{"id":"https://openalex.org/W3010337634","doi":"https://doi.org/10.3389/fgene.2020.00179","title":"In silico Metabolic Pathway Analysis Identifying Target Against Leishmaniasis \u2013 A Kinetic Modeling Approach","display_name":"In silico Metabolic Pathway Analysis Identifying Target Against Leishmaniasis \u2013 A Kinetic Modeling Approach","publication_year":2020,"publication_date":"2020-03-06","ids":{"openalex":"https://openalex.org/W3010337634","doi":"https://doi.org/10.3389/fgene.2020.00179","mag":"3010337634","pmid":"https://pubmed.ncbi.nlm.nih.gov/32211028","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7068213"},"language":"en","primary_location":{"id":"doi:10.3389/fgene.2020.00179","doi":"https://doi.org/10.3389/fgene.2020.00179","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fgene.2020.00179","pdf_url":"https://www.frontiersin.org/articles/10.3389/fgene.2020.00179/pdf","source":{"id":"https://openalex.org/S2597340651","display_name":"Frontiers in Genetics","issn_l":"1664-8021","issn":["1664-8021"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Genetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fgene.2020.00179/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103162770","display_name":"Nikita Bora","orcid":"https://orcid.org/0000-0001-9136-0818","observed_orcids":["https://orcid.org/0000-0001-9136-0818"]},"institutions":[{"id":"https://openalex.org/I126601174","display_name":"Tezpur University","ror":"https://ror.org/005x56091","country_code":"IN","type":"education","lineage":["https://openalex.org/I126601174"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Nikita Bora","raw_affiliation_strings":["Computational Biophysics Laboratory, Department of Molecular Biology and Biotechnology, Tezpur University, Tezpur, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biophysics Laboratory, Department of Molecular Biology and Biotechnology, Tezpur University, Tezpur, India","institution_ids":["https://openalex.org/I126601174"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030355052","display_name":"Anupam Nath Jha","orcid":"https://orcid.org/0000-0003-2304-2468","observed_orcids":["https://orcid.org/0000-0003-2304-2468"]},"institutions":[{"id":"https://openalex.org/I126601174","display_name":"Tezpur University","ror":"https://ror.org/005x56091","country_code":"IN","type":"education","lineage":["https://openalex.org/I126601174"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Anupam Nath Jha","raw_affiliation_strings":["Computational Biophysics Laboratory, Department of Molecular Biology and Biotechnology, Tezpur University, Tezpur, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biophysics Laboratory, Department of Molecular Biology and Biotechnology, Tezpur University, Tezpur, India","institution_ids":["https://openalex.org/I126601174"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5030355052"],"corresponding_institution_ids":["https://openalex.org/I126601174"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":3.4752,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.93463085,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"11","issue":null,"first_page":"179","last_page":"179"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":0.8705999851226807,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":0.8705999851226807,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.0706000030040741,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.04089999943971634,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/visceral-leishmaniasis","display_name":"visceral leishmaniasis","score":0.972000002861023},{"id":"https://openalex.org/keywords/leishmania-donovani","display_name":"Leishmania donovani","score":0.9990000128746033},{"id":"https://openalex.org/keywords/purine-salvage-pathway","display_name":"purine salvage pathway","score":0.9580000042915344},{"id":"https://openalex.org/keywords/drug-target-identification","display_name":"drug target identification","score":0.8759999871253967},{"id":"https://openalex.org/keywords/protein-protein-interaction-network","display_name":"protein-protein interaction network","score":0.7630000114440918},{"id":"https://openalex.org/keywords/adenylosuccinate-lyase","display_name":"adenylosuccinate lyase","score":0.9459999799728394},{"id":"https://openalex.org/keywords/inosine-5-monophosphate-dehydrogenase","display_name":"inosine 5'-monophosphate dehydrogenase","score":0.9869999885559082},{"id":"https://openalex.org/keywords/centrality-analysis","display_name":"centrality analysis","score":0.6840000152587891},{"id":"https://openalex.org/keywords/essential-enzymes","display_name":"essential enzymes","score":0.3499999940395355},{"id":"https://openalex.org/keywords/antiparasitic-drug-targets","display_name":"antiparasitic drug targets","score":0.5830000042915344}],"concepts":[{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.6137112379074097},{"id":"https://openalex.org/C2781333301","wikidata":"https://www.wikidata.org/wiki/Q1950752","display_name":"Leishmania donovani","level":4,"score":0.6030181050300598},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.6006418466567993},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.569504976272583},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5553600788116455},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5484148859977722},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.5167426466941833},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.4260683059692383},{"id":"https://openalex.org/C2776555147","wikidata":"https://www.wikidata.org/wiki/Q331283","display_name":"Leishmaniasis","level":2,"score":0.3395264744758606},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32969558238983154},{"id":"https://openalex.org/C2778689377","wikidata":"https://www.wikidata.org/wiki/Q2046113","display_name":"Visceral leishmaniasis","level":3,"score":0.2594073414802551},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.18897178769111633},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15438368916511536},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12979325652122498},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.12393206357955933},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fgene.2020.00179","doi":"https://doi.org/10.3389/fgene.2020.00179","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fgene.2020.00179","pdf_url":"https://www.frontiersin.org/articles/10.3389/fgene.2020.00179/pdf","source":{"id":"https://openalex.org/S2597340651","display_name":"Frontiers in Genetics","issn_l":"1664-8021","issn":["1664-8021"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Genetics","raw_type":"journal-article"},{"id":"pmid:32211028","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32211028","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in genetics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7068213","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7068213/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Genet","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:de18403eaa604e8582b391a8d352aa35","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/de18403eaa604e8582b391a8d352aa35","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Genetics, Vol 11 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fgene.2020.00179","doi":"https://doi.org/10.3389/fgene.2020.00179","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fgene.2020.00179","pdf_url":"https://www.frontiersin.org/articles/10.3389/fgene.2020.00179/pdf","source":{"id":"https://openalex.org/S2597340651","display_name":"Frontiers in Genetics","issn_l":"1664-8021","issn":["1664-8021"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3010337634.pdf","grobid_xml":"https://content.openalex.org/works/W3010337634.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W61925159","https://openalex.org/W121896805","https://openalex.org/W1816896070","https://openalex.org/W1968652333","https://openalex.org/W1971006771","https://openalex.org/W1972544795","https://openalex.org/W1983956209","https://openalex.org/W2007905920","https://openalex.org/W2010717419","https://openalex.org/W2017987256","https://openalex.org/W2034319293","https://openalex.org/W2036330755","https://openalex.org/W2042735590","https://openalex.org/W2042760907","https://openalex.org/W2046144222","https://openalex.org/W2051992969","https://openalex.org/W2060014742","https://openalex.org/W2063007776","https://openalex.org/W2063701689","https://openalex.org/W2066954635","https://openalex.org/W2077169276","https://openalex.org/W2077946350","https://openalex.org/W2080065479","https://openalex.org/W2080161281","https://openalex.org/W2081190990","https://openalex.org/W2084889403","https://openalex.org/W2091055640","https://openalex.org/W2091788742","https://openalex.org/W2092266284","https://openalex.org/W2094305273","https://openalex.org/W2096173332","https://openalex.org/W2100744247","https://openalex.org/W2102653059","https://openalex.org/W2103838923","https://openalex.org/W2103912979","https://openalex.org/W2105105987","https://openalex.org/W2106806321","https://openalex.org/W2106840724","https://openalex.org/W2107915297","https://openalex.org/W2117364474","https://openalex.org/W2137600992","https://openalex.org/W2141661990","https://openalex.org/W2144000913","https://openalex.org/W2145904172","https://openalex.org/W2146992057","https://openalex.org/W2148141042","https://openalex.org/W2159482845","https://openalex.org/W2159675211","https://openalex.org/W2180579609","https://openalex.org/W2340500207","https://openalex.org/W2599206524","https://openalex.org/W2601137540","https://openalex.org/W2618385853","https://openalex.org/W2770421951","https://openalex.org/W2793816505","https://openalex.org/W2794096376","https://openalex.org/W2794495999","https://openalex.org/W2795188988","https://openalex.org/W2810304836","https://openalex.org/W2887178378","https://openalex.org/W2903383142","https://openalex.org/W2924988727","https://openalex.org/W2964114900","https://openalex.org/W2967944122","https://openalex.org/W4294216483"],"related_works":["https://openalex.org/W3094077664","https://openalex.org/W2601137540","https://openalex.org/W4415322839","https://openalex.org/W2587426128","https://openalex.org/W4319812822","https://openalex.org/W2212310723","https://openalex.org/W4289204798","https://openalex.org/W4386490574","https://openalex.org/W2043548902","https://openalex.org/W2903383142"],"abstract_inverted_index":{"The":[0,34],"protozoan":[1],"L.":[2,162],"donovani,":[3],"from":[4,164],"trypanosomatids":[5],"family":[6],"is":[7,72,90,114,170],"a":[8,28,91,155,171,218,222,267],"deadly":[9],"human":[10],"pathogen":[11],"responsible":[12],"for":[13,63,93,119,158,190,271],"causing":[14],"Visceral":[15,346],"Leishmaniasis.":[16,347],"Unavailability":[17],"of":[18,36,61,69,77,102,111,125,177,184,198,207,225,236,243,247,254,261,276,313,330,345],"proper":[19],"treatment":[20,40,344],"in":[21,180,240,252,265],"the":[22,32,57,70,83,94,99,103,109,112,137,165,175,181,209,214,232,237,241,244,248,258,262,272,277,298,311,314,325,328,343],"developing":[23],"countries":[24],"has":[25,38,81],"served":[26],"as":[27],"major":[29],"threat":[30],"to":[31,42,52,97,107,146,187,213,220,289,307,310,333],"people.":[33],"absence":[35],"vaccines":[37],"made":[39],"possibilities":[41],"rely":[43],"solely":[44],"over":[45],"chemotherapy.":[46],"Also,":[47],"reduced":[48],"drug":[49,66,79],"efficacy":[50],"due":[51],"emerging":[53],"resistant":[54],"strains":[55],"magnifies":[56],"threat.":[58],"Despite":[59],"years":[60],"formulations":[62],"an":[64,196],"effective":[65],"therapy,":[67],"complexity":[68],"disease":[71],"also":[73],"unfortunately":[74],"increasing.":[75],"Absence":[76],"potential":[78,121],"targets":[80,118,160,287,341],"worsened":[82],"scenario.":[84],"Therefore":[85],"exploring":[86],"new":[87,116],"therapeutic":[88],"approach":[89],"priority":[92],"scientific":[95],"community":[96],"combat":[98],"disease.":[100],"One":[101],"most":[104],"reliable":[105],"ways":[106],"alter":[108],"adversities":[110],"infection":[113],"finding":[115],"biological":[117],"designing":[120],"drugs.":[122],"An":[123],"era":[124],"computational":[126,156],"biology":[127],"allows":[128],"identifying":[129],"targets,":[130],"assisting":[131],"experimental":[132,211],"studies.":[133],"It":[134,205],"includes":[135],"sorting":[136],"parasite\u2019s":[138],"metabolic":[139,199,249],"pathways":[140],"that":[141],"pins":[142],"out":[143],"proteins":[144,336],"essential":[145],"its":[147,191],"survival.":[148,192],"We":[149],"have":[150],"directed":[151],"our":[152],"study":[153,194,326],"towards":[154,174],"methodology":[157],"determining":[159],"against":[161,342],"donovani":[163],"\u201cpurine":[166],"salvage\u201d":[167],"pathway.":[168,228],"This":[169,193],"mainstay":[172],"pathway":[173,200,250,263],"maintenance":[176],"purine":[178],"amounts":[179],"parasitic":[182],"pool":[183],"nutrients":[185],"proving":[186],"be":[188,290,308,339],"mandatory":[189],"represents":[195],"integration":[197],"and":[201,284,303,320],"Protein-Protein":[202],"Interactions":[203],"analysis.":[204],"consists":[206],"incorporating":[208],"available":[210],"data":[212,230],"theoretical":[215],"methods":[216,332],"with":[217,292],"prospective":[219],"develop":[221],"kinetic":[223,321],"model":[224],"Purine":[226],"salvage":[227],"Simulation":[229],"revealed":[231],"time":[233],"course":[234],"mechanism":[235],"enzymes":[238,299],"involved":[239],"synthesis":[242],"metabolites.":[245],"Modeling":[246],"helped":[251],"marking":[253],"crucial":[255],"enzymes.":[256],"Additionally,":[257],"PPI":[259,278,319],"analysis":[260,275,296],"assisted":[264],"building":[266],"static":[268],"interaction":[269],"network":[270,279,316],"proteins.":[273],"Topological":[274],"through":[280],"centrality":[281],"measures":[282],"(MCC":[283],"Closeness)":[285],"detected":[286],"found":[288],"common":[291],"Dynamic":[293],"Modeling.":[294],"Structural":[295],"reveals":[297],"ADSL":[300],"(Adenylosuccinate":[301],"lyase)":[302],"IMPDH":[304],"(Inosine-5'-monophosphate":[305],"dehydrogenase)":[306],"central":[309],"role":[312],"modeled":[315],"based":[317],"on":[318],"modeling":[322],"techniques.":[323],"Hence,":[324],"presented":[327],"significance":[329],"integrating":[331],"identify":[334],"key":[335],"which":[337],"might":[338],"putative":[340]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-03-13T00:00:00"}