{"id":"https://openalex.org/W3010338076","doi":"https://doi.org/10.1093/nargab/lqaa015","title":"Mutation effect estimation on protein\u2013protein interactions using deep contextualized representation learning","display_name":"Mutation effect estimation on protein\u2013protein interactions using deep contextualized representation learning","publication_year":2020,"publication_date":"2020-03-05","ids":{"openalex":"https://openalex.org/W3010338076","doi":"https://doi.org/10.1093/nargab/lqaa015","mag":"3010338076","pmid":"https://pubmed.ncbi.nlm.nih.gov/32166223"},"language":"en","primary_location":{"id":"doi:10.1093/nargab/lqaa015","doi":"https://doi.org/10.1093/nargab/lqaa015","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nargab/lqaa015","pdf_url":"https://academic.oup.com/nargab/article-pdf/2/2/lqaa015/34054318/lqaa015.pdf","source":{"id":"https://openalex.org/S4210241000","display_name":"NAR Genomics and Bioinformatics","issn_l":"2631-9268","issn":["2631-9268"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NAR Genomics and Bioinformatics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nargab/article-pdf/2/2/lqaa015/34054318/lqaa015.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079740632","display_name":"Guangyu Zhou","orcid":"https://orcid.org/0000-0003-0897-6465","observed_orcids":["https://orcid.org/0000-0003-0897-6465"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guangyu Zhou","raw_affiliation_strings":["Department of Computer Science, University of California, Los Angeles, CA\u00a090095, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of California, Los Angeles, CA\u00a090095, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102861481","display_name":"Muhao Chen","orcid":"https://orcid.org/0000-0003-0118-3147","observed_orcids":["https://orcid.org/0000-0003-0118-3147"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Muhao Chen","raw_affiliation_strings":["Department of Computer Science, University of California, Los Angeles, CA\u00a090095, USA","Department of Computer and Information Science, University of Pennsylvania, Philadelphia, PA\u00a019104, USA"],"raw_orcid":"https://orcid.org/0000-0003-0118-3147","affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of California, Los Angeles, CA\u00a090095, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Computer and Information Science, University of Pennsylvania, Philadelphia, PA\u00a019104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073504925","display_name":"Chelsea J.\u2010T. Ju","orcid":"https://orcid.org/0000-0001-8674-5318","observed_orcids":["https://orcid.org/0000-0001-8674-5318"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chelsea J T Ju","raw_affiliation_strings":["Department of Computer Science, University of California, Los Angeles, CA\u00a090095, USA"],"raw_orcid":"https://orcid.org/0000-0001-8674-5318","affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of California, Los Angeles, CA\u00a090095, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100401124","display_name":"Zheng Wang","orcid":"https://orcid.org/0000-0002-8388-6139","observed_orcids":["https://orcid.org/0000-0002-8388-6139"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zheng Wang","raw_affiliation_strings":["Department of Computer Science, University of California, Los Angeles, CA\u00a090095, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of California, Los Angeles, CA\u00a090095, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048749901","display_name":"Jyun\u2010Yu Jiang","orcid":"https://orcid.org/0000-0002-1753-8099","observed_orcids":["https://orcid.org/0000-0002-1753-8099"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jyun-Yu Jiang","raw_affiliation_strings":["Department of Computer Science, University of California, Los Angeles, CA\u00a090095, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of California, Los Angeles, CA\u00a090095, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100392089","display_name":"Wei Wang","orcid":"https://orcid.org/0000-0002-8180-2886","observed_orcids":["https://orcid.org/0000-0002-8180-2886","https://orcid.org/0000-0003-1456-5275"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wei Wang","raw_affiliation_strings":["Department of Computer Science, University of California, Los Angeles, CA\u00a090095, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of California, Los Angeles, CA\u00a090095, USA","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100392089","https://openalex.org/A5102861481"],"corresponding_institution_ids":["https://openalex.org/I161318765","https://openalex.org/I79576946"],"apc_list":{"value":2766,"currency":"USD","value_usd":2766},"apc_paid":{"value":2766,"currency":"USD","value_usd":2766},"fwci":3.391,"has_fulltext":true,"cited_by_count":71,"citation_normalized_percentile":{"value":0.94187152,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"2","issue":"2","first_page":"lqaa015","last_page":"lqaa015"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.8690999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.8690999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.09969999641180038,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.9760000109672546},{"id":"https://openalex.org/keywords/point-mutations","display_name":"point mutations","score":0.7720000147819519},{"id":"https://openalex.org/keywords/mutation-effect-prediction","display_name":"mutation effect prediction","score":0.878000020980835},{"id":"https://openalex.org/keywords/deep-learning","display_name":"deep learning","score":0.5080000162124634},{"id":"https://openalex.org/keywords/buried-surface-area","display_name":"buried surface area","score":0.8320000171661377}],"concepts":[{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.6529155969619751},{"id":"https://openalex.org/C66746571","wikidata":"https://www.wikidata.org/wiki/Q1134833","display_name":"ENCODE","level":3,"score":0.6392191648483276},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6048081517219543},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.554596483707428},{"id":"https://openalex.org/C176944494","wikidata":"https://www.wikidata.org/wiki/Q1415380","display_name":"Point mutation","level":4,"score":0.55115807056427},{"id":"https://openalex.org/C2776359362","wikidata":"https://www.wikidata.org/wiki/Q2145286","display_name":"Representation (politics)","level":3,"score":0.5455204844474792},{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.5212926864624023},{"id":"https://openalex.org/C60908668","wikidata":"https://www.wikidata.org/wiki/Q690207","display_name":"Perceptron","level":3,"score":0.520576536655426},{"id":"https://openalex.org/C10010492","wikidata":"https://www.wikidata.org/wiki/Q3142557","display_name":"Protein sequencing","level":4,"score":0.46373477578163147},{"id":"https://openalex.org/C118505674","wikidata":"https://www.wikidata.org/wiki/Q42586063","display_name":"Encoder","level":2,"score":0.46151089668273926},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.4520535171031952},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4502701461315155},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.4388197064399719},{"id":"https://openalex.org/C125411270","wikidata":"https://www.wikidata.org/wiki/Q18653","display_name":"Encoding (memory)","level":2,"score":0.41931214928627014},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.4134843349456787},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.4029807448387146},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.32539284229278564},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.28845906257629395},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.2635042369365692},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2459508180618286},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12468135356903076},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C94625758","wikidata":"https://www.wikidata.org/wiki/Q7163","display_name":"Politics","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1093/nargab/lqaa015","doi":"https://doi.org/10.1093/nargab/lqaa015","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nargab/lqaa015","pdf_url":"https://academic.oup.com/nargab/article-pdf/2/2/lqaa015/34054318/lqaa015.pdf","source":{"id":"https://openalex.org/S4210241000","display_name":"NAR Genomics and Bioinformatics","issn_l":"2631-9268","issn":["2631-9268"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NAR Genomics and Bioinformatics","raw_type":"journal-article"},{"id":"doi:10.1101/2019.12.15.876953","doi":"https://doi.org/10.1101/2019.12.15.876953","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2019.12.15.876953","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2019/12/15/2019.12.15.876953.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:32166223","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32166223","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NAR genomics and bioinformatics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7059401","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7059401","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NAR Genom Bioinform","raw_type":"Text"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt320685tx","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/320685tx","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NAR Genomics and Bioinformatics, vol 2, iss 2","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1093/nargab/lqaa015","doi":"https://doi.org/10.1093/nargab/lqaa015","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nargab/lqaa015","pdf_url":"https://academic.oup.com/nargab/article-pdf/2/2/lqaa015/34054318/lqaa015.pdf","source":{"id":"https://openalex.org/S4210241000","display_name":"NAR Genomics and Bioinformatics","issn_l":"2631-9268","issn":["2631-9268"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NAR Genomics and Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.7200000286102295,"display_name":"Decent work and economic growth","id":"https://metadata.un.org/sdg/8"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1740316563","display_name":null,"funder_award_id":"DGE-1 829 071","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G2169460107","display_name":null,"funder_award_id":"U54-GM114833","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2894621321","display_name":null,"funder_award_id":"U01 HG008488","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G6758428026","display_name":"III: Medium: Collaborative Research: Toward Robust and Scalable Discovering of Significant Associations in Massive Genetic Data","funder_award_id":"1313606","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6839262176","display_name":"ABI Innovation: Next Generation Quantitative RNA Sequence Analysis","funder_award_id":"1565137","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7802898483","display_name":null,"funder_award_id":"R01 GM115833","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000016469","display_name":null,"funder_award_id":"U54 GM114833","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000126656","display_name":null,"funder_award_id":"R01GM115833","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000233952","display_name":null,"funder_award_id":"U01HG008488","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3010338076.pdf","grobid_xml":"https://content.openalex.org/works/W3010338076.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W1823111029","https://openalex.org/W1963697504","https://openalex.org/W1975390541","https://openalex.org/W1991955074","https://openalex.org/W1993109473","https://openalex.org/W1998222399","https://openalex.org/W2028358481","https://openalex.org/W2041836310","https://openalex.org/W2054488317","https://openalex.org/W2064675550","https://openalex.org/W2074592704","https://openalex.org/W2092387745","https://openalex.org/W2103459989","https://openalex.org/W2111326065","https://openalex.org/W2117541321","https://openalex.org/W2126103104","https://openalex.org/W2130479394","https://openalex.org/W2138913459","https://openalex.org/W2142808579","https://openalex.org/W2153207080","https://openalex.org/W2156125289","https://openalex.org/W2157331557","https://openalex.org/W2157807259","https://openalex.org/W2158714788","https://openalex.org/W2166757164","https://openalex.org/W2169077388","https://openalex.org/W2170747616","https://openalex.org/W2194775991","https://openalex.org/W2345331290","https://openalex.org/W2418847844","https://openalex.org/W2537623931","https://openalex.org/W2554576124","https://openalex.org/W2558879065","https://openalex.org/W2594386026","https://openalex.org/W2736280136","https://openalex.org/W2748251752","https://openalex.org/W2758881473","https://openalex.org/W2784920021","https://openalex.org/W2787560479","https://openalex.org/W2799487719","https://openalex.org/W2885583144","https://openalex.org/W2887976600","https://openalex.org/W2890911678","https://openalex.org/W2909727437","https://openalex.org/W2949787032","https://openalex.org/W2950374603","https://openalex.org/W2953103783","https://openalex.org/W2957436444","https://openalex.org/W6638444622","https://openalex.org/W6683258052","https://openalex.org/W6687483927","https://openalex.org/W6738383168","https://openalex.org/W6739901393","https://openalex.org/W6747620207","https://openalex.org/W6748634344","https://openalex.org/W6753648928","https://openalex.org/W6758485811"],"related_works":["https://openalex.org/W2468279273","https://openalex.org/W2354198838","https://openalex.org/W1989130879","https://openalex.org/W2103419012","https://openalex.org/W1974414866","https://openalex.org/W2183771695","https://openalex.org/W2003790670","https://openalex.org/W100270783","https://openalex.org/W1976952616","https://openalex.org/W3107297455"],"abstract_inverted_index":{"The":[0,230],"functional":[1],"impact":[2],"of":[3,11,15,22,45,61,107,117,124,145,181,203,226],"protein":[4,141,160,173],"mutations":[5,27,62,108],"is":[6,28,233],"reflected":[7],"on":[8,50,63,109,199,213,222],"the":[9,20,43,59,105,122,135,172,178,201,224],"alteration":[10],"conformation":[12],"and":[13,73,78,162,209],"thermodynamics":[14],"protein-protein":[16],"interactions":[17],"(PPIs).":[18],"Quantifying":[19],"changes":[21,180,202,225],"two":[23],"interacting":[24],"proteins":[25],"upon":[26,184],"commonly":[29],"carried":[30],"out":[31],"by":[32,53],"computational":[33],"approaches.":[34],"Hence,":[35],"extensive":[36,70],"research":[37],"efforts":[38],"have":[39,79],"been":[40],"put":[41],"to":[42,57,76,82,103,120,128,156,171,176],"extraction":[44],"energetic":[46],"or":[47],"structural":[48],"features":[49,68],"proteins,":[51],"followed":[52],"statistical":[54],"learning":[55,91],"methods":[56],"estimate":[58,104],"effects":[60,106,123],"PPI":[64,182],"properties.":[65],"Nonetheless,":[66],"such":[67],"require":[69],"human":[71],"labors":[72],"expert":[74],"knowledge":[75],"obtain,":[77],"limited":[80],"abilities":[81],"reflect":[83],"point":[84,126],"mutations.":[85,185],"We":[86],"present":[87],"an":[88],"end-to-end":[89],"deep":[90],"framework,":[92],"MuPIPR":[93,111,147,194,217],"(Mutation":[94],"Effects":[95],"in":[96,138],"Protein-protein":[97],"Interaction":[98],"PRediction":[99],"Using":[100],"Contextualized":[101],"Representations),":[102],"PPIs.":[110],"incorporates":[112],"a":[113,125,139,149,158],"contextualized":[114],"representation":[115],"mechanism":[116],"amino":[118,130],"acids":[119],"propagate":[121],"mutation":[127,164],"surrounding":[129],"acid":[131],"representations,":[132],"therefore":[133],"amplifying":[134],"subtle":[136],"change":[137],"long":[140],"sequence.":[142],"On":[143],"top":[144],"that,":[146,189],"leverages":[148],"Siamese":[150],"residual":[151],"recurrent":[152],"convolutional":[153],"neural":[154],"encoder":[155],"encode":[157],"wild-type":[159],"pair":[161,174],"its":[163],"pair.":[165],"Multi-layer":[166],"perceptron":[167],"regressors":[168],"are":[169],"applied":[170],"representations":[175],"predict":[177],"quantifiable":[179],"properties":[183],"Experimental":[186],"evaluations":[187],"show":[188],"with":[190],"only":[191],"sequence":[192],"information,":[193],"outperforms":[195],"various":[196],"state-of-the-art":[197,220],"systems":[198],"estimating":[200,223],"binding":[204],"affinity":[205],"for":[206],"SKEMPI":[207,214],"v1,":[208],"offers":[210],"comparable":[211],"performance":[212,221],"v2.":[215],"Meanwhile,":[216],"also":[218],"demonstrates":[219],"buried":[227],"surface":[228],"areas.":[229],"software":[231],"implementation":[232],"available":[234],"at":[235],"https://github.com/guangyu-zhou/MuPIPR.":[236]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":18},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":5}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}