{"id":"https://openalex.org/W3010258085","doi":"https://doi.org/10.1097/pec.0000000000001959","title":"Assessing the Impact of 3% Hypertonic Saline Hyperosmolar Therapy on Intubated Children With Isolated Traumatic Brain Injury by Cerebral Oximetry in a Pediatric Emergency Setting","display_name":"Assessing the Impact of 3% Hypertonic Saline Hyperosmolar Therapy on Intubated Children With Isolated Traumatic Brain Injury by Cerebral Oximetry in a Pediatric Emergency Setting","publication_year":2020,"publication_date":"2020-02-27","ids":{"openalex":"https://openalex.org/W3010258085","doi":"https://doi.org/10.1097/pec.0000000000001959","mag":"3010258085","pmid":"https://pubmed.ncbi.nlm.nih.gov/32106155"},"language":"en","primary_location":{"id":"doi:10.1097/pec.0000000000001959","doi":"https://doi.org/10.1097/pec.0000000000001959","is_oa":false,"landing_page_url":"https://doi.org/10.1097/pec.0000000000001959","pdf_url":null,"source":{"id":"https://openalex.org/S4210190147","display_name":"Pediatric Emergency Care","issn_l":"0749-5161","issn":["0749-5161","1535-1815"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Emergency Care","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Leigh-Ann Washer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Leigh-Ann Washer","raw_affiliation_strings":["Department of Pediatrics, University of Arkansas for Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Arkansas for Medical Sciences","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058217983","display_name":"Thomas J. Abramo","orcid":"https://orcid.org/0000-0003-2331-4582","observed_orcids":["https://orcid.org/0000-0003-2331-4582"]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Thomas Abramo","raw_affiliation_strings":["Department of Pediatrics, University of Arkansas for Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Arkansas for Medical Sciences","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023910409","display_name":"Hailey Hardgrave","orcid":"https://orcid.org/0000-0003-0388-8386","observed_orcids":["https://orcid.org/0000-0003-0388-8386"]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hailey Hardgrave","raw_affiliation_strings":["University of Arkansas for Medical Sciences, Little Rock, AR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arkansas for Medical Sciences, Little Rock, AR","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036038594","display_name":"Zena Leah Harris","orcid":"https://orcid.org/0000-0003-0110-8438","observed_orcids":["https://orcid.org/0000-0003-0110-8438"]},"institutions":[{"id":"https://openalex.org/I1294278766","display_name":"Lurie Children's Hospital","ror":"https://ror.org/03a6zw892","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1294278766"]},{"id":"https://openalex.org/I4210147348","display_name":"Northwestern Medicine","ror":"https://ror.org/04fzwnh64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210147348"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zena Leah Harris","raw_affiliation_strings":["Department of Pediatrics, Feinberg School of Medicine, Northwestern Medicine, Lurie Children's Hospital, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Feinberg School of Medicine, Northwestern Medicine, Lurie Children's Hospital, Chicago, IL","institution_ids":["https://openalex.org/I1294278766","https://openalex.org/I4210147348"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mark Meredith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156806","display_name":"Le Bonheur Children's Hospital","ror":"https://ror.org/056wg8a82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210156806"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Meredith","raw_affiliation_strings":["Department of Pediatrics, University of Tennessee, LeBonheur Children's Hospital, Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Tennessee, LeBonheur Children's Hospital, Memphis, TN","institution_ids":["https://openalex.org/I4210156806"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Katherine Moore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine Moore","raw_affiliation_strings":["University of Arkansas for Medical Sciences, Little Rock, AR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arkansas for Medical Sciences, Little Rock, AR","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Abudulah Dalabih","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Abudulah Dalabih","raw_affiliation_strings":["Department of Pediatrics, University of Arkansas for Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Arkansas for Medical Sciences","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":null,"display_name":"David Williams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1301864278","display_name":"Arkansas Children's Hospital","ror":"https://ror.org/01t33qq42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301864278"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Williams","raw_affiliation_strings":["Arkansas Children's Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arkansas Children's Hospital","institution_ids":["https://openalex.org/I1301864278"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Amy Jorgenson-Stough","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1301864278","display_name":"Arkansas Children's Hospital","ror":"https://ror.org/01t33qq42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301864278"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy Jorgenson-Stough","raw_affiliation_strings":["Arkansas Children's Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arkansas Children's Hospital","institution_ids":["https://openalex.org/I1301864278"]}]},{"author_position":"last","author":{"id":null,"display_name":"Lee Crawley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1301864278","display_name":"Arkansas Children's Hospital","ror":"https://ror.org/01t33qq42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301864278"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lee Crawley","raw_affiliation_strings":["Arkansas Children's Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arkansas Children's Hospital","institution_ids":["https://openalex.org/I1301864278"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5058217983"],"corresponding_institution_ids":["https://openalex.org/I79620101"],"apc_list":null,"apc_paid":null,"fwci":0.3811,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.57619562,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"37","issue":"12","first_page":"e791","last_page":"e804"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11467","display_name":"Trauma and Emergency Care Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypertonic-saline","display_name":"hypertonic saline","score":0.8640000224113464},{"id":"https://openalex.org/keywords/hyperosmolar-therapy","display_name":"hyperosmolar therapy","score":0.8759999871253967},{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":0.9179999828338623},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.6159999966621399},{"id":"https://openalex.org/keywords/intubation","display_name":"intubation","score":0.7540000081062317},{"id":"https://openalex.org/keywords/cerebral-near-infrared-spectroscopy","display_name":"cerebral oximetry","score":0.8640000224113464},{"id":"https://openalex.org/keywords/intracranial-pressure","display_name":"intracranial pressure","score":0.8989999890327454},{"id":"https://openalex.org/keywords/secondary-brain-injury","display_name":"secondary brain injury","score":0.621999979019165},{"id":"https://openalex.org/keywords/cerebrospinal-fluid-drainage","display_name":"cerebrospinal fluid drainage","score":0.8629999756813049},{"id":"https://openalex.org/keywords/pediatric-emergency-department","display_name":"pediatric emergency department","score":0.7170000076293945},{"id":"https://openalex.org/keywords/treatment-response-monitoring","display_name":"treatment response monitoring","score":0.5759999752044678},{"id":"https://openalex.org/keywords/glasgow-coma-scale","display_name":"Glasgow Coma Scale","score":0.6890000104904175}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9592000246047974},{"id":"https://openalex.org/C2781017439","wikidata":"https://www.wikidata.org/wiki/Q1995526","display_name":"Traumatic brain injury","level":2,"score":0.7358999848365784},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6966000199317932},{"id":"https://openalex.org/C3017567848","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Hypertonic saline","level":2,"score":0.6171000003814697},{"id":"https://openalex.org/C2780724011","wikidata":"https://www.wikidata.org/wiki/Q1295316","display_name":"Emergency department","level":2,"score":0.5640000104904175},{"id":"https://openalex.org/C2780124106","wikidata":"https://www.wikidata.org/wiki/Q1140495","display_name":"Pulse oximetry","level":2,"score":0.47920000553131104},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.4138999879360199},{"id":"https://openalex.org/C3019520628","wikidata":"https://www.wikidata.org/wiki/Q2920572","display_name":"Head trauma","level":2,"score":0.3928000032901764},{"id":"https://openalex.org/C2987404301","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care","level":2,"score":0.36480000615119934},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.3531000018119812},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.2957000136375427},{"id":"https://openalex.org/C2780954326","wikidata":"https://www.wikidata.org/wiki/Q1416096","display_name":"Intracranial pressure","level":2,"score":0.2881999909877777},{"id":"https://openalex.org/C2994270601","wikidata":"https://www.wikidata.org/wiki/Q1995526","display_name":"Brain trauma","level":3,"score":0.28760001063346863},{"id":"https://openalex.org/C2993523616","wikidata":"https://www.wikidata.org/wiki/Q17146697","display_name":"Neurological deficit","level":2,"score":0.25450000166893005}],"mesh":[{"descriptor_ui":"D000070642","descriptor_name":"Brain Injuries, Traumatic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D000070642","descriptor_name":"Brain Injuries, Traumatic","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000070642","descriptor_name":"Brain Injuries, Traumatic","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007427","descriptor_name":"Intracranial Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010092","descriptor_name":"Oximetry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012462","descriptor_name":"Saline Solution, Hypertonic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015600","descriptor_name":"Glasgow Coma Scale","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/pec.0000000000001959","doi":"https://doi.org/10.1097/pec.0000000000001959","is_oa":false,"landing_page_url":"https://doi.org/10.1097/pec.0000000000001959","pdf_url":null,"source":{"id":"https://openalex.org/S4210190147","display_name":"Pediatric Emergency Care","issn_l":"0749-5161","issn":["0749-5161","1535-1815"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Emergency Care","raw_type":"journal-article"},{"id":"pmid:32106155","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32106155","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric emergency care","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W118422716","https://openalex.org/W333323704","https://openalex.org/W566748824","https://openalex.org/W1470040304","https://openalex.org/W1502176921","https://openalex.org/W1572836601","https://openalex.org/W1901738541","https://openalex.org/W1970067353","https://openalex.org/W1974732765","https://openalex.org/W1984400181","https://openalex.org/W1996565131","https://openalex.org/W2011024894","https://openalex.org/W2025164911","https://openalex.org/W2036692942","https://openalex.org/W2061825871","https://openalex.org/W2065028944","https://openalex.org/W2071346998","https://openalex.org/W2082851412","https://openalex.org/W2084534828","https://openalex.org/W2093274439","https://openalex.org/W2137163826","https://openalex.org/W2140954157","https://openalex.org/W2160009615","https://openalex.org/W2339476776","https://openalex.org/W2407504013","https://openalex.org/W2414548857","https://openalex.org/W2415037469","https://openalex.org/W2470228050","https://openalex.org/W2560311344","https://openalex.org/W2761798954"],"related_works":["https://openalex.org/W2530980648","https://openalex.org/W2514028623","https://openalex.org/W2538229117","https://openalex.org/W201132159","https://openalex.org/W3155009431","https://openalex.org/W2810341252","https://openalex.org/W3015940183","https://openalex.org/W6959133697","https://openalex.org/W2057415164","https://openalex.org/W2330530052"],"abstract_inverted_index":{"BACKGROUND:":[0],"Intubated":[1],"pediatric":[2,65,74,227,691,830],"patients":[3,129,210,228,245,664,692,741,803],"with":[4,130,211,229,246,639,668,676,693,742,749],"isolated":[5,75,131,160,189,212,230,247,694,801],"traumatic":[6],"brain":[7,50],"injury":[8],"(TBI)":[9],"are":[10,86,167],"a":[11,724,733,778,814],"diagnostic":[12],"challenge":[13],"for":[14,284,300,321,343,359,381,403,425,430,443,451,459,467,474,482,490,498,503,519,530,541,552,562,573,584,595],"early":[15],"detection":[16],"of":[17,40,83,151,200,219,651,681,770,786],"altered":[18,163],"cerebral":[19,78,97,106,124,165,431,504,717,807],"physiology":[20,79,98,166],"instigated":[21],"by":[22,99,141],"trauma-induced":[23,716],"increased":[24,41,93,120],"intracranial":[25],"pressure":[26],"(ICP)":[27],"while":[28],"preventing":[29],"secondary":[30],"neuronal":[31],"damage":[32],"(secondary":[33],"insult":[34],"detection)":[35],"and":[36,80,105,111,144,174,184,206,222,278,288,294,312,325,334,353,363,372,383,394,407,416,446,454,462,477,485,493,522,533,544,565,576,587,617,646,671,703,708,729,732,765,821,834],"assessing":[37,133],"the":[38,112,119,126,134,152,158,187,198,621,648,677,710,715,759,767,826],"effects":[39,82,117,156,199,713],"ICP":[42],"therapeutic":[43,137,818],"interventions":[44],"(3%":[45],"hypertonic":[46],"saline":[47],"[HTS]).":[48],"Invasive":[49],"tissue":[51,102],"oxygen":[52],"monitoring":[53],"is":[54,63,139],"guiding":[55],"new":[56],"intensive":[57],"care":[58],"unit":[59],"TBI":[60,161,190,231,248,695,802],"management":[61],"but":[62],"not":[64],"emergency":[66,828],"department":[67,829],"(PED)":[68],"readily":[69],"accessible.":[70],"Objective":[71,149],"measurements":[72,150],"on":[73,118,157,180,203,608,714],"TBI-altered":[76],"bihemispheric":[77,96,123,164,172,204,220,633,701,743],"treatment":[81],"3%":[84,135,153,181,201,233,250,652,656,698,711,720,771,775,805],"HTS":[85,136,154,182,202,234,251,434,507,606,653,657,699,712,721,772,776],"currently":[87],"lacking.":[88,168],"Cerebral":[89],"oximetry":[90,808],"can":[91],"assess":[92],"ICP-induced":[94,121],"abnormal":[95,122],"measuring":[100],"regional":[101],"oxygenation":[103],"(rcSO2)":[104],"blood":[107],"volume":[108],"index":[109],"(CBVI)":[110],"mechanical":[113],"cerebrospinal":[114],"fluid":[115],"removal":[116],"physiology.In":[125],"PED":[127,159],"intubated":[128,188,209,226,244,690,800],"TBI,":[132],"response":[138],"solely":[140],"vital":[142],"signs":[143],"limited":[145],"clinical":[146],"assessment":[147,819,833],"skills.":[148],"hyperosmolar":[155],"patients'":[162],"We":[169],"believe":[170],"that":[171],"rcSO2":[173,205,221,285,322,360,404,445,461,476,492,521,564,610,614,636,643,659,673,702,728,737,746,755],"CBVI":[175,207,223,704,730],"could":[176],"elucidate":[177],"similar":[178],"data":[179],"impact":[183],"influence":[185],"in":[186,208,225,632,727,735,799,825],"patients.":[191],"OBJECTIVE:":[192],"This":[193],"study":[194],"aimed":[195],"to":[196,241,275,281,291,297,306,315,328,337,350,356,366,375,388,397,410,419,441,449,457,465,472,480,488,496,514,525,536,547,557,568,579,590],"analyze":[197],"TBI.":[213],"METHODS:":[214],"An":[215],"observational,":[216],"retrospective":[217],"analysis":[218],"readings":[224,674,705,731,747],"receiving":[232],"infusions,":[235,700],"was":[236],"performed.":[237],"RESULTS:":[238],"From":[239],"2010":[240],"2017,":[242],"207":[243],"received":[249,697],"infusions":[252],"(median":[253],"age,":[254],"2.9":[255],"[1.1-6.9":[256],"years];":[257],"preintubation":[258],"Glasgow":[259],"Coma":[260],"Scale":[261],"score,":[262],"7":[263],"[6-8]).":[264],"The":[265,427,500,627,719],"results":[266,429,502],"were":[267,435,508],"as":[268,436,509,813],"follows:":[269,437,510],"initial":[270,345,827],"pre-3%":[271,346,433],"HTS,":[272,303,347,385,806],"43%":[273],"(39.5%":[274],"47.5%;":[276],"left)":[277,293,311,333,352,371,393,415],"38%":[279],"(35%":[280],"42%;":[282],"right)":[283,299,320,342,358,380,402,424],"<":[286,309,318,323,340,369,391,400,413,560,571,582,593,615,625,637,686],"60%,":[287,324,616],"8":[289],"(-28":[290],"21;":[292],"-15":[295,494],"(-34":[296,448],"22;":[298],"CBVI;":[301,344,382,468,553],"post-3%":[302,384,506],"68.5%":[304],"(59.3%":[305],"76%,":[307],"P":[308,317,330,339,368,377,390,399,412,421,516,527,538,549,559,570,581,592,685],"0.0001;":[310,319,341,370,392,401,414],"62.5%":[313,577],"(56.0%":[314],"74.8%,":[316],"12":[326],"(-7":[327],"24,":[329,548],"=":[331,378,422,517,528,539,550],"0.04;":[332],"14":[335],"(-21":[336,464],"22,":[338,569,591],"90%":[348],"(83%":[349],"91%;":[351],"87%":[354],"(82%":[355],"92%;":[357],">":[361,405,644,756],"80%,":[362,406],"16.5":[364,408],"(6":[365,409],"33,":[367,411],"16.8":[373,417],"(-2.5":[374,418],"27.5,":[376,420],"0.005;":[379,423],"69%":[386],"(62%":[387],"72.5%,":[389],"63%":[395,534,555],"(59%":[396],"72%,":[398,537,558],"CBVI.":[426,499,596],"following":[428,501],"pathology":[432,505],"epidural:":[438,511],"85%":[439],"(58%":[440,513],"88.5%)":[442],"left":[444,452,475,483,520,531,563,574],"-9.25":[447],"19)":[450,481],"CBVI,":[453,484,532,575],"85.5%":[455],"(57.5%":[456],"89%)":[458],"right":[460,491,542,585],"-12.5":[463],"27)":[466],"subdural:":[469,554],"45%":[470],"(38%":[471],"54%)":[473],"-9.5":[478],"(-25":[479],"40%":[486],"(33%":[487],"49%)":[489],"(-30.5":[495],"5)":[497],"66%":[512],"69%,":[515],"0.03)":[518],"15":[523],"(-1":[524],"21,":[526],"0.0004)":[529],"(52%":[535],"0.009)":[540],"rcSO2,":[543,586],"15.5":[545],"(-22":[546],"0.02)":[551],"(56%":[556],"0.0001)":[561,572,583,594],"9":[566],"(-20":[567],"(48%":[578],"73%,":[580],"3":[588],"(-26":[589],"Overall,":[597,774],"heart":[598,789],"rate":[599,790],"showed":[600,613,791],"no":[601,792],"significant":[602,725,761,779,793],"change.":[603,794],"Three":[604],"percent":[605],"effect":[607],"interhemispheric":[609,641,736,753],"difference":[611],">10":[612],"subdural":[618,669],"hematomas":[619,670],"had":[620],"greatest":[622,628,649,760,768],"reduction":[623,734],"(P":[624],"0.001).":[626,687],"positive":[629,666,762,780],"changes":[630],"occurred":[631],"or":[634,744,750],"one-hemispheric":[635,745],"60%":[638],"an":[640,752],"discordance":[642,738],"10":[645,757],"required":[647,766],"number":[650],"infusions.":[654,773],"For":[655],"15%":[658,781],"change":[660,667,764,782],"time":[661,680],"effect,":[662],"all":[663],"achieved":[665],"hemispheric":[672],"<60%":[675,748],"shortest":[678],"achievement":[679],"1.2":[682],"minutes":[683,785],"(0.59-1.75;":[684],"CONCLUSIONS:":[688],"In":[689,740],"who":[696],"immediately":[706],"detected":[707],"trended":[709],"pathophysiology.":[718],"infusion":[722],"produced":[723,777],"improvement":[726],"differences.":[739],"without":[751],"discordance,":[754],"demonstrated":[758],"delta":[763],"numbers":[769],"within":[783],"2.1":[784],"infusion,":[787],"whereas":[788],"During":[795],"trauma":[796,831],"neuroresuscitation,":[797],"especially":[798],"requiring":[804],"has":[809],"shown":[810],"its":[811],"functionality":[812],"rapid":[815],"adjunct":[816],"neurological,":[817],"tool":[820],"should":[822],"be":[823],"considered":[824],"neurological":[832],"neuroresuscitation":[835],"regimen.":[836]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2020-03-13T00:00:00"}