{"id":"https://openalex.org/W3010204309","doi":"https://doi.org/10.17179/excli2018-1129","title":"Determination of the relationship between doxorubicin resistance and Wnt signaling pathway in HeLa and K562 cell lines","display_name":"Determination of the relationship between doxorubicin resistance and Wnt signaling pathway in HeLa and K562 cell lines","publication_year":2018,"publication_date":"2018-05-02","ids":{"openalex":"https://openalex.org/W3010204309","doi":"https://doi.org/10.17179/excli2018-1129","mag":"3010204309","pmid":"https://pubmed.ncbi.nlm.nih.gov/29805346","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5962902"},"language":"en","primary_location":{"id":"doi:10.17179/excli2018-1129","doi":"https://doi.org/10.17179/excli2018-1129","is_oa":true,"landing_page_url":"https://doi.org/10.17179/excli2018-1129","pdf_url":null,"source":{"id":"https://openalex.org/S39273986","display_name":"EXCLI journal","issn_l":"1611-2156","issn":["1611-2156"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","ddh","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310313779","host_organization_name":"IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund","host_organization_lineage":["https://openalex.org/P4310313779"],"host_organization_lineage_names":["IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EXCLI Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.excli.de/excli/article/view/464/1277","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061564444","display_name":"Pelin Mutlu","orcid":"https://orcid.org/0000-0001-7970-880X","observed_orcids":["https://orcid.org/0000-0001-7970-880X"]},"institutions":[{"id":"https://openalex.org/I201799495","display_name":"Middle East Technical University","ror":"https://ror.org/014weej12","country_code":"TR","type":"education","lineage":["https://openalex.org/I201799495"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Pelin Mutlu","raw_affiliation_strings":["Central Laboratory Molecular Biology and Biotechnology R&D, Middle East Technical University, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Laboratory Molecular Biology and Biotechnology R&D, Middle East Technical University, Ankara, Turkey","institution_ids":["https://openalex.org/I201799495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102746598","display_name":"Serap Yal\u00e7\u0131n Azarkan","orcid":"https://orcid.org/0000-0002-9584-266X","observed_orcids":["https://orcid.org/0000-0002-9584-266X"]},"institutions":[{"id":"https://openalex.org/I204483917","display_name":"Ahi Evran University","ror":"https://ror.org/05rrfpt58","country_code":"TR","type":"education","lineage":["https://openalex.org/I204483917"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Serap Yal\u00e7in Azarkan","raw_affiliation_strings":["Department of Molecular Biology and Genetics, Ahi Evran University, Kirsehir, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Ahi Evran University, Kirsehir, Turkey","institution_ids":["https://openalex.org/I204483917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025690322","display_name":"Negar Taghavi Pourianazar","orcid":"https://orcid.org/0000-0003-3250-1427","observed_orcids":["https://orcid.org/0000-0003-3250-1427"]},"institutions":[{"id":"https://openalex.org/I201799495","display_name":"Middle East Technical University","ror":"https://ror.org/014weej12","country_code":"TR","type":"education","lineage":["https://openalex.org/I201799495"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Negar Taghavi Pourianazar","raw_affiliation_strings":["Department of Biological Sciences, Middle East Technical University, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Middle East Technical University, Ankara, Turkey","institution_ids":["https://openalex.org/I201799495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015630921","display_name":"Meral Y\u00fccel","orcid":"https://orcid.org/0000-0001-5548-1161","observed_orcids":["https://orcid.org/0000-0001-5548-1161"]},"institutions":[{"id":"https://openalex.org/I201799495","display_name":"Middle East Technical University","ror":"https://ror.org/014weej12","country_code":"TR","type":"education","lineage":["https://openalex.org/I201799495"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Meral Y\u00fccel","raw_affiliation_strings":["Central Laboratory Molecular Biology and Biotechnology R&D, Middle East Technical University, Ankara, Turkey","Department of Biological Sciences, Middle East Technical University, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Laboratory Molecular Biology and Biotechnology R&D, Middle East Technical University, Ankara, Turkey","institution_ids":["https://openalex.org/I201799495"]},{"raw_affiliation_string":"Department of Biological Sciences, Middle East Technical University, Ankara, Turkey","institution_ids":["https://openalex.org/I201799495"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071755295","display_name":"Ufuk G\u00fcnd\u00fcz","orcid":"https://orcid.org/0000-0002-5158-7652","observed_orcids":["https://orcid.org/0000-0002-5158-7652"]},"institutions":[{"id":"https://openalex.org/I201799495","display_name":"Middle East Technical University","ror":"https://ror.org/014weej12","country_code":"TR","type":"education","lineage":["https://openalex.org/I201799495"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ufuk G\u00fcnd\u00fcz","raw_affiliation_strings":["Department of Biological Sciences, Middle East Technical University, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Middle East Technical University, Ankara, Turkey","institution_ids":["https://openalex.org/I201799495"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5061564444"],"corresponding_institution_ids":["https://openalex.org/I201799495"],"apc_list":null,"apc_paid":null,"fwci":0.4173,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.62562123,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"17","issue":null,"first_page":"386","last_page":"398"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.6425999999046326,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.6425999999046326,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.34769999980926514,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/doxorubicin-resistance","display_name":"doxorubicin resistance","score":0.9990000128746033},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.9860000014305115},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":0.7250000238418579},{"id":"https://openalex.org/keywords/k562-cells","display_name":"K562 cells","score":1.0},{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.800000011920929},{"id":"https://openalex.org/keywords/drug-resistance-genes","display_name":"drug resistance genes","score":0.6330000162124634},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.8190000057220459},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.6269999742507935},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.7289999723434448}],"concepts":[{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.887887716293335},{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.8799013495445251},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6220123171806335},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5675778388977051},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.5587469935417175},{"id":"https://openalex.org/C171122931","wikidata":"https://www.wikidata.org/wiki/Q6324626","display_name":"K562 cells","level":3,"score":0.5582519769668579},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.5089282989501953},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4913538992404938},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.48450466990470886},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46610674262046814},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.44060441851615906},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.43135517835617065},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40555357933044434},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24554091691970825},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.064581960439682}],"mesh":[],"locations_count":10,"locations":[{"id":"doi:10.17179/excli2018-1129","doi":"https://doi.org/10.17179/excli2018-1129","is_oa":true,"landing_page_url":"https://doi.org/10.17179/excli2018-1129","pdf_url":null,"source":{"id":"https://openalex.org/S39273986","display_name":"EXCLI journal","issn_l":"1611-2156","issn":["1611-2156"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","ddh","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310313779","host_organization_name":"IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund","host_organization_lineage":["https://openalex.org/P4310313779"],"host_organization_lineage_names":["IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EXCLI Journal","raw_type":"journal-article"},{"id":"pmh:oai:www.excli.de:article/464","doi":null,"is_oa":true,"landing_page_url":"https://www.excli.de/excli/article/view/464","pdf_url":"https://www.excli.de/excli/article/view/464/1277","source":{"id":"https://openalex.org/S39273986","display_name":"EXCLI journal","issn_l":"1611-2156","issn":["1611-2156"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","ddh","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310313779","host_organization_name":"IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund","host_organization_lineage":["https://openalex.org/P4310313779"],"host_organization_lineage_names":["IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"1611-2156","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:europepmc.org:4920935","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5962902","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:29805346","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29805346","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EXCLI journal","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5962902","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5962902/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EXCLI J","raw_type":"Text"},{"id":"pmh:oai:eldorado.tu-dortmund.de:2003/37102","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2003/37102","pdf_url":"http://hdl.handle.net/2003/37102","source":{"id":"https://openalex.org/S4306400811","display_name":"Technische Universit\u00e4t Dortmund Eldorado (Technische Universit\u00e4t Dortmund)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210148506","host_organization_name":"Erich-Brost-Institut","host_organization_lineage":["https://openalex.org/I4210148506"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:https://open.metu.edu.tr:11511/31648","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11511/31648","pdf_url":null,"source":{"id":"https://openalex.org/S4306402495","display_name":"OpenMETU (Middle East Technical University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I201799495","host_organization_name":"Middle East Technical University","host_organization_lineage":["https://openalex.org/I201799495"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"doi:10.17179/excli2018-1129","doi":"https://doi.org/10.17179/excli2018-1129","is_oa":true,"landing_page_url":"https://doi.org/10.17179/excli2018-1129","pdf_url":null,"source":{"id":"https://openalex.org/S7407053513","display_name":"Leibniz-Institut f\u00fcr Arbeitsforschung an der TU Dortmund (IfADo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.17877/de290r-19098","doi":"https://doi.org/10.17877/de290r-19098","is_oa":true,"landing_page_url":"https://doi.org/10.17877/de290r-19098","pdf_url":null,"source":{"id":"https://openalex.org/S4306400811","display_name":"Technische Universit\u00e4t Dortmund Eldorado (Technische Universit\u00e4t Dortmund)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210148506","host_organization_name":"Erich-Brost-Institut","host_organization_lineage":["https://openalex.org/I4210148506"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"mag:3010204309","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29805346","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:www.excli.de:article/464","doi":null,"is_oa":true,"landing_page_url":"https://www.excli.de/excli/article/view/464","pdf_url":"https://www.excli.de/excli/article/view/464/1277","source":{"id":"https://openalex.org/S39273986","display_name":"EXCLI journal","issn_l":"1611-2156","issn":["1611-2156"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","ddh","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310313779","host_organization_name":"IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund","host_organization_lineage":["https://openalex.org/P4310313779"],"host_organization_lineage_names":["IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"1611-2156","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322626","display_name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","ror":"https://ror.org/04w9kkr77"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3010204309.pdf","grobid_xml":"https://content.openalex.org/works/W3010204309.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1539234395","https://openalex.org/W1836452880","https://openalex.org/W1966803171","https://openalex.org/W1970797634","https://openalex.org/W1994229067","https://openalex.org/W2006718453","https://openalex.org/W2008848849","https://openalex.org/W2012919091","https://openalex.org/W2012962381","https://openalex.org/W2018652769","https://openalex.org/W2034351801","https://openalex.org/W2035809306","https://openalex.org/W2037438916","https://openalex.org/W2038368569","https://openalex.org/W2039952989","https://openalex.org/W2050933562","https://openalex.org/W2062517714","https://openalex.org/W2068380884","https://openalex.org/W2069409989","https://openalex.org/W2079959886","https://openalex.org/W2083263885","https://openalex.org/W2088415033","https://openalex.org/W2089165482","https://openalex.org/W2096491309","https://openalex.org/W2114946540","https://openalex.org/W2118910780","https://openalex.org/W2120316083","https://openalex.org/W2142473971","https://openalex.org/W2145455405","https://openalex.org/W2155884637","https://openalex.org/W2165781463","https://openalex.org/W2169244399","https://openalex.org/W2170582708","https://openalex.org/W2316715165","https://openalex.org/W2395339981","https://openalex.org/W2636036244","https://openalex.org/W2724999050","https://openalex.org/W2742567780","https://openalex.org/W4211089574","https://openalex.org/W4248066024"],"related_works":["https://openalex.org/W7066049952","https://openalex.org/W2267815771","https://openalex.org/W1990866231","https://openalex.org/W4407356459","https://openalex.org/W2135417461","https://openalex.org/W2155884637","https://openalex.org/W3000550329","https://openalex.org/W4415250488","https://openalex.org/W3029909752","https://openalex.org/W1983546164"],"abstract_inverted_index":{"Activation":[0],"of":[1,8,37,61,127,140,158,189,221,229],"the":[2,35,47,58,97,101,117,125,156,172,186,211,218],"Wnt":[3,74,102,196],"signaling":[4,75,103,197],"in":[5,25,34,41,57,70,83,100,107,110,116,137,143,149,177,195,214],"some":[6],"types":[7],"cancer":[9,128],"and":[10,44,73,85,88,146,166,179,192],"its":[11],"relation":[12],"with":[13],"chemotherapy":[14],"resistance":[15,72,129,173,208],"is":[16,30,39,232],"a":[17],"very":[18],"interesting":[19],"issue":[20],"that":[21,32,64,96,185,206],"has":[22,93,203],"been":[23,94,131,200,204],"emphasized":[24],"recent":[26],"years.":[27],"Although,":[28],"it":[29,183],"known":[31],"increase":[33],"activity":[36],"\u03b2-catenin":[38],"important":[40,69,123],"blast":[42],"transformation":[43],"drug":[45,71,176,213],"resistance,":[46],"underlying":[48],"mechanisms":[49],"are":[50,65,105],"still":[51],"unclear.":[52],"In":[53,152],"this":[54],"study,":[55],"changes":[56,109],"expression":[59,138,157,187,219],"levels":[60,139,188,220],"186":[62],"genes":[63,98,142,148,193,223,231],"thought":[66],"to":[67,133,164,174,210],"be":[68,134],"pathways":[76,104,198],"were":[77],"determined":[78],"by":[79],"using":[80],"qPCR":[81],"method":[82],"doxorubicin-sensitive":[84],"-resistant":[86],"HeLa":[87,178],"K562":[89,180],"cell":[90,154,181,216],"lines.":[91],"It":[92,202],"observed":[95],"involved":[99,106,194],"more":[108],"HeLa/Dox":[111,144],"cells":[112,119,145],"(36":[113],"genes)":[114],"than":[115],"K562/Dox":[118,150],"(17":[120],"genes).":[121],"Genes":[122],"for":[124,243],"development":[126],"have":[130,199,224],"found":[132,205],"significantly":[135,162],"different":[136,190,222],"18":[141],"20":[147],"cells.":[151],"both":[153,215],"lines,":[155,182,217],"ABCB1":[159],"gene":[160],"was":[161],"increased":[163],"160":[165],"103":[167],"fold,":[168],"respectively.":[169],"However,":[170],"despite":[171],"same":[175,212],"appears":[184],"oncogenes":[191],"altered.":[201],"although":[207],"develops":[209],"changed.":[225],"If":[226],"functional":[227],"analysis":[228],"these":[230,238],"performed":[233],"on":[234],"patient":[235],"population":[236],"groups,":[237],"molecules":[239],"may":[240],"become":[241],"candidates":[242],"novel":[244],"therapeutic":[245],"target":[246],"molecules.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2020-03-13T00:00:00"}
