{"id":"https://openalex.org/W3009718752","doi":null,"title":"Blocking follistatin-like 1 attenuates liver fibrosis in mice by regulating transforming growth factor-beta signaling.","display_name":"Blocking follistatin-like 1 attenuates liver fibrosis in mice by regulating transforming growth factor-beta signaling.","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W3009718752","mag":"3009718752","pmid":"https://pubmed.ncbi.nlm.nih.gov/31938206","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6958153"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6958153","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6958153","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6958153","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100445811","display_name":"Xiaohua Zhang","orcid":"https://orcid.org/0000-0002-8311-6898","observed_orcids":["https://orcid.org/0000-0002-8311-6898"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210116517","display_name":"Shandong Provincial Hospital","ror":"https://ror.org/02ar2nf05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-Hua Zhang","raw_affiliation_strings":["Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong University Jinan, Shandong Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong University Jinan, Shandong Province, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210116517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002600613","display_name":"Yong Chen","orcid":"https://orcid.org/0000-0003-4269-8518","observed_orcids":["https://orcid.org/0000-0003-4269-8518"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210116517","display_name":"Shandong Provincial Hospital","ror":"https://ror.org/02ar2nf05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yong Chen","raw_affiliation_strings":["Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong University Jinan, Shandong Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong University Jinan, Shandong Province, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210116517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100756326","display_name":"Bin Li","orcid":"https://orcid.org/0000-0002-8607-8874","observed_orcids":["https://orcid.org/0000-0002-8607-8874"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210116517","display_name":"Shandong Provincial Hospital","ror":"https://ror.org/02ar2nf05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Li","raw_affiliation_strings":["Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong University Jinan, Shandong Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong University Jinan, Shandong Province, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210116517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030014001","display_name":"Jiyong Liu","orcid":"https://orcid.org/0000-0003-0444-957X","observed_orcids":["https://orcid.org/0000-0003-0444-957X"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210116517","display_name":"Shandong Provincial Hospital","ror":"https://ror.org/02ar2nf05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ji-Yong Liu","raw_affiliation_strings":["Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong University Jinan, Shandong Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong University Jinan, Shandong Province, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210116517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100298003","display_name":"Chong-Mei Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210116517","display_name":"Shandong Provincial Hospital","ror":"https://ror.org/02ar2nf05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chong-Mei Yang","raw_affiliation_strings":["Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong University Jinan, Shandong Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong University Jinan, Shandong Province, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210116517"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012793599","display_name":"Mingze Ma","orcid":"https://orcid.org/0009-0004-5925-538X","observed_orcids":["https://orcid.org/0009-0004-5925-538X"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210116517","display_name":"Shandong Provincial Hospital","ror":"https://ror.org/02ar2nf05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ming-Ze Ma","raw_affiliation_strings":["Department of Infectious Diseases, Shandong Provincial Hospital Affiliated to Shandong University Jinan, Shandong Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Shandong Provincial Hospital Affiliated to Shandong University Jinan, Shandong Province, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210116517"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1422,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.55104116,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"11","issue":"3","first_page":"1112","last_page":"1122"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fstl1","display_name":"FSTL1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.9750000238418579},{"id":"https://openalex.org/keywords/hepatic-stellate-cell-activation","display_name":"hepatic stellate cell activation","score":0.8960000276565552},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.8920000195503235},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.8370000123977661},{"id":"https://openalex.org/keywords/collagen-type-i-alpha-1","display_name":"collagen type I alpha 1","score":0.7179999947547913},{"id":"https://openalex.org/keywords/neutralizing-antibodies","display_name":"neutralizing antibodies","score":0.871999979019165},{"id":"https://openalex.org/keywords/carbon-tetrachloride","display_name":"carbon tetrachloride","score":0.9039999842643738},{"id":"https://openalex.org/keywords/thioacetamide","display_name":"thioacetamide","score":0.9860000014305115},{"id":"https://openalex.org/keywords/stellate-cell-proliferation","display_name":"stellate cell proliferation","score":0.7829999923706055}],"concepts":[{"id":"https://openalex.org/C176891718","wikidata":"https://www.wikidata.org/wiki/Q1997459","display_name":"Hepatic stellate cell","level":2,"score":0.9643197059631348},{"id":"https://openalex.org/C2778831791","wikidata":"https://www.wikidata.org/wiki/Q408122","display_name":"Follistatin","level":2,"score":0.9400396347045898},{"id":"https://openalex.org/C2779770810","wikidata":"https://www.wikidata.org/wiki/Q23069155","display_name":"Sirius Red","level":3,"score":0.6932732462882996},{"id":"https://openalex.org/C2993667909","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Hepatic fibrosis","level":3,"score":0.65818190574646},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.5686434507369995},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.554033637046814},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5464015603065491},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5271287560462952},{"id":"https://openalex.org/C2781057625","wikidata":"https://www.wikidata.org/wiki/Q416253","display_name":"Thioacetamide","level":2,"score":0.5231853127479553},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4661954939365387},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3388552665710449},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21993494033813477},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.17190244793891907},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0884363055229187}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:6958153","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6958153","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},{"id":"pmid:31938206","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31938206","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental pathology","raw_type":"Journal Article"},{"id":"mag:3009718752","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31938206","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6958153","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6958153","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1846286601","https://openalex.org/W1856330428","https://openalex.org/W1863081076","https://openalex.org/W1893137314","https://openalex.org/W1979627163","https://openalex.org/W1989794180","https://openalex.org/W1995316564","https://openalex.org/W2002641607","https://openalex.org/W2014873058","https://openalex.org/W2023644659","https://openalex.org/W2026262705","https://openalex.org/W2031640133","https://openalex.org/W2042250615","https://openalex.org/W2047688382","https://openalex.org/W2054332232","https://openalex.org/W2079036008","https://openalex.org/W2080175347","https://openalex.org/W2099676796","https://openalex.org/W2100159558","https://openalex.org/W2118682137","https://openalex.org/W2120821168","https://openalex.org/W2138499387","https://openalex.org/W2168458474","https://openalex.org/W2173937422","https://openalex.org/W2174883334","https://openalex.org/W2175210850","https://openalex.org/W2177602167","https://openalex.org/W2182271660","https://openalex.org/W2196087732","https://openalex.org/W2196306129","https://openalex.org/W2196788724","https://openalex.org/W2201301173","https://openalex.org/W2202766849","https://openalex.org/W2208938692","https://openalex.org/W2218473508","https://openalex.org/W2218524235","https://openalex.org/W2219635718","https://openalex.org/W2221013699","https://openalex.org/W2221197034","https://openalex.org/W2253854241","https://openalex.org/W2256440089","https://openalex.org/W2258170482","https://openalex.org/W2294542771","https://openalex.org/W2409720748","https://openalex.org/W2412931541","https://openalex.org/W2413974049","https://openalex.org/W2417480590","https://openalex.org/W2464899799"],"related_works":["https://openalex.org/W2753628094","https://openalex.org/W3084871782","https://openalex.org/W6958425548","https://openalex.org/W2110858177","https://openalex.org/W2098144345","https://openalex.org/W3172347218","https://openalex.org/W3160080010","https://openalex.org/W4394002660","https://openalex.org/W3088774412","https://openalex.org/W6928951653"],"abstract_inverted_index":{"AIM:":[0],"To":[1],"elucidate":[2],"the":[3,43,82,96],"effect":[4,94,136],"of":[5,14,34,42,76,95,105,137],"inhibiting":[6],"follistatin-like":[7,24,97,121,138],"1":[8,25,98,122,139],"on":[9,101,140],"liver":[10,39,124,141],"fibrosis":[11,77,125,142],"and":[12,53,74,90,103,113,126],"activation":[13],"hepatic":[15,58,106,131],"stellate":[16,59,107,132],"cells":[17,60,108],"in":[18,36,45,78,130,149],"mice.":[19],"METHODS:":[20],"We":[21],"generated":[22],"a":[23,128],"neutralizing":[26,99],"antibody":[27,100],"that":[28],"can":[29],"inhibit":[30],"TGF-\u03b2":[31],"1-induced":[32],"expression":[33],"collagen1\u03b11":[35],"primary":[37,57],"mouse":[38,79],"fibroblasts.":[40],"All":[41],"mice":[44,62],"our":[46],"study":[47],"were":[48,63,85],"induced":[49],"with":[50],"carbon":[51],"tetrachloride":[52],"thioacetamide.":[54],"In":[55],"addition,":[56],"from":[61,65,81],"isolated":[64],"fresh":[66],"livers":[67,80],"using":[68,111],"density":[69],"gradient":[70],"separation.":[71],"The":[72,93,135],"degree":[73],"extent":[75],"different":[83],"groups":[84],"evaluated":[86],"by":[87],"Sirius":[88],"Red":[89],"Masson":[91],"staining.":[92],"proliferation":[102],"migration":[104],"was":[109],"detected":[110],"CCK-8":[112],"Transwell":[114],"assays,":[115],"respectively.":[116],"RESULTS:":[117],".":[118],"CONCLUSIONS:":[119],"Inhibiting":[120],"attenuates":[123],"causes":[127],"delay":[129],"cell":[133],"activation.":[134],"is":[143],"mainly":[144],"attributed":[145],"to":[146],"its":[147],"role":[148],"regulating":[150],"TGF-beta":[151],"signaling.":[152]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2020-03-13T00:00:00"}