{"id":"https://openalex.org/W3010334133","doi":"https://doi.org/10.1089/hum.2019.367","title":"Postmortem Analysis in a Clinical Trial of AAV2-NGF Gene Therapy for Alzheimer's Disease Identifies a Need for Improved Vector Delivery","display_name":"Postmortem Analysis in a Clinical Trial of AAV2-NGF Gene Therapy for Alzheimer's Disease Identifies a Need for Improved Vector Delivery","publication_year":2020,"publication_date":"2020-03-04","ids":{"openalex":"https://openalex.org/W3010334133","doi":"https://doi.org/10.1089/hum.2019.367","mag":"3010334133","pmid":"https://pubmed.ncbi.nlm.nih.gov/32126838","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7194314"},"language":"en","primary_location":{"id":"doi:10.1089/hum.2019.367","doi":"https://doi.org/10.1089/hum.2019.367","is_oa":false,"landing_page_url":"https://doi.org/10.1089/hum.2019.367","pdf_url":null,"source":{"id":"https://openalex.org/S39730559","display_name":"Human Gene Therapy","issn_l":"1043-0342","issn":["1043-0342","1557-7422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Gene Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7194314","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018312528","display_name":"Michael J. Castle","orcid":"https://orcid.org/0000-0001-7566-6454","observed_orcids":["https://orcid.org/0000-0001-7566-6454"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael J. Castle","raw_affiliation_strings":["Department of Neurosciences, University of California, San Diego, La Jolla, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, University of California, San Diego, La Jolla, California","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062372221","display_name":"Fernando C. Baltan\u00e1s","orcid":"https://orcid.org/0000-0001-8110-0991","observed_orcids":["https://orcid.org/0000-0001-8110-0991"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fernando C. Baltan\u00e1s","raw_affiliation_strings":["Department of Neurosciences, University of California, San Diego, La Jolla, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, University of California, San Diego, La Jolla, California","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018007672","display_name":"Imre Kov\u00e1cs","orcid":"https://orcid.org/0000-0003-2014-678X","observed_orcids":["https://orcid.org/0000-0003-2014-678X","https://orcid.org/0009-0002-9848-392X"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Imre Kovacs","raw_affiliation_strings":["Department of Neurosciences, University of California, San Diego, La Jolla, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, University of California, San Diego, La Jolla, California","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019972535","display_name":"Alan H. Nagahara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan H. Nagahara","raw_affiliation_strings":["Department of Neurosciences, University of California, San Diego, La Jolla, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, University of California, San Diego, La Jolla, California","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":null,"display_name":"David Barba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Barba","raw_affiliation_strings":["Department of Neurosurgery, University of California, San Diego, La Jolla, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of California, San Diego, La Jolla, California","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055508729","display_name":"Mark H. Tuszynski","orcid":"https://orcid.org/0000-0003-4182-1481","observed_orcids":["https://orcid.org/0000-0003-4182-1481"]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mark H. Tuszynski","raw_affiliation_strings":["Department of Neurosciences, University of California, San Diego, La Jolla, California","Veterans Administration Medical Center, San Diego, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, University of California, San Diego, La Jolla, California","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Veterans Administration Medical Center, San Diego, California","institution_ids":["https://openalex.org/I1322918889"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5018312528","https://openalex.org/A5055508729"],"corresponding_institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I36258959"],"apc_list":null,"apc_paid":null,"fwci":7.2194,"has_fulltext":false,"cited_by_count":116,"citation_normalized_percentile":{"value":0.98282471,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"31","issue":"7-8","first_page":"415","last_page":"422"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.8349999785423279,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.8349999785423279,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.15690000355243683,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nerve-growth-factor","display_name":"nerve growth factor","score":0.824999988079071},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.949999988079071},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.7649999856948853},{"id":"https://openalex.org/keywords/stereotactic-injection","display_name":"stereotactic injection","score":0.8429999947547913},{"id":"https://openalex.org/keywords/nucleus-basalis-of-meynert","display_name":"nucleus basalis of Meynert","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cholinergic-neurons","display_name":"cholinergic neurons","score":0.9750000238418579},{"id":"https://openalex.org/keywords/p75-ngf-receptor","display_name":"p75 NGF receptor","score":0.8930000066757202},{"id":"https://openalex.org/keywords/post-mortem-analysis","display_name":"post-mortem analysis","score":0.7639999985694885},{"id":"https://openalex.org/keywords/convection-enhanced-delivery","display_name":"convection-enhanced delivery","score":0.7649999856948853},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging-guidance","display_name":"magnetic resonance imaging guidance","score":0.6510000228881836}],"concepts":[{"id":"https://openalex.org/C2776287375","wikidata":"https://www.wikidata.org/wiki/Q3407681","display_name":"Basal forebrain","level":3,"score":0.8800435066223145},{"id":"https://openalex.org/C2778423431","wikidata":"https://www.wikidata.org/wiki/Q417782","display_name":"Nerve growth factor","level":3,"score":0.8780462741851807},{"id":"https://openalex.org/C104966671","wikidata":"https://www.wikidata.org/wiki/Q12167532","display_name":"Cholinergic neuron","level":3,"score":0.7077533602714539},{"id":"https://openalex.org/C2778205193","wikidata":"https://www.wikidata.org/wiki/Q1813830","display_name":"Nucleus basalis","level":4,"score":0.642695963382721},{"id":"https://openalex.org/C22885893","wikidata":"https://www.wikidata.org/wiki/Q4862743","display_name":"Cholinergic","level":2,"score":0.5691617131233215},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.5456448793411255},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5389946103096008},{"id":"https://openalex.org/C135983454","wikidata":"https://www.wikidata.org/wiki/Q2790163","display_name":"Gene delivery","level":4,"score":0.4625038802623749},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45757079124450684},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.4108530282974243},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3206147849559784},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31540292501449585},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1655866801738739},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1358022391796112},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09468021988868713}],"mesh":[{"descriptor_ui":"D000229","descriptor_name":"Dependovirus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D001344","descriptor_name":"Autopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009483","descriptor_name":"Neuropsychological Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020932","descriptor_name":"Nerve Growth Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D059329","descriptor_name":"Cholinergic Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066187","descriptor_name":"Basal Forebrain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1089/hum.2019.367","doi":"https://doi.org/10.1089/hum.2019.367","is_oa":false,"landing_page_url":"https://doi.org/10.1089/hum.2019.367","pdf_url":null,"source":{"id":"https://openalex.org/S39730559","display_name":"Human Gene Therapy","issn_l":"1043-0342","issn":["1043-0342","1557-7422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Gene Therapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7194314","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7194314","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hum Gene Ther","raw_type":"Text"},{"id":"pmid:32126838","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32126838","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human gene therapy","raw_type":"Clinical Trial, Phase I"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt7hv602z0","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/7hv602z0","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Human Gene Therapy, vol 31, iss 7-8","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7194314","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7194314","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hum Gene Ther","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W15418036","https://openalex.org/W155248772","https://openalex.org/W1609471181","https://openalex.org/W1639832183","https://openalex.org/W1719844260","https://openalex.org/W1820424262","https://openalex.org/W1961744561","https://openalex.org/W1981497654","https://openalex.org/W2008774736","https://openalex.org/W2011512156","https://openalex.org/W2037194302","https://openalex.org/W2042811786","https://openalex.org/W2047945439","https://openalex.org/W2050581000","https://openalex.org/W2060646430","https://openalex.org/W2069095254","https://openalex.org/W2089202437","https://openalex.org/W2091659898","https://openalex.org/W2092757238","https://openalex.org/W2092862588","https://openalex.org/W2093374391","https://openalex.org/W2111837903","https://openalex.org/W2128228199","https://openalex.org/W2135062838","https://openalex.org/W2148470186","https://openalex.org/W2149731696","https://openalex.org/W2151349288","https://openalex.org/W2153042097","https://openalex.org/W2153438315","https://openalex.org/W2154329712","https://openalex.org/W2161483044","https://openalex.org/W2167279371","https://openalex.org/W2167905535","https://openalex.org/W2256579886","https://openalex.org/W2412932806","https://openalex.org/W2434926675","https://openalex.org/W2548348201","https://openalex.org/W2580035316","https://openalex.org/W2597570800","https://openalex.org/W2708579841","https://openalex.org/W2790565614","https://openalex.org/W2791712907","https://openalex.org/W2792593254","https://openalex.org/W2901280365","https://openalex.org/W2907733456","https://openalex.org/W2916484252","https://openalex.org/W2916632122","https://openalex.org/W2982336273"],"related_works":["https://openalex.org/W2896751379","https://openalex.org/W2050581000","https://openalex.org/W2586450860","https://openalex.org/W2075436269","https://openalex.org/W2017605676","https://openalex.org/W1961744561","https://openalex.org/W2790565614","https://openalex.org/W2011754022","https://openalex.org/W2302402305","https://openalex.org/W2161483044"],"abstract_inverted_index":{"Nerve":[0],"growth":[1,190,220],"factor":[2,191,221],"(NGF)":[3],"gene":[4,42,128,192,222],"therapy":[5,43,193],"rescues":[6],"and":[7,105,113,172,210,217],"stimulates":[8],"cholinergic":[9,56,159,184],"neurons,":[10,185],"which":[11],"degenerate":[12],"in":[13,123],"Alzheimer's":[14],"disease":[15],"(AD).":[16],"In":[17,62],"a":[18,74,96],"recent":[19],"clinical":[20,199],"trial":[21],"for":[22,131,196,201],"AD,":[23],"intraparenchymal":[24],"adeno-associated":[25],"virus":[26],"serotype":[27],"2":[28,78],"(AAV2)-NGF":[29],"delivery":[30,121,212],"was":[31,148],"safe":[32],"but":[33],"did":[34,155,178],"not":[35,156,179],"improve":[36,214],"cognition.":[37],"Before":[38],"concluding":[39],"that":[40,50,189],"NGF":[41,112,116,127,154],"is":[44,194],"ineffective,":[45],"it":[46],"must":[47],"be":[48],"shown":[49],"AAV2-NGF":[51,85,102,139,146,177],"successfully":[52],"engaged":[53],"the":[54,59,90,114,142,164,182,215],"target":[55,183],"neurons":[57,160],"of":[58,77,84,89,93,99,111,138,145,163,219],"basal":[60],"forebrain.":[61],"this":[63],"study,":[64],"patients":[65],"with":[66],"clinically":[67],"diagnosed":[68],"early-":[69],"to":[70,169,213],"middle-stage":[71],"AD":[72,202],"received":[73],"total":[75],"dose":[76],"\u00d7":[79],"10":[80],"11":[81],"vector":[82],"genomes":[83],"by":[86,109],"stereotactic":[87,174],"injection":[88,166],"nucleus":[91],"basalis":[92],"Meynert.":[94],"After":[95],"mean":[97,143],"survival":[98],"4.0":[100],"years,":[101],"targeting,":[103],"spread,":[104],"expression":[106,129],"were":[107],"assessed":[108],"immunolabeling":[110],"low-affinity":[115],"receptor":[117],"p75":[118],"at":[119,132,136,161],"15":[120,165],"sites":[122,137,167],"3":[124],"autopsied":[125],"patients.":[126],"persisted":[130],"least":[133],"7":[134],"years":[135],"injection.":[140],"However,":[141],"distance":[144],"spread":[147,171,218],"only":[149],"0.96":[150],"\u00b1":[151],"0.34":[152],"mm.":[153],"directly":[157,180],"reach":[158],"any":[162],"due":[168],"limited":[170],"inaccurate":[173],"targeting.":[175],"Because":[176],"engage":[181],"we":[186],"cannot":[187],"conclude":[188],"ineffective":[195],"AD.":[197],"Upcoming":[198],"trials":[200],"will":[203],"utilize":[204],"real-time":[205],"magnetic":[206],"resonance":[207],"imaging":[208],"guidance":[209],"convection-enhanced":[211],"targeting":[216],"delivery.":[223]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":21},{"year":2024,"cited_by_count":34},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":23},{"year":2020,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-03-13T00:00:00"}