{"id":"https://openalex.org/W3009607961","doi":"https://doi.org/10.1089/thy.2019.0301","title":"BRAF V600E Transduction of an SV40-Immortalized Normal Human Thyroid Cell Line Induces Dedifferentiated Thyroid Carcinogenesis in a Mouse Xenograft Model","display_name":"BRAF V600E Transduction of an SV40-Immortalized Normal Human Thyroid Cell Line Induces Dedifferentiated Thyroid Carcinogenesis in a Mouse Xenograft Model","publication_year":2020,"publication_date":"2020-03-03","ids":{"openalex":"https://openalex.org/W3009607961","doi":"https://doi.org/10.1089/thy.2019.0301","mag":"3009607961","pmid":"https://pubmed.ncbi.nlm.nih.gov/32122255"},"language":"en","primary_location":{"id":"doi:10.1089/thy.2019.0301","doi":"https://doi.org/10.1089/thy.2019.0301","is_oa":false,"landing_page_url":"https://doi.org/10.1089/thy.2019.0301","pdf_url":null,"source":{"id":"https://openalex.org/S27569427","display_name":"Thyroid","issn_l":"1050-7256","issn":["1050-7256","1557-9077"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thyroid","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/190141","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100406595","display_name":"Minjun Kim","orcid":"https://orcid.org/0000-0002-0165-5282","observed_orcids":["https://orcid.org/0000-0002-0165-5282"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Minjun Kim","raw_affiliation_strings":["Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100401516","display_name":"Su\u2010jin Kim","orcid":"https://orcid.org/0000-0001-5511-3596","observed_orcids":["https://orcid.org/0000-0001-5511-3596"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I4405261737","display_name":"Seoul National University Cancer Hospital","ror":"https://ror.org/05rwxjy27","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I4405261737"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Su-jin Kim","raw_affiliation_strings":["Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea","Department of Surgery, Seoul National University College of Medicine, Seoul, Republic of Korea","Division of Surgery, Thyroid Center, Seoul National University Cancer Hospital, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Department of Surgery, Seoul National University College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Division of Surgery, Thyroid Center, Seoul National University Cancer Hospital, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I4405261737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101935763","display_name":"Zhen Xu","orcid":"https://orcid.org/0000-0001-8346-1539","observed_orcids":["https://orcid.org/0000-0001-8346-1539"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I4210131149","display_name":"Yanbian University Hospital","ror":"https://ror.org/037ve0v69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131149"]}],"countries":["CN","KR"],"is_corresponding":false,"raw_author_name":"Zhen Xu","raw_affiliation_strings":["Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea","Department of Surgery, YanBian University Hospital, Yanji, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Department of Surgery, YanBian University Hospital, Yanji, China","institution_ids":["https://openalex.org/I4210131149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074582144","display_name":"Seong Yun Ha","orcid":"https://orcid.org/0000-0002-9937-1180","observed_orcids":["https://orcid.org/0000-0002-9937-1180"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seong Yun Ha","raw_affiliation_strings":["Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085542751","display_name":"Jae Hwan Byeon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jae Hwan Byeon","raw_affiliation_strings":["Department of Statistics, Yonsei Graduate School of Public Health, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, Yonsei Graduate School of Public Health, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I193775966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110391600","display_name":"Eun Ji Kang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eun Ji Kang","raw_affiliation_strings":["Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101049920","display_name":"Seung-Hyun Shin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seung-Hyun Shin","raw_affiliation_strings":["Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033460268","display_name":"Seong\u2010Keun Yoo","orcid":"https://orcid.org/0000-0002-8749-7050","observed_orcids":["https://orcid.org/0000-0002-8749-7050"]},"institutions":[{"id":"https://openalex.org/I4210129256","display_name":"Macrogen (South Korea)","ror":"https://ror.org/03qan5r71","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210129256"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seong-Keun Yoo","raw_affiliation_strings":["Precision Medicine Institute, Macrogen, Inc., Seongnam, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Precision Medicine Institute, Macrogen, Inc., Seongnam, Republic of Korea","institution_ids":["https://openalex.org/I4210129256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019793254","display_name":"Hyeon\u2010Gun Jee","orcid":"https://orcid.org/0000-0002-5770-7416","observed_orcids":["https://orcid.org/0000-0002-5770-7416"]},"institutions":[{"id":"https://openalex.org/I2803058125","display_name":"Seoul National University Bundang Hospital","ror":"https://ror.org/00cb3km46","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I2803058125"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyeon-Gun Jee","raw_affiliation_strings":["Healthcare Innovation Park, Seoul National University Bundang Hospital, Seongnam, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Healthcare Innovation Park, Seoul National University Bundang Hospital, Seongnam, Republic of Korea","institution_ids":["https://openalex.org/I2803058125"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000798470","display_name":"Sang Gab Yoon","orcid":"https://orcid.org/0000-0001-5517-0507","observed_orcids":["https://orcid.org/0000-0001-5517-0507"]},"institutions":[{"id":"https://openalex.org/I2801674040","display_name":"Kosin University Gospel Hospital","ror":"https://ror.org/02xkmx604","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801674040"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sang Gab Yoon","raw_affiliation_strings":["Department of Surgery, Kosin University Gospel Hospital, Busan, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Kosin University Gospel Hospital, Busan, Republic of Korea","institution_ids":["https://openalex.org/I2801674040"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074538791","display_name":"Jin Wook Yi","orcid":"https://orcid.org/0000-0002-9296-8443","observed_orcids":["https://orcid.org/0000-0002-9296-8443"]},"institutions":[{"id":"https://openalex.org/I191879574","display_name":"Inha University","ror":"https://ror.org/01easw929","country_code":"KR","type":"education","lineage":["https://openalex.org/I191879574"]},{"id":"https://openalex.org/I4210153373","display_name":"Inha University Hospital","ror":"https://ror.org/04gj5px28","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I191879574","https://openalex.org/I4210153373"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jin Wook Yi","raw_affiliation_strings":["Department of Surgery, Inha University Hospital, Incheon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Inha University Hospital, Incheon, Republic of Korea","institution_ids":["https://openalex.org/I191879574","https://openalex.org/I4210153373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056013655","display_name":"Jeong Mo Bae","orcid":"https://orcid.org/0000-0003-0462-3072","observed_orcids":["https://orcid.org/0000-0003-0462-3072"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jeong Mo Bae","raw_affiliation_strings":["Department of Pathology, Seoul National University College of Medicine, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Seoul National University College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024301679","display_name":"Hyeong Won Yu","orcid":"https://orcid.org/0000-0001-7338-5157","observed_orcids":["https://orcid.org/0000-0001-7338-5157"]},"institutions":[{"id":"https://openalex.org/I2803058125","display_name":"Seoul National University Bundang Hospital","ror":"https://ror.org/00cb3km46","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I2803058125"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyeong Won Yu","raw_affiliation_strings":["Department of Surgery, Seoul National University Bundang Hospital, Seongnam, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Seoul National University Bundang Hospital, Seongnam, Republic of Korea","institution_ids":["https://openalex.org/I2803058125"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014614923","display_name":"Young Jun Chai","orcid":"https://orcid.org/0000-0001-8830-3433","observed_orcids":["https://orcid.org/0000-0001-8830-3433"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I4210100437","display_name":"SNUH SMG-SNU Boramae Medical Center","ror":"https://ror.org/014xqzt56","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I4210100437"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Young Jun Chai","raw_affiliation_strings":["Department of Surgery, Seoul National University Boramae Medical Center, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Seoul National University Boramae Medical Center, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I4210100437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030607871","display_name":"Sun Wook Cho","orcid":"https://orcid.org/0000-0002-7394-3830","observed_orcids":["https://orcid.org/0000-0002-7394-3830"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sun Wook Cho","raw_affiliation_strings":["Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023512903","display_name":"June Young Choi","orcid":"https://orcid.org/0000-0001-9990-607X","observed_orcids":["https://orcid.org/0000-0001-9990-607X","https://orcid.org/0000-0001-8830-3433"]},"institutions":[{"id":"https://openalex.org/I2803058125","display_name":"Seoul National University Bundang Hospital","ror":"https://ror.org/00cb3km46","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I2803058125"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"June Young Choi","raw_affiliation_strings":["Department of Surgery, Seoul National University Bundang Hospital, Seongnam, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Seoul National University Bundang Hospital, Seongnam, Republic of Korea","institution_ids":["https://openalex.org/I2803058125"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082709788","display_name":"Kyu Eun Lee","orcid":"https://orcid.org/0000-0002-2354-3599","observed_orcids":["https://orcid.org/0000-0002-2354-3599"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I4405261737","display_name":"Seoul National University Cancer Hospital","ror":"https://ror.org/05rwxjy27","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I4405261737"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Kyu Eun Lee","raw_affiliation_strings":["Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea","Department of Surgery, Seoul National University College of Medicine, Seoul, Republic of Korea","Division of Surgery, Thyroid Center, Seoul National University Cancer Hospital, Seoul, Republic of Korea","Kyu Eun Lee, MD, PhD, Department of Surgery, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Department of Surgery, Seoul National University College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Division of Surgery, Thyroid Center, Seoul National University Cancer Hospital, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I4405261737"]},{"raw_affiliation_string":"Kyu Eun Lee, MD, PhD, Department of Surgery, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005022842","display_name":"Wonshik Han","orcid":"https://orcid.org/0000-0001-7310-0764","observed_orcids":["https://orcid.org/0000-0001-7310-0764"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Wonshik Han","raw_affiliation_strings":["Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea","Department of Surgery, Seoul National University College of Medicine, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Department of Surgery, Seoul National University College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5056013655","https://openalex.org/A5082709788"],"corresponding_institution_ids":["https://openalex.org/I139264467","https://openalex.org/I4405261737"],"apc_list":null,"apc_paid":null,"fwci":1.4442,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.81998998,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"30","issue":"4","first_page":"487","last_page":"500"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/braf-v600e-mutation","display_name":"BRAF V600E mutation","score":0.9139999747276306},{"id":"https://openalex.org/keywords/thyroid-carcinogenesis","display_name":"thyroid carcinogenesis","score":0.7670000195503235},{"id":"https://openalex.org/keywords/lentiviral-transduction","display_name":"lentiviral transduction","score":0.7820000052452087},{"id":"https://openalex.org/keywords/mouse-xenograft-model","display_name":"xenograft mouse model","score":0.75},{"id":"https://openalex.org/keywords/vemurafenib","display_name":"vemurafenib","score":0.9049999713897705},{"id":"https://openalex.org/keywords/anaplastic-thyroid-carcinoma","display_name":"anaplastic thyroid carcinoma","score":0.8410000205039978},{"id":"https://openalex.org/keywords/transcriptome","display_name":"transcriptome","score":0.39899998903274536},{"id":"https://openalex.org/keywords/g1-s-cell-cycle-regulation","display_name":"G1/S cell cycle regulation","score":0.7509999871253967},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.9020000100135803},{"id":"https://openalex.org/keywords/differentially-expressed-genes","display_name":"differentially expressed genes","score":0.5870000123977661}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7958275079727173},{"id":"https://openalex.org/C2779761222","wikidata":"https://www.wikidata.org/wiki/Q826522","display_name":"Thyroid cancer","level":3,"score":0.6531152129173279},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6220331788063049},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5681144595146179},{"id":"https://openalex.org/C2781461381","wikidata":"https://www.wikidata.org/wiki/Q2292945","display_name":"Papillary thyroid cancer","level":4,"score":0.4989161491394043},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4412732422351837},{"id":"https://openalex.org/C2777605378","wikidata":"https://www.wikidata.org/wiki/Q3271319","display_name":"Cyclopamine","level":4,"score":0.4315493404865265},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.4172615110874176},{"id":"https://openalex.org/C2780256643","wikidata":"https://www.wikidata.org/wiki/Q3658382","display_name":"Anaplastic thyroid cancer","level":4,"score":0.41670578718185425},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3589168190956116},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3019408583641052},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2691483199596405},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.17461732029914856},{"id":"https://openalex.org/C88498014","wikidata":"https://www.wikidata.org/wiki/Q14859918","display_name":"Hedgehog signaling pathway","level":3,"score":0.09459191560745239},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09083449840545654},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06881281733512878}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013961","descriptor_name":"Thyroid Gland","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013961","descriptor_name":"Thyroid Gland","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013961","descriptor_name":"Thyroid Gland","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014161","descriptor_name":"Transduction, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014161","descriptor_name":"Transduction, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014161","descriptor_name":"Transduction, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048493","descriptor_name":"Proto-Oncogene Proteins B-raf","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048493","descriptor_name":"Proto-Oncogene Proteins B-raf","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048493","descriptor_name":"Proto-Oncogene Proteins B-raf","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054337","descriptor_name":"Cell Dedifferentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054337","descriptor_name":"Cell Dedifferentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054337","descriptor_name":"Cell Dedifferentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D064593","descriptor_name":"Heterografts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064593","descriptor_name":"Heterografts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064593","descriptor_name":"Heterografts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1089/thy.2019.0301","doi":"https://doi.org/10.1089/thy.2019.0301","is_oa":false,"landing_page_url":"https://doi.org/10.1089/thy.2019.0301","pdf_url":null,"source":{"id":"https://openalex.org/S27569427","display_name":"Thyroid","issn_l":"1050-7256","issn":["1050-7256","1557-9077"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thyroid","raw_type":"journal-article"},{"id":"pmid:32122255","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32122255","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thyroid : official journal of the American Thyroid Association","raw_type":"Journal Article"},{"id":"pmh:oai:ir.ymlib.yonsei.ac.kr:22282913/190141","doi":null,"is_oa":true,"landing_page_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/190141","pdf_url":null,"source":{"id":"https://openalex.org/S4306400691","display_name":"YUHSpace (Yonsei University Medical Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193775966","host_organization_name":"Yonsei University","host_organization_lineage":["https://openalex.org/I193775966"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:ir.ymlib.yonsei.ac.kr:22282913/190141","doi":null,"is_oa":true,"landing_page_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/190141","pdf_url":null,"source":{"id":"https://openalex.org/S4306400691","display_name":"YUHSpace (Yonsei University Medical Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193775966","host_organization_name":"Yonsei University","host_organization_lineage":["https://openalex.org/I193775966"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.5600000023841858,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1640319908","https://openalex.org/W1848939527","https://openalex.org/W1959323200","https://openalex.org/W1966426874","https://openalex.org/W1968134619","https://openalex.org/W1977731422","https://openalex.org/W1979051583","https://openalex.org/W1991662589","https://openalex.org/W2001692133","https://openalex.org/W2007483903","https://openalex.org/W2020748099","https://openalex.org/W2026646284","https://openalex.org/W2029192858","https://openalex.org/W2033787149","https://openalex.org/W2053432671","https://openalex.org/W2056023468","https://openalex.org/W2062493935","https://openalex.org/W2083394284","https://openalex.org/W2083426515","https://openalex.org/W2099281944","https://openalex.org/W2101888941","https://openalex.org/W2102146456","https://openalex.org/W2102278945","https://openalex.org/W2104005232","https://openalex.org/W2109994599","https://openalex.org/W2112555367","https://openalex.org/W2113825024","https://openalex.org/W2130662884","https://openalex.org/W2140777372","https://openalex.org/W2144465725","https://openalex.org/W2146428402","https://openalex.org/W2149000868","https://openalex.org/W2155009866","https://openalex.org/W2164436574","https://openalex.org/W2288903023","https://openalex.org/W2478132860","https://openalex.org/W2549942421","https://openalex.org/W2565422934","https://openalex.org/W2607160786","https://openalex.org/W2766581537","https://openalex.org/W2795875131","https://openalex.org/W2800908431","https://openalex.org/W2806967085","https://openalex.org/W2887928126","https://openalex.org/W2913765486","https://openalex.org/W2939930136","https://openalex.org/W3021763136"],"related_works":["https://openalex.org/W3150664920","https://openalex.org/W2070989607","https://openalex.org/W2758931657","https://openalex.org/W3197851477","https://openalex.org/W2143434569","https://openalex.org/W2028411003","https://openalex.org/W2885464665","https://openalex.org/W2409558739","https://openalex.org/W3160097740","https://openalex.org/W3022228189"],"abstract_inverted_index":{"Background:":[0],"Despite":[1],"active":[2],"studies":[3,246],"of":[4,8,17,23,71,92,229,247,252],"the":[5,15,21,36,68,93,160,177,199,226,248],"clinical":[6],"importance":[7],"BRAFV600E,":[9],"suitable":[10],"research":[11],"models":[12],"to":[13,66,243,245],"investigate":[14],"role":[16,70,224],"this":[18],"mutation":[19,94],"in":[20,132,140,159,225],"etiopathogenesis":[22,249],"human":[24,41,234],"thyroid":[25,42,154,190,195,235,255],"cancers":[26],"are":[27],"limited.":[28],"Thus,":[29],"we":[30],"generated":[31],"cell":[32,43,75,181,200,236],"lines":[33],"by":[34,98,109,203],"transducing":[35],"simian":[37],"virus":[38],"(SV)-40":[39],"immortalized":[40,232],"line":[44,76],"Nthy-ori":[45],"3-1":[46],"(Nthy)":[47],"with":[48,114,188,193],"lentiviral":[49],"vectors":[50],"expressing":[51],"either":[52],"BRAFWT":[53],"(Nthy/WT)":[54],"or":[55],"BRAFV600E.":[56,72],"Nthy/WT":[57,128],"and":[58,84,112,122,163,179,183,213,250],"Nthy/V600E":[59,134,150],"cells":[60],"were":[61,95,152,186],"then":[62],"xenografted":[63],"into":[64,80],"mice":[65],"evaluate":[67],"carcinogenic":[69,227],"Methods:":[73],"Each":[74],"was":[77,88,107,129],"subcutaneously":[78],"injected":[79],"NOD.Cg-Prkdcscid":[81],"Il2rgtm1Wjl/SzJ":[82],"mice,":[83],"a":[85,100,222],"pathological":[86,146],"analysis":[87,147,169],"performed.":[89],"The":[90,105,117],"effects":[91],"further":[96],"verified":[97],"using":[99],"BRAFV600E-selective":[101],"inhibitor":[102],"(PLX-4032,":[103],"vemurafenib).":[104],"transcriptome":[106],"analyzed":[108],"RNA":[110],"sequencing":[111],"compared":[113],"data":[115,217],"from":[116],"Cancer":[118],"Cell":[119],"Line":[120],"Encyclopedia":[121],"Gene":[123],"Expression":[124],"Omnibus.":[125],"Results:":[126],"While":[127],"not":[130],"tumorigenic":[131],"vivo,":[133],"formed":[135],"tumors":[136,151],"reaching":[137],"2784.343":[138],"mm3":[139],"4":[141],"weeks,":[142],"on":[143],"average.":[144],"A":[145,167],"indicated":[148],"that":[149,219],"dedifferentiated":[153],"cancer.":[155,196],"We":[156],"found":[157],"metastases":[158],"lung,":[161],"liver,":[162],"relevant":[164],"lymph":[165],"nodes.":[166],"transcriptomic":[168],"revealed":[170],"5512":[171],"differentially":[172],"expressed":[173],"genes":[174],"(DEGs)":[175],"between":[176],"mutant":[178],"wild-type":[180],"lines,":[182],"more":[184],"DEGs":[185],"shared":[187],"anaplastic":[189],"cancer":[191],"than":[192],"papillary":[194],"BRAFV600E":[197,220],"activated":[198],"cycle":[201],"mainly":[202],"regulating":[204],"G1/S":[205],"phases.":[206],"PLX-4032":[207],"treatment":[208,251],"significantly":[209],"inhibited":[210],"tumor":[211],"growth":[212],"metastasis.":[214],"Conclusions:":[215],"Our":[216],"show":[218],"plays":[221],"pivotal":[223],"transformation":[228],"an":[230],"SV40-transfected":[231],"normal":[233],"line.":[237],"This":[238],"xenograft":[239],"model":[240],"is":[241],"expected":[242],"contribute":[244],"highly":[253],"malignant":[254],"cancers.":[256]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2025-10-10T00:00:00"}