name":"vascular remodeling","score":0.9909999966621399},{"id":"https://openalex.org/keywords/pharmacotherapy-targets","display_name":"pharmacotherapy targets","score":0.6190000176429749},{"id":"https://openalex.org/keywords/lung-transplantation-outcomes","display_name":"lung transplantation outcomes","score":0.8759999871253967},{"id":"https://openalex.org/keywords/comorbidity","display_name":"comorbidities","score":0.6069999933242798}],"concepts":[{"id":"https://openalex.org/C34781881","wikidata":"https://www.wikidata.org/wiki/Q170379","display_name":"Lernaean Hydra","level":2,"score":0.8343510627746582},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6294418573379517},{"id":"https://openalex.org/C2780930700","wikidata":"https://www.wikidata.org/wiki/Q1128595","display_name":"Pulmonary hypertension","level":2,"score":0.5704914331436157},{"id":"https://openalex.org/C2781244666","wikidata":"https://www.wikidata.org/wiki/Q32446","display_name":"Pulmonary fibrosis","level":3,"score":0.5680517554283142},{"id":"https://openalex.org/C2778341716","wikidata":"https://www.wikidata.org/wiki/Q2290446","display_name":"Idiopathic pulmonary fibrosis","level":3,"score":0.5083720088005066},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.41127851605415344},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.40331965684890747},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3638325035572052},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.3506328761577606},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32591181993484497},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.199092298746109},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.07018682360649109}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006829","descriptor_name":"Hydra","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054990","descriptor_name":"Idiopathic Pulmonary Fibrosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D066253","descriptor_name":"Vascular Remodeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/bph.15036","doi":"https://doi.org/10.1111/bph.15036","is_oa":false,"landing_page_url":"https://doi.org/10.1111/bph.15036","pdf_url":null,"source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmid:32128790","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32128790","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7910027","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7910027","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Br J Pharmacol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7910027","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7910027","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Br J Pharmacol","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G208265151","display_name":"CardioPulmonary Vascular Biology COBRE","funder_award_id":"P20GM103652","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3411086315","display_name":"3'UTR Shortening in Pulmonary Vascular Disease","funder_award_id":"R01HL138510","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3805601104","display_name":"Short-Term Training Program to Increase Diversity in Health-Related Research","funder_award_id":"R25HL088992","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6953830803","display_name":"Targeting CHI3L1 and its receptors in Hermansky-Pudlak Syndrome-associated lung disease","funder_award_id":"R01HL146498","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000885793","display_name":"Sineoculis Homeobox Homolog 1 (Six1) in Pulmonary Fibrosis","funder_award_id":"R01HL157100","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":117,"referenced_works":["https://openalex.org/W99221530","https://openalex.org/W1584494699","https://openalex.org/W1901110635","https://openalex.org/W1904048577","https://openalex.org/W1938327838","https://openalex.org/W1963761265","https://openalex.org/W1966078763","https://openalex.org/W1972507748","https://openalex.org/W1972553225","https://openalex.org/W1973463627","https://openalex.org/W1980111004","https://openalex.org/W1988619959","https://openalex.org/W1999713206","https://openalex.org/W2002142072","https://openalex.org/W2014603754","https://openalex.org/W2019982202","https://openalex.org/W2029732141","https://openalex.org/W2039549436","https://openalex.org/W2057292199","https://openalex.org/W2065501812","https://openalex.org/W2067142583","https://openalex.org/W2073353515","https://openalex.org/W2073457491","https://openalex.org/W2073849521","https://openalex.org/W2077835439","https://openalex.org/W2080813710","https://openalex.org/W2082083390","https://openalex.org/W2089273856","https://openalex.org/W2089858213","https://openalex.org/W2095368090","https://openalex.org/W2099003712","https://openalex.org/W2101035102","https://openalex.org/W2104188024","https://openalex.org/W2108280422","https://openalex.org/W2109069036","https://openalex.org/W2110239825","https://openalex.org/W2113753962","https://openalex.org/W2113974411","https://openalex.org/W2118721390","https://openalex.org/W2120498387","https://openalex.org/W2121376498","https://openalex.org/W2122108156","https://openalex.org/W2125894929","https://openalex.org/W2126965678","https://openalex.org/W2131236880","https://openalex.org/W2132001965","https://openalex.org/W2137667272","https://openalex.org/W2138464262","https://openalex.org/W2138871107","https://openalex.org/W2141623508","https://openalex.org/W2143487186","https://openalex.org/W2145491879","https://openalex.org/W2149106879","https://openalex.org/W2152974152","https://openalex.org/W2158755381","https://openalex.org/W2159214565","https://openalex.org/W2163696757","https://openalex.org/W2166927274","https://openalex.org/W2167480393","https://openalex.org/W2168666423","https://openalex.org/W2169279681","https://openalex.org/W2181898446","https://openalex.org/W2184040777","https://openalex.org/W2185990044","https://openalex.org/W2191824243","https://openalex.org/W2193975711","https://openalex.org/W2221930001","https://openalex.org/W2267892322","https://openalex.org/W2331798828","https://openalex.org/W2339191750","https://openalex.org/W2351179052","https://openalex.org/W2432585686","https://openalex.org/W2440146477","https://openalex.org/W2464143787","https://openalex.org/W2467895234","https://openalex.org/W2483968246","https://openalex.org/W2535392697","https://openalex.org/W2555915692","https://openalex.org/W2583903597","https://openalex.org/W2588649905","https://openalex.org/W2596745043","https://openalex.org/W2626051864","https://openalex.org/W2730230537","https://openalex.org/W2742852552","https://openalex.org/W2743584582","https://openalex.org/W2750186979","https://openalex.org/W2751016427","https://openalex.org/W2754468979","https://openalex.org/W2762403983","https://openalex.org/W2766012717","https://openalex.org/W2777679721","https://openalex.org/W2785732377","https://openalex.org/W2791791599","https://openalex.org/W2794956042","https://openalex.org/W2796916466","https://openalex.org/W2800299042","https://openalex.org/W2804242024","https://openalex.org/W2805539079","https://openalex.org/W2805771055","https://openalex.org/W2888358601","https://openalex.org/W2889468418","https://openalex.org/W2890958810","https://openalex.org/W2901813854","https://openalex.org/W2902966106","https://openalex.org/W2904050973","https://openalex.org/W2904180601","https://openalex.org/W2904463477","https://openalex.org/W2904616423","https://openalex.org/W2906581013","https://openalex.org/W2909223530","https://openalex.org/W2913407230","https://openalex.org/W2914542634","https://openalex.org/W2921352727","https://openalex.org/W2942747746","https://openalex.org/W2971672999","https://openalex.org/W4246977781","https://openalex.org/W4252692455"],"related_works":["https://openalex.org/W6891544547","https://openalex.org/W1589903709","https://openalex.org/W2099003712","https://openalex.org/W2048432257","https://openalex.org/W2110456894","https://openalex.org/W2044693332","https://openalex.org/W2115339119","https://openalex.org/W2588649905","https://openalex.org/W3032110899","https://openalex.org/W7170133136"],"abstract_inverted_index":{"Idiopathic":[0],"pulmonary":[1,14,25],"fibrosis":[2,96],"(IPF)":[3],"is":[4,44,67,111],"a":[5,68,114],"fatal":[6],"lung":[7,32,63,95],"disease":[8,27,34],"where":[9],"the":[10,21,49,77,89,127],"additional":[11],"presence":[12,22],"of":[13,23,52,79,91,113],"hypertension":[15],"(PH)":[16],"reduces":[17],"survival.":[18],"In":[19,81],"particular,":[20],"coexistent":[24],"vascular":[26],"in":[28,36,76,123,130],"patients":[29],"with":[30,46,56],"advanced":[31],"parenchymal":[33],"results":[35],"worse":[37],"outcomes":[38,55,61],"than":[39],"either":[40],"diagnosis":[41],"alone.":[42],"This":[43,109],"true":[45],"respect":[47],"to":[48],"natural":[50],"histories":[51],"these":[53],"diseases,":[54],"medical":[57],"therapies,":[58],"and":[59,97,100,121],"even":[60],"following":[62],"transplantation.":[64],"Consequently,":[65],"there":[66],"striking":[69],"need":[70],"for":[71,74,105],"improved":[72],"treatments":[73],"PH":[75],"setting":[78],"IPF.":[80],"this":[82,131],"review,":[83],"we":[84],"summarize":[85],"existing":[86],"therapies":[87],"from":[88],"perspective":[90],"molecular":[92],"mechanisms":[93],"underlying":[94],"vasoconstriction/vascular":[98],"remodelling":[99],"discuss":[101],"potential":[102],"future":[103],"targets":[104],"pharmacotherapy.":[106],"LINKED":[107],"ARTICLES:":[108],"article":[110],"part":[112],"themed":[115],"issue":[116],"on":[117],"Risk":[118],"factors,":[119],"comorbidities,":[120],"comedications":[122],"cardioprotection.":[124],"To":[125],"view":[126],"other":[128],"articles":[129],"section":[132],"visit":[133],"http://onlinelibrary.wiley.com/doi/10.1111/bph.v178.1/issuetoc.":[134]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-03-13T00:00:00"}
