{"id":"https://openalex.org/W3010084573","doi":"https://doi.org/10.3390/biom10030382","title":"Reprogramming the Constant Region of Immunoglobulin G Subclasses for Enhanced Therapeutic Potency against Cancer","display_name":"Reprogramming the Constant Region of Immunoglobulin G Subclasses for Enhanced Therapeutic Potency against Cancer","publication_year":2020,"publication_date":"2020-03-01","ids":{"openalex":"https://openalex.org/W3010084573","doi":"https://doi.org/10.3390/biom10030382","mag":"3010084573","pmid":"https://pubmed.ncbi.nlm.nih.gov/32121592","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7175108"},"language":"en","primary_location":{"id":"doi:10.3390/biom10030382","doi":"https://doi.org/10.3390/biom10030382","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/biom10030382","pdf_url":"https://www.mdpi.com/2218-273X/10/3/382/pdf?version=1584959874","source":{"id":"https://openalex.org/S4210236520","display_name":"Biomolecules","issn_l":"2218-273X","issn":["2218-273X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2218-273X/10/3/382/pdf?version=1584959874","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022320636","display_name":"Tae Hyun Kang","orcid":"https://orcid.org/0000-0002-7825-5877","observed_orcids":["https://orcid.org/0000-0002-7825-5877"]},"institutions":[{"id":"https://openalex.org/I110273157","display_name":"Kookmin University","ror":"https://ror.org/0049erg63","country_code":"KR","type":"education","lineage":["https://openalex.org/I110273157"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Tae Hyun Kang","raw_affiliation_strings":["Biopharmaceutical Chemistry Major, School of Applied Chemistry, Kookmin University, Seoul 02707, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biopharmaceutical Chemistry Major, School of Applied Chemistry, Kookmin University, Seoul 02707, Korea","institution_ids":["https://openalex.org/I110273157"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044505570","display_name":"Sang Taek Jung","orcid":"https://orcid.org/0000-0001-7217-979X","observed_orcids":["https://orcid.org/0000-0001-7217-979X"]},"institutions":[{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Sang Taek Jung","raw_affiliation_strings":["Department of Biomedical Sciences, Graduate School of Medicine, Korea University, Seoul 02841, Korea"],"raw_orcid":"https://orcid.org/0000-0001-7217-979X","affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Graduate School of Medicine, Korea University, Seoul 02841, Korea","institution_ids":["https://openalex.org/I197347611"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5044505570"],"corresponding_institution_ids":["https://openalex.org/I197347611"],"apc_list":{"value":1800,"currency":"CHF","value_usd":1901},"apc_paid":{"value":1800,"currency":"CHF","value_usd":1901},"fwci":0.19,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.16115942,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"10","issue":"3","first_page":"382","last_page":"382"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/igg-subclasses","display_name":"IgG subclasses","score":0.8970000147819519},{"id":"https://openalex.org/keywords/antibody-drug-conjugates","display_name":"antibody-drug conjugates","score":0.7919999957084656},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.652999997138977},{"id":"https://openalex.org/keywords/fc-receptors","display_name":"Fc receptors","score":0.8130000233650208},{"id":"https://openalex.org/keywords/igg1","display_name":"IgG1","score":0.8690000176429749},{"id":"https://openalex.org/keywords/igg2","display_name":"IgG2","score":0.8809999823570251},{"id":"https://openalex.org/keywords/igg3","display_name":"IgG3","score":0.9819999933242798},{"id":"https://openalex.org/keywords/igg4","display_name":"IgG4","score":0.9990000128746033},{"id":"https://openalex.org/keywords/effector-function","display_name":"effector function","score":0.6240000128746033},{"id":"https://openalex.org/keywords/antibody-half-life","display_name":"antibody half-life","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.7544841766357422},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6360083222389221},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.617742121219635},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4904155433177948},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4854431748390198},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.45426103472709656},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.43656620383262634},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.4310838282108307},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4215085804462433},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3804028630256653},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.322762131690979},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.26311835646629333},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1265973448753357},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11909931898117065}],"mesh":[{"descriptor_ui":"D000074322","descriptor_name":"Antineoplastic Agents, Immunological","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007127","descriptor_name":"Immunoglobulin Constant Regions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007127","descriptor_name":"Immunoglobulin Constant Regions","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007135","descriptor_name":"Immunoglobulin Variable Region","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007135","descriptor_name":"Immunoglobulin Variable Region","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015202","descriptor_name":"Protein Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018796","descriptor_name":"Immunoconjugates","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018796","descriptor_name":"Immunoconjugates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3390/biom10030382","doi":"https://doi.org/10.3390/biom10030382","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/biom10030382","pdf_url":"https://www.mdpi.com/2218-273X/10/3/382/pdf?version=1584959874","source":{"id":"https://openalex.org/S4210236520","display_name":"Biomolecules","issn_l":"2218-273X","issn":["2218-273X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"journal-article"},{"id":"pmid:32121592","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32121592","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7175108","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7175108/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:6879f4e3eeaa4faea43fa0e501297d4d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6879f4e3eeaa4faea43fa0e501297d4d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomolecules, Vol 10, Iss 3, p 382 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/biom10030382","doi":"https://doi.org/10.3390/biom10030382","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/biom10030382","pdf_url":"https://www.mdpi.com/2218-273X/10/3/382/pdf?version=1584959874","source":{"id":"https://openalex.org/S4210236520","display_name":"Biomolecules","issn_l":"2218-273X","issn":["2218-273X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1338059005","display_name":null,"funder_award_id":"2017M3A9C8060541","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G1780227575","display_name":null,"funder_award_id":"2019R1A4A1029000","funder_id":"https://openalex.org/F4320328359","funder_display_name":"Ministry of Science and ICT, South Korea"},{"id":"https://openalex.org/G3737561125","display_name":null,"funder_award_id":"2019R1A4A1029000","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G4949452136","display_name":null,"funder_award_id":"2019R1F1A1059834","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G8169335062","display_name":null,"funder_award_id":"2019R1F1A1059834","funder_id":"https://openalex.org/F4320328359","funder_display_name":"Ministry of Science and ICT, South Korea"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320328359","display_name":"Ministry of Science and ICT, South Korea","ror":"https://ror.org/01wpjm123"},{"id":"https://openalex.org/F4320330906","display_name":"LG Chem","ror":"https://ror.org/04pjzv747"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3010084573.pdf","grobid_xml":"https://content.openalex.org/works/W3010084573.grobid-xml"},"referenced_works_count":109,"referenced_works":["https://openalex.org/W1494561978","https://openalex.org/W1495576644","https://openalex.org/W1518819083","https://openalex.org/W1529809181","https://openalex.org/W1555361166","https://openalex.org/W1675574531","https://openalex.org/W1809627231","https://openalex.org/W1902692042","https://openalex.org/W1903287340","https://openalex.org/W1912738970","https://openalex.org/W1930879408","https://openalex.org/W1950618346","https://openalex.org/W1966930760","https://openalex.org/W1969771214","https://openalex.org/W1971349333","https://openalex.org/W1971538318","https://openalex.org/W1971724092","https://openalex.org/W1973718144","https://openalex.org/W1973746851","https://openalex.org/W1982861708","https://openalex.org/W1986864699","https://openalex.org/W1990675339","https://openalex.org/W1991656907","https://openalex.org/W2003244776","https://openalex.org/W2004290717","https://openalex.org/W2006710185","https://openalex.org/W2009109361","https://openalex.org/W2010329820","https://openalex.org/W2011984976","https://openalex.org/W2017873446","https://openalex.org/W2018187711","https://openalex.org/W2020744745","https://openalex.org/W2034408745","https://openalex.org/W2037840717","https://openalex.org/W2038319340","https://openalex.org/W2041944580","https://openalex.org/W2042105881","https://openalex.org/W2042995283","https://openalex.org/W2050656150","https://openalex.org/W2055508595","https://openalex.org/W2061895065","https://openalex.org/W2068367973","https://openalex.org/W2068544809","https://openalex.org/W2072488277","https://openalex.org/W2074819793","https://openalex.org/W2075563259","https://openalex.org/W2075901113","https://openalex.org/W2078060454","https://openalex.org/W2080453088","https://openalex.org/W2081362512","https://openalex.org/W2086542713","https://openalex.org/W2086695584","https://openalex.org/W2089036873","https://openalex.org/W2090045809","https://openalex.org/W2091291743","https://openalex.org/W2093572741","https://openalex.org/W2100612316","https://openalex.org/W2104088439","https://openalex.org/W2110990893","https://openalex.org/W2112121482","https://openalex.org/W2115790682","https://openalex.org/W2117281169","https://openalex.org/W2120319857","https://openalex.org/W2121107218","https://openalex.org/W2128035403","https://openalex.org/W2128402413","https://openalex.org/W2128758225","https://openalex.org/W2134861285","https://openalex.org/W2137354517","https://openalex.org/W2143562636","https://openalex.org/W2146621458","https://openalex.org/W2160264356","https://openalex.org/W2166199281","https://openalex.org/W2166662937","https://openalex.org/W2168313542","https://openalex.org/W2284695989","https://openalex.org/W2303425311","https://openalex.org/W2345882213","https://openalex.org/W2409420104","https://openalex.org/W2410740967","https://openalex.org/W2425174489","https://openalex.org/W2465158514","https://openalex.org/W2549757281","https://openalex.org/W2560676548","https://openalex.org/W2587048937","https://openalex.org/W2587357756","https://openalex.org/W2596270747","https://openalex.org/W2610837173","https://openalex.org/W2612649234","https://openalex.org/W2614968685","https://openalex.org/W2616844168","https://openalex.org/W2674712403","https://openalex.org/W2757533087","https://openalex.org/W2767839389","https://openalex.org/W2769227721","https://openalex.org/W2792557198","https://openalex.org/W2798249501","https://openalex.org/W2801217997","https://openalex.org/W2810851878","https://openalex.org/W2885922569","https://openalex.org/W2896514092","https://openalex.org/W2897902093","https://openalex.org/W2912715649","https://openalex.org/W2918139903","https://openalex.org/W2922370696","https://openalex.org/W2925727197","https://openalex.org/W2963479022","https://openalex.org/W2988983475","https://openalex.org/W4230744147"],"related_works":["https://openalex.org/W2165437317","https://openalex.org/W3021099711","https://openalex.org/W2560676548","https://openalex.org/W4285086235","https://openalex.org/W2610782592","https://openalex.org/W2549403474","https://openalex.org/W4389436431","https://openalex.org/W7203820043","https://openalex.org/W4414891338","https://openalex.org/W13033643"],"abstract_inverted_index":{"The":[0],"constant":[1,45,73,82,134],"region":[2,24,46,74,83,135],"of":[3,43,51,59,75,94,131,136,142],"immunoglobulin":[4],"(Ig)":[5],"G":[6],"antibodies":[7],"is":[8,25],"responsible":[9,26],"for":[10,27,35,96,109],"their":[11],"effector":[12],"immune":[13],"mechanism":[14],"and":[15,47,67,79,118,127],"prolongs":[16],"serum":[17],"half-life,":[18],"while":[19],"the":[20,44,52,56,72,81,133,140],"fragment":[21],"variable":[22],"(Fv)":[23],"cellular":[28],"or":[29,49],"tissue":[30],"targeting.":[31],"Therefore,":[32],"antibody":[33,62,143],"engineering":[34],"cancer":[36,97,110,147],"therapeutics":[37],"focuses":[38],"on":[39,71,123],"both":[40,65],"functional":[41,57],"efficacy":[42,87,141],"tissue-":[48],"cell-specificity":[50],"Fv":[53],"region.":[54],"In":[55,102],"aspect":[58],"therapeutic":[60,86],"purposes,":[61],"engineers":[63],"in":[64,99,146],"academia":[66],"industry":[68],"have":[69],"capitalized":[70],"different":[76],"IgG":[77,107,137],"subclasses":[78,108],"engineered":[80],"to":[84,91,138],"enhance":[85],"against":[88],"cancer,":[89],"leading":[90],"a":[92],"number":[93],"successes":[95],"patients":[98],"clinical":[100],"settings.":[101],"this":[103],"article,":[104],"we":[105],"review":[106],"therapeutics,":[111],"including":[112],"i)":[113],"IgG1,":[114],"ii)":[115],"IgG2,":[116],"3,":[117],"4,":[119],"iii)":[120],"recent":[121],"findings":[122],"Fc":[124],"receptor":[125],"functions,":[126],"iv)":[128],"future":[129],"directions":[130],"reprogramming":[132],"maximize":[139],"drug":[144],"molecules":[145],"patients.":[148]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-03-13T00:00:00"}
