{"id":"https://openalex.org/W3010108800","doi":null,"title":"Yes-associated protein 1 promotes bladder cancer invasion by regulating epithelial-mesenchymal transition.","display_name":"Yes-associated protein 1 promotes bladder cancer invasion by regulating epithelial-mesenchymal transition.","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W3010108800","mag":"3010108800","pmid":"https://pubmed.ncbi.nlm.nih.gov/31933921","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6945140"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:5909286","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6945140","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6945140","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108058696","display_name":"Xing-Xing Chen","orcid":"https://orcid.org/0000-0003-1823-318X","observed_orcids":["https://orcid.org/0000-0003-1823-318X"]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]},{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I4210105182","display_name":"Zhuhai People's Hospital","ror":"https://ror.org/01k1x3b35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105182"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xingxing Chen","raw_affiliation_strings":["Department of Urology, Nanfang Hospital, Southern Medical University Guangzhou, P. R. China","Department of Urology, Zhuhai Hospital of Jinan University, Zhuhai People's Hospital Zhuhai, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Nanfang Hospital, Southern Medical University Guangzhou, P. R. China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]},{"raw_affiliation_string":"Department of Urology, Zhuhai Hospital of Jinan University, Zhuhai People's Hospital Zhuhai, P. R. China","institution_ids":["https://openalex.org/I159948400","https://openalex.org/I4210105182"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101509955","display_name":"Shi Li","orcid":"https://orcid.org/0000-0001-5261-2269","observed_orcids":["https://orcid.org/0000-0001-5261-2269"]},"institutions":[{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shi Li","raw_affiliation_strings":["Department of Urology, The First Affiliated Hospital of Wenzhou Medical University Wenzhou, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The First Affiliated Hospital of Wenzhou Medical University Wenzhou, P. R. China","institution_ids":["https://openalex.org/I2801769982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017182695","display_name":"Zhe Yu","orcid":"https://orcid.org/0000-0002-6908-6135","observed_orcids":["https://orcid.org/0000-0002-6908-6135"]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhe Yu","raw_affiliation_strings":["Department of Urology, Nanfang Hospital, Southern Medical University Guangzhou, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Nanfang Hospital, Southern Medical University Guangzhou, P. R. China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101856386","display_name":"Wanlong Tan","orcid":"https://orcid.org/0000-0001-6732-3267","observed_orcids":["https://orcid.org/0000-0001-6732-3267"]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wanlong Tan","raw_affiliation_strings":["Department of Urology, Nanfang Hospital, Southern Medical University Guangzhou, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Nanfang Hospital, Southern Medical University Guangzhou, P. R. China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5416,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.53477218,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"12","issue":"3","first_page":"1070","last_page":"1077"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/yap","display_name":"YAP","score":0.9810000061988831},{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":1.0},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9959999918937683},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.9760000109672546},{"id":"https://openalex.org/keywords/vimentin","display_name":"vimentin","score":0.9100000262260437},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":1.0},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8370000123977661},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6499999761581421},{"id":"https://openalex.org/keywords/sirna-knockdown","display_name":"siRNA knockdown","score":0.8299999833106995}],"concepts":[{"id":"https://openalex.org/C2780219982","wikidata":"https://www.wikidata.org/wiki/Q17544238","display_name":"YAP1","level":4,"score":0.884543776512146},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.8395607471466064},{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.7708076238632202},{"id":"https://openalex.org/C147447768","wikidata":"https://www.wikidata.org/wiki/Q411624","display_name":"Vimentin","level":3,"score":0.7016505599021912},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.6534197926521301},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6470798254013062},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6069387793540955},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5411393642425537},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.4871201515197754},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.42237597703933716},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41854768991470337},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.38692474365234375},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3680345416069031},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25038814544677734},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.17777547240257263},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.151851087808609},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.11048707365989685},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0681973397731781},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:5909286","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6945140","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:31933921","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31933921","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental pathology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6945140","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6945140/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},{"id":"mag:3010108800","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31933921","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5909286","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6945140","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W2006778392","https://openalex.org/W2028593825","https://openalex.org/W2041299023","https://openalex.org/W2064644124","https://openalex.org/W2070058781","https://openalex.org/W2078134150","https://openalex.org/W2082197744","https://openalex.org/W2085197940","https://openalex.org/W2086040324","https://openalex.org/W2089415023","https://openalex.org/W2100842035","https://openalex.org/W2111172225","https://openalex.org/W2114643610","https://openalex.org/W2136423480","https://openalex.org/W2140551998","https://openalex.org/W2151260549","https://openalex.org/W2167978765","https://openalex.org/W2235523093","https://openalex.org/W2312660079","https://openalex.org/W2339383329","https://openalex.org/W2507156929","https://openalex.org/W2741451060","https://openalex.org/W2741823133","https://openalex.org/W2743892039","https://openalex.org/W2779263916","https://openalex.org/W2790117705","https://openalex.org/W2797290792","https://openalex.org/W2802787991","https://openalex.org/W2883118359","https://openalex.org/W2893910941"],"related_works":["https://openalex.org/W4404277223","https://openalex.org/W3177329307","https://openalex.org/W3088130817","https://openalex.org/W3107396303","https://openalex.org/W4387297118","https://openalex.org/W2967480409","https://openalex.org/W4281625714","https://openalex.org/W3182643782","https://openalex.org/W3030527794","https://openalex.org/W2111172225"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"investigate":[2],"the":[3,82,125],"expression":[4,30,49,63,105],"of":[5,31,54,94,127],"Yes-associated":[6],"protein":[7],"1":[8],"(YAP1)":[9],"in":[10,18,22,40,67,98,116,145],"bladder":[11,23,41,71,99,117,128,146],"cancer,":[12],"and":[13,34,43,51,69,81,86,102,112,131,149],"to":[14,140],"study":[15],"its":[16],"role":[17,144],"regulating":[19],"epithelial-mesenchymal":[20,87,135],"transition":[21,88],"cancer":[24,42,72,100,118,129,147],"cells.":[25],"MATERIAL":[26],"AND":[27],"METHODS:":[28],"The":[29,46],"YAP1,":[32],"vimentin,":[33],"E-cadherin":[35],"was":[36,56,64,89],"detected":[37],"by":[38,58],"immunohistochemistry":[39],"para-carcinoma":[44],"tissues.":[45],"relation":[47],"between":[48],"levels":[50,93],"overall":[52,114],"survival":[53,115],"patients":[55],"evaluated":[57],"Kaplan-Meier":[59],"estimates.":[60],"Furthermore,":[61,120],"YAP1":[62,95,104,121,138],"knocked":[65],"down":[66],"T24":[68],"UMUC3":[70],"through":[73],"transfection":[74],"with":[75,108],"YAP1-targeted":[76],"small":[77],"interfering":[78],"RNA":[79],"(siRNA),":[80],"impact":[83],"on":[84],"invasiveness":[85],"detected.":[90],"RESULTS:":[91],"Expression":[92],"were":[96],"higher":[97],"tissues,":[101],"increased":[103],"significantly":[106,123],"correlated":[107],"poor":[109,113],"patient":[110],"outcomes":[111],"patients.":[119],"siRNA":[122],"attenuated":[124],"invasion":[126],"cells":[130],"could":[132],"reverse":[133],"their":[134],"transition.":[136],"CONCLUSION:":[137],"appears":[139],"play":[141],"an":[142],"important":[143],"progression":[148],"is":[150],"highlighted":[151],"as":[152],"a":[153],"novel":[154],"potential":[155],"therapeutic":[156],"target.":[157]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-03-13T00:00:00"}
